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The map label for this gene is mppA [H]

Identifier: 170680564

GI number: 170680564

Start: 1810415

End: 1812028

Strand: Reverse

Name: mppA [H]

Synonym: EcSMS35_1792

Alternate gene names: 170680564

Gene position: 1812028-1810415 (Counterclockwise)

Preceding gene: 170681201

Following gene: 170681889

Centisome position: 35.75

GC content: 48.45

Gene sequence:

>1614_bases
ATGAAGCACTCTGTTTCAGTCACGTGTTGTGTGCTGTTGGTCAGCAGCATTTCTCTTTCGTATGCTGCTGAAGTTCCGAG
CGGCACAGTACTGGCAGAGAAGCAGGAGCTGGTGCGCCACATTAAAGATGAGCCAGCGTCGCTGGATCCCGCTAAAGCCG
TGGGCCTGCCGGAGATTCAGGTCATTCGCGATCTGTTTGAAGGACTGGTGAATCAGAACGAGAAAGGGGAGATTGTCCCC
GGCGTTGCGACTCAGTGGAAAAGTAATGACAGCCGTATCTGGACTTTTACCCTGCGCGATAACGCAAAATGGGCGGATGG
CACACCGGTAACGGCGCAAGATTTTGTCTACAGCTGGCAACGTCTGGTGGACCCGAAAACGCTATCGCCATTTGCATGGT
TTGCCGCGCTGGCGGGAATCAACAACGCACAGGCGATTATTGATGGTAAAGCCACGCCTGACCAGCTTGGCGTCACCGCA
GTTGATGCCCATACTTTGAAAATCCAGCTTGATAAACCATTGCCGTGGTTTGTGAATTTAACCGCTAACTTTGCCTTCTT
CCCGGTGCAAAAAGCCAACGTAGAAAGCAGTAAAGAGTGGACGAAACCCGGAAATCTGATCGGCAATGGCGCTTATGTTC
TTAAAGAGCGCGTAGTCAATGAAAAACTGGTCGTAGTGCCGAATACCCATTATTGGGATAACGCCAAAACGGTACTGCAA
AAAGTGACCTTCCTGCCAATTAATCAGGAATCCGCAGCCACTAAGCGTTATCTCGCGGGGGATATTGATATCACCGAATC
CTTCCCGAAAAATATGTATCAGAAGTTGTTGAAGGATATTCCGGGGCAGGTTTATACGCCGCCGCAGCTCGGGACCTATT
ATTATGCGTTTAACACGCAAAAAGGGCCGACGGCAGATCAGCGCGTTCGCCTGGCATTAAGTATGACGATAGATCGCCGC
CTGATGACCGAAAAAGTGTTGGGGACGGGCGAAAAGCCAGCGTGGCATTTTACACCAGATGTTACCGCGGGATTTACGCC
GGAACCTTCGCCGTTTGAACAAATGAGTCAGGAAGAACTGAATGCGCAGGCAAAAACTTTGTTGAGCGCAGCTGGTTATG
GTCCGCAAAAACCGCTGAAGTTGACGCTTTTGTATAACACTTCAGAAAACCATCAAAAAATTGCGATTGCTGTAGCATCG
ATGTGGAAAAAGAACCTGGGCGTAGATGTTAAATTGCAAAACCAGGAATGGAAAACCTATATCGATAGCCGTAATACCGG
CAATTTTGATGTTATCCGCGCCTCGTGGGTAGGGGATTATAATGACCCCTCCACTTTCCTGACATTATTAACGTCAACGC
ATTCCGGGAATATTTCACGCTTTAACAATCCGGCATATGACAAAGTTCTGGCCCAGGCATCGACGGAAAATACCGTTAAA
GCGCGTAATGCCGATTACAACGCGGCAGAAAAAATCCTCATGGAGCAAGCACCGATTGCACCAATTTATCAATATACCAA
TGGACGATTAATCAAGCCGTGGCTGAAAGGTTATCCCATTAATAACCCTGAAGATGTGGCGTACAGTCGGACTATGTATA
TTGTGAAGCATTGA

Upstream 100 bases:

>100_bases
GATGCTTCCTTTGTCACTTTTTTGATGGAAGTTGTTTGCATTTCTTTAAGGCGAAACAAATAATTACGCATCAATTTTAA
TGTCGGTTAGAGGGAAACTT

Downstream 100 bases:

>100_bases
TGTGATGGGAACTGGCGTTACCCTTGTGGATAACGCCAGTGATGTCTGATTTAGCGACCCTGGTCCGGCGGTGTAATGTT
ATCCATATACAGCGTCTGGC

Product: periplasmic murein peptide-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MKHSVSVTCCVLLVSSISLSYAAEVPSGTVLAEKQELVRHIKDEPASLDPAKAVGLPEIQVIRDLFEGLVNQNEKGEIVP
GVATQWKSNDSRIWTFTLRDNAKWADGTPVTAQDFVYSWQRLVDPKTLSPFAWFAALAGINNAQAIIDGKATPDQLGVTA
VDAHTLKIQLDKPLPWFVNLTANFAFFPVQKANVESSKEWTKPGNLIGNGAYVLKERVVNEKLVVVPNTHYWDNAKTVLQ
KVTFLPINQESAATKRYLAGDIDITESFPKNMYQKLLKDIPGQVYTPPQLGTYYYAFNTQKGPTADQRVRLALSMTIDRR
LMTEKVLGTGEKPAWHFTPDVTAGFTPEPSPFEQMSQEELNAQAKTLLSAAGYGPQKPLKLTLLYNTSENHQKIAIAVAS
MWKKNLGVDVKLQNQEWKTYIDSRNTGNFDVIRASWVGDYNDPSTFLTLLTSTHSGNISRFNNPAYDKVLAQASTENTVK
ARNADYNAAEKILMEQAPIAPIYQYTNGRLIKPWLKGYPINNPEDVAYSRTMYIVKH

Sequences:

>Translated_537_residues
MKHSVSVTCCVLLVSSISLSYAAEVPSGTVLAEKQELVRHIKDEPASLDPAKAVGLPEIQVIRDLFEGLVNQNEKGEIVP
GVATQWKSNDSRIWTFTLRDNAKWADGTPVTAQDFVYSWQRLVDPKTLSPFAWFAALAGINNAQAIIDGKATPDQLGVTA
VDAHTLKIQLDKPLPWFVNLTANFAFFPVQKANVESSKEWTKPGNLIGNGAYVLKERVVNEKLVVVPNTHYWDNAKTVLQ
KVTFLPINQESAATKRYLAGDIDITESFPKNMYQKLLKDIPGQVYTPPQLGTYYYAFNTQKGPTADQRVRLALSMTIDRR
LMTEKVLGTGEKPAWHFTPDVTAGFTPEPSPFEQMSQEELNAQAKTLLSAAGYGPQKPLKLTLLYNTSENHQKIAIAVAS
MWKKNLGVDVKLQNQEWKTYIDSRNTGNFDVIRASWVGDYNDPSTFLTLLTSTHSGNISRFNNPAYDKVLAQASTENTVK
ARNADYNAAEKILMEQAPIAPIYQYTNGRLIKPWLKGYPINNPEDVAYSRTMYIVKH
>Mature_537_residues
MKHSVSVTCCVLLVSSISLSYAAEVPSGTVLAEKQELVRHIKDEPASLDPAKAVGLPEIQVIRDLFEGLVNQNEKGEIVP
GVATQWKSNDSRIWTFTLRDNAKWADGTPVTAQDFVYSWQRLVDPKTLSPFAWFAALAGINNAQAIIDGKATPDQLGVTA
VDAHTLKIQLDKPLPWFVNLTANFAFFPVQKANVESSKEWTKPGNLIGNGAYVLKERVVNEKLVVVPNTHYWDNAKTVLQ
KVTFLPINQESAATKRYLAGDIDITESFPKNMYQKLLKDIPGQVYTPPQLGTYYYAFNTQKGPTADQRVRLALSMTIDRR
LMTEKVLGTGEKPAWHFTPDVTAGFTPEPSPFEQMSQEELNAQAKTLLSAAGYGPQKPLKLTLLYNTSENHQKIAIAVAS
MWKKNLGVDVKLQNQEWKTYIDSRNTGNFDVIRASWVGDYNDPSTFLTLLTSTHSGNISRFNNPAYDKVLAQASTENTVK
ARNADYNAAEKILMEQAPIAPIYQYTNGRLIKPWLKGYPINNPEDVAYSRTMYIVKH

Specific function: Essential for the uptake of the murein peptide L-alanyl- gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha- linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system [H]

COG id: COG4166

COG function: function code E; ABC-type oligopeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI87081878, Length=537, Percent_Identity=99.2551210428305, Blast_Score=1102, Evalue=0.0,
Organism=Escherichia coli, GI1787495, Length=538, Percent_Identity=47.2118959107807, Blast_Score=503, Evalue=1e-144,
Organism=Escherichia coli, GI1789397, Length=537, Percent_Identity=41.8994413407821, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1787762, Length=538, Percent_Identity=28.4386617100372, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789887, Length=473, Percent_Identity=25.369978858351, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1789966, Length=467, Percent_Identity=22.0556745182013, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787052, Length=508, Percent_Identity=21.4566929133858, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 59918; Mature: 59918

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHSVSVTCCVLLVSSISLSYAAEVPSGTVLAEKQELVRHIKDEPASLDPAKAVGLPEIQ
CCCCCHHHHHHHHHHHHCCEEEECCCCCCEEHHHHHHHHHHCCCCCCCCHHHHCCCCHHH
VIRDLFEGLVNQNEKGEIVPGVATQWKSNDSRIWTFTLRDNAKWADGTPVTAQDFVYSWQ
HHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHH
RLVDPKTLSPFAWFAALAGINNAQAIIDGKATPDQLGVTAVDAHTLKIQLDKPLPWFVNL
HHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHCCEEEEEEEEEEEEECCCCCEEEEE
TANFAFFPVQKANVESSKEWTKPGNLIGNGAYVLKERVVNEKLVVVPNTHYWDNAKTVLQ
EECEEEEEEECCCCCCCCCCCCCCCEECCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHH
KVTFLPINQESAATKRYLAGDIDITESFPKNMYQKLLKDIPGQVYTPPQLGTYYYAFNTQ
HHHEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEECC
KGPTADQRVRLALSMTIDRRLMTEKVLGTGEKPAWHFTPDVTAGFTPEPSPFEQMSQEEL
CCCCHHHEEEEEEEEHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHH
NAQAKTLLSAAGYGPQKPLKLTLLYNTSENHQKIAIAVASMWKKNLGVDVKLQNQEWKTY
HHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEEHHHHHHCCCEEEEECCCCHHHH
IDSRNTGNFDVIRASWVGDYNDPSTFLTLLTSTHSGNISRFNNPAYDKVLAQASTENTVK
CCCCCCCCEEEEEEEECCCCCCHHHEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCEE
ARNADYNAAEKILMEQAPIAPIYQYTNGRLIKPWLKGYPINNPEDVAYSRTMYIVKH
ECCCCCHHHHHHHHHCCCCCCEEEECCCEEECHHHCCCCCCCCCCCEEEEEEEEEEC
>Mature Secondary Structure
MKHSVSVTCCVLLVSSISLSYAAEVPSGTVLAEKQELVRHIKDEPASLDPAKAVGLPEIQ
CCCCCHHHHHHHHHHHHCCEEEECCCCCCEEHHHHHHHHHHCCCCCCCCHHHHCCCCHHH
VIRDLFEGLVNQNEKGEIVPGVATQWKSNDSRIWTFTLRDNAKWADGTPVTAQDFVYSWQ
HHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHH
RLVDPKTLSPFAWFAALAGINNAQAIIDGKATPDQLGVTAVDAHTLKIQLDKPLPWFVNL
HHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHCCEEEEEEEEEEEEECCCCCEEEEE
TANFAFFPVQKANVESSKEWTKPGNLIGNGAYVLKERVVNEKLVVVPNTHYWDNAKTVLQ
EECEEEEEEECCCCCCCCCCCCCCCEECCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHH
KVTFLPINQESAATKRYLAGDIDITESFPKNMYQKLLKDIPGQVYTPPQLGTYYYAFNTQ
HHHEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEECC
KGPTADQRVRLALSMTIDRRLMTEKVLGTGEKPAWHFTPDVTAGFTPEPSPFEQMSQEEL
CCCCHHHEEEEEEEEHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHH
NAQAKTLLSAAGYGPQKPLKLTLLYNTSENHQKIAIAVASMWKKNLGVDVKLQNQEWKTY
HHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEEHHHHHHCCCEEEEECCCCHHHH
IDSRNTGNFDVIRASWVGDYNDPSTFLTLLTSTHSGNISRFNNPAYDKVLAQASTENTVK
CCCCCCCCEEEEEEEECCCCCCHHHEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCEE
ARNADYNAAEKILMEQAPIAPIYQYTNGRLIKPWLKGYPINNPEDVAYSRTMYIVKH
ECCCCCHHHHHHHHHCCCCCCEEEECCCEEECHHHCCCCCCCCCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9495761; 9097039; 9278503 [H]