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The map label for this gene is uvrB

Identifier: 170755543

GI number: 170755543

Start: 3697602

End: 3699590

Strand: Reverse

Name: uvrB

Synonym: CLD_1121

Alternate gene names: 170755543

Gene position: 3699590-3697602 (Counterclockwise)

Preceding gene: 170756601

Following gene: 170757626

Centisome position: 93.47

GC content: 29.61

Gene sequence:

>1989_bases
ATGAACCAATTTAAGGTAATTTCAAAATTTAATCCTACAGGAGATCAACCTAAAGCTATAAAATCTATTGCTAAAGGTAT
AGAAAAAAGAGAAAAATTTCAAACTTTAATAGGCGTGACCGGATCAGGTAAAACTTTTACTATGGCAAATATTATAGAAA
AAGTTCAAAAGCCTACTTTAGTTTTAGCTCATAATAAAACGCTGGCAGCACAATTATGCTCAGAATTTAGAGAGTTTTTT
CCTAATAATGCAGTAGAATATTTTGTATCTTATTATGATTATTATCAACCAGAAGCATACGTAGCTCAAAGTGATACATA
TATAGAAAAAGATGCATCTATAAATGATGAAATAGACAAATTAAGGCACTCAGCCACATCAGCTTTATTTGAAAGAAAAG
ATGTAATAATTGTTGCTTCTGTATCTTGTATATATGGACTTGGTAATCCAGAAGAGTATAAGAAGTTAACTATATCGTTA
AGAGAAGGTATGGAGAAGGATAGAGATGAAATAATTAAAAAATTAGTAGAAATACAATATGAAAGAAATGACATAGATTT
TTCTAGAGGTACTTTTAGAGTAAAAGGTGATGTTTTAGATATTTTTCCTGCTTCATCTAGTAGCAAAGCAGTAAGAGTAG
AATTTTTTGGTGACGAAATAGATAGAATAAAAGAATTTGATGTTTTAACAGGAGAAACTATAACTAAGTTAAAACATATA
TCTATATTCCCAGCATCTCACTTTGCAACTTCAAAGGATAGATTGGAAGTTGCTATAAAAGATATAGAAGAAGAGCTAGA
AGAAAGAGTAAAAGAATTAGTATCTCAGGATAAAATATTAGAGGCTCAAAGATTAAAGCAGAGAACTAATTTTGATATAG
AAATGATGAGAGAAGTTGGATACTGTACAGGCATTGAAAATTATTCAAGAGTGTTAGATGGAAGAGCAAAAGGAACACCA
CCTCAGACCCTTTTAGATTATTTTCCACAGGATTTTCTTCTTTTTATAGATGAAAGTCATGTAACTTTGCCACAGGTAAA
AGCTATGCAGGCAGGAGATAAATCTAGAAAAGATTCTTTGGTGGAATATGGATTCAGGTTGCCTTGTGCCTATGATAATA
GGCCTCTTACCTTTAAGGAATTTGAAAATAAATTAAATCAAGTAGTTTTCGTAAGTGCTACACCAGCAAAATATGAATTA
GAATATTCAACTAACACAGCAGAGCAAGTAATAAGGCCTACAGGACTTTTAGATCCTGAAATAATTGTAAAACCAGTAAA
GGGACAGATAGACGACTTATATACTAGCATACAAGAAACAATTAAAAGAGGATTTAGAATTCTAGTAACTACATTAACAA
AAAAAATGGCAGAAGACTTGACTGATTATTTAAAAGAAATGGGAGTAAAAACTAGATATTTACATTCAGATATAGATACT
ATAGAAAGAATGAAAATAATACATGATCTTAGAAAAGGAGAATTTCATGTTTTAGTAGGAATAAACTTGCTAAGAGAAGG
ATTGGATATACCAGAAGTAGCTTTAGTTACAATATTAGATGCAGATAAAGAGGGATTTTTAAGATCAGAAACATCTCTTA
TACAGACTGTCGGAAGAGCAGCAAGAAACTCTGAAAGTAAGGTAATTATGTATGGGGATGTTATAACCAAATCCATGGAA
AAGACTATAAAAGAAACTAATAGAAGAAGAAAAATACAAATGGAATATAATGAAGAACATGGAATTGTTCCTAAAACTAT
AATAAAAGATATAAGAGAAGTAATTCAAATAAGTGATATAGCAGAGGAAAGAAAAGAATATGACAATTTAAATGAAGCAT
TAAAATCTTATAATAATGATATAGATAAATTAATAGAGAAATATGAAGAAGAAATGAAAGAGGCAGCACAAAATTTACAG
TTTGAAAAAGCGGCTCATTTGAGAGATGTAATATACAAATTAAAAAAAGATAAAGAAACAGAACTTTAA

