Click here to switch to the map view.

The map label for this gene is parC [H]

Identifier: 170748445

GI number: 170748445

Start: 2154874

End: 2157120

Strand: Reverse

Name: parC [H]

Synonym: Mrad2831_2027

Alternate gene names: 170748445

Gene position: 2157120-2154874 (Counterclockwise)

Preceding gene: 170748446

Following gene: 170748439

Centisome position: 35.49

GC content: 69.6

Gene sequence:

>2247_bases
ATGGGCCAGCCCTTCGAGCCGCCGTCCGGCGACGGGATCGAGAGCGTCGAGCTGAAATCCGCGCTGGAGGAGCGCTACCT
CGCCTACGCGCTCTCCACGATCATGCACCGGGCCCTGCCGGACGCCCGCGACGGGTTGAAGCCCGTGCACCGGCGCATTC
TGTACGGGATGCGGCTGCTCCGGCTCGACCCGACCACCGCGCACAAGAAATGCGCCAAGATCGTCGGCGACGTGATGGGC
GATTTCCACCCGCACGGCGACCAGGCGATCTACGACGCGCTGGTGCGGCTCTCCCAGGACTTCGCCCAGCGCTACCCGCT
GGTCGACGGCCAGGGCAACTTCGGCAACATCGACGGCGATGGCCCGGCCGCCTACCGCTACACCGAGGCGCGGCTCACCG
AGGTCGCGCGCCTCCTGCTCGACGGGATCGACGAGGACACGGTCGATTTCCGCCCCTCCTACAACGGCGAGAAGGAGGAG
CCGGTCGTCCTGCCGGCGGCCTTCCCGAACCTGCTGGCCAACGGCAGCCAGGGCATCGCGGTCGGCATGGCGACCTCGAT
CCCGCCGCACAACGCCGCCGAGCTGTGCGACGCGGCGCTCTACCTGATCAACCATCCCGAGGCGACCTCGGGTCAGCTCG
CCAAGTTCGTCCAGGGGCCGGATTTCCCGACCGGCGGCATCCTGATCGACTCGGCCGAGTCGGTCGCCGAGGCCTACCGG
ACCGGCCGCGGCGCCTTCCGGGTCCGGGCCCGCTGGGCCAAGGAGGATCTCGGCCGCGGCACTTGGAACATCGTCGTCAC
CGAGATTCCCTACGGCATCCCGAAGGGCCGGCTGATCGAGAAGATGGCCGAGCTGCTGCAGGAGAAGAAGCTGCCGCTCC
TCGCCGACGTGCGCGACGAATCGGCCGAGGACGTGCGCATCGTGCTGGAGCCGCGCTCGCGCACGGTCGATCCCGTGATC
CTGATGGAATCTTTGTTCCGGCTGACCGAGCTGGAGGCGCGGATTCCGCTCAACCTCAACGTCCTGGTCGGCGGCCTCGT
GCCGAAGGTGATCGGGCTCGCCGAGTGCCTGCGGGAATGGGTCGACCACCGCCGCGTGGTGCTGCAGCGCCGCTCGCGCT
ACCGCCTCGGCCAGATCGACCGGCGCCTTGAGATCCTGGGCGGCCTGCTCATCGTCTATCTCGACCTCGACGAGGTGATC
CGCATCATCCGCGAGGAGGACGAGCCGAAGGCCGCCCTCATGGCCCGGTTCGAGCTGACCGAGATCCAGGCCAACGCGAT
CCTCGACACCCGCCTGCGCTCCCTGCGCAAGCTCGAGGAGATGGAGTTGAAGCGCGAGTTCGACGCGCTCACCGCCGAGA
AGGCCGAGATCGACGCCCTGCTCGCTTCCGAGCCGGCGCAGTGGAAGGCGATCCAGGCGCAGATCCGCGCCGTGAAGAAG
ACCTTCGGGCCCGAGACCAAGCTGGGCCGCCGCCGCACGACGCTGGCGAGCCCGCCGGATGTCGGCGGCATCGACTTTAC
GGCGGCGCTGGTCGAGCGCGAGCCCATCACCGTGATCGTCTCGACCAAGGGCTGGATCCGGGCACTCAAGGGCCACGTGG
CGGACCTCTCCGGCGTGGCGTTCAAGGGCGACGACACCCTGAAGATCGCCTTCCCGACCGAGACCACGCAGAAGATCCTG
TTGCTCGCCACCAACGGCAAGGTGTTCACGCTGGAGGCCTCGAAGCTGCCGGGCGGGCGCGGCTTCGGCGACCCGGTCCG
GCTGATGGCCGACCTCGACGACGGCACCGAGATCGTGGCGGCGCTGCCCTACCGGCCGGAGACCAAGCTGCTGATCGCGG
GCTCCGACGGGCGCGGCTTCGTGGCGCCCGCGGACGCGCTGGTGGCCAACACCCGCAAGGGCAAGAACGTGCTGGGCCTC
GACGGCGACGCCACGGCCGCCGTGCTGGTACCGGCCGACGGCGACCACGTGGCGGTGGTGAACACCGAGAAGCTGCTCCT
GATCTTCCCGGTCTCCGAGGTGGCGGAACTCGCCCGCGGCAAGGGCGTGCGGCTCCAGCGCTGCCGCAGCGGAAGCCTCC
TCGACGCGCACGTCTTCAAGCTGGCGGACGGTCTGCCCTGGCAGGACGGCTCGGCCGAAGGCCGACTCGCCAACGTCTCG
GTGCTGGAGAAATGGCTCGGCCACAGGGCCGAGGTCGGGCTGATGATGGCGCGCAGCTTCCCGAAATTCGAGCGGTTCGG
GCGTTGA

Upstream 100 bases:

>100_bases
GGGTCTGGATTCCGGGCTCGCCTCCGGCGCCCCGGAATGACGGATTGCTGCATGAGGTGGCGCCGCCGTTCGGCGGCCCC
GCCCTGAGACAGGAGCCGTC

Downstream 100 bases:

>100_bases
GGGAGGCCGGGGGCGCTCCAGTGCCCCCTCCCGGCCTGAGGTGCCAGTGCTCGCTGGACCCATCCTTCTGGACGGCTCCA
CCGCAGCTCAGGACGAGGGC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 748; Mature: 747

Protein sequence:

>748_residues
MGQPFEPPSGDGIESVELKSALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLLRLDPTTAHKKCAKIVGDVMG
DFHPHGDQAIYDALVRLSQDFAQRYPLVDGQGNFGNIDGDGPAAYRYTEARLTEVARLLLDGIDEDTVDFRPSYNGEKEE
PVVLPAAFPNLLANGSQGIAVGMATSIPPHNAAELCDAALYLINHPEATSGQLAKFVQGPDFPTGGILIDSAESVAEAYR
TGRGAFRVRARWAKEDLGRGTWNIVVTEIPYGIPKGRLIEKMAELLQEKKLPLLADVRDESAEDVRIVLEPRSRTVDPVI
LMESLFRLTELEARIPLNLNVLVGGLVPKVIGLAECLREWVDHRRVVLQRRSRYRLGQIDRRLEILGGLLIVYLDLDEVI
RIIREEDEPKAALMARFELTEIQANAILDTRLRSLRKLEEMELKREFDALTAEKAEIDALLASEPAQWKAIQAQIRAVKK
TFGPETKLGRRRTTLASPPDVGGIDFTAALVEREPITVIVSTKGWIRALKGHVADLSGVAFKGDDTLKIAFPTETTQKIL
LLATNGKVFTLEASKLPGGRGFGDPVRLMADLDDGTEIVAALPYRPETKLLIAGSDGRGFVAPADALVANTRKGKNVLGL
DGDATAAVLVPADGDHVAVVNTEKLLLIFPVSEVAELARGKGVRLQRCRSGSLLDAHVFKLADGLPWQDGSAEGRLANVS
VLEKWLGHRAEVGLMMARSFPKFERFGR

Sequences:

>Translated_748_residues
MGQPFEPPSGDGIESVELKSALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLLRLDPTTAHKKCAKIVGDVMG
DFHPHGDQAIYDALVRLSQDFAQRYPLVDGQGNFGNIDGDGPAAYRYTEARLTEVARLLLDGIDEDTVDFRPSYNGEKEE
PVVLPAAFPNLLANGSQGIAVGMATSIPPHNAAELCDAALYLINHPEATSGQLAKFVQGPDFPTGGILIDSAESVAEAYR
TGRGAFRVRARWAKEDLGRGTWNIVVTEIPYGIPKGRLIEKMAELLQEKKLPLLADVRDESAEDVRIVLEPRSRTVDPVI
LMESLFRLTELEARIPLNLNVLVGGLVPKVIGLAECLREWVDHRRVVLQRRSRYRLGQIDRRLEILGGLLIVYLDLDEVI
RIIREEDEPKAALMARFELTEIQANAILDTRLRSLRKLEEMELKREFDALTAEKAEIDALLASEPAQWKAIQAQIRAVKK
TFGPETKLGRRRTTLASPPDVGGIDFTAALVEREPITVIVSTKGWIRALKGHVADLSGVAFKGDDTLKIAFPTETTQKIL
LLATNGKVFTLEASKLPGGRGFGDPVRLMADLDDGTEIVAALPYRPETKLLIAGSDGRGFVAPADALVANTRKGKNVLGL
DGDATAAVLVPADGDHVAVVNTEKLLLIFPVSEVAELARGKGVRLQRCRSGSLLDAHVFKLADGLPWQDGSAEGRLANVS
VLEKWLGHRAEVGLMMARSFPKFERFGR
>Mature_747_residues
GQPFEPPSGDGIESVELKSALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLLRLDPTTAHKKCAKIVGDVMGD
FHPHGDQAIYDALVRLSQDFAQRYPLVDGQGNFGNIDGDGPAAYRYTEARLTEVARLLLDGIDEDTVDFRPSYNGEKEEP
VVLPAAFPNLLANGSQGIAVGMATSIPPHNAAELCDAALYLINHPEATSGQLAKFVQGPDFPTGGILIDSAESVAEAYRT
GRGAFRVRARWAKEDLGRGTWNIVVTEIPYGIPKGRLIEKMAELLQEKKLPLLADVRDESAEDVRIVLEPRSRTVDPVIL
MESLFRLTELEARIPLNLNVLVGGLVPKVIGLAECLREWVDHRRVVLQRRSRYRLGQIDRRLEILGGLLIVYLDLDEVIR
IIREEDEPKAALMARFELTEIQANAILDTRLRSLRKLEEMELKREFDALTAEKAEIDALLASEPAQWKAIQAQIRAVKKT
FGPETKLGRRRTTLASPPDVGGIDFTAALVEREPITVIVSTKGWIRALKGHVADLSGVAFKGDDTLKIAFPTETTQKILL
LATNGKVFTLEASKLPGGRGFGDPVRLMADLDDGTEIVAALPYRPETKLLIAGSDGRGFVAPADALVANTRKGKNVLGLD
GDATAAVLVPADGDHVAVVNTEKLLLIFPVSEVAELARGKGVRLQRCRSGSLLDAHVFKLADGLPWQDGSAEGRLANVSV
LEKWLGHRAEVGLMMARSFPKFERFGR

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=180, Percent_Identity=30.5555555555556, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789396, Length=681, Percent_Identity=40.3817914831131, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1788562, Length=753, Percent_Identity=35.9893758300133, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17535065, Length=447, Percent_Identity=25.7270693512304, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=363, Percent_Identity=23.9669421487603, Blast_Score=73, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=180, Percent_Identity=29.4444444444444, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136538, Length=208, Percent_Identity=28.8461538461538, Blast_Score=73, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 82099; Mature: 81967

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQPFEPPSGDGIESVELKSALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHE
RLDPTTAHKKCAKIVGDVMGDFHPHGDQAIYDALVRLSQDFAQRYPLVDGQGNFGNIDGD
EECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GPAAYRYTEARLTEVARLLLDGIDEDTVDFRPSYNGEKEEPVVLPAAFPNLLANGSQGIA
CCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCCCCEE
VGMATSIPPHNAAELCDAALYLINHPEATSGQLAKFVQGPDFPTGGILIDSAESVAEAYR
EEEECCCCCCCHHHHHHHHHHEECCCCCCCHHHHHHHCCCCCCCCCEEEECHHHHHHHHH
TGRGAFRVRARWAKEDLGRGTWNIVVTEIPYGIPKGRLIEKMAELLQEKKLPLLADVRDE
CCCCEEEEEEHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCCC
SAEDVRIVLEPRSRTVDPVILMESLFRLTELEARIPLNLNVLVGGLVPKVIGLAECLREW
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
VDHRRVVLQRRSRYRLGQIDRRLEILGGLLIVYLDLDEVIRIIREEDEPKAALMARFELT
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHH
EIQANAILDTRLRSLRKLEEMELKREFDALTAEKAEIDALLASEPAQWKAIQAQIRAVKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TFGPETKLGRRRTTLASPPDVGGIDFTAALVEREPITVIVSTKGWIRALKGHVADLSGVA
HCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCEE
FKGDDTLKIAFPTETTQKILLLATNGKVFTLEASKLPGGRGFGDPVRLMADLDDGTEIVA
ECCCCEEEEEECCCCCCEEEEEEECCEEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEE
ALPYRPETKLLIAGSDGRGFVAPADALVANTRKGKNVLGLDGDATAAVLVPADGDHVAVV
ECCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCEEEECCCCCCEEEEEECCCCEEEEE
NTEKLLLIFPVSEVAELARGKGVRLQRCRSGSLLDAHVFKLADGLPWQDGSAEGRLANVS
ECCEEEEEECHHHHHHHHCCCCCEEHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEHHH
VLEKWLGHRAEVGLMMARSFPKFERFGR
HHHHHHCCHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure 
GQPFEPPSGDGIESVELKSALEERYLAYALSTIMHRALPDARDGLKPVHRRILYGMRLL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHE
RLDPTTAHKKCAKIVGDVMGDFHPHGDQAIYDALVRLSQDFAQRYPLVDGQGNFGNIDGD
EECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GPAAYRYTEARLTEVARLLLDGIDEDTVDFRPSYNGEKEEPVVLPAAFPNLLANGSQGIA
CCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCCCCEE
VGMATSIPPHNAAELCDAALYLINHPEATSGQLAKFVQGPDFPTGGILIDSAESVAEAYR
EEEECCCCCCCHHHHHHHHHHEECCCCCCCHHHHHHHCCCCCCCCCEEEECHHHHHHHHH
TGRGAFRVRARWAKEDLGRGTWNIVVTEIPYGIPKGRLIEKMAELLQEKKLPLLADVRDE
CCCCEEEEEEHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCCC
SAEDVRIVLEPRSRTVDPVILMESLFRLTELEARIPLNLNVLVGGLVPKVIGLAECLREW
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
VDHRRVVLQRRSRYRLGQIDRRLEILGGLLIVYLDLDEVIRIIREEDEPKAALMARFELT
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHH
EIQANAILDTRLRSLRKLEEMELKREFDALTAEKAEIDALLASEPAQWKAIQAQIRAVKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TFGPETKLGRRRTTLASPPDVGGIDFTAALVEREPITVIVSTKGWIRALKGHVADLSGVA
HCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCEE
FKGDDTLKIAFPTETTQKILLLATNGKVFTLEASKLPGGRGFGDPVRLMADLDDGTEIVA
ECCCCEEEEEECCCCCCEEEEEEECCEEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEE
ALPYRPETKLLIAGSDGRGFVAPADALVANTRKGKNVLGLDGDATAAVLVPADGDHVAVV
ECCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCEEEECCCCCCEEEEEECCCCEEEEE
NTEKLLLIFPVSEVAELARGKGVRLQRCRSGSLLDAHVFKLADGLPWQDGSAEGRLANVS
ECCEEEEEECHHHHHHHHCCCCCEEHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEHHH
VLEKWLGHRAEVGLMMARSFPKFERFGR
HHHHHHCCHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]