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The map label for this gene is glmS

Identifier: 170026433

GI number: 170026433

Start: 4668141

End: 4669970

Strand: Direct

Name: glmS

Synonym: YPK_4229

Alternate gene names: 170026433

Gene position: 4668141-4669970 (Clockwise)

Preceding gene: 170026432

Following gene: 170026435

Centisome position: 99.55

GC content: 47.27

Gene sequence:

>1830_bases
ATGTGTGGAATTGTTGGCGCAGTAGCGCAACGTGATATCGCTGAGATTCTGATCGAAGGCTTACGTCGCCTTGAATACCG
TGGCTATGACTCCGCTGGTTTAGCGGTAGTTGATAGTGAAGGTCACCTGACTCGTTTACGTAGGGTGGGTAAGGTTCATG
CTTTGTCTGATGCTGCTGAAAAGCAGGATTTACACGGTGGCACGGGCATAGCTCATACCCGCTGGGCTACCCATGGGGAG
CCGTCAGAGGCTAATGCACACCCTCATGTTTCTGACTATATCTCCGTCGTGCATAACGGCATTATTGAGAATCATGAACC
GTTACGTGAATTATTAATTAGCCGTGGCTATCGTTTTAGCTCTGAAACTGACACCGAAGTTATTGCTCACTTAGTACATT
GGGAGCAGCAGCAAGGGGGGTCTTTGCTGGAAGTTGTGAAACGTGTGATTCCGCAATTACGCGGTGCATACGGTACTGTT
GTGATGGATAGCCGTGACCCAAGTCGTCTGATTGCCGCTCGTTCAGGTAGCCCGCTGGTGATCGGGTGCGGTGTGGGTGA
AAACTTTATTGCTTCTGACCAGCTTGCTTTACTGCCAGTTACTCGCCGGTTTATCTTCTTGGAAGAAGGTGATGTGGTTG
AAGTTACTCGCCGGAGCATCTCTATCTTTGATAAGCAGGGTAATGCTATTGAGCGCCCTGAAATCGAATCTCAGGTGCAA
TACGATGCGGGTGATAAAGGTATTTACCGCCATTACATGCAGAAAGAAATTTATGAACAGCCAATGGCGATTAAGAATAC
GCTGGAAGGCCGTTTAAGCCACGGGATGATTGATCTGTCAGAACTTGGCCCAAAAGCTGATGCCCTGTTGGCAGAGGTTC
AACATATTCAAATCATTGCCTGCGGTACGTCTTACAACTCAGGGATGGTTTCTCGTTATTGGTTTGAGTCTTTAGCGGGT
GTGCCATGTGATGTCGAAATTGCCTCTGAATTTCGTTATCGCAAATCAGCTGTGCGTCCAAATAGCCTGTTGATCACTTT
GTCACAATCTGGCGAAACGGCTGATACTCTGGCAGCTCTGCGTTTATCTAAAGAGTTGGGGTATTTAGGTTCACTGGCCA
TTTGTAACGTTGCAGGATCTTCTTTAGTTCGCGAATCAGATTTAGCGCTGATGACCAAAGCAGGCACTGAGATTGGTGTT
GCTTCAACAAAAGCCTTTACCACTCAATTGACTGTTTTGCTGATGCTGGTGGGGCGTATAGGTAAGCTGAAAGGTGCTGA
TGCCAGCCTGGAGCACGATATTGTCCATGCGTTACAGGCATTGCCTGCACGTATTGAGCAGATGTTATCTCTGGATAAAA
CCATTGAAGCGTTGGCTGAAGGTTTCTCTGATAAGCATCATGCACTGTTCCTTGGCCGTGGTGATCAATACCCGATCGCA
ATGGAAGGGGCGCTGAAGCTGAAGGAGATCTCTTATATTCACGCAGAGGCTTACGCTGCGGGTGAATTGAAGCATGGCCC
ATTGGCATTGATTGATGCGGATATGCCGGTCATTGTGGTGGCACCGAACAATGAATTATTGGAAAAACTCAAATCCAATA
TTGAAGAAGTGCGTGCTCGTGGTGGTTTGCTATACGTGTTTGCTGATCAAGATGCCGGGTTCACTGATAGCGAAGGTATG
AAAATAATTCAGCTGCCACATGTCGAAGAAATTATTGCGCCTATCTTCTATACCGTACCGCTACAGCTACTGTCTTATCA
TGTCGCGCTGATTAAAGGCACTGATGTGGATCAGCCACGTAACTTGGCAAAATCAGTAACGGTTGAATAA

Upstream 100 bases:

>100_bases
CCCCAACTCTACAGGCTCGGGGAGCCCGGAAAATCCGGATCAATCAGGTCACTGACATCGAAAAGGTCCTAATAAGGGAC
CTTACATAGGAATAAAACAG

Downstream 100 bases:

>100_bases
GTTGCTCTAAGATAGGGTATTAACGAAAGAATAGCGTATTAACGAAAGCCGGCAAATTTGTCGGCTTTTTTGTCTTTATT
TTTAAATAATCAGTTATTAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGAVAQRDIAEILIEGLRRLEYRGYDSAGLAVVDSEGHLTRLRRVGKVHALSDAAEKQDLHGGTGIAHTRWATHGE
PSEANAHPHVSDYISVVHNGIIENHEPLRELLISRGYRFSSETDTEVIAHLVHWEQQQGGSLLEVVKRVIPQLRGAYGTV
VMDSRDPSRLIAARSGSPLVIGCGVGENFIASDQLALLPVTRRFIFLEEGDVVEVTRRSISIFDKQGNAIERPEIESQVQ
YDAGDKGIYRHYMQKEIYEQPMAIKNTLEGRLSHGMIDLSELGPKADALLAEVQHIQIIACGTSYNSGMVSRYWFESLAG
VPCDVEIASEFRYRKSAVRPNSLLITLSQSGETADTLAALRLSKELGYLGSLAICNVAGSSLVRESDLALMTKAGTEIGV
ASTKAFTTQLTVLLMLVGRIGKLKGADASLEHDIVHALQALPARIEQMLSLDKTIEALAEGFSDKHHALFLGRGDQYPIA
MEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGLLYVFADQDAGFTDSEGM
KIIQLPHVEEIIAPIFYTVPLQLLSYHVALIKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGAVAQRDIAEILIEGLRRLEYRGYDSAGLAVVDSEGHLTRLRRVGKVHALSDAAEKQDLHGGTGIAHTRWATHGE
PSEANAHPHVSDYISVVHNGIIENHEPLRELLISRGYRFSSETDTEVIAHLVHWEQQQGGSLLEVVKRVIPQLRGAYGTV
VMDSRDPSRLIAARSGSPLVIGCGVGENFIASDQLALLPVTRRFIFLEEGDVVEVTRRSISIFDKQGNAIERPEIESQVQ
YDAGDKGIYRHYMQKEIYEQPMAIKNTLEGRLSHGMIDLSELGPKADALLAEVQHIQIIACGTSYNSGMVSRYWFESLAG
VPCDVEIASEFRYRKSAVRPNSLLITLSQSGETADTLAALRLSKELGYLGSLAICNVAGSSLVRESDLALMTKAGTEIGV
ASTKAFTTQLTVLLMLVGRIGKLKGADASLEHDIVHALQALPARIEQMLSLDKTIEALAEGFSDKHHALFLGRGDQYPIA
MEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGLLYVFADQDAGFTDSEGM
KIIQLPHVEEIIAPIFYTVPLQLLSYHVALIKGTDVDQPRNLAKSVTVE
>Mature_609_residues
MCGIVGAVAQRDIAEILIEGLRRLEYRGYDSAGLAVVDSEGHLTRLRRVGKVHALSDAAEKQDLHGGTGIAHTRWATHGE
PSEANAHPHVSDYISVVHNGIIENHEPLRELLISRGYRFSSETDTEVIAHLVHWEQQQGGSLLEVVKRVIPQLRGAYGTV
VMDSRDPSRLIAARSGSPLVIGCGVGENFIASDQLALLPVTRRFIFLEEGDVVEVTRRSISIFDKQGNAIERPEIESQVQ
YDAGDKGIYRHYMQKEIYEQPMAIKNTLEGRLSHGMIDLSELGPKADALLAEVQHIQIIACGTSYNSGMVSRYWFESLAG
VPCDVEIASEFRYRKSAVRPNSLLITLSQSGETADTLAALRLSKELGYLGSLAICNVAGSSLVRESDLALMTKAGTEIGV
ASTKAFTTQLTVLLMLVGRIGKLKGADASLEHDIVHALQALPARIEQMLSLDKTIEALAEGFSDKHHALFLGRGDQYPIA
MEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGLLYVFADQDAGFTDSEGM
KIIQLPHVEEIIAPIFYTVPLQLLSYHVALIKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=39.0350877192982, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=39.2753623188406, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI29570798, Length=266, Percent_Identity=25.5639097744361, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790167, Length=609, Percent_Identity=85.0574712643678, Blast_Score=1075, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=277, Percent_Identity=28.158844765343, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17539970, Length=433, Percent_Identity=39.4919168591224, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17532899, Length=518, Percent_Identity=35.3281853281853, Blast_Score=285, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=38.6574074074074, Blast_Score=282, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6322745, Length=451, Percent_Identity=37.9157427937916, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323731, Length=436, Percent_Identity=30.9633027522936, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=39.7058823529412, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=36.3372093023256, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI28573187, Length=269, Percent_Identity=27.1375464684015, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24659598, Length=265, Percent_Identity=23.7735849056604, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_YERPE (Q8Z9S8)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0500
- RefSeq:   NP_671423.1
- RefSeq:   NP_995287.1
- RefSeq:   YP_002348969.1
- ProteinModelPortal:   Q8Z9S8
- SMR:   Q8Z9S8
- IntAct:   Q8Z9S8
- GeneID:   1149079
- GeneID:   1176946
- GeneID:   2766761
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO4118
- KEGG:   ypk:y4132
- KEGG:   ypm:YP_4025
- HOGENOM:   HBG645312
- OMA:   LGIGENF
- ProtClustDB:   PRK00331
- BioCyc:   YPES187410:Y4132-MONOMER
- BioCyc:   YPES214092:YPO4118-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 66526; Mature: 66526

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 604-604

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAQRDIAEILIEGLRRLEYRGYDSAGLAVVDSEGHLTRLRRVGKVHALSDAAE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
KQDLHGGTGIAHTRWATHGEPSEANAHPHVSDYISVVHNGIIENHEPLRELLISRGYRFS
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
SETDTEVIAHLVHWEQQQGGSLLEVVKRVIPQLRGAYGTVVMDSRDPSRLIAARSGSPLV
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCEE
IGCGVGENFIASDQLALLPVTRRFIFLEEGDVVEVTRRSISIFDKQGNAIERPEIESQVQ
EECCCCCCCCCCCCEEEEEEEEEEEEEECCCEEEHHHHHHHEEECCCCCCCCCCCHHHHC
YDAGDKGIYRHYMQKEIYEQPMAIKNTLEGRLSHGMIDLSELGPKADALLAEVQHIQIIA
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEHHHCCCHHHHHHHHHCEEEEEE
CGTSYNSGMVSRYWFESLAGVPCDVEIASEFRYRKSAVRPNSLLITLSQSGETADTLAAL
ECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHH
RLSKELGYLGSLAICNVAGSSLVRESDLALMTKAGTEIGVASTKAFTTQLTVLLMLVGRI
HHHHHHCCCCCHHHHHHCCHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
GKLKGADASLEHDIVHALQALPARIEQMLSLDKTIEALAEGFSDKHHALFLGRGDQYPIA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEE
MEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRAR
ECCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGLLYVFADQDAGFTDSEGMKIIQLPHVEEIIAPIFYTVPLQLLSYHVALIKGTDVDQPR
CCEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGAVAQRDIAEILIEGLRRLEYRGYDSAGLAVVDSEGHLTRLRRVGKVHALSDAAE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
KQDLHGGTGIAHTRWATHGEPSEANAHPHVSDYISVVHNGIIENHEPLRELLISRGYRFS
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
SETDTEVIAHLVHWEQQQGGSLLEVVKRVIPQLRGAYGTVVMDSRDPSRLIAARSGSPLV
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCEE
IGCGVGENFIASDQLALLPVTRRFIFLEEGDVVEVTRRSISIFDKQGNAIERPEIESQVQ
EECCCCCCCCCCCCEEEEEEEEEEEEEECCCEEEHHHHHHHEEECCCCCCCCCCCHHHHC
YDAGDKGIYRHYMQKEIYEQPMAIKNTLEGRLSHGMIDLSELGPKADALLAEVQHIQIIA
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEHHHCCCHHHHHHHHHCEEEEEE
CGTSYNSGMVSRYWFESLAGVPCDVEIASEFRYRKSAVRPNSLLITLSQSGETADTLAAL
ECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHH
RLSKELGYLGSLAICNVAGSSLVRESDLALMTKAGTEIGVASTKAFTTQLTVLLMLVGRI
HHHHHHCCCCCHHHHHHCCHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
GKLKGADASLEHDIVHALQALPARIEQMLSLDKTIEALAEGFSDKHHALFLGRGDQYPIA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEE
MEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRAR
ECCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGLLYVFADQDAGFTDSEGMKIIQLPHVEEIIAPIFYTVPLQLLSYHVALIKGTDVDQPR
CCEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430