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The map label for this gene is argE

Identifier: 170026297

GI number: 170026297

Start: 4518372

End: 4519535

Strand: Direct

Name: argE

Synonym: YPK_4090

Alternate gene names: 170026297

Gene position: 4518372-4519535 (Clockwise)

Preceding gene: 170026288

Following gene: 170026298

Centisome position: 96.35

GC content: 50.34

Gene sequence:

>1164_bases
ATGAAATTACCTCCATTTATTGAGCTGTACCGGGCGTTAATTGCAACGCCTTCGATCAGCGCCGCTGATAGTGCCCTCGA
CCAAAGTAATGAGGCATTAATCAATTTGTTAGCCGGATGGTTTGCAGACCTGGGTTTTCGCGTCGAGATCCAGCCGGTGC
CTGATACTCGCCACAAATTTAACCTGTTAGCCAGCATTGGCGAAAATGAAAACGGGGAAGGTCATGGCGGGTTATTGCTG
GCGGGTCATACCGATACTGTCCCTTACGATGAAGGGCGCTGGACCCGCGATCCCTTCACCTTGACCGAGCATGACCATAA
ACTCTATGGCTTGGGTACCGCAGATATGAAAGGCTTTTTTGCTTTTATTCTGGATGCGGTGCGCGATATTGATGCCAGCA
AGTTGACCAAACCGCTCTATATTTTGGCAACTGCCGATGAAGAGACCACCATGGCAGGTGCGCGTTATTTTGCTGCGAAT
ACCCAGCTACGCCCTGACTTCGCGATTATCGGCGAGCCAACCTCACTGCAACCTGTCCGTGCGCACAAAGGCCATATCTC
CAACGCCATTCGTATTACCGGCCAGTCTGGGCACTCCAGTGATCCGGCCCGGGGGGTTAATGCTATTGATTTGATGCATG
AATCTATTACGCAATTGATGGCGCTGCGTACCACACTGCAAGAGCGTTATCACAATCCAGCGTTTACTATTCCTTATCCC
ACCATGAATTTTGGTCATATTAATGGCGGTGATGCGGCAAACCGTATCTGTGCGTGTTGTGAATTACATATGGATATCCG
TCCGTTACCGGGCCTGACATTAAGTGATTTAAATGAGTTAATGACCGAAGCGCTGGAACCGGTGAGTCAACGCTGGCCGG
GGCGTCTCAGTATTGATGAGTTGCACCCTCCGATCCCTGGCTATGAGTGCCCAACAGACCATCATATGGTCGGCGTGATC
GAGAAACTGCTCGGTGAGCGCACTGCGGTGGTGAACTATTGCACCGAAGCCCCTTTTATTCAGCAAGTCTGCCCGACATT
AGTGCTGGGGCCAGGTTCGATTAATCAGGCACATCAGCCAGATGAATTTATTGATATGGCCTTTATCGAACCAACACGTG
AGCTGATTGGTCAGCTAGTTGACCACTTTTGCCAGCAGAAATAA

Upstream 100 bases:

>100_bases
GTCAGTTTAGGTTCCCTTTCGCTCAAGCTTACTGTATTTTTATTCACAATTACTGCATGAATATTGATACTATCCTAACC
AAAGGCTGTCAACAGTGAAG

Downstream 100 bases:

>100_bases
CTATAATGGGGTAGACGATCAATATTGCCGATAAGCCAGACTGATAATCTCACCTCAGTAATTAAATTTCAGAAATATCC
CTAAAATTGATGTTTTTTTA

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKLPPFIELYRALIATPSISAADSALDQSNEALINLLAGWFADLGFRVEIQPVPDTRHKFNLLASIGENENGEGHGGLLL
AGHTDTVPYDEGRWTRDPFTLTEHDHKLYGLGTADMKGFFAFILDAVRDIDASKLTKPLYILATADEETTMAGARYFAAN
TQLRPDFAIIGEPTSLQPVRAHKGHISNAIRITGQSGHSSDPARGVNAIDLMHESITQLMALRTTLQERYHNPAFTIPYP
TMNFGHINGGDAANRICACCELHMDIRPLPGLTLSDLNELMTEALEPVSQRWPGRLSIDELHPPIPGYECPTDHHMVGVI
EKLLGERTAVVNYCTEAPFIQQVCPTLVLGPGSINQAHQPDEFIDMAFIEPTRELIGQLVDHFCQQK

Sequences:

>Translated_387_residues
MKLPPFIELYRALIATPSISAADSALDQSNEALINLLAGWFADLGFRVEIQPVPDTRHKFNLLASIGENENGEGHGGLLL
AGHTDTVPYDEGRWTRDPFTLTEHDHKLYGLGTADMKGFFAFILDAVRDIDASKLTKPLYILATADEETTMAGARYFAAN
TQLRPDFAIIGEPTSLQPVRAHKGHISNAIRITGQSGHSSDPARGVNAIDLMHESITQLMALRTTLQERYHNPAFTIPYP
TMNFGHINGGDAANRICACCELHMDIRPLPGLTLSDLNELMTEALEPVSQRWPGRLSIDELHPPIPGYECPTDHHMVGVI
EKLLGERTAVVNYCTEAPFIQQVCPTLVLGPGSINQAHQPDEFIDMAFIEPTRELIGQLVDHFCQQK
>Mature_387_residues
MKLPPFIELYRALIATPSISAADSALDQSNEALINLLAGWFADLGFRVEIQPVPDTRHKFNLLASIGENENGEGHGGLLL
AGHTDTVPYDEGRWTRDPFTLTEHDHKLYGLGTADMKGFFAFILDAVRDIDASKLTKPLYILATADEETTMAGARYFAAN
TQLRPDFAIIGEPTSLQPVRAHKGHISNAIRITGQSGHSSDPARGVNAIDLMHESITQLMALRTTLQERYHNPAFTIPYP
TMNFGHINGGDAANRICACCELHMDIRPLPGLTLSDLNELMTEALEPVSQRWPGRLSIDELHPPIPGYECPTDHHMVGVI
EKLLGERTAVVNYCTEAPFIQQVCPTLVLGPGSINQAHQPDEFIDMAFIEPTRELIGQLVDHFCQQK

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily

Homologues:

Organism=Escherichia coli, GI1790395, Length=383, Percent_Identity=77.8067885117493, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI1788816, Length=264, Percent_Identity=28.7878787878788, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789236, Length=378, Percent_Identity=24.6031746031746, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17551016, Length=361, Percent_Identity=24.9307479224377, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGE_YERP3 (A7FCZ8)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001399126.1
- ProteinModelPortal:   A7FCZ8
- SMR:   A7FCZ8
- STRING:   A7FCZ8
- GeneID:   5387501
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_0126
- eggNOG:   COG0624
- HOGENOM:   HBG728841
- OMA:   RICGQCA
- ProtClustDB:   PRK05111
- BioCyc:   YPSE349747:YPSIP31758_0126-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_01108
- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650
- TIGRFAMs:   TIGR01892

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20; SSF55031 Peptidase_M20_dimer

EC number: =3.5.1.16

Molecular weight: Translated: 42691; Mature: 42691

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00758 ARGE_DAPE_CPG2_1; PS00759 ARGE_DAPE_CPG2_2

Important sites: ACT_SITE 87-87 ACT_SITE 149-149

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPPFIELYRALIATPSISAADSALDQSNEALINLLAGWFADLGFRVEIQPVPDTRHKF
CCCCHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHH
NLLASIGENENGEGHGGLLLAGHTDTVPYDEGRWTRDPFTLTEHDHKLYGLGTADMKGFF
HHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEECCCCCEEEECCCHHHHHHH
AFILDAVRDIDASKLTKPLYILATADEETTMAGARYFAANTQLRPDFAIIGEPTSLQPVR
HHHHHHHHCCCHHHCCCCEEEEEECCCCHHHHHHHEEECCCCCCCCEEEECCCCCCCCHH
AHKGHISNAIRITGQSGHSSDPARGVNAIDLMHESITQLMALRTTLQERYHNPAFTIPYP
HHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
TMNFGHINGGDAANRICACCELHMDIRPLPGLTLSDLNELMTEALEPVSQRWPGRLSIDE
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
LHPPIPGYECPTDHHMVGVIEKLLGERTAVVNYCTEAPFIQQVCPTLVLGPGSINQAHQP
CCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHCHHEEECCCCCCCCCCC
DEFIDMAFIEPTRELIGQLVDHFCQQK
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLPPFIELYRALIATPSISAADSALDQSNEALINLLAGWFADLGFRVEIQPVPDTRHKF
CCCCHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHH
NLLASIGENENGEGHGGLLLAGHTDTVPYDEGRWTRDPFTLTEHDHKLYGLGTADMKGFF
HHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEECCCCCEEEECCCHHHHHHH
AFILDAVRDIDASKLTKPLYILATADEETTMAGARYFAANTQLRPDFAIIGEPTSLQPVR
HHHHHHHHCCCHHHCCCCEEEEEECCCCHHHHHHHEEECCCCCCCCEEEECCCCCCCCHH
AHKGHISNAIRITGQSGHSSDPARGVNAIDLMHESITQLMALRTTLQERYHNPAFTIPYP
HHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
TMNFGHINGGDAANRICACCELHMDIRPLPGLTLSDLNELMTEALEPVSQRWPGRLSIDE
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
LHPPIPGYECPTDHHMVGVIEKLLGERTAVVNYCTEAPFIQQVCPTLVLGPGSINQAHQP
CCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHCHHEEECCCCCCCCCCC
DEFIDMAFIEPTRELIGQLVDHFCQQK
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA