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The map label for this gene is lysC

Identifier: 170756182

GI number: 170756182

Start: 3623647

End: 3624849

Strand: Reverse

Name: lysC

Synonym: CLD_1184

Alternate gene names: 170756182

Gene position: 3624849-3623647 (Counterclockwise)

Preceding gene: 170757097

Following gene: 170755777

Centisome position: 91.58

GC content: 29.18

Gene sequence:

>1203_bases
ATGGCAACAATCGTTCAAAAATATGGAGGTACATCTGTAGCAACAGTAGAAAAGATAAAAAACATAGCCAAATCCATCGT
AAAAAGAAAAAGGGAAGGAAATGATATAGTAGTTGTTGTTTCTGCTATGGGACACACTACAGATAATCTTATAAATTTAG
CTAAAGATATAAGCAATGTACCAGATAAAAGAGAATTAGATGCATTAATTTCTACAGGGGAAATGGTATCATCTTCACTT
TTATCTATGGCAATTAAGGAACTAGGGGAAGATGCTATAAGTTATACTGCTTATCAAATCAATATAAGCACTAATGGACA
ACATGGAAAATCTTTAATAAATGATATAGATAAAAAAAAGATAGATAAAAGCTTAAAGGAAGGAAAGGTTGTTGTTGTCG
CAGGATTTCAAGGAATAAATTGTGATGGTAACATAACAACTTTAGGTAGAGGGGGGTCTGATACCTCAGCAGTAGCAATA
GCAGCAAAGCTAAATAATGCTATATGTGAAATATACACAGATGTAGATGGAATATATAGTGTAGATCCAAGAGTACATGA
TAGAGCTAAAAAATTAGATTATATAGATTATGAAGAAATGTTAGAATTATCTAGCTTAGGTGCCCAGGTGATGCATTCAA
GATCTATAGAATTAGCTGAAAAATATAATATACCCATTTATGTAGGATTAAGTAATAGTAATATCAAGGGAACAGTTATT
AGGGGGATGAATAATATGAATATGGAAATGAAATCAGTAACAGGATTAGCAACTAGTGATGATGATGTTGCAATAACAAT
GGAAGATATAAATGAAAATATAAACATAGTAGCAGATATATTTAGTAAATTAGCAGAAAAGCAGATTAATGTAGATATGA
TAAGCCAAACAGCACCTATAAATAGTAGAATAAGTCTATCCTTTACTATACCAAAAGAAGATTTACAGGAAGGCATGAAG
ATAATAAAAAATTATGCATCAAAGGATAAAATAAAAATTGATGAAAACTTAACTAAATTTTCTATAGTGGGAATAGGAAT
GAAAAATACATCCGGTGTAGCAGCTAAAATGTTAAAAATTTTTAGTGATAATAATATAAAGGTAAAAATGATAACAACCT
CAGAAATAAGAATCACTTGTGCAATAAATGTAAGGGATAAAATAAATGCTATAAATTTAGTAGTAAAAGAATTTAATTTA
TAA

Upstream 100 bases:

>100_bases
TGCATTATTTTTTATTTTTATAAAATACATAAGTTAGAGTATTTATTAAATTTTAGAGAAACATTTAAAATATTTTATTT
ATAAATAGGGGGGTATTTAT

Downstream 100 bases:

>100_bases
ATAGGATGTGGGAGTATGAAACTTTTTGGAAGTATGAATATAAAGAACAATAATTTATATATAGGTGAAATAAATACGTT
AGACTTGGCTAAGAAATTTA

Product: aspartokinase II

Products: NA

Alternate protein names: Aspartate kinase 2; Aspartokinase II [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MATIVQKYGGTSVATVEKIKNIAKSIVKRKREGNDIVVVVSAMGHTTDNLINLAKDISNVPDKRELDALISTGEMVSSSL
LSMAIKELGEDAISYTAYQINISTNGQHGKSLINDIDKKKIDKSLKEGKVVVVAGFQGINCDGNITTLGRGGSDTSAVAI
AAKLNNAICEIYTDVDGIYSVDPRVHDRAKKLDYIDYEEMLELSSLGAQVMHSRSIELAEKYNIPIYVGLSNSNIKGTVI
RGMNNMNMEMKSVTGLATSDDDVAITMEDINENINIVADIFSKLAEKQINVDMISQTAPINSRISLSFTIPKEDLQEGMK
IIKNYASKDKIKIDENLTKFSIVGIGMKNTSGVAAKMLKIFSDNNIKVKMITTSEIRITCAINVRDKINAINLVVKEFNL

Sequences:

>Translated_400_residues
MATIVQKYGGTSVATVEKIKNIAKSIVKRKREGNDIVVVVSAMGHTTDNLINLAKDISNVPDKRELDALISTGEMVSSSL
LSMAIKELGEDAISYTAYQINISTNGQHGKSLINDIDKKKIDKSLKEGKVVVVAGFQGINCDGNITTLGRGGSDTSAVAI
AAKLNNAICEIYTDVDGIYSVDPRVHDRAKKLDYIDYEEMLELSSLGAQVMHSRSIELAEKYNIPIYVGLSNSNIKGTVI
RGMNNMNMEMKSVTGLATSDDDVAITMEDINENINIVADIFSKLAEKQINVDMISQTAPINSRISLSFTIPKEDLQEGMK
IIKNYASKDKIKIDENLTKFSIVGIGMKNTSGVAAKMLKIFSDNNIKVKMITTSEIRITCAINVRDKINAINLVVKEFNL
>Mature_399_residues
ATIVQKYGGTSVATVEKIKNIAKSIVKRKREGNDIVVVVSAMGHTTDNLINLAKDISNVPDKRELDALISTGEMVSSSLL
SMAIKELGEDAISYTAYQINISTNGQHGKSLINDIDKKKIDKSLKEGKVVVVAGFQGINCDGNITTLGRGGSDTSAVAIA
AKLNNAICEIYTDVDGIYSVDPRVHDRAKKLDYIDYEEMLELSSLGAQVMHSRSIELAEKYNIPIYVGLSNSNIKGTVIR
GMNNMNMEMKSVTGLATSDDDVAITMEDINENINIVADIFSKLAEKQINVDMISQTAPINSRISLSFTIPKEDLQEGMKI
IKNYASKDKIKIDENLTKFSIVGIGMKNTSGVAAKMLKIFSDNNIKVKMITTSEIRITCAINVRDKINAINLVVKEFNL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=468, Percent_Identity=25.8547008547009, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1790455, Length=372, Percent_Identity=25.5376344086022, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1790376, Length=405, Percent_Identity=25.9259259259259, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320893, Length=299, Percent_Identity=28.4280936454849, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43680; Mature: 43549

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIVQKYGGTSVATVEKIKNIAKSIVKRKREGNDIVVVVSAMGHTTDNLINLAKDISNV
CCCEEHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCC
PDKRELDALISTGEMVSSSLLSMAIKELGEDAISYTAYQINISTNGQHGKSLINDIDKKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEEEECCCCHHHHHHHHHHHHH
IDKSLKEGKVVVVAGFQGINCDGNITTLGRGGSDTSAVAIAAKLNNAICEIYTDVDGIYS
HHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCCCCEEEEEHHCCCEEEEEECCCCEEE
VDPRVHDRAKKLDYIDYEEMLELSSLGAQVMHSRSIELAEKYNIPIYVGLSNSNIKGTVI
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCCCCCEEEE
RGMNNMNMEMKSVTGLATSDDDVAITMEDINENINIVADIFSKLAEKQINVDMISQTAPI
ECCCCCCEEEHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCC
NSRISLSFTIPKEDLQEGMKIIKNYASKDKIKIDENLTKFSIVGIGMKNTSGVAAKMLKI
CCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCHHHHHHHHH
FSDNNIKVKMITTSEIRITCAINVRDKINAINLVVKEFNL
HCCCCEEEEEEEECEEEEEEEEECCCCCCCEEEEEEECCC
>Mature Secondary Structure 
ATIVQKYGGTSVATVEKIKNIAKSIVKRKREGNDIVVVVSAMGHTTDNLINLAKDISNV
CCEEHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCC
PDKRELDALISTGEMVSSSLLSMAIKELGEDAISYTAYQINISTNGQHGKSLINDIDKKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEEEECCCCHHHHHHHHHHHHH
IDKSLKEGKVVVVAGFQGINCDGNITTLGRGGSDTSAVAIAAKLNNAICEIYTDVDGIYS
HHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCCCCEEEEEHHCCCEEEEEECCCCEEE
VDPRVHDRAKKLDYIDYEEMLELSSLGAQVMHSRSIELAEKYNIPIYVGLSNSNIKGTVI
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCCCCCEEEE
RGMNNMNMEMKSVTGLATSDDDVAITMEDINENINIVADIFSKLAEKQINVDMISQTAPI
ECCCCCCEEEHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCC
NSRISLSFTIPKEDLQEGMKIIKNYASKDKIKIDENLTKFSIVGIGMKNTSGVAAKMLKI
CCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCHHHHHHHHH
FSDNNIKVKMITTSEIRITCAINVRDKINAINLVVKEFNL
HCCCCEEEEEEEECEEEEEEEEECCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1444390 [H]