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The map label for this gene is dfrA [H]

Identifier: 170751792

GI number: 170751792

Start: 5725772

End: 5726758

Strand: Direct

Name: dfrA [H]

Synonym: Mrad2831_5422

Alternate gene names: 170751792

Gene position: 5725772-5726758 (Clockwise)

Preceding gene: 170751781

Following gene: 170751793

Centisome position: 94.21

GC content: 71.94

Gene sequence:

>987_bases
GTGCTGATCACCGGCGCGAGCGGTTTCCTCGGCTCAGCCCTGGTCGACGTGTTCCGCCGGGCCGGCTTCCCGGTGCGCAT
CCTCGTGCGCGCCTCGAGCCCTCGCCGAAACCTCACCTGGACCGACGTGGAGATCGCCGAGGGCGACATGCGCGACCCGG
CCGCCGTGGCGGCGGCGATGCGCGGCCAGCGCTACCTCATCCATGCCGCGGCCGATTACCGGCTCTGGGCGCCGGACATG
GAGGAGATCGTCCGGACCAACCGCGACGGCACGCGCCTGATGATGCGTGCCGCCCTCGAGGCCGGGGTGGAGCGGGTCGT
CTACACGTCGAGCGTTGCGACGATCAGACCGCCGGCCGACGGCGTCACGCCCTCCGACGAGACCATGCCGCTGACGCCCG
AGACCGCGATCGGCGCCTACAAGCGCAGCAAGGTCGTGGCCGAGCGCGTGGTCGAGGAGATGGTCGCCCGGGACGGCCTG
CCGGCGGTGATCGTCAACCCGTCGACGCCGATCGGTCCCCGCGACGTCAAGCCGACGCCGACCGGGCGGATCATCCAGGA
GGCGGCGCTCGGCAAGATGCCGGCCTTCGTCGACACCGGCCTCAACCTCGCTCACGTGGACGACGTGGCCCAGGGGCATC
TGCTGGCGCTGCGCAGGGGGCGGATCGGCGAGCGCTACATCCTCGGCGGCGAGGACGTGTTCCTCTCGCAGATGCTCGCC
GACATCGCCGGCATGGTCGGCCGCAAGCCGCCGACCGTGAACCTGCCCCGGGCCGCCGTGTACCCGGTGGCGTTCTTCGC
GCAGCTCGCCGCCCGGGTCACCGGCAGGCAGCCCTTCGCGACGATCGACGGGATCCGCATGTCGCGCTACCGGATGTTCT
TCTCGGACCGGAAGGCGCGCGCCGAGCTCGGCTACACGGCCCGGCCCTACCGCGAGGGTCTGTCCGACGCGATCACGTGG
TTCCGGGAGGCGGGCTACCTCGCATGA

Upstream 100 bases:

>100_bases
GCGGCGCGGCTGGGGATCCCCGGCCGCGCTGGTTTTTCGGTAATCCTCCAGATCCGCGATGGCAGAGGCCCCATCTTACG
GCCCCTCCGAGGTCGGTCCC

Downstream 100 bases:

>100_bases
GCACCCTCGATTCCGCCACCGCGACGCGCTCCGGCAAGGGCCACCGGGACGAGAATTTCCCCGTCGCCTCGCACCTGATC
CATCCCCGCCACCGGGGCGC

Product: hopanoid-associated sugar epimerase

Products: NA

Alternate protein names: DFR; Dihydrokaempferol 4-reductase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MLITGASGFLGSALVDVFRRAGFPVRILVRASSPRRNLTWTDVEIAEGDMRDPAAVAAAMRGQRYLIHAAADYRLWAPDM
EEIVRTNRDGTRLMMRAALEAGVERVVYTSSVATIRPPADGVTPSDETMPLTPETAIGAYKRSKVVAERVVEEMVARDGL
PAVIVNPSTPIGPRDVKPTPTGRIIQEAALGKMPAFVDTGLNLAHVDDVAQGHLLALRRGRIGERYILGGEDVFLSQMLA
DIAGMVGRKPPTVNLPRAAVYPVAFFAQLAARVTGRQPFATIDGIRMSRYRMFFSDRKARAELGYTARPYREGLSDAITW
FREAGYLA

Sequences:

>Translated_328_residues
MLITGASGFLGSALVDVFRRAGFPVRILVRASSPRRNLTWTDVEIAEGDMRDPAAVAAAMRGQRYLIHAAADYRLWAPDM
EEIVRTNRDGTRLMMRAALEAGVERVVYTSSVATIRPPADGVTPSDETMPLTPETAIGAYKRSKVVAERVVEEMVARDGL
PAVIVNPSTPIGPRDVKPTPTGRIIQEAALGKMPAFVDTGLNLAHVDDVAQGHLLALRRGRIGERYILGGEDVFLSQMLA
DIAGMVGRKPPTVNLPRAAVYPVAFFAQLAARVTGRQPFATIDGIRMSRYRMFFSDRKARAELGYTARPYREGLSDAITW
FREAGYLA
>Mature_328_residues
MLITGASGFLGSALVDVFRRAGFPVRILVRASSPRRNLTWTDVEIAEGDMRDPAAVAAAMRGQRYLIHAAADYRLWAPDM
EEIVRTNRDGTRLMMRAALEAGVERVVYTSSVATIRPPADGVTPSDETMPLTPETAIGAYKRSKVVAERVVEEMVARDGL
PAVIVNPSTPIGPRDVKPTPTGRIIQEAALGKMPAFVDTGLNLAHVDDVAQGHLLALRRGRIGERYILGGEDVFLSQMLA
DIAGMVGRKPPTVNLPRAAVYPVAFFAQLAARVTGRQPFATIDGIRMSRYRMFFSDRKARAELGYTARPYREGLSDAITW
FREAGYLA

Specific function: INVOLVED IN THE SYNTHESIS OF ENTEROBACTERIAL COMMON ANTIGEN (ECA) AND REQUIRED FOR SYNTHESIS OF LIPOPOLYSACCHARIDE O-SIDE CHAINS. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroflavonol-4-reductase family [H]

Homologues:

Organism=Homo sapiens, GI116268111, Length=353, Percent_Identity=28.0453257790368, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI310132178, Length=354, Percent_Identity=25.4237288135593, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI310113012, Length=354, Percent_Identity=25.4237288135593, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI239745448, Length=354, Percent_Identity=25.4237288135593, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI193211614, Length=241, Percent_Identity=26.1410788381743, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI8393516, Length=241, Percent_Identity=26.1410788381743, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71987463, Length=337, Percent_Identity=27.0029673590504, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17570557, Length=332, Percent_Identity=25.9036144578313, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321437, Length=354, Percent_Identity=26.5536723163842, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR017829
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.219 [H]

Molecular weight: Translated: 35871; Mature: 35871

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLITGASGFLGSALVDVFRRAGFPVRILVRASSPRRNLTWTDVEIAEGDMRDPAAVAAAM
CEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHH
RGQRYLIHAAADYRLWAPDMEEIVRTNRDGTRLMMRAALEAGVERVVYTSSVATIRPPAD
CCCEEEEEEECCCEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHEEEECCCEEECCCCC
GVTPSDETMPLTPETAIGAYKRSKVVAERVVEEMVARDGLPAVIVNPSTPIGPRDVKPTP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
TGRIIQEAALGKMPAFVDTGLNLAHVDDVAQGHLLALRRGRIGERYILGGEDVFLSQMLA
CHHHHHHHHHCCCCHHHHCCCCHHHHHHHHCCHHHHHHCCCCCCEEEECCCHHHHHHHHH
DIAGMVGRKPPTVNLPRAAVYPVAFFAQLAARVTGRQPFATIDGIRMSRYRMFFSDRKAR
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHCCHHH
AELGYTARPYREGLSDAITWFREAGYLA
HHCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLITGASGFLGSALVDVFRRAGFPVRILVRASSPRRNLTWTDVEIAEGDMRDPAAVAAAM
CEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHH
RGQRYLIHAAADYRLWAPDMEEIVRTNRDGTRLMMRAALEAGVERVVYTSSVATIRPPAD
CCCEEEEEEECCCEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHEEEECCCEEECCCCC
GVTPSDETMPLTPETAIGAYKRSKVVAERVVEEMVARDGLPAVIVNPSTPIGPRDVKPTP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
TGRIIQEAALGKMPAFVDTGLNLAHVDDVAQGHLLALRRGRIGERYILGGEDVFLSQMLA
CHHHHHHHHHCCCCHHHHCCCCHHHHHHHHCCHHHHHHCCCCCCEEEECCCHHHHHHHHH
DIAGMVGRKPPTVNLPRAAVYPVAFFAQLAARVTGRQPFATIDGIRMSRYRMFFSDRKAR
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHCCHHH
AELGYTARPYREGLSDAITWFREAGYLA
HHCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]