Click here to switch to the map view.

The map label for this gene is pleC [H]

Identifier: 170751605

GI number: 170751605

Start: 5544452

End: 5545618

Strand: Direct

Name: pleC [H]

Synonym: Mrad2831_5226

Alternate gene names: 170751605

Gene position: 5544452-5545618 (Clockwise)

Preceding gene: 170751604

Following gene: 170751606

Centisome position: 91.22

GC content: 71.21

Gene sequence:

>1167_bases
GTGACGAACCCGACCCGCATCCTGCTGATCGACGACGACGCGGTCGACCGCGCGGCCGTGCGGCGGGCGCTCGCCAAGTC
CGGCCTCGCCCACACCCTGACGGAGGCGGCCGGAGGCGAGGATGGCGAGCGCCTCGCCTCCGAGGAAACGTTCGACTGCA
TCCTGCTCGACTATCGCCTGCCGGGCATCGACACGTTCGCGCTCCTGAAGACCCTGCTGGCGGCCGAGGGCGAGGCGCGG
GCGGTGCTGATGCTGACCGGCGAGGCCGACCCGGACCTGGCGACGCGGCTGATGCGGACCGGCGCGCTGGACTACATCGA
CAAGGCCGAGGTCACGCCTTCCGGCCTGGCGCGGGCGATCCGCTTCGCCGAGGCTCGGCGCGCCTTCCAGGCGGAACTCG
CCGAAGCCCGTCGCGAGGCGGAGGCGAAGTCGCTCGAACTCGACACGCTGAACCGGCAGAAATCGCTGCTGTTCTCGATC
ATCGCCCACGACCTGCGCAACCCGTTCCAGGCGCTGCTCGGCCTGTCGGAAGTGCTCGGAAAGGCCGTCGCGGCGCGCGA
CCCCGCCTCCATCGAGCGCCGCGCCAAGGGAATCCACGAGGCGGCGACGCAGGCCTACGCCCTGCTGGAGAGCCTGTTCT
CCTGGGCGAGCCTGCAGATGGACACGTTGGCGGTCACCCTCACCGACGTCGACCTCGGCATCCTGGCCGGAGACGTCCTG
AAGGGAGCCGCCGAGGCCGCCTCGGACAAGGGCCTGAGCTTGGAAGCGTCCTGCGACCGCACGGTGGTGCGTGCGCAGCG
GGACATGCTCGCCACGGTGTTGCGCAACCTCGTCAGCAACGCGATCAAGTTCACGCTGCCCGGCGGCACCATCACGGTCG
CCGCCCGGCGTGAGGGCGACGCGGTCGAGATCTCCGTCACGGACACCGGCGTCGGCATGCCGCCGGGCAGGGTGGACGAC
CTGTTCAGGCTGGACCGGCGGACGACGACGAACGGGACGGCGGGCGAGCGCGGGAGCGGCCTGGGCCTGCTGCTGTGCCG
GGACCTCGTCGAGCGCCAGGGTGGCGTGCTCGAAGTCAGGAGCGCCATAGACCGGGGGACGACCTTCCTGTTCCGGCTGC
CCGTATCCCGCACCGCGCACCTCGTATCGACCGCCACGGCATCCTGA

Upstream 100 bases:

>100_bases
GCTACATCGTCAAGCGCGACCCGGCCAACACCTTCATGGAAGCGGTGGCGCTCCTGGAGCACTACTGGAAGGTGGTCGAG
TTTCCTGCATAGTCCCCATC

Downstream 100 bases:

>100_bases
CGGTCCGATCAGGCATGGCCTCGCAAGTCGAGTTTCATGGTTTCGCCGCCGGTGCAGGGGTGTCCCCTTGCCGGTGCGTG
GTCGTCGCCATCCCAAGCAA

Product: response regulator receiver sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTNPTRILLIDDDAVDRAAVRRALAKSGLAHTLTEAAGGEDGERLASEETFDCILLDYRLPGIDTFALLKTLLAAEGEAR
AVLMLTGEADPDLATRLMRTGALDYIDKAEVTPSGLARAIRFAEARRAFQAELAEARREAEAKSLELDTLNRQKSLLFSI
IAHDLRNPFQALLGLSEVLGKAVAARDPASIERRAKGIHEAATQAYALLESLFSWASLQMDTLAVTLTDVDLGILAGDVL
KGAAEAASDKGLSLEASCDRTVVRAQRDMLATVLRNLVSNAIKFTLPGGTITVAARREGDAVEISVTDTGVGMPPGRVDD
LFRLDRRTTTNGTAGERGSGLGLLLCRDLVERQGGVLEVRSAIDRGTTFLFRLPVSRTAHLVSTATAS

Sequences:

>Translated_388_residues
MTNPTRILLIDDDAVDRAAVRRALAKSGLAHTLTEAAGGEDGERLASEETFDCILLDYRLPGIDTFALLKTLLAAEGEAR
AVLMLTGEADPDLATRLMRTGALDYIDKAEVTPSGLARAIRFAEARRAFQAELAEARREAEAKSLELDTLNRQKSLLFSI
IAHDLRNPFQALLGLSEVLGKAVAARDPASIERRAKGIHEAATQAYALLESLFSWASLQMDTLAVTLTDVDLGILAGDVL
KGAAEAASDKGLSLEASCDRTVVRAQRDMLATVLRNLVSNAIKFTLPGGTITVAARREGDAVEISVTDTGVGMPPGRVDD
LFRLDRRTTTNGTAGERGSGLGLLLCRDLVERQGGVLEVRSAIDRGTTFLFRLPVSRTAHLVSTATAS
>Mature_387_residues
TNPTRILLIDDDAVDRAAVRRALAKSGLAHTLTEAAGGEDGERLASEETFDCILLDYRLPGIDTFALLKTLLAAEGEARA
VLMLTGEADPDLATRLMRTGALDYIDKAEVTPSGLARAIRFAEARRAFQAELAEARREAEAKSLELDTLNRQKSLLFSII
AHDLRNPFQALLGLSEVLGKAVAARDPASIERRAKGIHEAATQAYALLESLFSWASLQMDTLAVTLTDVDLGILAGDVLK
GAAEAASDKGLSLEASCDRTVVRAQRDMLATVLRNLVSNAIKFTLPGGTITVAARREGDAVEISVTDTGVGMPPGRVDDL
FRLDRRTTTNGTAGERGSGLGLLLCRDLVERQGGVLEVRSAIDRGTTFLFRLPVSRTAHLVSTATAS

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=249, Percent_Identity=30.9236947791165, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI48994928, Length=264, Percent_Identity=28.4090909090909, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788713, Length=238, Percent_Identity=27.7310924369748, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=26.6968325791855, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789149, Length=270, Percent_Identity=25.5555555555556, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=24.8031496062992, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=27.3127753303965, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790861, Length=243, Percent_Identity=26.7489711934156, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=234, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=268, Percent_Identity=25.3731343283582, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788393, Length=224, Percent_Identity=27.6785714285714, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786783, Length=239, Percent_Identity=29.7071129707113, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41479; Mature: 41348

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPTRILLIDDDAVDRAAVRRALAKSGLAHTLTEAAGGEDGERLASEETFDCILLDYRL
CCCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHCCCCCEEEEEEEEC
PGIDTFALLKTLLAAEGEARAVLMLTGEADPDLATRLMRTGALDYIDKAEVTPSGLARAI
CCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RFAEARRAFQAELAEARREAEAKSLELDTLNRQKSLLFSIIAHDLRNPFQALLGLSEVLG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
KAVAARDPASIERRAKGIHEAATQAYALLESLFSWASLQMDTLAVTLTDVDLGILAGDVL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEECHHHHHHHHHH
KGAAEAASDKGLSLEASCDRTVVRAQRDMLATVLRNLVSNAIKFTLPGGTITVAARREGD
HHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCC
AVEISVTDTGVGMPPGRVDDLFRLDRRTTTNGTAGERGSGLGLLLCRDLVERQGGVLEVR
EEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEHHH
SAIDRGTTFLFRLPVSRTAHLVSTATAS
HHHHCCCEEEEECCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TNPTRILLIDDDAVDRAAVRRALAKSGLAHTLTEAAGGEDGERLASEETFDCILLDYRL
CCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHCCCCCEEEEEEEEC
PGIDTFALLKTLLAAEGEARAVLMLTGEADPDLATRLMRTGALDYIDKAEVTPSGLARAI
CCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RFAEARRAFQAELAEARREAEAKSLELDTLNRQKSLLFSIIAHDLRNPFQALLGLSEVLG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
KAVAARDPASIERRAKGIHEAATQAYALLESLFSWASLQMDTLAVTLTDVDLGILAGDVL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEECHHHHHHHHHH
KGAAEAASDKGLSLEASCDRTVVRAQRDMLATVLRNLVSNAIKFTLPGGTITVAARREGD
HHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCC
AVEISVTDTGVGMPPGRVDDLFRLDRRTTTNGTAGERGSGLGLLLCRDLVERQGGVLEVR
EEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEHHH
SAIDRGTTFLFRLPVSRTAHLVSTATAS
HHHHCCCEEEEECCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]