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The map label for this gene is mmgC [H]

Identifier: 170751475

GI number: 170751475

Start: 5417596

End: 5418825

Strand: Reverse

Name: mmgC [H]

Synonym: Mrad2831_5095

Alternate gene names: 170751475

Gene position: 5418825-5417596 (Counterclockwise)

Preceding gene: 170751476

Following gene: 170751472

Centisome position: 89.16

GC content: 69.27

Gene sequence:

>1230_bases
ATGAACGCTCCGATGCGCCCTCCGGGCAGCGCCTCACCGTCGGCCCCGGCCTCGGCCCGCTTCGTCTGGGACGATCCCTT
CCTGCTGGAGGATCAGCTCACCGAGGACGAGCGGGCGATCCGCGACGTCGCCCAGAGCTTCGCGCAGGAGCAGCTTCTCC
CGGGGATCGTCGAGGCCTACGCCACCGAGAAGACCGATCCCGGCCTGTTCCGGAAGATGGGCGAACTCGGTCTCCTCGGC
GTGACCCTCCCCGAGGAGTACGGCTGCGCGGGCGCCTCCTACGTGGCCTACGGGCTGGTGGCGCGGGCGGTCGAGGCGGT
GGATTCCGGCTACCGCTCGATGATGAGCGTGCAGTCCTCCCTCGTCATGTACCCGATCCACGCCTACGGCTCGGAGGAGC
AGCGGCAGAAGTTCCTGCCGAAGCTCGCCTCGGGCGAGTGGATCGGCTGCTTCGGCCTGACCGAGCCCGATGCCGGCTCG
GACCCGGCCGGGATGAAGACCAAGGCCGAGAAGATCGACGGCGGCTACCGGATCTCCGGCGCCAAGATGTGGATCTCGAA
CGCGCCCTTCGCGGACGTGTTCGTGGTCTGGGCGAAGTCCGACGCGCACGAGGGCGCGATACGCGGCTTCGTCCTCGAGA
AGGGCATGAAGGGCCTGTCCGCACCGACGCTCAAGGGCAAGCTGTCCCTGCGCGCCTCGACCACCGGCGAGATCGTCATG
GAGGGCGTCGAGGTCGGTGAGGACGCGCTCTTGCCGAACGTCTCGGGGCTCAAGGGGCCGTTCGGCTGCCTCAACCGGGC
GCGCTACGGCATCTCGTGGGGCGCGATGGGCGCCGCCGAGGATTGCTGGCACCGCGCCCGCAGCTACACCCTGGAGCGCA
AGCAGTTCGGCCGGCCCCTGGCGCAGACGCAGCTCGTCCAGAAGAAGCTCGCCGACATGCAGACCGAGATCGCGCTGGGC
CTCCAGGCCTCGCTCCGGGTCGGGCGGCTGATGGACGAGGGCCGGATGGCCCCGGAGATGATCTCGCTGGTCAAGCGCAA
CAATTGCGGCAAGGCGCTGGACATCGCCCGCACCGCCCGGGACATGCACGGCGGCAACGGCATCATGGGCGAGTACCACG
TGATGCGCCACGCCCAGAACCTCGAGACGGTGAACACCTACGAGGGCACCCACGACGTCCACGCCCTGATCCTGGGCCGG
GCGCAGACGGGGCTGCAGGCGTTCTTCTGA

Upstream 100 bases:

>100_bases
GCGTCACCGCGCGCGTTGGACCGGGCGCCGCGCGGGTCTAGGGTAGGCCCAAGCGCGCGGGCCGCGAGGACCCGCGCTTC
CCTGCAGGCGAGGAATTTCG

Downstream 100 bases:

>100_bases
GATCCAGGAACGCGCCTCCCACCCGCACCCACATCCTGAGGTGCGGGCGGGATATCACCGCAGCGCTGGGGTGGGCTTAC
TCCCCGCCCTCGTCGCCGGC

Product: acyl-CoA dehydrogenase domain-containing protein

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MNAPMRPPGSASPSAPASARFVWDDPFLLEDQLTEDERAIRDVAQSFAQEQLLPGIVEAYATEKTDPGLFRKMGELGLLG
VTLPEEYGCAGASYVAYGLVARAVEAVDSGYRSMMSVQSSLVMYPIHAYGSEEQRQKFLPKLASGEWIGCFGLTEPDAGS
DPAGMKTKAEKIDGGYRISGAKMWISNAPFADVFVVWAKSDAHEGAIRGFVLEKGMKGLSAPTLKGKLSLRASTTGEIVM
EGVEVGEDALLPNVSGLKGPFGCLNRARYGISWGAMGAAEDCWHRARSYTLERKQFGRPLAQTQLVQKKLADMQTEIALG
LQASLRVGRLMDEGRMAPEMISLVKRNNCGKALDIARTARDMHGGNGIMGEYHVMRHAQNLETVNTYEGTHDVHALILGR
AQTGLQAFF

Sequences:

>Translated_409_residues
MNAPMRPPGSASPSAPASARFVWDDPFLLEDQLTEDERAIRDVAQSFAQEQLLPGIVEAYATEKTDPGLFRKMGELGLLG
VTLPEEYGCAGASYVAYGLVARAVEAVDSGYRSMMSVQSSLVMYPIHAYGSEEQRQKFLPKLASGEWIGCFGLTEPDAGS
DPAGMKTKAEKIDGGYRISGAKMWISNAPFADVFVVWAKSDAHEGAIRGFVLEKGMKGLSAPTLKGKLSLRASTTGEIVM
EGVEVGEDALLPNVSGLKGPFGCLNRARYGISWGAMGAAEDCWHRARSYTLERKQFGRPLAQTQLVQKKLADMQTEIALG
LQASLRVGRLMDEGRMAPEMISLVKRNNCGKALDIARTARDMHGGNGIMGEYHVMRHAQNLETVNTYEGTHDVHALILGR
AQTGLQAFF
>Mature_409_residues
MNAPMRPPGSASPSAPASARFVWDDPFLLEDQLTEDERAIRDVAQSFAQEQLLPGIVEAYATEKTDPGLFRKMGELGLLG
VTLPEEYGCAGASYVAYGLVARAVEAVDSGYRSMMSVQSSLVMYPIHAYGSEEQRQKFLPKLASGEWIGCFGLTEPDAGS
DPAGMKTKAEKIDGGYRISGAKMWISNAPFADVFVVWAKSDAHEGAIRGFVLEKGMKGLSAPTLKGKLSLRASTTGEIVM
EGVEVGEDALLPNVSGLKGPFGCLNRARYGISWGAMGAAEDCWHRARSYTLERKQFGRPLAQTQLVQKKLADMQTEIALG
LQASLRVGRLMDEGRMAPEMISLVKRNNCGKALDIARTARDMHGGNGIMGEYHVMRHAQNLETVNTYEGTHDVHALILGR
AQTGLQAFF

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=390, Percent_Identity=64.6153846153846, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI7669494, Length=370, Percent_Identity=63.5135135135135, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI226958412, Length=405, Percent_Identity=31.358024691358, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4501859, Length=365, Percent_Identity=30.6849315068493, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=31.7919075144509, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI4557233, Length=374, Percent_Identity=31.283422459893, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=30.9333333333333, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=30.9333333333333, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4557235, Length=388, Percent_Identity=29.639175257732, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI76496475, Length=388, Percent_Identity=29.639175257732, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI4501857, Length=367, Percent_Identity=29.700272479564, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=29.023746701847, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI21361497, Length=399, Percent_Identity=27.3182957393484, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786223, Length=369, Percent_Identity=24.390243902439, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI87081958, Length=337, Percent_Identity=24.6290801186944, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=64.1752577319588, Blast_Score=523, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17538396, Length=375, Percent_Identity=32.8, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=31.5508021390374, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=30.1369863013699, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17569725, Length=374, Percent_Identity=29.6791443850267, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=34.3629343629344, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71985184, Length=402, Percent_Identity=28.1094527363184, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=28.7234042553192, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=28.3068783068783, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=34.6320346320346, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71985192, Length=307, Percent_Identity=28.9902280130293, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=29.7794117647059, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=25.5936675461741, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17551932, Length=421, Percent_Identity=23.0403800475059, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17505929, Length=351, Percent_Identity=24.2165242165242, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562446, Length=255, Percent_Identity=27.4509803921569, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19920834, Length=403, Percent_Identity=58.8089330024814, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=30.958904109589, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24660351, Length=389, Percent_Identity=32.133676092545, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=29.6, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI21355753, Length=377, Percent_Identity=29.7082228116711, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=31.0991957104558, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI281363737, Length=357, Percent_Identity=27.7310924369748, Blast_Score=142, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 44355; Mature: 44355

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPMRPPGSASPSAPASARFVWDDPFLLEDQLTEDERAIRDVAQSFAQEQLLPGIVEAY
CCCCCCCCCCCCCCCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ATEKTDPGLFRKMGELGLLGVTLPEEYGCAGASYVAYGLVARAVEAVDSGYRSMMSVQSS
HCCCCCCHHHHHHHCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVMYPIHAYGSEEQRQKFLPKLASGEWIGCFGLTEPDAGSDPAGMKTKAEKIDGGYRISG
HEEEEHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEECC
AKMWISNAPFADVFVVWAKSDAHEGAIRGFVLEKGMKGLSAPTLKGKLSLRASTTGEIVM
EEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHH
EGVEVGEDALLPNVSGLKGPFGCLNRARYGISWGAMGAAEDCWHRARSYTLERKQFGRPL
HHHHCCCHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCH
AQTQLVQKKLADMQTEIALGLQASLRVGRLMDEGRMAPEMISLVKRNNCGKALDIARTAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHH
DMHGGNGIMGEYHVMRHAQNLETVNTYEGTHDVHALILGRAQTGLQAFF
HHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHEEHHHHHHHHHCC
>Mature Secondary Structure
MNAPMRPPGSASPSAPASARFVWDDPFLLEDQLTEDERAIRDVAQSFAQEQLLPGIVEAY
CCCCCCCCCCCCCCCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ATEKTDPGLFRKMGELGLLGVTLPEEYGCAGASYVAYGLVARAVEAVDSGYRSMMSVQSS
HCCCCCCHHHHHHHCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVMYPIHAYGSEEQRQKFLPKLASGEWIGCFGLTEPDAGSDPAGMKTKAEKIDGGYRISG
HEEEEHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEECC
AKMWISNAPFADVFVVWAKSDAHEGAIRGFVLEKGMKGLSAPTLKGKLSLRASTTGEIVM
EEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHH
EGVEVGEDALLPNVSGLKGPFGCLNRARYGISWGAMGAAEDCWHRARSYTLERKQFGRPL
HHHHCCCHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCH
AQTQLVQKKLADMQTEIALGLQASLRVGRLMDEGRMAPEMISLVKRNNCGKALDIARTAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHH
DMHGGNGIMGEYHVMRHAQNLETVNTYEGTHDVHALILGRAQTGLQAFF
HHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]