Click here to switch to the map view.

The map label for this gene is cyaA [H]

Identifier: 170746736

GI number: 170746736

Start: 312804

End: 314384

Strand: Reverse

Name: cyaA [H]

Synonym: Mrad2831_0289

Alternate gene names: 170746736

Gene position: 314384-312804 (Counterclockwise)

Preceding gene: 170746739

Following gene: 170746734

Centisome position: 5.17

GC content: 68.44

Gene sequence:

>1581_bases
ATGGGGCCGCTCCTCGTGGCGGCGATCCTGTTCGGCCTGGTCGGGCTGCCGGTCGCGGTGTGGCTCGACCTGCGCGGCCT
GTCCGAGCGCATGCTCGCCACGCAGGCGATCGAGACCGGCCGGATCATCGATCAGATGCGCAGCTTCTACGCCAGTGACG
TGGTCCAGGCGGTCAACGCGGCGACGGGCCGGGTCGAGACGCGGCACGATTACAAGGGCGTACCGAACGCGATCCCGATC
CCCGCGACGCTCTCCCTGGAGCTCGGCGAGCGGATCAGCGGCGGGGACGGCGCGGTGAAGTATCGCTTCGTCTCCGATCT
CCCTTTCAAGGACCGCAAGCCGCACGATCTCGACGCGTTCGAGATCCAGGCGCTGGCGGACCTCCGGGCCCGTCCCCAGA
CCGGATTCGTCAGCGAGACGACGGGATCGATCTTCGATCGGCAGGTGCGCATCGCGGCGCCGATCCGCATGGAATCCGCC
TGCGTGCGCTGCCACAACGCCCATCCCCTGAGCCCGAAGACGGACTGGAAGGTCGGCGACGTCCGCGGCATCCAGGAGAT
CGTCCTGCACCAGCCGATCGCCGCCAACGTCTTCGCCTTCAAGTACCTGCTCGGCTACTTCATCCTGGCGGCGCTCGCCG
GCACCACCGTCCTGCTGCTGCAGGCGCGACAGTCGCGCCTCATCGACCGGATGAATCGCGAGCTGACCGAGTCCAACGGC
TTTCTGGCGTCGGTCTCGGTGCAGATCGCGAAGTACATCTCGCCCCAGGTCTACAAGAGCATCTTCAGCGGCGAGCGGGA
CGTGTCGGTGGCGACCGAGCGCAAGAAGCTGACGATCTTCTTCTCCGACATCAAGGACTTCACCGCCACCACCGAGCGCC
TGCAGCCCGAGGAGCTGACCGCACTCCTCAACGAGTACCTGACCGAGATGACCGCCATCGCGGTCAAGCACGGCGGCACG
GTGGACAAGTATATCGGGGACGCGATGCTGGTCTTCTTCGGCGATCCGGAGAGCCGGGGCGTCCGCGAGGACGCGCAGGC
CTGCGTCCGGATGGCGATCGAGATGCAGACGCGCCTCGGCCAGCTCAATGCCCGCTGGCGGCGGTCCGGCATCGAGCGCC
CGTTCCAGGCGCGGATCGGGATCAACACGGGCTACTGCAACGTCGGCAACTTCGGCAGCGACGAGCGGATGGACTACACG
ATCATCGGCGCGGAAGCGAACCTCGCCGCCCGCCTCCAGGCGGCCGCGATGCCGGGCGGCATCACCCTGAGCTACGAAAC
CTACGCGCTGGTGAGCGATATCGTCCAGGCGAGCCCGCAGGAGCCGATCCGCATGAAGGGCATCAGCCGCGAGGTCGTCC
CCTACGCCGTCGAGGGCGACCTCACCGCCGAGGCGACCGAGACGATCTTCTCCGAGCACGCCCGGGGGATCGACTTCTAC
GTCGACGTGGACGCGCTCGAGTTGGAGGGTGCGGCGCGGCTCCGGAAGCGCCTGCTCGATACCCTCGCCGCCGTCGACCG
CCGGATGATCGGCGCGGGCGCCCCACCGGAGGCCGGCCCCCGGCCCTCCGCGGCCAGCTGA

Upstream 100 bases:

>100_bases
CTGTATATGGAAGGAGCCAAGCAAGGGGCTATGTGCTGGTGCCTCGGGGTTGTGGGTGATGTCGGGTTTTGACGAGTCGG
TCGCGCGCCAGCAGCGATTC

Downstream 100 bases:

>100_bases
CGTCCGGCCAGTGGTCACGAGCTGCCAGGTCCCCGCGAGCCTCACGAGGGAGAAGAGATCAACCGACGGTTTGGCGCCGA
CCACGGAGGTGTCCGGTATG

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MGPLLVAAILFGLVGLPVAVWLDLRGLSERMLATQAIETGRIIDQMRSFYASDVVQAVNAATGRVETRHDYKGVPNAIPI
PATLSLELGERISGGDGAVKYRFVSDLPFKDRKPHDLDAFEIQALADLRARPQTGFVSETTGSIFDRQVRIAAPIRMESA
CVRCHNAHPLSPKTDWKVGDVRGIQEIVLHQPIAANVFAFKYLLGYFILAALAGTTVLLLQARQSRLIDRMNRELTESNG
FLASVSVQIAKYISPQVYKSIFSGERDVSVATERKKLTIFFSDIKDFTATTERLQPEELTALLNEYLTEMTAIAVKHGGT
VDKYIGDAMLVFFGDPESRGVREDAQACVRMAIEMQTRLGQLNARWRRSGIERPFQARIGINTGYCNVGNFGSDERMDYT
IIGAEANLAARLQAAAMPGGITLSYETYALVSDIVQASPQEPIRMKGISREVVPYAVEGDLTAEATETIFSEHARGIDFY
VDVDALELEGAARLRKRLLDTLAAVDRRMIGAGAPPEAGPRPSAAS

Sequences:

>Translated_526_residues
MGPLLVAAILFGLVGLPVAVWLDLRGLSERMLATQAIETGRIIDQMRSFYASDVVQAVNAATGRVETRHDYKGVPNAIPI
PATLSLELGERISGGDGAVKYRFVSDLPFKDRKPHDLDAFEIQALADLRARPQTGFVSETTGSIFDRQVRIAAPIRMESA
CVRCHNAHPLSPKTDWKVGDVRGIQEIVLHQPIAANVFAFKYLLGYFILAALAGTTVLLLQARQSRLIDRMNRELTESNG
FLASVSVQIAKYISPQVYKSIFSGERDVSVATERKKLTIFFSDIKDFTATTERLQPEELTALLNEYLTEMTAIAVKHGGT
VDKYIGDAMLVFFGDPESRGVREDAQACVRMAIEMQTRLGQLNARWRRSGIERPFQARIGINTGYCNVGNFGSDERMDYT
IIGAEANLAARLQAAAMPGGITLSYETYALVSDIVQASPQEPIRMKGISREVVPYAVEGDLTAEATETIFSEHARGIDFY
VDVDALELEGAARLRKRLLDTLAAVDRRMIGAGAPPEAGPRPSAAS
>Mature_525_residues
GPLLVAAILFGLVGLPVAVWLDLRGLSERMLATQAIETGRIIDQMRSFYASDVVQAVNAATGRVETRHDYKGVPNAIPIP
ATLSLELGERISGGDGAVKYRFVSDLPFKDRKPHDLDAFEIQALADLRARPQTGFVSETTGSIFDRQVRIAAPIRMESAC
VRCHNAHPLSPKTDWKVGDVRGIQEIVLHQPIAANVFAFKYLLGYFILAALAGTTVLLLQARQSRLIDRMNRELTESNGF
LASVSVQIAKYISPQVYKSIFSGERDVSVATERKKLTIFFSDIKDFTATTERLQPEELTALLNEYLTEMTAIAVKHGGTV
DKYIGDAMLVFFGDPESRGVREDAQACVRMAIEMQTRLGQLNARWRRSGIERPFQARIGINTGYCNVGNFGSDERMDYTI
IGAEANLAARLQAAAMPGGITLSYETYALVSDIVQASPQEPIRMKGISREVVPYAVEGDLTAEATETIFSEHARGIDFYV
DVDALELEGAARLRKRLLDTLAAVDRRMIGAGAPPEAGPRPSAAS

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI4504217, Length=227, Percent_Identity=25.5506607929515, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193207841, Length=179, Percent_Identity=30.1675977653631, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17534659, Length=258, Percent_Identity=25.968992248062, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 57657; Mature: 57526

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPLLVAAILFGLVGLPVAVWLDLRGLSERMLATQAIETGRIIDQMRSFYASDVVQAVNA
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATGRVETRHDYKGVPNAIPIPATLSLELGERISGGDGAVKYRFVSDLPFKDRKPHDLDAF
HCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHH
EIQALADLRARPQTGFVSETTGSIFDRQVRIAAPIRMESACVRCHNAHPLSPKTDWKVGD
HHHHHHHHHCCCCCCCCCCCCCHHHHCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCHH
VRGIQEIVLHQPIAANVFAFKYLLGYFILAALAGTTVLLLQARQSRLIDRMNRELTESNG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FLASVSVQIAKYISPQVYKSIFSGERDVSVATERKKLTIFFSDIKDFTATTERLQPEELT
EEEEHHHHHHHHCCHHHHHHHHCCCCCCEEEECCEEEEEEEHHHHHHHHHHHHCCHHHHH
ALLNEYLTEMTAIAVKHGGTVDKYIGDAMLVFFGDPESRGVREDAQACVRMAIEMQTRLG
HHHHHHHHHHHHHHHHCCCCHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
QLNARWRRSGIERPFQARIGINTGYCNVGNFGSDERMDYTIIGAEANLAARLQAAAMPGG
HHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCC
ITLSYETYALVSDIVQASPQEPIRMKGISREVVPYAVEGDLTAEATETIFSEHARGIDFY
EEEEEHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEE
VDVDALELEGAARLRKRLLDTLAAVDRRMIGAGAPPEAGPRPSAAS
EECCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GPLLVAAILFGLVGLPVAVWLDLRGLSERMLATQAIETGRIIDQMRSFYASDVVQAVNA
CHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATGRVETRHDYKGVPNAIPIPATLSLELGERISGGDGAVKYRFVSDLPFKDRKPHDLDAF
HCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHH
EIQALADLRARPQTGFVSETTGSIFDRQVRIAAPIRMESACVRCHNAHPLSPKTDWKVGD
HHHHHHHHHCCCCCCCCCCCCCHHHHCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCHH
VRGIQEIVLHQPIAANVFAFKYLLGYFILAALAGTTVLLLQARQSRLIDRMNRELTESNG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FLASVSVQIAKYISPQVYKSIFSGERDVSVATERKKLTIFFSDIKDFTATTERLQPEELT
EEEEHHHHHHHHCCHHHHHHHHCCCCCCEEEECCEEEEEEEHHHHHHHHHHHHCCHHHHH
ALLNEYLTEMTAIAVKHGGTVDKYIGDAMLVFFGDPESRGVREDAQACVRMAIEMQTRLG
HHHHHHHHHHHHHHHHCCCCHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
QLNARWRRSGIERPFQARIGINTGYCNVGNFGSDERMDYTIIGAEANLAARLQAAAMPGG
HHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCC
ITLSYETYALVSDIVQASPQEPIRMKGISREVVPYAVEGDLTAEATETIFSEHARGIDFY
EEEEEHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEE
VDVDALELEGAARLRKRLLDTLAAVDRRMIGAGAPPEAGPRPSAAS
EECCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]