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The map label for this gene is lon [H]

Identifier: 170751516

GI number: 170751516

Start: 5459795

End: 5462221

Strand: Direct

Name: lon [H]

Synonym: Mrad2831_5136

Alternate gene names: 170751516

Gene position: 5459795-5462221 (Clockwise)

Preceding gene: 170751515

Following gene: 170751517

Centisome position: 89.83

GC content: 66.67

Gene sequence:

>2427_bases
ATGTCACAGTCGAAATCGCGCCAGCCGGTGGTCCCGGGTTCGACGGGCTCCTACGCCGTCCTCCCCCTGCGCGACATCGT
CGTCTTCCCGCACATGATCGTGCCCCTGTTCGTGGGCCGCGAGAAGTCGATCCGCGCCCTCGAGGAGGCCGTCCGCACCG
ACCGCCACATCCTGCTCGCCACCCAGATCAACGCGGGCGACGACGACCCGGCGACCGACGCGATCTACAAGATCGGTACC
CTCGCCTCGGTGCTCCAGCTGCTGAAGCTGCCCGACGGCACCGTGAAGGTGCTGGTCGAGGGCGTCGGCCGCGCGAAGGT
CGTGGACTTCACCCGCTCGGACGAGTTCTACGAGGCGACCGCCGAGGCGCTCCACGACGAGCTCGGCGACCGCGTCGAGG
CCGAGGCGCTCGCGCGCTCCGTGCTCTCGGAGTTCGAGAACTACGTCAAGCTCAACAAGAAGATCTCCCCCGAGGTCGTC
TCCGCCGTGACGCAGATCGACGAGCCGTCGAAGCTCGCCGACACGATCGGCTCGCACCTGCTCGTCAAGATCTCCGACAA
GCAGGGCATCTTGGAGACCCCCACGGTGGCGCAGCGCCTCGAGCGCGTGCTGTCGCTGATGGAGAGCGAGATCTCCGTGC
TCCAGGTGGAGAAGCGCATCCGGACCCGCGTCAAGCGGCAGATGGAGAAGACCCAGCGCGAGTACTACCTGAACGAGCAG
ATGAAGGCGATCCAGAAGGAGCTGGGCGACTCCGAGGATGGCCGCGACGAGCTGGCCGAGCTGGAAGAGAAGATCGAGAA
GACCAAGCTCTCCAAGGAGGCCCGCGACAAGGCCACCGCCGAGCTGAAGAAGCTGCGGCAGATGTCGCCGATGTCGGCCG
AGGCGACCGTCGTGCGCAACTACCTCGACTGGATGCTCGGCATCCCGTGGGGCAAGCGCTCGAAGATCAAGAAGGACCTG
CTCGGCGCCCAGGCGCTGCTCGACGAGGACCATTTCGGCCTCGACAAGGTCAAGGAGCGGATCGTCGAGTACCTCGCCGT
GCAGCAGCGGGCGAACAAGCTCACCGGCCCGATCCTGTGCCTCGTCGGTCCCCCCGGCGTCGGCAAGACCTCGCTCGGCA
AGTCCATCGCCAAGGCGACGGGTCGCGAGTTCGTCCGGATGTCGCTCGGCGGCGTGCGCGATGAGGCCGAGATCCGCGGT
CACCGCCGGACCTATATCGGTTCGATGCCCGGCAAGATCGTGCAGTCGATGCGCAAGGCCAAAACCTCGAACCCGCTCAT
CCTGCTCGACGAGATCGACAAGATGGGCATGGACTTCCGCGGCGATCCGTCGGCGGCGCTCCTCGAGGTTCTCGACCCTG
AGCAGAACAGCACCTTCAACGACCACTACCTGGAGGTGGATTACGACCTCTCGAACGTGATGTTCGTGACCACGGCCAAC
ACCCTCAACATCCCGGGCCCGCTCATGGACCGGATGGAGGTGATCCGCATCGCCGGGTACACCGAGGAGGAGAAGGTCGA
GATCGCGCGCAAGCACCTGATCCCGAACGCCCTGAAGAAGCACGGCCTCGGGACGCACGAGTGGTCGATCGACGATGACG
GACTGATGATGCTGGTCCGCCGCTACACGCGGGAGGCCGGCGTCCGCAACCTGGAGCGCGAGCTGTCCAACCTGATCCGC
AAGGCGGTGAAGGAGATCCTGATCACCAAGACCAAGTCGGTCGCGGTGACCCCGGAGACCCTTCCGGTCTTCCTCGGCCC
GCCGAAGTTCCGCTACGGCGAGATCGACGCGGACGATCAGGTCGGTGTGGTGACGGGTCTGGCCTGGACCGAGGTCGGCG
GCGAGCTGCTGACGATCGAGGGCGTCATGATGCCCGGCAAGGGCAAGATGACGGTCACCGGCAACCTGAAGGACGTGATG
AAGGAGTCGATCTCGGCGGCGGCGAGCTACGTCCGCTCCCGGGCGATCGATTTCGGGATCGAGCCGCCGCTCTTCGATCG
GCGCGACATCCACGTCCACGTTCCGGAGGGGGCGACCCCGAAGGACGGTCCGTCGGCCGGCATCGCCATGGCCACCGCGA
TCATCTCGACGCTGACCGGGATCCCGGTCCGCCGAGACGTCGCGATGACCGGCGAGGTGACGCTCCGCGGCCGGGTCCTG
CCGATCGGCGGCCTGAAGGAGAAGCTGCTCGCCGCGCTCCGCGGCGGCATCAAGACGGTGCTGATCCCCGAGGAGAACGC
CAAGGACATCGCCGAGGTGCCCGACAGCGTGAAGAACGGCCTGGAGATCATCCCGGTCTCGCGGATGGATCAGGTGCTGG
AGAAGGCGTTGGTCCGCCAACCGGAGGCGATCGAGTGGGAGGAGCCGCTGCCGGTGGCCAAGCCCGCCCGCACCGAAGAG
GACGGCGCGGCCTTCGTGGCCCACTGA

Upstream 100 bases:

>100_bases
AGTTAGCGAAATCCGACCCTCGCGGCCCGGTCGGCACCTGGCTGTAGGCGCGCTCCGTGCATGGGGGCGCCGAACCGGGC
GTCCCTGAGAGGAAGTCAGC

Downstream 100 bases:

>100_bases
GCGTCCTGACTGAGTGAGACGAGCCCCCGGCGCCCTGAGCCCCGGGGGCTTCTTCGTGCGCGGATCCAGGCACGGAGGAC
CGGATGCGTATCCTGCTGAT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 808; Mature: 807

Protein sequence:

>808_residues
MSQSKSRQPVVPGSTGSYAVLPLRDIVVFPHMIVPLFVGREKSIRALEEAVRTDRHILLATQINAGDDDPATDAIYKIGT
LASVLQLLKLPDGTVKVLVEGVGRAKVVDFTRSDEFYEATAEALHDELGDRVEAEALARSVLSEFENYVKLNKKISPEVV
SAVTQIDEPSKLADTIGSHLLVKISDKQGILETPTVAQRLERVLSLMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQ
MKAIQKELGDSEDGRDELAELEEKIEKTKLSKEARDKATAELKKLRQMSPMSAEATVVRNYLDWMLGIPWGKRSKIKKDL
LGAQALLDEDHFGLDKVKERIVEYLAVQQRANKLTGPILCLVGPPGVGKTSLGKSIAKATGREFVRMSLGGVRDEAEIRG
HRRTYIGSMPGKIVQSMRKAKTSNPLILLDEIDKMGMDFRGDPSAALLEVLDPEQNSTFNDHYLEVDYDLSNVMFVTTAN
TLNIPGPLMDRMEVIRIAGYTEEEKVEIARKHLIPNALKKHGLGTHEWSIDDDGLMMLVRRYTREAGVRNLERELSNLIR
KAVKEILITKTKSVAVTPETLPVFLGPPKFRYGEIDADDQVGVVTGLAWTEVGGELLTIEGVMMPGKGKMTVTGNLKDVM
KESISAAASYVRSRAIDFGIEPPLFDRRDIHVHVPEGATPKDGPSAGIAMATAIISTLTGIPVRRDVAMTGEVTLRGRVL
PIGGLKEKLLAALRGGIKTVLIPEENAKDIAEVPDSVKNGLEIIPVSRMDQVLEKALVRQPEAIEWEEPLPVAKPARTEE
DGAAFVAH

Sequences:

>Translated_808_residues
MSQSKSRQPVVPGSTGSYAVLPLRDIVVFPHMIVPLFVGREKSIRALEEAVRTDRHILLATQINAGDDDPATDAIYKIGT
LASVLQLLKLPDGTVKVLVEGVGRAKVVDFTRSDEFYEATAEALHDELGDRVEAEALARSVLSEFENYVKLNKKISPEVV
SAVTQIDEPSKLADTIGSHLLVKISDKQGILETPTVAQRLERVLSLMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQ
MKAIQKELGDSEDGRDELAELEEKIEKTKLSKEARDKATAELKKLRQMSPMSAEATVVRNYLDWMLGIPWGKRSKIKKDL
LGAQALLDEDHFGLDKVKERIVEYLAVQQRANKLTGPILCLVGPPGVGKTSLGKSIAKATGREFVRMSLGGVRDEAEIRG
HRRTYIGSMPGKIVQSMRKAKTSNPLILLDEIDKMGMDFRGDPSAALLEVLDPEQNSTFNDHYLEVDYDLSNVMFVTTAN
TLNIPGPLMDRMEVIRIAGYTEEEKVEIARKHLIPNALKKHGLGTHEWSIDDDGLMMLVRRYTREAGVRNLERELSNLIR
KAVKEILITKTKSVAVTPETLPVFLGPPKFRYGEIDADDQVGVVTGLAWTEVGGELLTIEGVMMPGKGKMTVTGNLKDVM
KESISAAASYVRSRAIDFGIEPPLFDRRDIHVHVPEGATPKDGPSAGIAMATAIISTLTGIPVRRDVAMTGEVTLRGRVL
PIGGLKEKLLAALRGGIKTVLIPEENAKDIAEVPDSVKNGLEIIPVSRMDQVLEKALVRQPEAIEWEEPLPVAKPARTEE
DGAAFVAH
>Mature_807_residues
SQSKSRQPVVPGSTGSYAVLPLRDIVVFPHMIVPLFVGREKSIRALEEAVRTDRHILLATQINAGDDDPATDAIYKIGTL
ASVLQLLKLPDGTVKVLVEGVGRAKVVDFTRSDEFYEATAEALHDELGDRVEAEALARSVLSEFENYVKLNKKISPEVVS
AVTQIDEPSKLADTIGSHLLVKISDKQGILETPTVAQRLERVLSLMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQM
KAIQKELGDSEDGRDELAELEEKIEKTKLSKEARDKATAELKKLRQMSPMSAEATVVRNYLDWMLGIPWGKRSKIKKDLL
GAQALLDEDHFGLDKVKERIVEYLAVQQRANKLTGPILCLVGPPGVGKTSLGKSIAKATGREFVRMSLGGVRDEAEIRGH
RRTYIGSMPGKIVQSMRKAKTSNPLILLDEIDKMGMDFRGDPSAALLEVLDPEQNSTFNDHYLEVDYDLSNVMFVTTANT
LNIPGPLMDRMEVIRIAGYTEEEKVEIARKHLIPNALKKHGLGTHEWSIDDDGLMMLVRRYTREAGVRNLERELSNLIRK
AVKEILITKTKSVAVTPETLPVFLGPPKFRYGEIDADDQVGVVTGLAWTEVGGELLTIEGVMMPGKGKMTVTGNLKDVMK
ESISAAASYVRSRAIDFGIEPPLFDRRDIHVHVPEGATPKDGPSAGIAMATAIISTLTGIPVRRDVAMTGEVTLRGRVLP
IGGLKEKLLAALRGGIKTVLIPEENAKDIAEVPDSVKNGLEIIPVSRMDQVLEKALVRQPEAIEWEEPLPVAKPARTEED
GAAFVAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=669, Percent_Identity=42.0029895366218, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI31377667, Length=780, Percent_Identity=39.2307692307692, Blast_Score=520, Evalue=1e-147,
Organism=Escherichia coli, GI1786643, Length=767, Percent_Identity=62.5814863102999, Blast_Score=991, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=655, Percent_Identity=42.5954198473282, Blast_Score=513, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17556486, Length=547, Percent_Identity=38.5740402193784, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=724, Percent_Identity=41.4364640883978, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666867, Length=681, Percent_Identity=42.143906020558, Blast_Score=527, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221513036, Length=681, Percent_Identity=42.143906020558, Blast_Score=526, Evalue=1e-149,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89255; Mature: 89124

