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The map label for this gene is uao [H]

Identifier: 170746648

GI number: 170746648

Start: 205182

End: 206024

Strand: Reverse

Name: uao [H]

Synonym: Mrad2831_0199

Alternate gene names: 170746648

Gene position: 206024-205182 (Counterclockwise)

Preceding gene: 170746652

Following gene: 170746647

Centisome position: 3.39

GC content: 70.46

Gene sequence:

>843_bases
ATGGCCCTGACGGCATCGCGGTACGGCAAGGAACGGGTCCGGGTGCTGCGCCTCGCCCGTGACGGCGACCACCACACGCC
GCGCGAAGTGACCCTGTCGGTCATGCTGACCGGGCGCTTCGAGGCCGCCTGGACCGGGGGTGACAACCGCGCTTCCATCG
CCACCGACAGCATCCGGAACATCGTCAACGTCACGGCAGCGCGGAACCTCGCGCTCGACGCCGAGGGATTCGTCGTCGCG
GTCGCGCGGGTGCTGCTCGAGACCTATCCCCAGGTCGAGACGGTGGCGATCGAGGCGGAGGAGGTCCGCTGGCTGCGGCA
CGCGATCGCCGACGCGCCGCACGGCCATACCTTCACGCGAGACGGGAACGGCGCCGGCTTCGCGGGTCTCACCGCCGATC
GGAGCGGCTCGACCCTGCGCTCCGGTCTGCGCGGGTACACCTTCATGAAGACCACGCAGTCGGGCTGGACGGGCTTCGTG
GCGGACCAGTACCGGACCCTGCCAGATACGACCGACCGCATCGCCGCCACCAGCATGGACGCGACCTGGACCTGGGCCTC
GGCCCCGCAGGATCACGGCGCGGCCAATGCCCGGATCCTCGCGACGCTGCTGACCGTGTTCGGCACCACCTACAGCCGCG
GGATCCAGGACAGCATGTACCGGATGGGCGAGGCGGCCCTGGCCGCCGTCCCGGAACTGGCCGAGATCGGCTTCGTCATG
CCCAACAAGCACTACCTGCCGATCGACCTCGCGCCGTTCGGCCTCGACAACCCGGGCACGGTCTTCCTGCCGACCGACGA
GCCCTACGGCCGCATCGAGGCGACGATCGGCCGGACGGGCTGA

Upstream 100 bases:

>100_bases
CCGCACCGACACGTTCGAACCTTGGCGCCCCCACGCGCGTCGGCCTAGGATGAATAAGATTTGCGTGAGATGGCCGGCGA
CGGTCCGGTCGGAGATCCCC

Downstream 100 bases:

>100_bases
CGCGGGCACCGACGCCGGCCTCGTCCCGCGGCGGGCGTGTCGGACCGACCGGACGCCGCACGTCATCGTGCGGCGTCGTA
GGGCGAGATGCGGCGCTTCG

Product: urate oxidase

Products: NA

Alternate protein names: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; Uricase; Urate oxidase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MALTASRYGKERVRVLRLARDGDHHTPREVTLSVMLTGRFEAAWTGGDNRASIATDSIRNIVNVTAARNLALDAEGFVVA
VARVLLETYPQVETVAIEAEEVRWLRHAIADAPHGHTFTRDGNGAGFAGLTADRSGSTLRSGLRGYTFMKTTQSGWTGFV
ADQYRTLPDTTDRIAATSMDATWTWASAPQDHGAANARILATLLTVFGTTYSRGIQDSMYRMGEAALAAVPELAEIGFVM
PNKHYLPIDLAPFGLDNPGTVFLPTDEPYGRIEATIGRTG

Sequences:

>Translated_280_residues
MALTASRYGKERVRVLRLARDGDHHTPREVTLSVMLTGRFEAAWTGGDNRASIATDSIRNIVNVTAARNLALDAEGFVVA
VARVLLETYPQVETVAIEAEEVRWLRHAIADAPHGHTFTRDGNGAGFAGLTADRSGSTLRSGLRGYTFMKTTQSGWTGFV
ADQYRTLPDTTDRIAATSMDATWTWASAPQDHGAANARILATLLTVFGTTYSRGIQDSMYRMGEAALAAVPELAEIGFVM
PNKHYLPIDLAPFGLDNPGTVFLPTDEPYGRIEATIGRTG
>Mature_279_residues
ALTASRYGKERVRVLRLARDGDHHTPREVTLSVMLTGRFEAAWTGGDNRASIATDSIRNIVNVTAARNLALDAEGFVVAV
ARVLLETYPQVETVAIEAEEVRWLRHAIADAPHGHTFTRDGNGAGFAGLTADRSGSTLRSGLRGYTFMKTTQSGWTGFVA
DQYRTLPDTTDRIAATSMDATWTWASAPQDHGAANARILATLLTVFGTTYSRGIQDSMYRMGEAALAAVPELAEIGFVMP
NKHYLPIDLAPFGLDNPGTVFLPTDEPYGRIEATIGRTG

Specific function: Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin [H]

COG id: COG3648

COG function: function code Q; Uricase (urate oxidase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the uricase family [H]

Homologues:

Organism=Drosophila melanogaster, GI17136576, Length=314, Percent_Identity=27.0700636942675, Blast_Score=131, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018020
- InterPro:   IPR017580
- InterPro:   IPR002042
- InterPro:   IPR019842 [H]

Pfam domain/function: PF09349 OHCU_decarbox; PF01014 Uricase [H]

EC number: =1.7.3.3 [H]

Molecular weight: Translated: 30329; Mature: 30198

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTASRYGKERVRVLRLARDGDHHTPREVTLSVMLTGRFEAAWTGGDNRASIATDSIRN
CCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECEEEEEECCCCCCCHHHHHHHH
IVNVTAARNLALDAEGFVVAVARVLLETYPQVETVAIEAEEVRWLRHAIADAPHGHTFTR
HHHHHHHCCEEECCCHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCCCEEE
DGNGAGFAGLTADRSGSTLRSGLRGYTFMKTTQSGWTGFVADQYRTLPDTTDRIAATSMD
CCCCCCEECEECCCCCHHHHHCCCCCEEEEECCCCCCEEEHHHCCCCCCCCHHHEEECCC
ATWTWASAPQDHGAANARILATLLTVFGTTYSRGIQDSMYRMGEAALAAVPELAEIGFVM
CEEEECCCCCCCCCCHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHCCHHHHCCEEC
PNKHYLPIDLAPFGLDNPGTVFLPTDEPYGRIEATIGRTG
CCCEEEEEECCCCCCCCCCEEEEECCCCCCCEEEECCCCC
>Mature Secondary Structure 
ALTASRYGKERVRVLRLARDGDHHTPREVTLSVMLTGRFEAAWTGGDNRASIATDSIRN
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECEEEEEECCCCCCCHHHHHHHH
IVNVTAARNLALDAEGFVVAVARVLLETYPQVETVAIEAEEVRWLRHAIADAPHGHTFTR
HHHHHHHCCEEECCCHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCCCEEE
DGNGAGFAGLTADRSGSTLRSGLRGYTFMKTTQSGWTGFVADQYRTLPDTTDRIAATSMD
CCCCCCEECEECCCCCHHHHHCCCCCEEEEECCCCCCEEEHHHCCCCCCCCHHHEEECCC
ATWTWASAPQDHGAANARILATLLTVFGTTYSRGIQDSMYRMGEAALAAVPELAEIGFVM
CEEEECCCCCCCCCCHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHCCHHHHCCEEC
PNKHYLPIDLAPFGLDNPGTVFLPTDEPYGRIEATIGRTG
CCCEEEEEECCCCCCCCCCEEEEECCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8907179 [H]