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The map label for this gene is apxIB [H]

Identifier: 170746841

GI number: 170746841

Start: 445859

End: 447559

Strand: Reverse

Name: apxIB [H]

Synonym: Mrad2831_0403

Alternate gene names: 170746841

Gene position: 447559-445859 (Counterclockwise)

Preceding gene: 170746842

Following gene: 170746840

Centisome position: 7.36

GC content: 67.78

Gene sequence:

>1701_bases
ATGGATGCGACGAAACACAAACCGCTGACGCTCGCGGAAGCCTGCAGGCTCATCGGCCGTTTCCTCAGGCCGGAGGCCGG
TTTCGTCTGGACTGCGGTCGTCTACGGCATCGCCGTGGCGCTCCTGGGCCTCGCCGTGCCGGTGTCGGTGCAGCTCCTGA
TCAACTCGGTGGCCAACACTGCGCTGCCGGCGCCCCTGTTCGTCCTGTCCGGGCTGCTCCTCGGCCTGCTGCTCGCCGCC
GCCCTGCTGAGCGCCGCGCGGATCTATGTTTTGGCGCTGTTCGAGAGGCGCGTGTTCGCGAGAACCGTCGCGGACATCAC
CCTGCGCGCCCTCCATGCCAGAAACCCGCATTTCGACGATGCACGCCGCGGCGACCTGTTCAATCGCTTCTTCGACCTCA
TGACGGTCCAGAAGGCGGTACCGCATCTTCTGGTCGGCGGCTTTGCGATCCTCCTGCAGTCCGGGATCGGCCTCGTCCTG
ACGAGTTTCTATCATCCGTTCTTCCTCGCCTTTAATCTGGTCGTGGTCGCCGTGCTCGTCGGCATCGCGTTCCTCTGGGC
GGCGCCGGCGGTCCGGTCCGGCGCGGCGCTGAGCCATGCCAAGCATGAGACGGCACGCTGGCTTGAGAGCGTCGGCAGTT
CGAACGGCTTCTACAGGCATGGTGGTCGCCTCACGACCGCGCTTGCCCGTTCCGAGGCTTTGACCGCCACCTACGCGAGG
GTGCATCGCCGCCATTTCCGTCACACCTTCGCACAGACCATCGGATTCCTCATGGTCTACGCCATTGCGAGCGCTGGGCT
TTTGGCGATGGGTGGGTGGCTCATCCTGCAAGGGCAGTTATCGCTCGGGCAACTCGTGGCGGCGGAACTCGTCCTGTCGA
GCGCCTTCTATGGGATCTCGCAACTGGGCTCCCACGCGCGGACCTTCTACGACCTCGTCGCGGCGCTCCACGAGCTGTCG
CTGTTCGAAGAGATCGAGCAGGCCGACGGCGGCGGGGGGAACGGCCCTGGTCCGGCCGACGGGAACCTGTGCTTGCGCGA
CGTCGAGCACGATGGCCTGCGCTTCGACTTCGCGGTCGAGCGCGGCGAGATCCTCGCCGTGGCCGCCGGCGAAGGTGTCG
AGCAGGCAATTGCGGACCTCATCGAGAGGAGGGTCCGGCCCGTGCGCGGCTGGGTGATGGTCGGGGGAGCCGACATCGCG
GCCTTCGGTCCGGAGGGTCTGCAGTCCGAGATCCTCGTCCTGGATCGGCCGACGCTGCCCGAGACGACCATCCGCCAGTA
CCTGTCGGGCGACGACGAGTCGTGCCTCGCTCGGATGGACGAGTGCCTAGAACGTGTCGGGCTGGCTGAGCGCATCCGGC
GCCTGCCCTCCGGTCTCGACACCGCCTTGTCCAAGTCCGGCTTGCCGCTCTCAACGGGCGAGGTCGTCGCCCTAAAGCTG
GCCGCCGCCCTCTTGCGGCCGCCAAAGCTCCTCGTCCTGCCGACGCTCCTCGACCTGTTGCCACCGGATCGCATCGGGGC
TGCGCTCGCGGGGTTCCGGGAGGCGGGCACGACGGTGCTGCATGTCACCCGCCGCCCCCCGATGCCGGTTCACGACGACC
AGATCCGCCTGGGCGCCCACGGATACGGGCGCGCGGCCGGACGTGTGGACCCGCTCGACAAGACGACGCCGACGGAGAAG
CCCCATGCTGTCGCGGCCTGA

Upstream 100 bases:

>100_bases
CATCCCACGGTTTTCTCCTCATTCTGAGGCCGCGCCCCGCCTCCGGGCCGGGACCGTCGTCCTCGCCCGCCCTCAATCCG
GTCTCGAAGGTCCTCGCTAC

Downstream 100 bases:

>100_bases
ACATCTCCATCGCTTTCCGACCCTGACCGCGATCCGGCCTCCGCGTGCGGTGGTCGTCCTCGGCTGGATCATCGGGCTCG
GAACCGTCGTCGCAGTCCTG

Product: bacteriocin/lantibiotic ABC transporter

Products: NA

Alternate protein names: APX-IB; Cytolysin IB; CLY-IB; HLY-IB; RTX-I toxin determinant B [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MDATKHKPLTLAEACRLIGRFLRPEAGFVWTAVVYGIAVALLGLAVPVSVQLLINSVANTALPAPLFVLSGLLLGLLLAA
ALLSAARIYVLALFERRVFARTVADITLRALHARNPHFDDARRGDLFNRFFDLMTVQKAVPHLLVGGFAILLQSGIGLVL
TSFYHPFFLAFNLVVVAVLVGIAFLWAAPAVRSGAALSHAKHETARWLESVGSSNGFYRHGGRLTTALARSEALTATYAR
VHRRHFRHTFAQTIGFLMVYAIASAGLLAMGGWLILQGQLSLGQLVAAELVLSSAFYGISQLGSHARTFYDLVAALHELS
LFEEIEQADGGGGNGPGPADGNLCLRDVEHDGLRFDFAVERGEILAVAAGEGVEQAIADLIERRVRPVRGWVMVGGADIA
AFGPEGLQSEILVLDRPTLPETTIRQYLSGDDESCLARMDECLERVGLAERIRRLPSGLDTALSKSGLPLSTGEVVALKL
AAALLRPPKLLVLPTLLDLLPPDRIGAALAGFREAGTTVLHVTRRPPMPVHDDQIRLGAHGYGRAAGRVDPLDKTTPTEK
PHAVAA

Sequences:

>Translated_566_residues
MDATKHKPLTLAEACRLIGRFLRPEAGFVWTAVVYGIAVALLGLAVPVSVQLLINSVANTALPAPLFVLSGLLLGLLLAA
ALLSAARIYVLALFERRVFARTVADITLRALHARNPHFDDARRGDLFNRFFDLMTVQKAVPHLLVGGFAILLQSGIGLVL
TSFYHPFFLAFNLVVVAVLVGIAFLWAAPAVRSGAALSHAKHETARWLESVGSSNGFYRHGGRLTTALARSEALTATYAR
VHRRHFRHTFAQTIGFLMVYAIASAGLLAMGGWLILQGQLSLGQLVAAELVLSSAFYGISQLGSHARTFYDLVAALHELS
LFEEIEQADGGGGNGPGPADGNLCLRDVEHDGLRFDFAVERGEILAVAAGEGVEQAIADLIERRVRPVRGWVMVGGADIA
AFGPEGLQSEILVLDRPTLPETTIRQYLSGDDESCLARMDECLERVGLAERIRRLPSGLDTALSKSGLPLSTGEVVALKL
AAALLRPPKLLVLPTLLDLLPPDRIGAALAGFREAGTTVLHVTRRPPMPVHDDQIRLGAHGYGRAAGRVDPLDKTTPTEK
PHAVAA
>Mature_566_residues
MDATKHKPLTLAEACRLIGRFLRPEAGFVWTAVVYGIAVALLGLAVPVSVQLLINSVANTALPAPLFVLSGLLLGLLLAA
ALLSAARIYVLALFERRVFARTVADITLRALHARNPHFDDARRGDLFNRFFDLMTVQKAVPHLLVGGFAILLQSGIGLVL
TSFYHPFFLAFNLVVVAVLVGIAFLWAAPAVRSGAALSHAKHETARWLESVGSSNGFYRHGGRLTTALARSEALTATYAR
VHRRHFRHTFAQTIGFLMVYAIASAGLLAMGGWLILQGQLSLGQLVAAELVLSSAFYGISQLGSHARTFYDLVAALHELS
LFEEIEQADGGGGNGPGPADGNLCLRDVEHDGLRFDFAVERGEILAVAAGEGVEQAIADLIERRVRPVRGWVMVGGADIA
AFGPEGLQSEILVLDRPTLPETTIRQYLSGDDESCLARMDECLERVGLAERIRRLPSGLDTALSKSGLPLSTGEVVALKL
AAALLRPPKLLVLPTLLDLLPPDRIGAALAGFREAGTTVLHVTRRPPMPVHDDQIRLGAHGYGRAAGRVDPLDKTTPTEK
PHAVAA

Specific function: Involved in the transport of the toxin RTX-I as well as that of RTX-II [H]

COG id: COG1132

COG function: function code V; ABC-type multidrug transport system, ATPase and permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 peptidase C39 domain [H]

Homologues:

Organism=Homo sapiens, GI255708477, Length=414, Percent_Identity=24.6376811594203, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI148612844, Length=414, Percent_Identity=24.6376811594203, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI42741659, Length=285, Percent_Identity=25.6140350877193, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI9961250, Length=294, Percent_Identity=24.8299319727891, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4505771, Length=294, Percent_Identity=24.8299319727891, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI9961252, Length=300, Percent_Identity=26.3333333333333, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17558664, Length=552, Percent_Identity=23.9130434782609, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193202349, Length=471, Percent_Identity=24.203821656051, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17541710, Length=193, Percent_Identity=29.0155440414508, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593
- InterPro:   IPR010132
- InterPro:   IPR005074 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran; PF03412 Peptidase_C39 [H]

EC number: NA

Molecular weight: Translated: 60678; Mature: 60678

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATKHKPLTLAEACRLIGRFLRPEAGFVWTAVVYGIAVALLGLAVPVSVQLLINSVANT
CCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALPAPLFVLSGLLLGLLLAAALLSAARIYVLALFERRVFARTVADITLRALHARNPHFDD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ARRGDLFNRFFDLMTVQKAVPHLLVGGFAILLQSGIGLVLTSFYHPFFLAFNLVVVAVLV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIAFLWAAPAVRSGAALSHAKHETARWLESVGSSNGFYRHGGRLTTALARSEALTATYAR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHH
VHRRHFRHTFAQTIGFLMVYAIASAGLLAMGGWLILQGQLSLGQLVAAELVLSSAFYGIS
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
QLGSHARTFYDLVAALHELSLFEEIEQADGGGGNGPGPADGNLCLRDVEHDGLRFDFAVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEC
RGEILAVAAGEGVEQAIADLIERRVRPVRGWVMVGGADIAAFGPEGLQSEILVLDRPTLP
CCCEEEEECCCCHHHHHHHHHHHHCCHHCCEEEECCCCEECCCCCCCCCCEEEEECCCCC
ETTIRQYLSGDDESCLARMDECLERVGLAERIRRLPSGLDTALSKSGLPLSTGEVVALKL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHH
AAALLRPPKLLVLPTLLDLLPPDRIGAALAGFREAGTTVLHVTRRPPMPVHDDQIRLGAH
HHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCC
GYGRAAGRVDPLDKTTPTEKPHAVAA
CCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDATKHKPLTLAEACRLIGRFLRPEAGFVWTAVVYGIAVALLGLAVPVSVQLLINSVANT
CCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALPAPLFVLSGLLLGLLLAAALLSAARIYVLALFERRVFARTVADITLRALHARNPHFDD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ARRGDLFNRFFDLMTVQKAVPHLLVGGFAILLQSGIGLVLTSFYHPFFLAFNLVVVAVLV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIAFLWAAPAVRSGAALSHAKHETARWLESVGSSNGFYRHGGRLTTALARSEALTATYAR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHH
VHRRHFRHTFAQTIGFLMVYAIASAGLLAMGGWLILQGQLSLGQLVAAELVLSSAFYGIS
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
QLGSHARTFYDLVAALHELSLFEEIEQADGGGGNGPGPADGNLCLRDVEHDGLRFDFAVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEC
RGEILAVAAGEGVEQAIADLIERRVRPVRGWVMVGGADIAAFGPEGLQSEILVLDRPTLP
CCCEEEEECCCCHHHHHHHHHHHHCCHHCCEEEECCCCEECCCCCCCCCCEEEEECCCCC
ETTIRQYLSGDDESCLARMDECLERVGLAERIRRLPSGLDTALSKSGLPLSTGEVVALKL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHH
AAALLRPPKLLVLPTLLDLLPPDRIGAALAGFREAGTTVLHVTRRPPMPVHDDQIRLGAH
HHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCC
GYGRAAGRVDPLDKTTPTEKPHAVAA
CCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1860823; 1937809; 8181764 [H]