Upstream 100 bases:

>100_bases
CCTAAAAATGTACCTAAAAATACATCCGTAATAAAAGTTAAAAGTGAAAAATTTCAAGACATATTAGAAAAAATTAAAAA
CAAAGATAAGGATGAATAAG

Downstream 100 bases:

>100_bases
GGAGTGTAATAACAAATAATGAAGGATAAAATTATTATTAAAGGCGCTAAGGTTAATAATTTAAAAAATATAAATCTTCA
GTTGCCGAGAGATAAGTATA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTLVLAHNKTLAAQLCSEFREFF
PNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDKLRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLTISL
REGMEKDRDEIIKKLVEIQYERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKLKHI
SIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVGYCTGIENYSRVLDGRAKGTP
PQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSLVEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAKYEL
EYSTNTAEQVIRPTGLLDPEIIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSDIDT
IERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRAARNSESKVIMYGDVITKSME
KTIKETNRRRKIQMEYNEEHGIVPKTIIKDIREVIQISDIAEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQNLQ
FEKAAHLRDVIYKLKKDKETEL

Sequences:

>Translated_662_residues
MNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTLVLAHNKTLAAQLCSEFREFF
PNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDKLRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLTISL
REGMEKDRDEIIKKLVEIQYERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKLKHI
SIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVGYCTGIENYSRVLDGRAKGTP
PQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSLVEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAKYEL
EYSTNTAEQVIRPTGLLDPEIIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSDIDT
IERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRAARNSESKVIMYGDVITKSME
KTIKETNRRRKIQMEYNEEHGIVPKTIIKDIREVIQISDIAEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQNLQ
FEKAAHLRDVIYKLKKDKETEL
>Mature_662_residues
MNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTLVLAHNKTLAAQLCSEFREFF
PNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDKLRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLTISL
REGMEKDRDEIIKKLVEIQYERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKLKHI
SIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVGYCTGIENYSRVLDGRAKGTP
PQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSLVEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAKYEL
EYSTNTAEQVIRPTGLLDPEIIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSDIDT
IERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRAARNSESKVIMYGDVITKSME
KTIKETNRRRKIQMEYNEEHGIVPKTIIKDIREVIQISDIAEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQNLQ
FEKAAHLRDVIYKLKKDKETEL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=663, Percent_Identity=56.7119155354449, Blast_Score=758, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=229, Percent_Identity=24.0174672489083, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_CLOB1 (A7FYY1)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385704.1
- ProteinModelPortal:   A7FYY1
- SMR:   A7FYY1
- STRING:   A7FYY1
- GeneID:   5398144
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3443
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   CBOT441770:CLB_3443-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76218; Mature: 76218

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTL
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHCCCEE
VLAHNKTLAAQLCSEFREFFPNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDK
EEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCEECCCCCCCHHHHH
LRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLTISLREGMEKDRDEIIKKLVEIQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKLKHI
CCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHE
SIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVG
EEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YCTGIENYSRVLDGRAKGTPPQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSL
HHCCHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCHHHHHH
VEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAKYELEYSTNTAEQVIRPTGLLDPE
HHCCCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCEEEEEECCCHHHHHHCCCCCCCHH
IIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSDIDT
HEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRA
HHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
ARNSESKVIMYGDVITKSMEKTIKETNRRRKIQMEYNEEHGIVPKTIIKDIREVIQISDI
HCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
AEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQNLQFEKAAHLRDVIYKLKKDKET
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
EL
CC
>Mature Secondary Structure
MNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTL
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHCCCEE
VLAHNKTLAAQLCSEFREFFPNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDK
EEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCEECCCCCCCHHHHH
LRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLTISLREGMEKDRDEIIKKLVEIQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKLKHI
CCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHE
SIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVG
EEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YCTGIENYSRVLDGRAKGTPPQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSL
HHCCHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCHHHHHH
VEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAKYELEYSTNTAEQVIRPTGLLDPE
HHCCCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCEEEEEECCCHHHHHHCCCCCCCHH
IIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSDIDT
HEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRA
HHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
ARNSESKVIMYGDVITKSMEKTIKETNRRRKIQMEYNEEHGIVPKTIIKDIREVIQISDI
HCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
AEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQNLQFEKAAHLRDVIYKLKKDKET
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
EL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA