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The map label for this gene is glmU [H]

Identifier: 170026432

GI number: 170026432

Start: 4666570

End: 4667940

Strand: Direct

Name: glmU [H]

Synonym: YPK_4228

Alternate gene names: 170026432

Gene position: 4666570-4667940 (Clockwise)

Preceding gene: 170026431

Following gene: 170026433

Centisome position: 99.51

GC content: 47.48

Gene sequence:

>1371_bases
ATGTCTAACAGCTCAATGAGTGTCGTCATCCTTGCCGCGGGTAAGGGGACACGTATGTATTCCGACCTTCCTAAGGTATT
GCACCCATTGGCAGGTAAGCCAATGGTTCAGCATGTTATTGATGCTGCCATGAAGCTAGGTGCACAACATGTTCATCTGG
TTTATGGGCACGGGGGTGAGTTACTGAAGAAGACCTTGGCCGATCCATCCTTGAATTGGGTATTACAGGCTGAGCAACTG
GGTACTGGCCATGCGATGCAGCAAGCTGCCCCACATTTTGCTGATGATGAAGATATTTTGATGTTGTATGGCGATGTGCC
GCTGATCTCTGTTGATACGCTACAACGTCTGCTGGCCGCTAAGCCCGAGGGCGGGATTGGCTTGTTGACAGTAAAACTGG
ATAACCCAAGCGGTTATGGCCGTATCGTTCGTGAGAATGGCGATGTCGTCGGGATCGTTGAACATAAAGATGCCAGCGAT
GCACAACGGGAAATCAACGAGATCAATACGGGGATTCTGGTCGCAAATGGGCGCGATTTAAAACGCTGGCTATCATTGTT
GGATAATAATAATGCTCAAGGTGAGTTTTATATCACTGACATTATTGCGTTAGCGCATGCCGATGGTAAGAAAATTGCCA
CTGTCCATCCTACCCGTTTGAGTGAAGTGGAAGGGGTGAATAATCGCCTGCAATTGTCTGCTCTTGAGCGCGTATTTCAG
ACAGAACAAGCGGAAAAATTATTGTTAGCGGGCGTGATGCTATTGGATCCCTCCCGTTTTGATTTGCGCGGAGAATTAAC
TCATGGTCGCGATATTACTATCGATACCAATGTCATTATTGAAGGTCATGTGATTTTAGGTGACCGGGTGCGAATTGGTA
CGGGGTGTGTACTCAAAAACTGTGTGATTGGTGATGACTCAGAAATAAGCCCATATACCGTTTTAGAAGATGCCCGCCTG
GATGCCAACTGTACTGTTGGGCCATTTGCTCGTCTGCGTCCTGGCGCTGAATTGGCTGAAGGTGCACATGTTGGTAATTT
TGTTGAAATCAAAAAAGCCCGTTTGGGTAAAGGCTCTAAAGCCGGTCATCTCTCTTATCTAGGTGACGCTGAGATTGGGG
CTGGCGTCAATATTGGCGCGGGAACTATAACGTGTAACTATGACGGGGCTAATAAGTTTAAAACTATTATTGGCGATGAT
GTTTTTGTCGGATCGGATACTCAATTAGTTGCCCCGGTCACCGTTGCAAACGGTGCAACCATTGGCGCGGGTACGACTGT
CACCCGTGATGTTGCCGAAAATGAATTAGTCATCAGCCGGGTTAAGCAGGTTCATATTCAGGGATGGAAGCGCCCGGTAA
AGAAAAAGTAA

Upstream 100 bases:

>100_bases
GCCACGCGGGTTGTGTACGTTTTTCGTTGAGAAATATGTAGTAATTATTTCGGTAAACAGGTTTACTTCCGTCTATTAAA
TTGGAGTTATCAGGTTGCTT

Downstream 100 bases:

>100_bases
CGTTATTAAAAGCACCCTTCAAGGTGAATTATGCTTCTTTGAAGGGATGTTTTGCCCTGTATTTTTGGTTTACTGAAAAT
ACAGTACAAAACATAATAAT

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSNSSMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAQHVHLVYGHGGELLKKTLADPSLNWVLQAEQL
GTGHAMQQAAPHFADDEDILMLYGDVPLISVDTLQRLLAAKPEGGIGLLTVKLDNPSGYGRIVRENGDVVGIVEHKDASD
AQREINEINTGILVANGRDLKRWLSLLDNNNAQGEFYITDIIALAHADGKKIATVHPTRLSEVEGVNNRLQLSALERVFQ
TEQAEKLLLAGVMLLDPSRFDLRGELTHGRDITIDTNVIIEGHVILGDRVRIGTGCVLKNCVIGDDSEISPYTVLEDARL
DANCTVGPFARLRPGAELAEGAHVGNFVEIKKARLGKGSKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKFKTIIGDD
VFVGSDTQLVAPVTVANGATIGAGTTVTRDVAENELVISRVKQVHIQGWKRPVKKK

Sequences:

>Translated_456_residues
MSNSSMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAQHVHLVYGHGGELLKKTLADPSLNWVLQAEQL
GTGHAMQQAAPHFADDEDILMLYGDVPLISVDTLQRLLAAKPEGGIGLLTVKLDNPSGYGRIVRENGDVVGIVEHKDASD
AQREINEINTGILVANGRDLKRWLSLLDNNNAQGEFYITDIIALAHADGKKIATVHPTRLSEVEGVNNRLQLSALERVFQ
TEQAEKLLLAGVMLLDPSRFDLRGELTHGRDITIDTNVIIEGHVILGDRVRIGTGCVLKNCVIGDDSEISPYTVLEDARL
DANCTVGPFARLRPGAELAEGAHVGNFVEIKKARLGKGSKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKFKTIIGDD
VFVGSDTQLVAPVTVANGATIGAGTTVTRDVAENELVISRVKQVHIQGWKRPVKKK
>Mature_455_residues
SNSSMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAQHVHLVYGHGGELLKKTLADPSLNWVLQAEQLG
TGHAMQQAAPHFADDEDILMLYGDVPLISVDTLQRLLAAKPEGGIGLLTVKLDNPSGYGRIVRENGDVVGIVEHKDASDA
QREINEINTGILVANGRDLKRWLSLLDNNNAQGEFYITDIIALAHADGKKIATVHPTRLSEVEGVNNRLQLSALERVFQT
EQAEKLLLAGVMLLDPSRFDLRGELTHGRDITIDTNVIIEGHVILGDRVRIGTGCVLKNCVIGDDSEISPYTVLEDARLD
ANCTVGPFARLRPGAELAEGAHVGNFVEIKKARLGKGSKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKFKTIIGDDV
FVGSDTQLVAPVTVANGATIGAGTTVTRDVAENELVISRVKQVHIQGWKRPVKKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=456, Percent_Identity=82.2368421052632, Blast_Score=769, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 48841; Mature: 48709

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSSMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAQHVHLVYGHGGE
CCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCHH
LLKKTLADPSLNWVLQAEQLGTGHAMQQAAPHFADDEDILMLYGDVPLISVDTLQRLLAA
HHHHHHCCCCCEEEEEECCCCCCHHHHHCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHC
KPEGGIGLLTVKLDNPSGYGRIVRENGDVVGIVEHKDASDAQREINEINTGILVANGRDL
CCCCCEEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHCCCCEEEECCCCH
KRWLSLLDNNNAQGEFYITDIIALAHADGKKIATVHPTRLSEVEGVNNRLQLSALERVFQ
HHHHHHHCCCCCCCEEEEEEEEEEECCCCCEEEEECCCHHHHHCCCCCEEHHHHHHHHHH
TEQAEKLLLAGVMLLDPSRFDLRGELTHGRDITIDTNVIIEGHVILGDRVRIGTGCVLKN
HHHHHHHHHHCEEEECCCCCCEEEEECCCCEEEEECEEEEEEEEEECCEEEECCCEEEEE
CVIGDDSEISPYTVLEDARLDANCTVGPFARLRPGAELAEGAHVGNFVEIKKARLGKGSK
EEECCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCHHHCCCCCCCEEEEHHHHCCCCCC
AGHLSYLGDAEIGAGVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVANGAT
CCCEEEECCCCCCCCEEECCCEEEEECCCCCHHHHEECCCEEECCCCEEEEEEEEECCCE
IGAGTTVTRDVAENELVISRVKQVHIQGWKRPVKKK
ECCCCEEEHHHHCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SNSSMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAQHVHLVYGHGGE
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCHH
LLKKTLADPSLNWVLQAEQLGTGHAMQQAAPHFADDEDILMLYGDVPLISVDTLQRLLAA
HHHHHHCCCCCEEEEEECCCCCCHHHHHCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHC
KPEGGIGLLTVKLDNPSGYGRIVRENGDVVGIVEHKDASDAQREINEINTGILVANGRDL
CCCCCEEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHCCCCEEEECCCCH
KRWLSLLDNNNAQGEFYITDIIALAHADGKKIATVHPTRLSEVEGVNNRLQLSALERVFQ
HHHHHHHCCCCCCCEEEEEEEEEEECCCCCEEEEECCCHHHHHCCCCCEEHHHHHHHHHH
TEQAEKLLLAGVMLLDPSRFDLRGELTHGRDITIDTNVIIEGHVILGDRVRIGTGCVLKN
HHHHHHHHHHCEEEECCCCCCEEEEECCCCEEEEECEEEEEEEEEECCEEEECCCEEEEE
CVIGDDSEISPYTVLEDARLDANCTVGPFARLRPGAELAEGAHVGNFVEIKKARLGKGSK
EEECCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCHHHCCCCCCCEEEEHHHHCCCCCC
AGHLSYLGDAEIGAGVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVANGAT
CCCEEEECCCCCCCCEEECCCEEEEECCCCCHHHHEECCCEEECCCCEEEEEEEEECCCE
IGAGTTVTRDVAENELVISRVKQVHIQGWKRPVKKK
ECCCCEEEHHHHCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA