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The map label for this gene is prrA [H]

Identifier: 170746954

GI number: 170746954

Start: 556608

End: 557312

Strand: Reverse

Name: prrA [H]

Synonym: Mrad2831_0520

Alternate gene names: 170746954

Gene position: 557312-556608 (Counterclockwise)

Preceding gene: 170746955

Following gene: 170746953

Centisome position: 9.17

GC content: 69.5

Gene sequence:

>705_bases
ATGACGCGGATCCTGATCGTCGAGGACGATATCGACATTCGCGGCCTCCTCGCCCGGGGTCTCGAAGCCGAGGGATTCGA
GGTCGGGACGGCGGCCTGCGTCGACGAAGCGCTGAAGGCCGCCCACGATCCGGCCCCGGGCGCCGTGCTCCTCGACATCA
ACCTCCCGGACGGATCGGGCCACGACGTCTGCCGGTCCCTGCGGGAGGGCGGCTTCCCCGGAGCGATCCTGTTCCTCTCT
GCCCGGGACGAGATCCGCGACCGCGCCGAAGGCCTGGCGCTCGGCGCCGACGACTACATCGTCAAGCCGTTCGAGTTCGA
CGAATTGGTCGCCCGCCTGCGGACCCATCTGATGCGGCGCGAGCAGGCGGAGGCGCCGCGCTCGCGCATCACCGCCGGCA
AGCTGATGCTCGACCTCGAGACCCGGCAAGCGAGCTGCGGCGAGGCCAGCGCCCGCCTCACGCCCCGCGAGGCCGACCTG
CTCGCCATGCTGATGGAGAATATCGGCAAGCCGGTCTCCCGCGCCGACATCTTCGACCGGCTCTGGGCCAGCCAGGGCGG
GCTCTCCCTCAACGTGGTCGACGTCTATATCGGCTACCTGCGCTCCAAGATGGCCGATTTCGTGCGCTACGGCGGGCCGG
GCCTCGTCACCGTGCGCGGCAAAGGATTCATGCTCGAACTGCGCGGTCCCGACTTCCGCCAGTGA

Upstream 100 bases:

>100_bases
CCCTGGACATCCCGGCCTGCGATCCGGCATGGGAAACGGGCGCGGCCGACGGCGCTGCTGTCGGTGCCCGAGTGGGCGCG
CAGGTGAAGGAGTCGGCCGC

Downstream 100 bases:

>100_bases
GCCACTGTACTTTAGTCGCAGGGTCGCCTGTTTCGTGATGGTTTCCGGACGCTTAGGAAGTCTCTCACGAAAAATTTGGG
AGGATCCGGCAACTTAGTGC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTRILIVEDDIDIRGLLARGLEAEGFEVGTAACVDEALKAAHDPAPGAVLLDINLPDGSGHDVCRSLREGGFPGAILFLS
ARDEIRDRAEGLALGADDYIVKPFEFDELVARLRTHLMRREQAEAPRSRITAGKLMLDLETRQASCGEASARLTPREADL
LAMLMENIGKPVSRADIFDRLWASQGGLSLNVVDVYIGYLRSKMADFVRYGGPGLVTVRGKGFMLELRGPDFRQ

Sequences:

>Translated_234_residues
MTRILIVEDDIDIRGLLARGLEAEGFEVGTAACVDEALKAAHDPAPGAVLLDINLPDGSGHDVCRSLREGGFPGAILFLS
ARDEIRDRAEGLALGADDYIVKPFEFDELVARLRTHLMRREQAEAPRSRITAGKLMLDLETRQASCGEASARLTPREADL
LAMLMENIGKPVSRADIFDRLWASQGGLSLNVVDVYIGYLRSKMADFVRYGGPGLVTVRGKGFMLELRGPDFRQ
>Mature_233_residues
TRILIVEDDIDIRGLLARGLEAEGFEVGTAACVDEALKAAHDPAPGAVLLDINLPDGSGHDVCRSLREGGFPGAILFLSA
RDEIRDRAEGLALGADDYIVKPFEFDELVARLRTHLMRREQAEAPRSRITAGKLMLDLETRQASCGEASARLTPREADLL
AMLMENIGKPVSRADIFDRLWASQGGLSLNVVDVYIGYLRSKMADFVRYGGPGLVTVRGKGFMLELRGPDFRQ

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=37.9464285714286, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786784, Length=234, Percent_Identity=38.8888888888889, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786911, Length=205, Percent_Identity=37.0731707317073, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=36.7256637168142, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=32.7433628318584, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1786599, Length=233, Percent_Identity=34.3347639484979, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=35.1111111111111, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=31.6742081447964, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=32.3275862068966, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788394, Length=203, Percent_Identity=33.4975369458128, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=32.6086956521739, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=32.7510917030568, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=33.9449541284404, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=31.6455696202532, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25598; Mature: 25467

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRILIVEDDIDIRGLLARGLEAEGFEVGTAACVDEALKAAHDPAPGAVLLDINLPDGSG
CCEEEEEECCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
HDVCRSLREGGFPGAILFLSARDEIRDRAEGLALGADDYIVKPFEFDELVARLRTHLMRR
HHHHHHHHHCCCCEEEEEEECHHHHHHHHCCEEECCCCCEECCCCHHHHHHHHHHHHHHH
EQAEAPRSRITAGKLMLDLETRQASCGEASARLTPREADLLAMLMENIGKPVSRADIFDR
HHHHCCHHHCCHHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHH
LWASQGGLSLNVVDVYIGYLRSKMADFVRYGGPGLVTVRGKGFMLELRGPDFRQ
HHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCC
>Mature Secondary Structure 
TRILIVEDDIDIRGLLARGLEAEGFEVGTAACVDEALKAAHDPAPGAVLLDINLPDGSG
CEEEEEECCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
HDVCRSLREGGFPGAILFLSARDEIRDRAEGLALGADDYIVKPFEFDELVARLRTHLMRR
HHHHHHHHHCCCCEEEEEEECHHHHHHHHCCEEECCCCCEECCCCHHHHHHHHHHHHHHH
EQAEAPRSRITAGKLMLDLETRQASCGEASARLTPREADLLAMLMENIGKPVSRADIFDR
HHHHCCHHHCCHHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHH
LWASQGGLSLNVVDVYIGYLRSKMADFVRYGGPGLVTVRGKGFMLELRGPDFRQ
HHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]