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSKSRQPVVPGSTGSYAVLPLRDIVVFPHMIVPLFVGREKSIRALEEAVRTDRHILLA
CCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEE
TQINAGDDDPATDAIYKIGTLASVLQLLKLPDGTVKVLVEGVGRAKVVDFTRSDEFYEAT
EEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEECCCCHHHHHH
AEALHDELGDRVEAEALARSVLSEFENYVKLNKKISPEVVSAVTQIDEPSKLADTIGSHL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHCCCEE
LVKISDKQGILETPTVAQRLERVLSLMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQ
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKAIQKELGDSEDGRDELAELEEKIEKTKLSKEARDKATAELKKLRQMSPMSAEATVVRN
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
YLDWMLGIPWGKRSKIKKDLLGAQALLDEDHFGLDKVKERIVEYLAVQQRANKLTGPILC
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEE
LVGPPGVGKTSLGKSIAKATGREFVRMSLGGVRDEAEIRGHRRTYIGSMPGKIVQSMRKA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHH
KTSNPLILLDEIDKMGMDFRGDPSAALLEVLDPEQNSTFNDHYLEVDYDLSNVMFVTTAN
CCCCCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECC
TLNIPGPLMDRMEVIRIAGYTEEEKVEIARKHLIPNALKKHGLGTHEWSIDDDGLMMLVR
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCHHHHHHH
RYTREAGVRNLERELSNLIRKAVKEILITKTKSVAVTPETLPVFLGPPKFRYGEIDADDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEECCCCCCCCCCCCCCC
VGVVTGLAWTEVGGELLTIEGVMMPGKGKMTVTGNLKDVMKESISAAASYVRSRAIDFGI
CCCEECCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
EPPLFDRRDIHVHVPEGATPKDGPSAGIAMATAIISTLTGIPVRRDVAMTGEVTLRGRVL
CCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCEEEEEEEE
PIGGLKEKLLAALRGGIKTVLIPEENAKDIAEVPDSVKNGLEIIPVSRMDQVLEKALVRQ
ECCCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCHHHHCCCEEEEHHHHHHHHHHHHHCC
PEAIEWEEPLPVAKPARTEEDGAAFVAH
CCCCCCCCCCCCCCCCCCCCCCCEECCC
>Mature Secondary Structure 
SQSKSRQPVVPGSTGSYAVLPLRDIVVFPHMIVPLFVGREKSIRALEEAVRTDRHILLA
CCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEE
TQINAGDDDPATDAIYKIGTLASVLQLLKLPDGTVKVLVEGVGRAKVVDFTRSDEFYEAT
EEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEECCCCHHHHHH
AEALHDELGDRVEAEALARSVLSEFENYVKLNKKISPEVVSAVTQIDEPSKLADTIGSHL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHCCCEE
LVKISDKQGILETPTVAQRLERVLSLMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQ
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKAIQKELGDSEDGRDELAELEEKIEKTKLSKEARDKATAELKKLRQMSPMSAEATVVRN
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
YLDWMLGIPWGKRSKIKKDLLGAQALLDEDHFGLDKVKERIVEYLAVQQRANKLTGPILC
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEE
LVGPPGVGKTSLGKSIAKATGREFVRMSLGGVRDEAEIRGHRRTYIGSMPGKIVQSMRKA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHH
KTSNPLILLDEIDKMGMDFRGDPSAALLEVLDPEQNSTFNDHYLEVDYDLSNVMFVTTAN
CCCCCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECC
TLNIPGPLMDRMEVIRIAGYTEEEKVEIARKHLIPNALKKHGLGTHEWSIDDDGLMMLVR
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCHHHHHHH
RYTREAGVRNLERELSNLIRKAVKEILITKTKSVAVTPETLPVFLGPPKFRYGEIDADDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEECCCCCCCCCCCCCCC
VGVVTGLAWTEVGGELLTIEGVMMPGKGKMTVTGNLKDVMKESISAAASYVRSRAIDFGI
CCCEECCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
EPPLFDRRDIHVHVPEGATPKDGPSAGIAMATAIISTLTGIPVRRDVAMTGEVTLRGRVL
CCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCEEEEEEEE
PIGGLKEKLLAALRGGIKTVLIPEENAKDIAEVPDSVKNGLEIIPVSRMDQVLEKALVRQ
ECCCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCHHHHCCCEEEEHHHHHHHHHHHHHCC
PEAIEWEEPLPVAKPARTEEDGAAFVAH
CCCCCCCCCCCCCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA