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The map label for this gene is mutM [H]

Identifier: 170026359

GI number: 170026359

Start: 4584852

End: 4585661

Strand: Reverse

Name: mutM [H]

Synonym: YPK_4152

Alternate gene names: 170026359

Gene position: 4585661-4584852 (Counterclockwise)

Preceding gene: 170026360

Following gene: 170026352

Centisome position: 97.79

GC content: 48.89

Gene sequence:

>810_bases
ATGCCTGAATTACCAGAAGTTGAAACCAGCCGCCGCGGGATCGAACCTTATCTTGTCGGCCAGACAATCCTTTATGCTGT
GGTCAGAAATGCCCGTTTACGCTGGCCGGTATCCGATGAAATTCTAACACTTAGCGATCAACCCGTACTGAGTGTCCAAC
GCCGGGCGAAGTATTTACTGCTAGAGCTGCCTAAAGGCTGGATCATCATACATTTAGGTATGTCAGGTAGCCTGCGCGTA
TTATCTGAAGAGACTGCAGCTGAAAAGCACGATCATGTCGATTTGGTGGTCAGTAACGGAAAAATATTGCGTTATACCGA
CCCACGACGTTTTGGTGCCTGGTTGTGGGCGAAAGACCTTGAGACCAGTAATGTATTAGCCCATTTAGGGCCAGAACCAC
TAAGTGATGAATTTACTGCGCAATATCTGTTCGATAAATCACGTAATAAACGCACATTGATTAAACCGTGGTTGATGGAT
AACAAAGTGGTCGTCGGAGTGGGTAACATTTATGCGAGCGAATCACTGTTTGCTGCTGGGATTTTGCCAGATCGTGCCGC
AGGCTCATTGACTGACGCTGAATCCGTATTGCTGGTAGCAACGATAAAAGCCGTGTTATTGCATTCGATTGAGCAGGGCG
GCACCACATTACGTGATTTTCTGCAGTCGGATGGTAAACCAGGGTATTTCGCGCAAGAGTTGCAGGTCTATGGGCGTGCG
GGTGAACCATGTCGGCAGTGTGGGCATCCCATTGAAATAGCGAAACACGGGCAGCGCAGCACGTTCTTTTGCCGCCACTG
CCAGCATTGA

Upstream 100 bases:

>100_bases
GAAGCTAAAATTAAGTAATTTTAGCGGACTAAGAAAAACCCGGCCTTGGCCGGGTTTTTTATTATATAAAGTACAGTGAG
ATACGTTGAAAGGAGGTTAA

Downstream 100 bases:

>100_bases
GAGGTTTAGGCCAATTTGGCCAATAATGCTTTGGTAACCGGTTTGGGCAGGAATGGCGTGATATCCCCACCGTGGCGCGC
CACTTCTTTCACTAATGAGG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MPELPEVETSRRGIEPYLVGQTILYAVVRNARLRWPVSDEILTLSDQPVLSVQRRAKYLLLELPKGWIIIHLGMSGSLRV
LSEETAAEKHDHVDLVVSNGKILRYTDPRRFGAWLWAKDLETSNVLAHLGPEPLSDEFTAQYLFDKSRNKRTLIKPWLMD
NKVVVGVGNIYASESLFAAGILPDRAAGSLTDAESVLLVATIKAVLLHSIEQGGTTLRDFLQSDGKPGYFAQELQVYGRA
GEPCRQCGHPIEIAKHGQRSTFFCRHCQH

Sequences:

>Translated_269_residues
MPELPEVETSRRGIEPYLVGQTILYAVVRNARLRWPVSDEILTLSDQPVLSVQRRAKYLLLELPKGWIIIHLGMSGSLRV
LSEETAAEKHDHVDLVVSNGKILRYTDPRRFGAWLWAKDLETSNVLAHLGPEPLSDEFTAQYLFDKSRNKRTLIKPWLMD
NKVVVGVGNIYASESLFAAGILPDRAAGSLTDAESVLLVATIKAVLLHSIEQGGTTLRDFLQSDGKPGYFAQELQVYGRA
GEPCRQCGHPIEIAKHGQRSTFFCRHCQH
>Mature_268_residues
PELPEVETSRRGIEPYLVGQTILYAVVRNARLRWPVSDEILTLSDQPVLSVQRRAKYLLLELPKGWIIIHLGMSGSLRVL
SEETAAEKHDHVDLVVSNGKILRYTDPRRFGAWLWAKDLETSNVLAHLGPEPLSDEFTAQYLFDKSRNKRTLIKPWLMDN
KVVVGVGNIYASESLFAAGILPDRAAGSLTDAESVLLVATIKAVLLHSIEQGGTTLRDFLQSDGKPGYFAQELQVYGRAG
EPCRQCGHPIEIAKHGQRSTFFCRHCQH

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=268, Percent_Identity=79.8507462686567, Blast_Score=444, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30111; Mature: 29980

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETSRRGIEPYLVGQTILYAVVRNARLRWPVSDEILTLSDQPVLSVQRRAKYLL
CCCCCCCCHHHCCCCCCHHHHHHHHHHHHCCEEECCCCCCEEEECCCCHHHHHHHHCEEE
LELPKGWIIIHLGMSGSLRVLSEETAAEKHDHVDLVVSNGKILRYTDPRRFGAWLWAKDL
EECCCCEEEEEECCCCCEEEEECHHHHHCCCCEEEEEECCEEEEECCCCHHHHEEEECCC
ETSNVLAHLGPEPLSDEFTAQYLFDKSRNKRTLIKPWLMDNKVVVGVGNIYASESLFAAG
CCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCEEECCEEECCEEEEEECCCCCCCCEEEEC
ILPDRAAGSLTDAESVLLVATIKAVLLHSIEQGGTTLRDFLQSDGKPGYFAQELQVYGRA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHCCC
GEPCRQCGHPIEIAKHGQRSTFFCRHCQH
CCHHHHCCCEEEHHHCCCCCCCHHHCCCC
>Mature Secondary Structure 
PELPEVETSRRGIEPYLVGQTILYAVVRNARLRWPVSDEILTLSDQPVLSVQRRAKYLL
CCCCCCCHHHCCCCCCHHHHHHHHHHHHCCEEECCCCCCEEEECCCCHHHHHHHHCEEE
LELPKGWIIIHLGMSGSLRVLSEETAAEKHDHVDLVVSNGKILRYTDPRRFGAWLWAKDL
EECCCCEEEEEECCCCCEEEEECHHHHHCCCCEEEEEECCEEEEECCCCHHHHEEEECCC
ETSNVLAHLGPEPLSDEFTAQYLFDKSRNKRTLIKPWLMDNKVVVGVGNIYASESLFAAG
CCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCEEECCEEECCEEEEEECCCCCCCCEEEEC
ILPDRAAGSLTDAESVLLVATIKAVLLHSIEQGGTTLRDFLQSDGKPGYFAQELQVYGRA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHCCC
GEPCRQCGHPIEIAKHGQRSTFFCRHCQH
CCHHHHCCCEEEHHHCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA