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The map label for this gene is proA [H]

Identifier: 170026328

GI number: 170026328

Start: 4554933

End: 4555646

Strand: Direct

Name: proA [H]

Synonym: YPK_4121

Alternate gene names: 170026328

Gene position: 4554933-4555646 (Clockwise)

Preceding gene: 170026327

Following gene: 170026329

Centisome position: 97.13

GC content: 54.06

Gene sequence:

>714_bases
ATGAGCCTGGTTAATATGAAAGGGGTCGTGGTCACAAACATTGAACGAGCTGAACTAGCCCTGTTACAACGTTTCGCTGA
ATATGGCGTGGCAACAGTGCATGAAGCTCAACTGCGGCAGGGACTATTGGATGAGCGAATTAAACCTATTCAGCAAGGGC
GCTGTATTGCTGGCAATGCGGTGACGGTATTGGTTACACCCGGAGATAACTGGATGTTCCATGTTGCCGTAGAGCAGTGT
CAGCCTGGCGATGTGTTGCTCGTTGCGCCGACCTCCGAATGCCATGATGGCTTTTTTGGTGACCTGCTCGCGACCTCACT
GCTGGCGCGCGGCGTGGTGGCATTGGTTGGAGATATCGGGATCCGAGATAGCCAGACGCTGCGCGAAATGAATTTCCCTG
TGTGGTCGCGTGCGGTTTGGGCACAAGGTACGGTGAAAGCCTCGCTTGGCTCGGTCAATGTGCCGGTGATCTGCGCGGGT
CAGTTGGTCAACCCCGGCGATATTGTGGTGGCAGACGATGATGGCGTAGTCATTGTGCCAAGAGAACAAGCCACCGCGAT
TGCTGATGCGGCACAGACACGGGTAGATCTTGAAACGAGCAAACGTCAGCGTCTGGCTAATGGCGAGCTCGGGCTGGATA
TCTATCAAATGCGTGCCCCTCTGGCGAAAAAAGGGCTGCGTTACGTCAATAGTCTCAACGCGTTAAAGTCATAA

Upstream 100 bases:

>100_bases
GGGTACAAGCAAAACGCAACATCGGCATTGCCAGTACCAAGACCATTATTCATGGCGAAGGTTATCAAAGCCTCTTCCCT
CGCGTCACGGAGGATCTGTC

Downstream 100 bases:

>100_bases
GAATAAATATTCCTCTTGCCAGTAAGTTTCAGTATTACAACACCTTAGAAAAGGGAAACTACAGCATGAAAAATAAGATA
TGGAAGTTGTGTATCTTAGT

Product: hypothetical protein

Products: NA

Alternate protein names: 4-hydroxy-2-oxoglutarate aldolase [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MSLVNMKGVVVTNIERAELALLQRFAEYGVATVHEAQLRQGLLDERIKPIQQGRCIAGNAVTVLVTPGDNWMFHVAVEQC
QPGDVLLVAPTSECHDGFFGDLLATSLLARGVVALVGDIGIRDSQTLREMNFPVWSRAVWAQGTVKASLGSVNVPVICAG
QLVNPGDIVVADDDGVVIVPREQATAIADAAQTRVDLETSKRQRLANGELGLDIYQMRAPLAKKGLRYVNSLNALKS

Sequences:

>Translated_237_residues
MSLVNMKGVVVTNIERAELALLQRFAEYGVATVHEAQLRQGLLDERIKPIQQGRCIAGNAVTVLVTPGDNWMFHVAVEQC
QPGDVLLVAPTSECHDGFFGDLLATSLLARGVVALVGDIGIRDSQTLREMNFPVWSRAVWAQGTVKASLGSVNVPVICAG
QLVNPGDIVVADDDGVVIVPREQATAIADAAQTRVDLETSKRQRLANGELGLDIYQMRAPLAKKGLRYVNSLNALKS
>Mature_236_residues
SLVNMKGVVVTNIERAELALLQRFAEYGVATVHEAQLRQGLLDERIKPIQQGRCIAGNAVTVLVTPGDNWMFHVAVEQCQ
PGDVLLVAPTSECHDGFFGDLLATSLLARGVVALVGDIGIRDSQTLREMNFPVWSRAVWAQGTVKASLGSVNVPVICAGQ
LVNPGDIVVADDDGVVIVPREQATAIADAAQTRVDLETSKRQRLANGELGLDIYQMRAPLAKKGLRYVNSLNALKS

Specific function: Plays a role in protocatechuate degradation. Has a broad substrate specificity and catalyzes the aldol cleavage of 4- hydroxy-4-methyl-2-oxoglutarate, 4-hydroxy-2-oxoglutarate and 4- carboxy-4-hydroxy-2-oxoadipate, and the decarboxylation of oxaloacetate.

COG id: COG0684

COG function: function code H; Demethylmenaquinone methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014165
- InterPro:   IPR005493 [H]

Pfam domain/function: PF03737 Methyltransf_6 [H]

EC number: =4.1.1.3; =4.1.3.16; =4.1.3.17 [H]

Molecular weight: Translated: 25496; Mature: 25365

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVNMKGVVVTNIERAELALLQRFAEYGVATVHEAQLRQGLLDERIKPIQQGRCIAGNA
CCCCCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCE
VTVLVTPGDNWMFHVAVEQCQPGDVLLVAPTSECHDGFFGDLLATSLLARGVVALVGDIG
EEEEEECCCCEEEEEEEECCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
IRDSQTLREMNFPVWSRAVWAQGTVKASLGSVNVPVICAGQLVNPGDIVVADDDGVVIVP
CCCCHHHHHCCCCHHHHHHHCCCEEEECCCCCCCCEEEECCCCCCCCEEEECCCCEEEEE
REQATAIADAAQTRVDLETSKRQRLANGELGLDIYQMRAPLAKKGLRYVNSLNALKS
CCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLVNMKGVVVTNIERAELALLQRFAEYGVATVHEAQLRQGLLDERIKPIQQGRCIAGNA
CCCCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCE
VTVLVTPGDNWMFHVAVEQCQPGDVLLVAPTSECHDGFFGDLLATSLLARGVVALVGDIG
EEEEEECCCCEEEEEEEECCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
IRDSQTLREMNFPVWSRAVWAQGTVKASLGSVNVPVICAGQLVNPGDIVVADDDGVVIVP
CCCCHHHHHCCCCHHHHHHHCCCEEEECCCCCCCCEEEECCCCCCCCEEEECCCCEEEEE
REQATAIADAAQTRVDLETSKRQRLANGELGLDIYQMRAPLAKKGLRYVNSLNALKS
CCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11826967 [H]