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The map label for this gene is uvrD [H]

Identifier: 170751333

GI number: 170751333

Start: 5269703

End: 5272096

Strand: Reverse

Name: uvrD [H]

Synonym: Mrad2831_4951

Alternate gene names: 170751333

Gene position: 5272096-5269703 (Counterclockwise)

Preceding gene: 170751335

Following gene: 170751332

Centisome position: 86.74

GC content: 71.93

Gene sequence:

>2394_bases
ATGCAGAACCGTCCGCATCCGCAGGCCGCCGGGGACGGCGCGCCCGCCACGTCCATCGCCGCCCGCGCCATGGGCGCCCT
CCGCCGCGAGTCGGCCGGCTACCTCGAGGGGCTGAACCCCGAGCAGCGCCGCGCCGTCGAGACCACGGAGGGCCCGGTCC
TGGTGCTGGCCGGCGCCGGCACCGGCAAGACCCGGGTGCTGACCACCCGCATCGCCCACCTGATCGCCACCGGGCGGGCG
CGTCCCTTCGACATCCTGGCGGTGACCTTCACCAACAAGGCCGCCCGGGAGATGAAGCACCGGATCGGCGCGCTGATCGG
GCCGGCCGGCGAGGGCATGCCCTGGCTCGGCACCTTCCACGCCATCGGCACCAAGATCCTGCGCCGCCACGCCGAGCTGG
TCGGGCTCAAATCCGACTTCACCATCCTCGGCACCGACGACCAGCTCCGGCTGATGAAGCAGGTCATCGCCGACCAGAAC
GTCGACGAGAAGCGCTGGCCGGCCCGGGCCCTGTCGCACGCCGTCGACGGCTGGAAGAACCGCGGCCTCGGCCCCGAGCA
GGTGCCCCCGGGCGAGGCCGCGGCCTTCGCGTTCGGCAAGGGCGGCGCCCTCTACACGGCCTACCAGGCCCGGCTCGCGA
CGCTGAACGCCGTCGATTTCGGCGATCTCCTGCTGCTCTGCCTCAAGCTCTGGCGGGAGAACCCCGACGTCCTGGCCAAT
TACCAGGACCGGTTCCGCTACATCCTGGTCGACGAGTACCAGGACACCAACGTCGCCCAGTACCTGTGGCTGCGCCTGCT
GGCGCAGGCCCGGAAGAACATCGCCTGCGTGGGCGACGACGACCAGTCGATCTACGGCTGGCGCGGCGCCGAGGTCGACA
ACATCCTGCGCTTCGAGCACGACTTCCCGGGCGCGGTGGTGGTGCGGCTGGAGCGCAACTACCGCTCCACCGGCCACATC
CTGGCCGCCGCCTCCGGGCTGATCGCCAAGAACGAGAGCCGCCTCGGCAAGACCCTGCGCACCGACGACGAGCCGGGCGA
GCGCGTCACCGTCACGGGCGCGTGGGATTCCGAGGAGGAGGCGCGGATGCTCGCCGAGTCGATCGAATCCCTCCAGTCCA
AGCAGCACCCCCTGTCGGAGATCGCCGTGCTGGTGCGGATCTCCGCGCAGATGCGCGAGATCGAGGACCGGTTCGTCCAG
CTCGGGCTGCCCTACCGGGTCATCGGCGGCCCGCGCTTCTACGAGCGCGCCGAGATCCGCGACGCGCTGGCCTACCTGCG
CGCCACCGTGAACGTCAGCGACGACCTCGCCTTCGAGCGGATCGTGAACACGCCGAAGCGCGGCCTGGGCGACGCTACCC
TGCAGCAGCTCCACACCTACGGCCGCGCCAACCGGCTGCCGCTGCGGATCGCCGCGGAGCGCCTGTGCGAGACCGACGAG
CTGAAGCCCCGGGTCCGCTCCACCCTGCGGGCGCTCACCGAGAGTTTCTCGCGGTGGGCGCGGCTCGTGGAATCGCAGCC
GCACAGCGAGGTCGCGCAGACCATCCTTGAGGAGTCCGGCTACACCGAGATGTGGCAGAAGGACCGCTCCGCCGACGCCG
CCGGCCGGCTGGAGAACCTGAAGGAATTCGTCCGCTCCATGGAGGAGTTCCCCGACCTCGCGGCCTTCCTGGAGCACGTC
TCCCTGGTGATGGAGGCCTCCGAGGCCGAGGGCGCCGAGCGGGTCTCGCTGATGACGCTCCACGCCGCCAAGGGGCTCGA
GTTCGACACCGTGTTCCTTCCCGGCTGGGAGGACGGCCTGTTCCCGAACCAGCGCGCGCTGGACGAGAGCGGCCGGGCGG
GCCTGGAGGAGGAGCGGCGCCTCGCCCATGTCGGCCTGACCCGGGCGCGCAAGCGCGCGAAGCTGTCCTTCGCGGTCAAC
CGGCGCATCCACGGGCTCTGGTCCTCGACCATCCCGTCCCGGTTCATCGACGAGCTGCCCGAGACGGCGGTCGACGTGGT
CGAGGCCCCCGCCCAATTCTCCGCCGGCACCTCGCGGTTCGACCGCAACCCGGCGCCGTTCGGGTCGAGCTACGGCACGC
CGGGCTGGCAGCGGGCGCAGGCCAACACCGCGCCGGGCGGCCGGTCCGGGTTCGGCGCCGCGGGCGGCTTCCGCGCGGCG
GCCCCGGGCGGCCGGTCCGGCGGCCAAGCGGGCGGTCCGCGCCAGATCGAGGGCGAGCTGATCGCCAAGTCGACCGGCGC
GCCCTCGGCCTTCCAGGCCGGCCAGCGGGTCTTCCACACCAAGTTCGGCCCCGGAACGGTCGCCGCGGTCGACGGCAACA
AGCTGACCGTTGACTTCGACAAGGCCGGCCGGAAGATGGTCCTCGACAGCTTCGTCCAGGCCGGATCAAGCTAG

Upstream 100 bases:

>100_bases
CCGGATCGTCCCGGCGCGGGCAGCCGCGTTTCATGGCTCCGCCCCCCTTCGCGGCGCGAACGGCCTCGACGCCGTTCGCG
ATTTGGTCCAGGGAAGCGGG

Downstream 100 bases:

>100_bases
TCCCGCCGACCAAGCCCGGACGTGTCAGGGCGGCAGGGTCGGCCGGCTTCGCCCGTGCGGGCGGGGAGGATCGCGATCGT
GCCGGATGCCGCGTCACCGC

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 797; Mature: 797

Protein sequence:

>797_residues
MQNRPHPQAAGDGAPATSIAARAMGALRRESAGYLEGLNPEQRRAVETTEGPVLVLAGAGTGKTRVLTTRIAHLIATGRA
RPFDILAVTFTNKAAREMKHRIGALIGPAGEGMPWLGTFHAIGTKILRRHAELVGLKSDFTILGTDDQLRLMKQVIADQN
VDEKRWPARALSHAVDGWKNRGLGPEQVPPGEAAAFAFGKGGALYTAYQARLATLNAVDFGDLLLLCLKLWRENPDVLAN
YQDRFRYILVDEYQDTNVAQYLWLRLLAQARKNIACVGDDDQSIYGWRGAEVDNILRFEHDFPGAVVVRLERNYRSTGHI
LAAASGLIAKNESRLGKTLRTDDEPGERVTVTGAWDSEEEARMLAESIESLQSKQHPLSEIAVLVRISAQMREIEDRFVQ
LGLPYRVIGGPRFYERAEIRDALAYLRATVNVSDDLAFERIVNTPKRGLGDATLQQLHTYGRANRLPLRIAAERLCETDE
LKPRVRSTLRALTESFSRWARLVESQPHSEVAQTILEESGYTEMWQKDRSADAAGRLENLKEFVRSMEEFPDLAAFLEHV
SLVMEASEAEGAERVSLMTLHAAKGLEFDTVFLPGWEDGLFPNQRALDESGRAGLEEERRLAHVGLTRARKRAKLSFAVN
RRIHGLWSSTIPSRFIDELPETAVDVVEAPAQFSAGTSRFDRNPAPFGSSYGTPGWQRAQANTAPGGRSGFGAAGGFRAA
APGGRSGGQAGGPRQIEGELIAKSTGAPSAFQAGQRVFHTKFGPGTVAAVDGNKLTVDFDKAGRKMVLDSFVQAGSS

Sequences:

>Translated_797_residues
MQNRPHPQAAGDGAPATSIAARAMGALRRESAGYLEGLNPEQRRAVETTEGPVLVLAGAGTGKTRVLTTRIAHLIATGRA
RPFDILAVTFTNKAAREMKHRIGALIGPAGEGMPWLGTFHAIGTKILRRHAELVGLKSDFTILGTDDQLRLMKQVIADQN
VDEKRWPARALSHAVDGWKNRGLGPEQVPPGEAAAFAFGKGGALYTAYQARLATLNAVDFGDLLLLCLKLWRENPDVLAN
YQDRFRYILVDEYQDTNVAQYLWLRLLAQARKNIACVGDDDQSIYGWRGAEVDNILRFEHDFPGAVVVRLERNYRSTGHI
LAAASGLIAKNESRLGKTLRTDDEPGERVTVTGAWDSEEEARMLAESIESLQSKQHPLSEIAVLVRISAQMREIEDRFVQ
LGLPYRVIGGPRFYERAEIRDALAYLRATVNVSDDLAFERIVNTPKRGLGDATLQQLHTYGRANRLPLRIAAERLCETDE
LKPRVRSTLRALTESFSRWARLVESQPHSEVAQTILEESGYTEMWQKDRSADAAGRLENLKEFVRSMEEFPDLAAFLEHV
SLVMEASEAEGAERVSLMTLHAAKGLEFDTVFLPGWEDGLFPNQRALDESGRAGLEEERRLAHVGLTRARKRAKLSFAVN
RRIHGLWSSTIPSRFIDELPETAVDVVEAPAQFSAGTSRFDRNPAPFGSSYGTPGWQRAQANTAPGGRSGFGAAGGFRAA
APGGRSGGQAGGPRQIEGELIAKSTGAPSAFQAGQRVFHTKFGPGTVAAVDGNKLTVDFDKAGRKMVLDSFVQAGSS
>Mature_797_residues
MQNRPHPQAAGDGAPATSIAARAMGALRRESAGYLEGLNPEQRRAVETTEGPVLVLAGAGTGKTRVLTTRIAHLIATGRA
RPFDILAVTFTNKAAREMKHRIGALIGPAGEGMPWLGTFHAIGTKILRRHAELVGLKSDFTILGTDDQLRLMKQVIADQN
VDEKRWPARALSHAVDGWKNRGLGPEQVPPGEAAAFAFGKGGALYTAYQARLATLNAVDFGDLLLLCLKLWRENPDVLAN
YQDRFRYILVDEYQDTNVAQYLWLRLLAQARKNIACVGDDDQSIYGWRGAEVDNILRFEHDFPGAVVVRLERNYRSTGHI
LAAASGLIAKNESRLGKTLRTDDEPGERVTVTGAWDSEEEARMLAESIESLQSKQHPLSEIAVLVRISAQMREIEDRFVQ
LGLPYRVIGGPRFYERAEIRDALAYLRATVNVSDDLAFERIVNTPKRGLGDATLQQLHTYGRANRLPLRIAAERLCETDE
LKPRVRSTLRALTESFSRWARLVESQPHSEVAQTILEESGYTEMWQKDRSADAAGRLENLKEFVRSMEEFPDLAAFLEHV
SLVMEASEAEGAERVSLMTLHAAKGLEFDTVFLPGWEDGLFPNQRALDESGRAGLEEERRLAHVGLTRARKRAKLSFAVN
RRIHGLWSSTIPSRFIDELPETAVDVVEAPAQFSAGTSRFDRNPAPFGSSYGTPGWQRAQANTAPGGRSGFGAAGGFRAA
APGGRSGGQAGGPRQIEGELIAKSTGAPSAFQAGQRVFHTKFGPGTVAAVDGNKLTVDFDKAGRKMVLDSFVQAGSS

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=779, Percent_Identity=40.8215661103979, Blast_Score=537, Evalue=1e-153,
Organism=Escherichia coli, GI48994965, Length=667, Percent_Identity=38.2308845577211, Blast_Score=391, Evalue=1e-109,
Organism=Escherichia coli, GI1787196, Length=423, Percent_Identity=26.7139479905437, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322369, Length=456, Percent_Identity=32.4561403508772, Blast_Score=177, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6324477, Length=472, Percent_Identity=23.5169491525424, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 87307; Mature: 87307

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNRPHPQAAGDGAPATSIAARAMGALRRESAGYLEGLNPEQRRAVETTEGPVLVLAGAG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHCCCCCCCEEEEECCC
TGKTRVLTTRIAHLIATGRARPFDILAVTFTNKAAREMKHRIGALIGPAGEGMPWLGTFH
CCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHEECCCCCCCCCHHHHH
AIGTKILRRHAELVGLKSDFTILGTDDQLRLMKQVIADQNVDEKRWPARALSHAVDGWKN
HHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
RGLGPEQVPPGEAAAFAFGKGGALYTAYQARLATLNAVDFGDLLLLCLKLWRENPDVLAN
CCCCCCCCCCCCHHEEEECCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHCCC
YQDRFRYILVDEYQDTNVAQYLWLRLLAQARKNIACVGDDDQSIYGWRGAEVDNILRFEH
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHCC
DFPGAVVVRLERNYRSTGHILAAASGLIAKNESRLGKTLRTDDEPGERVTVTGAWDSEEE
CCCCEEEEEEECCCCCCCCHHHHHCCHHCCCHHHHCCHHCCCCCCCCEEEEEECCCCHHH
ARMLAESIESLQSKQHPLSEIAVLVRISAQMREIEDRFVQLGLPYRVIGGPRFYERAEIR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHH
DALAYLRATVNVSDDLAFERIVNTPKRGLGDATLQQLHTYGRANRLPLRIAAERLCETDE
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
LKPRVRSTLRALTESFSRWARLVESQPHSEVAQTILEESGYTEMWQKDRSADAAGRLENL
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHH
KEFVRSMEEFPDLAAFLEHVSLVMEASEAEGAERVSLMTLHAAKGLEFDTVFLPGWEDGL
HHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEHHHCCCCEEEEECCCCCCCC
FPNQRALDESGRAGLEEERRLAHVGLTRARKRAKLSFAVNRRIHGLWSSTIPSRFIDELP
CCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ETAVDVVEAPAQFSAGTSRFDRNPAPFGSSYGTPGWQRAQANTAPGGRSGFGAAGGFRAA
HHHHHHHHCCHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
APGGRSGGQAGGPRQIEGELIAKSTGAPSAFQAGQRVFHTKFGPGTVAAVDGNKLTVDFD
CCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHEEECCCCCEEEEECCCEEEEEHH
KAGRKMVLDSFVQAGSS
HCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MQNRPHPQAAGDGAPATSIAARAMGALRRESAGYLEGLNPEQRRAVETTEGPVLVLAGAG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHCCCCCCCEEEEECCC
TGKTRVLTTRIAHLIATGRARPFDILAVTFTNKAAREMKHRIGALIGPAGEGMPWLGTFH
CCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHEECCCCCCCCCHHHHH
AIGTKILRRHAELVGLKSDFTILGTDDQLRLMKQVIADQNVDEKRWPARALSHAVDGWKN
HHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
RGLGPEQVPPGEAAAFAFGKGGALYTAYQARLATLNAVDFGDLLLLCLKLWRENPDVLAN
CCCCCCCCCCCCHHEEEECCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHCCC
YQDRFRYILVDEYQDTNVAQYLWLRLLAQARKNIACVGDDDQSIYGWRGAEVDNILRFEH
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHCC
DFPGAVVVRLERNYRSTGHILAAASGLIAKNESRLGKTLRTDDEPGERVTVTGAWDSEEE
CCCCEEEEEEECCCCCCCCHHHHHCCHHCCCHHHHCCHHCCCCCCCCEEEEEECCCCHHH
ARMLAESIESLQSKQHPLSEIAVLVRISAQMREIEDRFVQLGLPYRVIGGPRFYERAEIR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHH
DALAYLRATVNVSDDLAFERIVNTPKRGLGDATLQQLHTYGRANRLPLRIAAERLCETDE
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
LKPRVRSTLRALTESFSRWARLVESQPHSEVAQTILEESGYTEMWQKDRSADAAGRLENL
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHH
KEFVRSMEEFPDLAAFLEHVSLVMEASEAEGAERVSLMTLHAAKGLEFDTVFLPGWEDGL
HHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEHHHCCCCEEEEECCCCCCCC
FPNQRALDESGRAGLEEERRLAHVGLTRARKRAKLSFAVNRRIHGLWSSTIPSRFIDELP
CCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ETAVDVVEAPAQFSAGTSRFDRNPAPFGSSYGTPGWQRAQANTAPGGRSGFGAAGGFRAA
HHHHHHHHCCHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
APGGRSGGQAGGPRQIEGELIAKSTGAPSAFQAGQRVFHTKFGPGTVAAVDGNKLTVDFD
CCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHEEECCCCCEEEEECCCEEEEEHH
KAGRKMVLDSFVQAGSS
HCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA