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The map label for this gene is rmlA2 [H]

Identifier: 170026238

GI number: 170026238

Start: 4442150

End: 4443082

Strand: Reverse

Name: rmlA2 [H]

Synonym: YPK_4028

Alternate gene names: 170026238

Gene position: 4443082-4442150 (Counterclockwise)

Preceding gene: 170026239

Following gene: 170026237

Centisome position: 94.75

GC content: 48.77

Gene sequence:

>933_bases
ATGTATCAGGAAATTGTATGTATCAGGAGATTGTATGTATCAGGAGAACGTATGAAAGGCATAATTCTGGCTGGTGGTTC
AGGTTCCCGATTACACCCCATCACCCGTGGCGTCTCTAAGCAGTTGCTTCCCATCTACGATAAACCCATGATCTATTACC
CGCTGTCAGTATTGATGCTGGCAGGGATCCGTGACGTGTTGATTATCTCAACCCCGGAAGACTTACCATCGTTTCAGCGT
TTGTTGGGCAACGGTGATGAGTTTGGTATTAATCTGAGTTATGCCGCGCAGCCTAGCCCAGACGGGCTGGCACAGGCATT
TATCATTGGTGAAGCGTTTATTGATAATGAGCCATGCTGTTTGGTGCTCGGTGATAATATCTACTTCGGCCAAGGCTTTA
GTCCAAAACTGAAAGCTGTCGCCGCGCGTCAGCAGGGCGCGACTGTTTTCGGCTATCAGGTGATGGATCCAGAGCGCTTT
GGCGTAGTGGAGTTTGATGACAACTTCCGCGCGTTGTCTATTGAAGAAAAACCGAGCCAGCCAAAATCAAATTGGGCGGT
GACCGGGCTCTATTTCTACGATAACCAAGTGGTTGATTTTGCCAAGCAGGTTAAACCTTCTGCTCGCGGTGAACTGGAAA
TTACCAGCATTAATCAAATGTATCTGGATCGCGGTGAGTTAACGGTTGAGCTGCTAGGGCGCGGTTTTGCCTGGCTGGAT
ACCGGCACCCATGACAGCCTGATCGAAGCCAGTACTTTTGTTCAAACGGTTGAAAAACGCCAAGGTTTTAAAATTGCTTG
TTTGGAAGAGATTGCCTGGCGTAACGGTTGGTTGGATGATGATGGCGTAAAACGTGCGGCAACCGCGCTGGCGAAAACCG
GTTATGGCAAATATCTGTTGGATCTGTTACATGCCCGTCCACGCCAGTATTGA

Upstream 100 bases:

>100_bases
GAGACACCAAAGTCGATTAATCATCGGGATGGCGTCATCCAGTCGTTTACATGATGTTTTGCCTGTGTATAGCCTCTGCC
TGATGGTCTCAGGAGATGGT

Downstream 100 bases:

>100_bases
GCCACTGGGCTGGGAAAGTGAATTTTTCCAGCGCCAAAGTGCAAAATTGATTTTTTCCGACTCAGCCCCGCCACTTAACC
CGGCTGAGTTGGCTGCTTTT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 2; dTDP-glucose pyrophosphorylase 2; dTDP-glucose synthase 2 [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MYQEIVCIRRLYVSGERMKGIILAGGSGSRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIRDVLIISTPEDLPSFQR
LLGNGDEFGINLSYAAQPSPDGLAQAFIIGEAFIDNEPCCLVLGDNIYFGQGFSPKLKAVAARQQGATVFGYQVMDPERF
GVVEFDDNFRALSIEEKPSQPKSNWAVTGLYFYDNQVVDFAKQVKPSARGELEITSINQMYLDRGELTVELLGRGFAWLD
TGTHDSLIEASTFVQTVEKRQGFKIACLEEIAWRNGWLDDDGVKRAATALAKTGYGKYLLDLLHARPRQY

Sequences:

>Translated_310_residues
MYQEIVCIRRLYVSGERMKGIILAGGSGSRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIRDVLIISTPEDLPSFQR
LLGNGDEFGINLSYAAQPSPDGLAQAFIIGEAFIDNEPCCLVLGDNIYFGQGFSPKLKAVAARQQGATVFGYQVMDPERF
GVVEFDDNFRALSIEEKPSQPKSNWAVTGLYFYDNQVVDFAKQVKPSARGELEITSINQMYLDRGELTVELLGRGFAWLD
TGTHDSLIEASTFVQTVEKRQGFKIACLEEIAWRNGWLDDDGVKRAATALAKTGYGKYLLDLLHARPRQY
>Mature_310_residues
MYQEIVCIRRLYVSGERMKGIILAGGSGSRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIRDVLIISTPEDLPSFQR
LLGNGDEFGINLSYAAQPSPDGLAQAFIIGEAFIDNEPCCLVLGDNIYFGQGFSPKLKAVAARQQGATVFGYQVMDPERF
GVVEFDDNFRALSIEEKPSQPKSNWAVTGLYFYDNQVVDFAKQVKPSARGELEITSINQMYLDRGELTVELLGRGFAWLD
TGTHDSLIEASTFVQTVEKRQGFKIACLEEIAWRNGWLDDDGVKRAATALAKTGYGKYLLDLLHARPRQY

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790224, Length=293, Percent_Identity=86.6894197952219, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1788351, Length=284, Percent_Identity=65.4929577464789, Blast_Score=400, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI133931050, Length=229, Percent_Identity=24.8908296943231, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=277, Percent_Identity=26.3537906137184, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355443, Length=254, Percent_Identity=24.4094488188976, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24644084, Length=254, Percent_Identity=24.4094488188976, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 34565; Mature: 34565

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQEIVCIRRLYVSGERMKGIILAGGSGSRLHPITRGVSKQLLPIYDKPMIYYPLSVLML
CCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHCCHHCCCCCCCCCEEEHHHHHHHH
AGIRDVLIISTPEDLPSFQRLLGNGDEFGINLSYAAQPSPDGLAQAFIIGEAFIDNEPCC
HCCCEEEEEECCCCCHHHHHHHCCCCCEEEEEEEECCCCCCHHHHEEEEEHHHCCCCCEE
LVLGDNIYFGQGFSPKLKAVAARQQGATVFGYQVMDPERFGVVEFDDNFRALSIEEKPSQ
EEECCEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCEEEEEECCCCCC
PKSNWAVTGLYFYDNQVVDFAKQVKPSARGELEITSINQMYLDRGELTVELLGRGFAWLD
CCCCEEEEEEEEECCHHHHHHHHCCCCCCCCEEEEEHHHHHHCCCCEEEEECCCCEEEEE
TGTHDSLIEASTFVQTVEKRQGFKIACLEEIAWRNGWLDDDGVKRAATALAKTGYGKYLL
CCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHH
DLLHARPRQY
HHHHCCCCCC
>Mature Secondary Structure
MYQEIVCIRRLYVSGERMKGIILAGGSGSRLHPITRGVSKQLLPIYDKPMIYYPLSVLML
CCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHCCHHCCCCCCCCCEEEHHHHHHHH
AGIRDVLIISTPEDLPSFQRLLGNGDEFGINLSYAAQPSPDGLAQAFIIGEAFIDNEPCC
HCCCEEEEEECCCCCHHHHHHHCCCCCEEEEEEEECCCCCCHHHHEEEEEHHHCCCCCEE
LVLGDNIYFGQGFSPKLKAVAARQQGATVFGYQVMDPERFGVVEFDDNFRALSIEEKPSQ
EEECCEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCEEEEEECCCCCC
PKSNWAVTGLYFYDNQVVDFAKQVKPSARGELEITSINQMYLDRGELTVELLGRGFAWLD
CCCCEEEEEEEEECCHHHHHHHHCCCCCCCCEEEEEHHHHHHCCCCEEEEECCCCEEEEE
TGTHDSLIEASTFVQTVEKRQGFKIACLEEIAWRNGWLDDDGVKRAATALAKTGYGKYLL
CCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHH
DLLHARPRQY
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]