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The map label for this gene is tdh [H]

Identifier: 170026351

GI number: 170026351

Start: 4576406

End: 4577431

Strand: Reverse

Name: tdh [H]

Synonym: YPK_4144

Alternate gene names: 170026351

Gene position: 4577431-4576406 (Counterclockwise)

Preceding gene: 170026352

Following gene: 170026347

Centisome position: 97.61

GC content: 47.95

Gene sequence:

>1026_bases
ATGAAAGCACTTTCTAAACTGAAAGCAGAAGAAGGCATTTGGATGACCGATGTGCCACAGCCAGAGCTGGGTCACAACGA
TATCATGATCAAAATTCGCAAAACGGCTATCTGTGGTACTGACGTACATATTTATAATTGGGATGAATGGTCACAAAAAA
CCATCCCCGTACCCATGGTCGTTGGCCATGAATATGTCGGTGAAGTGGTGGCCATTGGGCAGGAAGTTAAAGGGTTTAAT
ATTGGTGACCGGGTGTCTGGTGAAGGCCATATTACCTGTGGTCACTGCCGTAACTGCCGTGGTGGTCGTACCCACCTTTG
TCGTAATACGGTGGGTGTTGGCGTGAATCGCCCTGGTTCGTTTGCCGAATATTTGGTGATCCCTGCTTTTAACGCGTTCA
AGATCCCAGACAATATTTCTGATGAGCTTGCGGCTATTTTTGACCCCTTCGGCAATGCAGTTCATACCGCGTTATCTTTT
GATTTAGTCGGCGAGGATGTGTTGGTCTCCGGGGCTGGCCCAATTGGTATTATGGCCGCCGCAGTCTGTAAGCATGTGGG
TGCTCGTCATGTTGTCATCACTGATGTGAATGAATATCGCCTGGATCTGGCCCGTAAAATGGGCGTGACCCGTGCCGTTA
ACGTCAGCAAAGAGAACCTAAATGACGTTATGACGGAATTGGGCATGACCGAAGGGTTTGATGTGGGCTTGGAGATGTCA
GGTGCTCCCCCGGCTTTCCGTTCATTACTTAATTCAATGAATCATGGTGGTCGTATAGCGATGCTGGGAATACCGCCGTC
TGATATGTCGATCGACTGGAATCAGGTTATCTTTAAGGGGCTGTTTATAAAGGGAATTTATGGCCGTGAGATGTTCGAAA
CCTGGTACAAAATGGCCGCGTTGATTCAATCTGGTTTGGACTTAACTCCGATCATTACCCACCGTTTCCCTATTGATGAA
TTCCAGCAAGGGTTTGACGCCATGCGTTCGGGTAAATCAGGCAAAGTGGTATTAAGCTGGGATTAG

Upstream 100 bases:

>100_bases
CCAGATGTCTGCAGGCCATACCACTGAGCAAGTTGAACGTGCCATCGAGGCATTTGTGCGTATTGGTAAGCAACTTAACG
TTATTGCGTAAGGGATTTTC

Downstream 100 bases:

>100_bases
TTTATCCCCTTCGGGCTTGGTGTTGCAAAACTACCCGCTGCGATACCAAGCCCTTGTCAGGATTTACGTTTTTTGCGGTG
GCCGCCTTACCGCAATTTGA

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKALSKLKAEEGIWMTDVPQPELGHNDIMIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVAIGQEVKGFN
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTVGVGVNRPGSFAEYLVIPAFNAFKIPDNISDELAAIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGIMAAAVCKHVGARHVVITDVNEYRLDLARKMGVTRAVNVSKENLNDVMTELGMTEGFDVGLEMS
GAPPAFRSLLNSMNHGGRIAMLGIPPSDMSIDWNQVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLTPIITHRFPIDE
FQQGFDAMRSGKSGKVVLSWD

Sequences:

>Translated_341_residues
MKALSKLKAEEGIWMTDVPQPELGHNDIMIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVAIGQEVKGFN
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTVGVGVNRPGSFAEYLVIPAFNAFKIPDNISDELAAIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGIMAAAVCKHVGARHVVITDVNEYRLDLARKMGVTRAVNVSKENLNDVMTELGMTEGFDVGLEMS
GAPPAFRSLLNSMNHGGRIAMLGIPPSDMSIDWNQVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLTPIITHRFPIDE
FQQGFDAMRSGKSGKVVLSWD
>Mature_341_residues
MKALSKLKAEEGIWMTDVPQPELGHNDIMIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVAIGQEVKGFN
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTVGVGVNRPGSFAEYLVIPAFNAFKIPDNISDELAAIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGIMAAAVCKHVGARHVVITDVNEYRLDLARKMGVTRAVNVSKENLNDVMTELGMTEGFDVGLEMS
GAPPAFRSLLNSMNHGGRIAMLGIPPSDMSIDWNQVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLTPIITHRFPIDE
FQQGFDAMRSGKSGKVVLSWD

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=335, Percent_Identity=27.4626865671642, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI4501929, Length=372, Percent_Identity=26.0752688172043, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI34577061, Length=349, Percent_Identity=26.3610315186246, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4501933, Length=372, Percent_Identity=25.8064516129032, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI262073058, Length=352, Percent_Identity=26.1363636363636, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI71743840, Length=352, Percent_Identity=26.1363636363636, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI156523966, Length=349, Percent_Identity=24.3553008595989, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501939, Length=343, Percent_Identity=24.4897959183673, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI71565152, Length=359, Percent_Identity=23.1197771587744, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI71565154, Length=348, Percent_Identity=25.2873563218391, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=92.375366568915, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1788075, Length=368, Percent_Identity=31.25, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=28.5714285714286, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1787863, Length=318, Percent_Identity=29.874213836478, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87082125, Length=344, Percent_Identity=30.8139534883721, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI226510992, Length=330, Percent_Identity=27.2727272727273, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788407, Length=343, Percent_Identity=27.1137026239067, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI87081918, Length=327, Percent_Identity=28.7461773700306, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1786825, Length=400, Percent_Identity=27.75, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790718, Length=307, Percent_Identity=25.4071661237785, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786552, Length=358, Percent_Identity=27.3743016759777, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786518, Length=285, Percent_Identity=26.3157894736842, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=336, Percent_Identity=31.8452380952381, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=30.8383233532934, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17562584, Length=134, Percent_Identity=35.0746268656716, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=187, Percent_Identity=32.0855614973262, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=143, Percent_Identity=33.5664335664336, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=25.4010695187166, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=374, Percent_Identity=25.1336898395722, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323099, Length=323, Percent_Identity=30.9597523219814, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322619, Length=309, Percent_Identity=28.1553398058252, Blast_Score=129, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6319955, Length=309, Percent_Identity=27.831715210356, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=377, Percent_Identity=27.3209549071618, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=26.7029972752044, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=318, Percent_Identity=25.7861635220126, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=278, Percent_Identity=29.136690647482, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=324, Percent_Identity=28.3950617283951, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=277, Percent_Identity=28.8808664259928, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=284, Percent_Identity=27.4647887323944, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323980, Length=258, Percent_Identity=30.6201550387597, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=337, Percent_Identity=26.1127596439169, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=26.5060240963855, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=26.2048192771084, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=25.1989389920424, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45551930, Length=191, Percent_Identity=26.7015706806283, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221457811, Length=191, Percent_Identity=26.7015706806283, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550770, Length=191, Percent_Identity=26.7015706806283, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37334; Mature: 37334

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALSKLKAEEGIWMTDVPQPELGHNDIMIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV
CCHHHHHHHHCCCEECCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCCCCCCEEE
VGHEYVGEVVAIGQEVKGFNIGDRVSGEGHITCGHCRNCRGGRTHLCRNTVGVGVNRPGS
ECHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCC
FAEYLVIPAFNAFKIPDNISDELAAIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAA
CEEEEEEECCCCEECCCCCHHHHHHHHHHCCHHHHHHHHHEECCCEEEEECCCHHHHHHH
AVCKHVGARHVVITDVNEYRLDLARKMGVTRAVNVSKENLNDVMTELGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHCCCHHEECCCHHHHHHHHHHHCCCCCCCCCEEEC
GAPPAFRSLLNSMNHGGRIAMLGIPPSDMSIDWNQVIFKGLFIKGIYGREMFETWYKMAA
CCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIQSGLDLTPIITHRFPIDEFQQGFDAMRSGKSGKVVLSWD
HHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKALSKLKAEEGIWMTDVPQPELGHNDIMIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV
CCHHHHHHHHCCCEECCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCCCCCCEEE
VGHEYVGEVVAIGQEVKGFNIGDRVSGEGHITCGHCRNCRGGRTHLCRNTVGVGVNRPGS
ECHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCC
FAEYLVIPAFNAFKIPDNISDELAAIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAA
CEEEEEEECCCCEECCCCCHHHHHHHHHHCCHHHHHHHHHEECCCEEEEECCCHHHHHHH
AVCKHVGARHVVITDVNEYRLDLARKMGVTRAVNVSKENLNDVMTELGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHCCCHHEECCCHHHHHHHHHHHCCCCCCCCCEEEC
GAPPAFRSLLNSMNHGGRIAMLGIPPSDMSIDWNQVIFKGLFIKGIYGREMFETWYKMAA
CCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIQSGLDLTPIITHRFPIDEFQQGFDAMRSGKSGKVVLSWD
HHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]