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The map label for this gene is tcyB [H]

Identifier: 170751306

GI number: 170751306

Start: 5243682

End: 5244362

Strand: Reverse

Name: tcyB [H]

Synonym: Mrad2831_4923

Alternate gene names: 170751306

Gene position: 5244362-5243682 (Counterclockwise)

Preceding gene: 170751307

Following gene: 170751305

Centisome position: 86.29

GC content: 71.51

Gene sequence:

>681_bases
GTGCCGCACTGGCTCGACCTCATGCTCCAGTCGCTGGGGCCGCTGCTCGCGGCCGGCCTGCGCTTCACGGTGCCGCTGAC
GCTCATCGCCTTCGCGCTCGGCCTCGCGCTGGGACTCGGCACCGCCCTCGTGCGGCTGTTCGCGCCCCGGCCGCTGGCGG
CGTTGGCGTGGCTCTACGTGTGGATCTTCCGGGGCACGCCGCTCCTCGTGCAGCTGTTCGTGATCTTCTACGGCCTGCCG
AGCACCGGCATCCTGATCGACGCCTTCCCGGCCGCCGTGATCGGGTTCACCCTCAACGTCGGCGCCTACACGTCCGAGAT
CGTCCGCGCCGCCATCGCCTCCATCCCGAAGGGGCAGTGGGAGGCGGCCTACGCCACCGGGATGACGCCGGTCCAGGCCC
TGCGCCGCACGATCCTGCCCCAGGCGGCGCGGGTGGCGGTGCCGTCGCTGGCGAACTCCTTCATCGCGCTGGTGAAGGAC
ACCTCGCTCGCGGCCGCCATCACGGTGCCGGAGCTGTTCCAGGCGGCCCAGCGCATCGTCGCCGTCACCTACGAGCCGCT
GATCCTCTACATCGAGGTGGCGCTGATCTACCTCGTCCTGTCGACGCTGCTGTCCTGGCTCCAGACGCTGCTGGAGCGGC
GCCTCGGGCGCTACGGCGGCTACCTGGAGGCCCGCGCGTGA

Upstream 100 bases:

>100_bases
CGGGGCCGACGTCTCCAAGTAACCCGTCCGCGGCGCGCCCGCCCGGGCGCCGATCCCGCACAGCCCGCCGCTCGATCCGC
CCGGTAGGAGACGCCGCCCC

Downstream 100 bases:

>100_bases
TCGCCCTGTCGGCCATCGAGAAGCGCTTCGGCGACAACCCCGTCCTGCGGGGCGTCGACCTCGCGGTCCCGGAGGGGCGG
GTCACGGCGCTGATCGGCCC

Product: polar amino acid ABC transporter inner membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MPHWLDLMLQSLGPLLAAGLRFTVPLTLIAFALGLALGLGTALVRLFAPRPLAALAWLYVWIFRGTPLLVQLFVIFYGLP
STGILIDAFPAAVIGFTLNVGAYTSEIVRAAIASIPKGQWEAAYATGMTPVQALRRTILPQAARVAVPSLANSFIALVKD
TSLAAAITVPELFQAAQRIVAVTYEPLILYIEVALIYLVLSTLLSWLQTLLERRLGRYGGYLEARA

Sequences:

>Translated_226_residues
MPHWLDLMLQSLGPLLAAGLRFTVPLTLIAFALGLALGLGTALVRLFAPRPLAALAWLYVWIFRGTPLLVQLFVIFYGLP
STGILIDAFPAAVIGFTLNVGAYTSEIVRAAIASIPKGQWEAAYATGMTPVQALRRTILPQAARVAVPSLANSFIALVKD
TSLAAAITVPELFQAAQRIVAVTYEPLILYIEVALIYLVLSTLLSWLQTLLERRLGRYGGYLEARA
>Mature_225_residues
PHWLDLMLQSLGPLLAAGLRFTVPLTLIAFALGLALGLGTALVRLFAPRPLAALAWLYVWIFRGTPLLVQLFVIFYGLPS
TGILIDAFPAAVIGFTLNVGAYTSEIVRAAIASIPKGQWEAAYATGMTPVQALRRTILPQAARVAVPSLANSFIALVKDT
SLAAAITVPELFQAAQRIVAVTYEPLILYIEVALIYLVLSTLLSWLQTLLERRLGRYGGYLEARA

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable) [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788226, Length=217, Percent_Identity=52.9953917050691, Blast_Score=207, Evalue=3e-55,
Organism=Escherichia coli, GI1787030, Length=204, Percent_Identity=37.7450980392157, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1788645, Length=226, Percent_Identity=36.283185840708, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1787086, Length=216, Percent_Identity=34.2592592592593, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1786873, Length=211, Percent_Identity=34.1232227488152, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1788646, Length=218, Percent_Identity=31.651376146789, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1787087, Length=227, Percent_Identity=30.8370044052863, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786874, Length=219, Percent_Identity=29.6803652968037, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI87082239, Length=217, Percent_Identity=32.7188940092166, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI48994930, Length=133, Percent_Identity=33.0827067669173, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24462; Mature: 24330

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHWLDLMLQSLGPLLAAGLRFTVPLTLIAFALGLALGLGTALVRLFAPRPLAALAWLYV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
WIFRGTPLLVQLFVIFYGLPSTGILIDAFPAAVIGFTLNVGAYTSEIVRAAIASIPKGQW
HHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
EAAYATGMTPVQALRRTILPQAARVAVPSLANSFIALVKDTSLAAAITVPELFQAAQRIV
HHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AVTYEPLILYIEVALIYLVLSTLLSWLQTLLERRLGRYGGYLEARA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PHWLDLMLQSLGPLLAAGLRFTVPLTLIAFALGLALGLGTALVRLFAPRPLAALAWLYV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
WIFRGTPLLVQLFVIFYGLPSTGILIDAFPAAVIGFTLNVGAYTSEIVRAAIASIPKGQW
HHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
EAAYATGMTPVQALRRTILPQAARVAVPSLANSFIALVKDTSLAAAITVPELFQAAQRIV
HHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AVTYEPLILYIEVALIYLVLSTLLSWLQTLLERRLGRYGGYLEARA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377 [H]