Click here to switch to the map view.

The map label for this gene is vanR [H]

Identifier: 170757016

GI number: 170757016

Start: 3641678

End: 3642370

Strand: Reverse

Name: vanR [H]

Synonym: CLD_1171

Alternate gene names: 170757016

Gene position: 3642370-3641678 (Counterclockwise)

Preceding gene: 170755018

Following gene: 170756242

Centisome position: 92.02

GC content: 27.71

Gene sequence:

>693_bases
TTGAGTTATAAAATATTAATAGTAGATGATGATAAGACCATAGTAGAATTTTTACAAATATTTTTAATTAAAGAAGGGTA
TGAGGTAAGGATTTCTTATAATGGAGAAGAGGCTTTAGATAAAATAAGAAGTGAACAATTTAATTTGATTCTAATGGATA
TAATGATGCCTAAATTAGATGGATTTGAAGCTATTAAAAGAATAAGAAAACTTACCAATATTCCTATTATATTTTTAACT
GCAAAAGATAGTCAGCAAGATAAAATTAAAGGCTTTATTTCTGGATGTGACGACTACATAACAAAGCCCTTTGATTTAGT
AGAGCTTTCTTTAAGAGTGTCCGCTATACTTAAAAGAGTTAGCACAAGTGTAGCTGAAGAAAATAAGGATATTATAAAAG
TAAAGGATTTAGAATTAAATTTAAAAGAGCACACATTATATAAAGAAAAAAATGAAATAAAGCTTACTCCAAAGGAATTT
GACATTTTATTTTTGCTTGCTAGAAATAAGGGAAGAATTTTTCCTTCAAGTGAGATATATGAAAGGGTATGGGGACAAGA
ATTTTTAGAAAATGACAATAGCTTGTTGACCCATATTAGAAATTTAAGAGAAAAGCTAAGTGATACTGTAAAAAACTCAA
AATACATTAAAACTGTTTGGGGAGTGGGTTATAAGATTGAAAAGGAAGCTTAG

Upstream 100 bases:

>100_bases
GATGCATTTTAAATAACTTATTTGGCACAGAGATATATTTCTTTTTAGTACAAAGTGTTATTTGGTATAATTACATGGGA
TATGTAAGGGGGAGTGCTAA

Downstream 100 bases:

>100_bases
AATTGGATTAACAACAGAACTGATGCTACTTTTTGTTATATCTTTAGTAATTACAATTTTTGGAATGATGATGGTTTTAG
GGAGCCTAAATATTTCATCG

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MSYKILIVDDDKTIVEFLQIFLIKEGYEVRISYNGEEALDKIRSEQFNLILMDIMMPKLDGFEAIKRIRKLTNIPIIFLT
AKDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRVSTSVAEENKDIIKVKDLELNLKEHTLYKEKNEIKLTPKEF
DILFLLARNKGRIFPSSEIYERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA

Sequences:

>Translated_230_residues
MSYKILIVDDDKTIVEFLQIFLIKEGYEVRISYNGEEALDKIRSEQFNLILMDIMMPKLDGFEAIKRIRKLTNIPIIFLT
AKDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRVSTSVAEENKDIIKVKDLELNLKEHTLYKEKNEIKLTPKEF
DILFLLARNKGRIFPSSEIYERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA
>Mature_229_residues
SYKILIVDDDKTIVEFLQIFLIKEGYEVRISYNGEEALDKIRSEQFNLILMDIMMPKLDGFEAIKRIRKLTNIPIIFLTA
KDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRVSTSVAEENKDIIKVKDLELNLKEHTLYKEKNEIKLTPKEFD
ILFLLARNKGRIFPSSEIYERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.5991189427313, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=32.8828828828829, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=30.316742081448, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=35.5555555555556, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=29.3859649122807, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=32.8888888888889, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=30.3964757709251, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=32.5892857142857, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=29.2035398230088, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=31.4159292035398, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=29.5964125560538, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=30.5676855895196, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=27.1111111111111, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1790437, Length=102, Percent_Identity=36.2745098039216, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=36.2068965517241, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790299, Length=137, Percent_Identity=28.4671532846715, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788905, Length=109, Percent_Identity=33.9449541284404, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1788191, Length=122, Percent_Identity=27.0491803278689, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI145693157, Length=120, Percent_Identity=30, Blast_Score=61, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323034, Length=139, Percent_Identity=32.3741007194245, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322000, Length=157, Percent_Identity=29.2993630573248, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322044, Length=110, Percent_Identity=34.5454545454545, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26888; Mature: 26756

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYKILIVDDDKTIVEFLQIFLIKEGYEVRISYNGEEALDKIRSEQFNLILMDIMMPKLD
CCEEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCEEEEEHHCCCCC
GFEAIKRIRKLTNIPIIFLTAKDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRV
CHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHH
STSVAEENKDIIKVKDLELNLKEHTLYKEKNEIKLTPKEFDILFLLARNKGRIFPSSEIY
HHHHHHCCCCEEEEEEEEECHHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCCCCHHHH
ERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCEEEECCC
>Mature Secondary Structure 
SYKILIVDDDKTIVEFLQIFLIKEGYEVRISYNGEEALDKIRSEQFNLILMDIMMPKLD
CEEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCEEEEEHHCCCCC
GFEAIKRIRKLTNIPIIFLTAKDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRV
CHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHH
STSVAEENKDIIKVKDLELNLKEHTLYKEKNEIKLTPKEFDILFLLARNKGRIFPSSEIY
HHHHHHCCCCEEEEEEEEECHHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCCCCHHHH
ERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]