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The map label for this gene is map [H]

Identifier: 170747020

GI number: 170747020

Start: 632313

End: 633140

Strand: Reverse

Name: map [H]

Synonym: Mrad2831_0586

Alternate gene names: 170747020

Gene position: 633140-632313 (Counterclockwise)

Preceding gene: 170747025

Following gene: 170747019

Centisome position: 10.42

GC content: 68.84

Gene sequence:

>828_bases
ATGCAGCAGGAACAGGCCAGTGCGCAGGGTGCGCGCCGCGCCCCGGAACCGCCGATCCACGGTCCCGAGGGATTCGAGGG
CATGCGCCGCGCGGGGCGGCTCACCGCCGAGGCCCTCGACCTGCTGATGGAGGCGACGCAGCCCGGCGTCACTACCGAGG
AGCTCGACAAGCTCGCCTACACCTTCGCGATGGATCACGGCGCCTATCCGGCCTCGCTCCTCTACCGCGGCTATCCGAAG
TCGATCTGCACCTCGATCAACCACGTGGTCTGCCACGGCATCCCCAACGACAAACCGCTGCGCGAGGGCGACATCGTCAA
CCTCGACATCTGCCTGATCCTCGACGGCTGGCACGGCGATTCGAGCCGGATGGCCTATGTCGGCGAGGTGCCCCGCAAGG
CCCAGCGCCTGTGCGAGATCACCTACGAGGCGCTGATGCGCGGCGTCGCCGCCGTGAAGCCCGGCGGCTCGACCAACGAT
ATCGGCCGGGCGATCCAGTCCTACGCCGAGGGCGAGCGCTGCTCGGTGGTGCGCGACTTCTGCGGCCACGGCCTCGGGCG
CACCTATCACGACGCGCCCACGATCCTGCACTACGTCGAGGCCAGCTACGACGTGCCGTTCAAGCCCGGACAGTTCTTCA
CGATCGAGCCGATGATCAATCTCGGCCGGCCCGCCGTGAAGGTCCTGGGCGACGGCTGGACCGCCGTGACCCGCGACCGC
TCGCTCTCCGCCCAGTTCGAGCACACGGTCGGCGTCACCGAGACCGGCGTCGAGATCTTCACGATCTCGCCGAAGGGGCT
GCATCAGCCCGTCAACCCGGCCGCCTGA

Upstream 100 bases:

>100_bases
AGCCTCGCCCGACCGGTGACCGATGCGGCTTGGACTCCCGCGCCCCGCGCCGTACATAAGGCGGAGCCCGATTGACGCCG
CCGCGAAAAAAGTCCCGATC

Downstream 100 bases:

>100_bases
CCGGCCGTGTCGCCGCGGCCGGACGACGGTGAGGCGGGGCTGTTCGCCGACAGCGCCGCCCCGTCCCCGGTCGAGAAGGA
GGCGCCGCACTACCACGGCC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MQQEQASAQGARRAPEPPIHGPEGFEGMRRAGRLTAEALDLLMEATQPGVTTEELDKLAYTFAMDHGAYPASLLYRGYPK
SICTSINHVVCHGIPNDKPLREGDIVNLDICLILDGWHGDSSRMAYVGEVPRKAQRLCEITYEALMRGVAAVKPGGSTND
IGRAIQSYAEGERCSVVRDFCGHGLGRTYHDAPTILHYVEASYDVPFKPGQFFTIEPMINLGRPAVKVLGDGWTAVTRDR
SLSAQFEHTVGVTETGVEIFTISPKGLHQPVNPAA

Sequences:

>Translated_275_residues
MQQEQASAQGARRAPEPPIHGPEGFEGMRRAGRLTAEALDLLMEATQPGVTTEELDKLAYTFAMDHGAYPASLLYRGYPK
SICTSINHVVCHGIPNDKPLREGDIVNLDICLILDGWHGDSSRMAYVGEVPRKAQRLCEITYEALMRGVAAVKPGGSTND
IGRAIQSYAEGERCSVVRDFCGHGLGRTYHDAPTILHYVEASYDVPFKPGQFFTIEPMINLGRPAVKVLGDGWTAVTRDR
SLSAQFEHTVGVTETGVEIFTISPKGLHQPVNPAA
>Mature_275_residues
MQQEQASAQGARRAPEPPIHGPEGFEGMRRAGRLTAEALDLLMEATQPGVTTEELDKLAYTFAMDHGAYPASLLYRGYPK
SICTSINHVVCHGIPNDKPLREGDIVNLDICLILDGWHGDSSRMAYVGEVPRKAQRLCEITYEALMRGVAAVKPGGSTND
IGRAIQSYAEGERCSVVRDFCGHGLGRTYHDAPTILHYVEASYDVPFKPGQFFTIEPMINLGRPAVKVLGDGWTAVTRDR
SLSAQFEHTVGVTETGVEIFTISPKGLHQPVNPAA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=255, Percent_Identity=46.2745098039216, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI40385867, Length=242, Percent_Identity=40.0826446280992, Blast_Score=195, Evalue=4e-50,
Organism=Escherichia coli, GI1786364, Length=246, Percent_Identity=50.8130081300813, Blast_Score=259, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI71996291, Length=240, Percent_Identity=43.75, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323273, Length=261, Percent_Identity=42.911877394636, Blast_Score=223, Evalue=2e-59,
Organism=Drosophila melanogaster, GI21355531, Length=263, Percent_Identity=43.7262357414449, Blast_Score=228, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24583427, Length=247, Percent_Identity=42.1052631578947, Blast_Score=207, Evalue=6e-54,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29961; Mature: 29961

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQEQASAQGARRAPEPPIHGPEGFEGMRRAGRLTAEALDLLMEATQPGVTTEELDKLAY
CCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHH
TFAMDHGAYPASLLYRGYPKSICTSINHVVCHGIPNDKPLREGDIVNLDICLILDGWHGD
HHHHCCCCCHHHHHHCCCCHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEEEEECCCCC
SSRMAYVGEVPRKAQRLCEITYEALMRGVAAVKPGGSTNDIGRAIQSYAEGERCSVVRDF
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
CGHGLGRTYHDAPTILHYVEASYDVPFKPGQFFTIEPMINLGRPAVKVLGDGWTAVTRDR
HCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCHHHCCCCEEEEECCCCEEEECCC
SLSAQFEHTVGVTETGVEIFTISPKGLHQPVNPAA
CCCCHHHHHCCCEECCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MQQEQASAQGARRAPEPPIHGPEGFEGMRRAGRLTAEALDLLMEATQPGVTTEELDKLAY
CCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHH
TFAMDHGAYPASLLYRGYPKSICTSINHVVCHGIPNDKPLREGDIVNLDICLILDGWHGD
HHHHCCCCCHHHHHHCCCCHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEEEEECCCCC
SSRMAYVGEVPRKAQRLCEITYEALMRGVAAVKPGGSTNDIGRAIQSYAEGERCSVVRDF
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
CGHGLGRTYHDAPTILHYVEASYDVPFKPGQFFTIEPMINLGRPAVKVLGDGWTAVTRDR
HCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCHHHCCCCEEEEECCCCEEEECCC
SLSAQFEHTVGVTETGVEIFTISPKGLHQPVNPAA
CCCCHHHHHCCCEECCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]