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The map label for this gene is trpE [H]

Identifier: 170077304

GI number: 170077304

Start: 709762

End: 711282

Strand: Reverse

Name: trpE [H]

Synonym: SYNPCC7002_A0681

Alternate gene names: 170077304

Gene position: 711282-709762 (Counterclockwise)

Preceding gene: 170077305

Following gene: 170077297

Centisome position: 23.65

GC content: 52.01

Gene sequence:

>1521_bases
ATGATTTTTCCTGATTTCGAGCAGTTTCGGCATCTCAGTCAACAGGGTAATTTTATTCCGGTCTATCAGGAGTGGGTGGC
GGATCTCGAAACGCCAGTGTCGGCTTGGTACAAGGTTTGTGCAGATCAACCCTACAATTTTCTGTTGGAGTCCGTTGAGG
GGGGCGAAAATATTGGTCGCTATAGTTTCCTCGGTTGCGATCCGGTTTGGGTCTTAGAAAATAAAGGCGATCGCACCACG
CAAAAATTCCGTGATGGGGCTGTCCAAGAATTTAGCGGCAATCCCTTTGATGTGTTGGCCCAATGTCTCGCCAGCATTAA
GCCTGTCCAACTGTCGGAATTACCACCGGGGATTGGTGGTCTATTTGGGATGTGGGGCTATGAGTTGATGCGCTGGATCG
AACCACGGGTGCCGGTGTACGAACGCCAAGAAGAGGATCTACCCGATGGCCTCTGGATGCAAATTGATAGCTTGATCATT
TTTGACCAAGTTAAACGCAAGATTTGGGTCATCACCTATGCTGACCTGCGGGATCCGGCGGTGCCCCTAGAAGAAGCCTA
CCTAAATGCCTGCGATCGCGTGACGAAATTAGTCCTCAAGCTCAAGTTGCCTTTGCCTGTTGCCGCCAAACCCTTAGAAT
GGCTCGCCAACCCAGACGGGGAAGCCCTCAAGTACGAAAGCAACACTTCCCAAGCACAGTTTTGCCAGAACGTCGCCAAG
GCAAAGGAATACATTAAGGCCGGAGATATTTTTCAGGTGGTGCTTTCCCAGCGGCTCCAGACGAGCTACGAAGGCCATCC
CTTTGATCTCTACCGTTCCCTGCGCCTGATTAACCCTTCTCCCTACATGTCTTTTTACAATTTTGGGGATTGGCAACTCA
TCGGCTCTAGCCCAGAGATTATGGTCAAAGCCGAGCAAACGCCAGACGGAAAACTCCAGGCGATGCTCCGACCGATTGCG
GGCACGCGACGCCGGGGGAAAACCCAAGCTGAGGATTTAGCGTTAGAAAAAGACCTCTTGGCCGACCCTAAGGAAATCGC
TGAACACGTGATGCTTGTGGATTTGGGCCGCAATGACCTCGGTCGCGTCTGCGAAAAAGGCACGGTCACAGTTGGGGATT
TGATGATCATCGAACGTTATTCTCACGTGATGCACATCGTGAGTAATGTGATGGGAGATTTAGCCCCCGACCAATCGGCT
TGGAATTTATTACAGGCTTGTTTTCCCGCCGGAACAGTCAGCGGTGCGCCGAAAATTCGCGCTTTAGAAATTATCAACGA
ACTGGAACCCGAACGACGTGGCCCCTACTCTGGCGTCTACGGTTACTACGATTTTGAAGGCCAACTGAATACGGCGATTA
CGATCCGGAGCATGATTGTGCGATCGCAGGGGAATCAGCACCAGGTCTTTGTCCAGGCGGGCGCGGGCATCGTCGCAGAC
TCCGAGCCGGAACGGGAATACCAAGAAACCCTTGATAAGGCCAGGGGGATGTTGGAAGCGATTCGCTGCCTTCAGGTTTA
A

Upstream 100 bases:

>100_bases
TGAACAAAAGGCTTCCGCTTCTTTGTGTCTAGCTCTATTTTTACTTTTATCTACCGTCCCAGCGGCCCTCCATGTGCCCC
AGGCGACCGACGCATTTCCT

Downstream 100 bases:

>100_bases
TGACGTCTGGGGACAGGGAATTTTAAAACATCGTTGAATCCAGGATTACAGCATCTCCCACTGAAATCTTGCCGGAGCTT
GTGGGCATGAGGTTAATGCC

Product: anthranilate synthetase alpha-subunit

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MIFPDFEQFRHLSQQGNFIPVYQEWVADLETPVSAWYKVCADQPYNFLLESVEGGENIGRYSFLGCDPVWVLENKGDRTT
QKFRDGAVQEFSGNPFDVLAQCLASIKPVQLSELPPGIGGLFGMWGYELMRWIEPRVPVYERQEEDLPDGLWMQIDSLII
FDQVKRKIWVITYADLRDPAVPLEEAYLNACDRVTKLVLKLKLPLPVAAKPLEWLANPDGEALKYESNTSQAQFCQNVAK
AKEYIKAGDIFQVVLSQRLQTSYEGHPFDLYRSLRLINPSPYMSFYNFGDWQLIGSSPEIMVKAEQTPDGKLQAMLRPIA
GTRRRGKTQAEDLALEKDLLADPKEIAEHVMLVDLGRNDLGRVCEKGTVTVGDLMIIERYSHVMHIVSNVMGDLAPDQSA
WNLLQACFPAGTVSGAPKIRALEIINELEPERRGPYSGVYGYYDFEGQLNTAITIRSMIVRSQGNQHQVFVQAGAGIVAD
SEPEREYQETLDKARGMLEAIRCLQV

Sequences:

>Translated_506_residues
MIFPDFEQFRHLSQQGNFIPVYQEWVADLETPVSAWYKVCADQPYNFLLESVEGGENIGRYSFLGCDPVWVLENKGDRTT
QKFRDGAVQEFSGNPFDVLAQCLASIKPVQLSELPPGIGGLFGMWGYELMRWIEPRVPVYERQEEDLPDGLWMQIDSLII
FDQVKRKIWVITYADLRDPAVPLEEAYLNACDRVTKLVLKLKLPLPVAAKPLEWLANPDGEALKYESNTSQAQFCQNVAK
AKEYIKAGDIFQVVLSQRLQTSYEGHPFDLYRSLRLINPSPYMSFYNFGDWQLIGSSPEIMVKAEQTPDGKLQAMLRPIA
GTRRRGKTQAEDLALEKDLLADPKEIAEHVMLVDLGRNDLGRVCEKGTVTVGDLMIIERYSHVMHIVSNVMGDLAPDQSA
WNLLQACFPAGTVSGAPKIRALEIINELEPERRGPYSGVYGYYDFEGQLNTAITIRSMIVRSQGNQHQVFVQAGAGIVAD
SEPEREYQETLDKARGMLEAIRCLQV
>Mature_506_residues
MIFPDFEQFRHLSQQGNFIPVYQEWVADLETPVSAWYKVCADQPYNFLLESVEGGENIGRYSFLGCDPVWVLENKGDRTT
QKFRDGAVQEFSGNPFDVLAQCLASIKPVQLSELPPGIGGLFGMWGYELMRWIEPRVPVYERQEEDLPDGLWMQIDSLII
FDQVKRKIWVITYADLRDPAVPLEEAYLNACDRVTKLVLKLKLPLPVAAKPLEWLANPDGEALKYESNTSQAQFCQNVAK
AKEYIKAGDIFQVVLSQRLQTSYEGHPFDLYRSLRLINPSPYMSFYNFGDWQLIGSSPEIMVKAEQTPDGKLQAMLRPIA
GTRRRGKTQAEDLALEKDLLADPKEIAEHVMLVDLGRNDLGRVCEKGTVTVGDLMIIERYSHVMHIVSNVMGDLAPDQSA
WNLLQACFPAGTVSGAPKIRALEIINELEPERRGPYSGVYGYYDFEGQLNTAITIRSMIVRSQGNQHQVFVQAGAGIVAD
SEPEREYQETLDKARGMLEAIRCLQV

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=391, Percent_Identity=38.8746803069054, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1788114, Length=468, Percent_Identity=30.5555555555556, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1786809, Length=271, Percent_Identity=29.1512915129151, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082077, Length=271, Percent_Identity=27.6752767527675, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=506, Percent_Identity=35.9683794466403, Blast_Score=307, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6324361, Length=409, Percent_Identity=24.9388753056235, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57154; Mature: 57154

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFPDFEQFRHLSQQGNFIPVYQEWVADLETPVSAWYKVCADQPYNFLLESVEGGENIGR
CCCCCHHHHHHHHHCCCEEEHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
YSFLGCDPVWVLENKGDRTTQKFRDGAVQEFSGNPFDVLAQCLASIKPVQLSELPPGIGG
EEEECCCEEEEEECCCCHHHHHHHCCCHHHCCCCCHHHHHHHHHHCCCCCHHCCCCCHHH
LFGMWGYELMRWIEPRVPVYERQEEDLPDGLWMQIDSLIIFDQVKRKIWVITYADLRDPA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCC
VPLEEAYLNACDRVTKLVLKLKLPLPVAAKPLEWLANPDGEALKYESNTSQAQFCQNVAK
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEECCCCCHHHHHHHHHH
AKEYIKAGDIFQVVLSQRLQTSYEGHPFDLYRSLRLINPSPYMSFYNFGDWQLIGSSPEI
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHEECCCEEEECCCCCE
MVKAEQTPDGKLQAMLRPIAGTRRRGKTQAEDLALEKDLLADPKEIAEHVMLVDLGRNDL
EEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHEEEEECCCCHH
GRVCEKGTVTVGDLMIIERYSHVMHIVSNVMGDLAPDQSAWNLLQACFPAGTVSGAPKIR
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHH
ALEIINELEPERRGPYSGVYGYYDFEGQLNTAITIRSMIVRSQGNQHQVFVQAGAGIVAD
HHHHHHHHCHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCEECC
SEPEREYQETLDKARGMLEAIRCLQV
CCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIFPDFEQFRHLSQQGNFIPVYQEWVADLETPVSAWYKVCADQPYNFLLESVEGGENIGR
CCCCCHHHHHHHHHCCCEEEHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
YSFLGCDPVWVLENKGDRTTQKFRDGAVQEFSGNPFDVLAQCLASIKPVQLSELPPGIGG
EEEECCCEEEEEECCCCHHHHHHHCCCHHHCCCCCHHHHHHHHHHCCCCCHHCCCCCHHH
LFGMWGYELMRWIEPRVPVYERQEEDLPDGLWMQIDSLIIFDQVKRKIWVITYADLRDPA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCC
VPLEEAYLNACDRVTKLVLKLKLPLPVAAKPLEWLANPDGEALKYESNTSQAQFCQNVAK
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEECCCCCHHHHHHHHHH
AKEYIKAGDIFQVVLSQRLQTSYEGHPFDLYRSLRLINPSPYMSFYNFGDWQLIGSSPEI
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHEECCCEEEECCCCCE
MVKAEQTPDGKLQAMLRPIAGTRRRGKTQAEDLALEKDLLADPKEIAEHVMLVDLGRNDL
EEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHEEEEECCCCHH
GRVCEKGTVTVGDLMIIERYSHVMHIVSNVMGDLAPDQSAWNLLQACFPAGTVSGAPKIR
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHH
ALEIINELEPERRGPYSGVYGYYDFEGQLNTAITIRSMIVRSQGNQHQVFVQAGAGIVAD
HHHHHHHHCHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCEECC
SEPEREYQETLDKARGMLEAIRCLQV
CCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 3141423 [H]