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The map label for this gene is cyaA

Identifier: 170026226

GI number: 170026226

Start: 4425317

End: 4427869

Strand: Reverse

Name: cyaA

Synonym: YPK_4015

Alternate gene names: 170026226

Gene position: 4427869-4425317 (Counterclockwise)

Preceding gene: 170026231

Following gene: 170026223

Centisome position: 94.42

GC content: 49.31

Gene sequence:

>2553_bases
TTGTACCTCTACATCGAGACACTGAAACAGCGACTGGATGCGATCAACCAATTACGAGTCGATCGCGCTTTGGCGGCCAT
GGGTCCAGCCTTCCAAAAGGTCTACAGTCTGCTACCGATCCTACTACATTGTCATCATCCGCAGATGCCGGGCTACCTTG
ATGGTAACGTTCCCCATGGCGTCTGTCTTTTCACACCTAATGAAATACAACAAGATTATCTTGCTGACGTTGAAGCTCGG
TGGGGCGAACCTCTGGCACCAAGTGCGGGGGGCGAACTGCCGATTACCGGCGTCTATTCCATGGGGAGCACCTCCTCTAT
TGGGCAGTGCCACACATCGGATTTAGACATCTGGGTGTGCCACCAGGCTTGGTTGGATACTGAAGAGCGTAATCAACTCC
AGCAAAAATGTAGCCTGTTGGAAAAGTGGGCGGCATCAATGGGGGTCGAGGTCAGCTTCTTCCTGGTTGATGAAAACCGC
TTCCGCCATAATGCCAGTGGCAGCTTGGGGGGGGAGGATTGCGGCTCGACTCAACATATCCTGTTATTGGATGAATTTTA
CCGTAGCGCGGTTCGCCTGGCAGGGAAACGTATTCTGTGGAATATGGTCCCGGTTAAAGAAGAAGAGCATTACGATGATT
ACGTGCTGTCACTTTATGCGCAAGGTGTACTGACGCCGAACGAATGGCTCGATCTGGGCGGTTTAAGCACGCTATCAGCA
GAAGAGTATTTCGGTGCCAGTTTGTGGCAACTGTATAAAAGTATCGATTCGCCATATAAAGCGGTGCTTAAAACATTGTT
GTTGGAAGCCTATTCTTGGGAATACCCCAACTCCCAACTGCTGGCGATGGAAATCAAACAACACTTGCACGCCGGCGAAA
TTGTCTCGTTTGGTCTTGATGCTTACTGCATGATGCTTGATCGTGTTACCCGTTATTTGATCCAAATTAATGACACCACG
CGTTTAAACCTGGTGCGTCGCTGCTTCTACCTGAAAGTGTGTGAGAAACTGTCGCGGACACCAGCCAGTACGGGTTGGCG
GCGTGAGGTTCTCAGCCAATTGGTGAGTGAGTGGGGTTGGAGCAATGAAAAACTGGCGGTGCTGGATAATCGCGCTAACT
GGAAGATCGAACGGGTGCGTGAAGCGCATAACGAATTATTAGATGCGATGATGCAGAGCTACCGTAATTTGATCCGCTTT
GCTCGCCGTAATAATCTGAGTGTCAGTGCCAGCCCACAGGATATCGGCGTCTTGACCCGTAAGTTATATGCGGCGTTTGA
AGCGTTGCCGGGTAAAGTCACATTGGTTAACCCGCAAATTTCACCTGATTTATCGGAAGAGCATCTGACATTTATCCATG
TCCCTGCTGGCCGCGCTAACCGCCCTGGCTGGTATCTGTATAATCAAGCTCCGTCAATGGATGCTATTGTCAGCCATCAA
CCGCTTGAATATAACCGCTATCTGAACAAACTGGTCTCTTGGGCTTATTTCAATGGCTTATTGACCAGTAAAACGCACCT
GCATATTAAAAGCGCCAATCTGTGTGATACGGTCAAGTTGCAGGAACTGGTGACCGACATTTCACATCACTTCCCGCTGC
GCTTAGCTGCACCAACGCCGAAAGCGCTGTACAGTCCGTGTGAAATTCGCCATTTGGCGATTATCGTCAATTTGGAACAT
GATCCGACGACCACCTTCCGTAATCAGGTGGTGCATTTTGATTTCCGTAAACTGGATGTGTTCAGTTTTGGTGAGCAGCA
GCAGTGTCTGGTGGGCAGTATCGATTTGTTGTATCGCAACTCATGGAATGAAGTGCGCACCTTGCATTTCAGCGGTGAGC
AGGCGGTACTGGAAGCGCTGAAAACCATTTTAGGCAAAATGCATCAGGACGCTGCGCCACCGGAATCAGTGGATGTGTTC
TGCTACAGCCAGCATTTACGCGGTTTGATCCGCACCCGTATTCAGCAATTGGTGTCTGAATGTATTGACCTGCGCTTGTC
CAGTACTCGTCAGGAACCGGGCCGTTTTAAAGCGGTACGGGTTTCCGGCCAGACGTGGGGCTTGTTCTTCGAGCGTTTGA
GTGTCTCGGTACAAAAGTTGGAAAATGCTGTTGAATTTTACGGTGCGATTTCCAATAACAAATTGCACGGGTTATCGGTT
CAGGTCGAAACCAACCAAATTCATTTGCCGCCAGTGGTTGATGGTTTTGCCAGCGAAGGGATTATTCAGTTCTTTTTCGA
AGGCACTGCCGATGAAAAAGGCTTCAATATTTATATCTTGGATGAAGCAAACCGGGTTGAGGTTTATCACCATTGCGAGG
GCAGTAAAGAAGAGTTGGTGCGGGATGTCAGCCGGTTCTATTCGTCTTCTCACGATCGCTTTACTTATGGCTCCAGCTTT
ATCAACTTTAACCTGCCGCAGTTCTACCAAATTGTGCAGTTAGATGGCCGCACTCAGGTGATCCCGTTCCGCAGCAATAC
GTTATCGCAGTTGTGCGCCAATATTGCCGAAAAAGAAGCCAGCTTACCGACCAAACAATGCCAGTTGCATTGA

Upstream 100 bases:

>100_bases
ATAAAATGTTTTTTGTGTTTTTCAACAAAAGACGCAAAGCAATAAGCGAATTTGGAGCACGGGCTTTTTTCCAGACACCG
GAATAATCAGGCGAGACGTC

Downstream 100 bases:

>100_bases
TATGCTGATTTGCAGAAAAAAGGACACGTAAAAATCGTGTGAGGTTATTGACAAAGTGCCCGCGACGGAGAGAACAGGCA
GATCGTAAAGACGCCGTAAA

Product: adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase; Adenylyl cyclase

Number of amino acids: Translated: 850; Mature: 850

Protein sequence:

>850_residues
MYLYIETLKQRLDAINQLRVDRALAAMGPAFQKVYSLLPILLHCHHPQMPGYLDGNVPHGVCLFTPNEIQQDYLADVEAR
WGEPLAPSAGGELPITGVYSMGSTSSIGQCHTSDLDIWVCHQAWLDTEERNQLQQKCSLLEKWAASMGVEVSFFLVDENR
FRHNASGSLGGEDCGSTQHILLLDEFYRSAVRLAGKRILWNMVPVKEEEHYDDYVLSLYAQGVLTPNEWLDLGGLSTLSA
EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNSQLLAMEIKQHLHAGEIVSFGLDAYCMMLDRVTRYLIQINDTT
RLNLVRRCFYLKVCEKLSRTPASTGWRREVLSQLVSEWGWSNEKLAVLDNRANWKIERVREAHNELLDAMMQSYRNLIRF
ARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEEHLTFIHVPAGRANRPGWYLYNQAPSMDAIVSHQ
PLEYNRYLNKLVSWAYFNGLLTSKTHLHIKSANLCDTVKLQELVTDISHHFPLRLAAPTPKALYSPCEIRHLAIIVNLEH
DPTTTFRNQVVHFDFRKLDVFSFGEQQQCLVGSIDLLYRNSWNEVRTLHFSGEQAVLEALKTILGKMHQDAAPPESVDVF
CYSQHLRGLIRTRIQQLVSECIDLRLSSTRQEPGRFKAVRVSGQTWGLFFERLSVSVQKLENAVEFYGAISNNKLHGLSV
QVETNQIHLPPVVDGFASEGIIQFFFEGTADEKGFNIYILDEANRVEVYHHCEGSKEELVRDVSRFYSSSHDRFTYGSSF
INFNLPQFYQIVQLDGRTQVIPFRSNTLSQLCANIAEKEASLPTKQCQLH

Sequences:

>Translated_850_residues
MYLYIETLKQRLDAINQLRVDRALAAMGPAFQKVYSLLPILLHCHHPQMPGYLDGNVPHGVCLFTPNEIQQDYLADVEAR
WGEPLAPSAGGELPITGVYSMGSTSSIGQCHTSDLDIWVCHQAWLDTEERNQLQQKCSLLEKWAASMGVEVSFFLVDENR
FRHNASGSLGGEDCGSTQHILLLDEFYRSAVRLAGKRILWNMVPVKEEEHYDDYVLSLYAQGVLTPNEWLDLGGLSTLSA
EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNSQLLAMEIKQHLHAGEIVSFGLDAYCMMLDRVTRYLIQINDTT
RLNLVRRCFYLKVCEKLSRTPASTGWRREVLSQLVSEWGWSNEKLAVLDNRANWKIERVREAHNELLDAMMQSYRNLIRF
ARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEEHLTFIHVPAGRANRPGWYLYNQAPSMDAIVSHQ
PLEYNRYLNKLVSWAYFNGLLTSKTHLHIKSANLCDTVKLQELVTDISHHFPLRLAAPTPKALYSPCEIRHLAIIVNLEH
DPTTTFRNQVVHFDFRKLDVFSFGEQQQCLVGSIDLLYRNSWNEVRTLHFSGEQAVLEALKTILGKMHQDAAPPESVDVF
CYSQHLRGLIRTRIQQLVSECIDLRLSSTRQEPGRFKAVRVSGQTWGLFFERLSVSVQKLENAVEFYGAISNNKLHGLSV
QVETNQIHLPPVVDGFASEGIIQFFFEGTADEKGFNIYILDEANRVEVYHHCEGSKEELVRDVSRFYSSSHDRFTYGSSF
INFNLPQFYQIVQLDGRTQVIPFRSNTLSQLCANIAEKEASLPTKQCQLH
>Mature_850_residues
MYLYIETLKQRLDAINQLRVDRALAAMGPAFQKVYSLLPILLHCHHPQMPGYLDGNVPHGVCLFTPNEIQQDYLADVEAR
WGEPLAPSAGGELPITGVYSMGSTSSIGQCHTSDLDIWVCHQAWLDTEERNQLQQKCSLLEKWAASMGVEVSFFLVDENR
FRHNASGSLGGEDCGSTQHILLLDEFYRSAVRLAGKRILWNMVPVKEEEHYDDYVLSLYAQGVLTPNEWLDLGGLSTLSA
EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNSQLLAMEIKQHLHAGEIVSFGLDAYCMMLDRVTRYLIQINDTT
RLNLVRRCFYLKVCEKLSRTPASTGWRREVLSQLVSEWGWSNEKLAVLDNRANWKIERVREAHNELLDAMMQSYRNLIRF
ARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEEHLTFIHVPAGRANRPGWYLYNQAPSMDAIVSHQ
PLEYNRYLNKLVSWAYFNGLLTSKTHLHIKSANLCDTVKLQELVTDISHHFPLRLAAPTPKALYSPCEIRHLAIIVNLEH
DPTTTFRNQVVHFDFRKLDVFSFGEQQQCLVGSIDLLYRNSWNEVRTLHFSGEQAVLEALKTILGKMHQDAAPPESVDVF
CYSQHLRGLIRTRIQQLVSECIDLRLSSTRQEPGRFKAVRVSGQTWGLFFERLSVSVQKLENAVEFYGAISNNKLHGLSV
QVETNQIHLPPVVDGFASEGIIQFFFEGTADEKGFNIYILDEANRVEVYHHCEGSKEELVRDVSRFYSSSHDRFTYGSSF
INFNLPQFYQIVQLDGRTQVIPFRSNTLSQLCANIAEKEASLPTKQCQLH

Specific function: Unknown

COG id: COG3072

COG function: function code F; Adenylate cyclase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylyl cyclase class-1 family

Homologues:

Organism=Escherichia coli, GI1790238, Length=831, Percent_Identity=83.7545126353791, Blast_Score=1469, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYAA_YERPE (P40127)

Other databases:

- EMBL:   U22968
- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AH0468
- RefSeq:   NP_667720.1
- RefSeq:   NP_994490.1
- RefSeq:   YP_002348726.1
- ProteinModelPortal:   P40127
- IntAct:   P40127
- GeneID:   1145329
- GeneID:   1176683
- GeneID:   2766773
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO3848
- KEGG:   ypk:y0382
- KEGG:   ypm:YP_3199
- HOGENOM:   HBG678054
- OMA:   LWQLYKG
- ProtClustDB:   PRK09450
- BioCyc:   YPES187410:Y0382-MONOMER
- BioCyc:   YPES214092:YPO3848-MONOMER
- BRENDA:   4.6.1.1
- GO:   GO:0005737
- InterPro:   IPR000274
- PIRSF:   PIRSF001444

Pfam domain/function: PF01295 Adenylate_cycl

EC number: =4.6.1.1

Molecular weight: Translated: 96908; Mature: 96908

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01092 ADENYLATE_CYCLASE_1_1; PS01093 ADENYLATE_CYCLASE_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLYIETLKQRLDAINQLRVDRALAAMGPAFQKVYSLLPILLHCHHPQMPGYLDGNVPHG
CEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
VCLFTPNEIQQDYLADVEARWGEPLAPSAGGELPITGVYSMGSTSSIGQCHTSDLDIWVC
EEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEE
HQAWLDTEERNQLQQKCSLLEKWAASMGVEVSFFLVDENRFRHNASGSLGGEDCGSTQHI
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEE
LLLDEFYRSAVRLAGKRILWNMVPVKEEEHYDDYVLSLYAQGVLTPNEWLDLGGLSTLSA
EEHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCH
EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNSQLLAMEIKQHLHAGEIVSFGLD
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHH
AYCMMLDRVTRYLIQINDTTRLNLVRRCFYLKVCEKLSRTPASTGWRREVLSQLVSEWGW
HHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
SNEKLAVLDNRANWKIERVREAHNELLDAMMQSYRNLIRFARRNNLSVSASPQDIGVLTR
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHH
KLYAAFEALPGKVTLVNPQISPDLSEEHLTFIHVPAGRANRPGWYLYNQAPSMDAIVSHQ
HHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHCCC
PLEYNRYLNKLVSWAYFNGLLTSKTHLHIKSANLCDTVKLQELVTDISHHFPLRLAAPTP
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCC
KALYSPCEIRHLAIIVNLEHDPTTTFRNQVVHFDFRKLDVFSFGEQQQCLVGSIDLLYRN
HHHCCCCCEEEEEEEEEECCCCCHHHHCCEEEEEEEEEEEECCCCCCCHHHHCCHHEEEC
SWNEVRTLHFSGEQAVLEALKTILGKMHQDAAPPESVDVFCYSQHLRGLIRTRIQQLVSE
CCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
CIDLRLSSTRQEPGRFKAVRVSGQTWGLFFERLSVSVQKLENAVEFYGAISNNKLHGLSV
HHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
QVETNQIHLPPVVDGFASEGIIQFFFEGTADEKGFNIYILDEANRVEVYHHCEGSKEELV
EEECCEEECCCHHCCHHCCCCEEEEECCCCCCCCCEEEEECCCCCEEEEEECCCCHHHHH
RDVSRFYSSSHDRFTYGSSFINFNLPQFYQIVQLDGRTQVIPFRSNTLSQLCANIAEKEA
HHHHHHHCCCCCCEEECCCEEECCCHHHHHHEEECCCEEEEEECCCHHHHHHHHHHHHHH
SLPTKQCQLH
CCCCHHCCCC
>Mature Secondary Structure
MYLYIETLKQRLDAINQLRVDRALAAMGPAFQKVYSLLPILLHCHHPQMPGYLDGNVPHG
CEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
VCLFTPNEIQQDYLADVEARWGEPLAPSAGGELPITGVYSMGSTSSIGQCHTSDLDIWVC
EEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEE
HQAWLDTEERNQLQQKCSLLEKWAASMGVEVSFFLVDENRFRHNASGSLGGEDCGSTQHI
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEE
LLLDEFYRSAVRLAGKRILWNMVPVKEEEHYDDYVLSLYAQGVLTPNEWLDLGGLSTLSA
EEHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCH
EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNSQLLAMEIKQHLHAGEIVSFGLD
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHH
AYCMMLDRVTRYLIQINDTTRLNLVRRCFYLKVCEKLSRTPASTGWRREVLSQLVSEWGW
HHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
SNEKLAVLDNRANWKIERVREAHNELLDAMMQSYRNLIRFARRNNLSVSASPQDIGVLTR
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHH
KLYAAFEALPGKVTLVNPQISPDLSEEHLTFIHVPAGRANRPGWYLYNQAPSMDAIVSHQ
HHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHCCC
PLEYNRYLNKLVSWAYFNGLLTSKTHLHIKSANLCDTVKLQELVTDISHHFPLRLAAPTP
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCC
KALYSPCEIRHLAIIVNLEHDPTTTFRNQVVHFDFRKLDVFSFGEQQQCLVGSIDLLYRN
HHHCCCCCEEEEEEEEEECCCCCHHHHCCEEEEEEEEEEEECCCCCCCHHHHCCHHEEEC
SWNEVRTLHFSGEQAVLEALKTILGKMHQDAAPPESVDVFCYSQHLRGLIRTRIQQLVSE
CCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
CIDLRLSSTRQEPGRFKAVRVSGQTWGLFFERLSVSVQKLENAVEFYGAISNNKLHGLSV
HHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
QVETNQIHLPPVVDGFASEGIIQFFFEGTADEKGFNIYILDEANRVEVYHHCEGSKEELV
EEECCEEECCCHHCCHHCCCCEEEEECCCCCCCCCEEEEECCCCCEEEEEECCCCHHHHH
RDVSRFYSSSHDRFTYGSSFINFNLPQFYQIVQLDGRTQVIPFRSNTLSQLCANIAEKEA
HHHHHHHCCCCCCEEECCCEEECCCHHHHHHEEECCCEEEEEECCCHHHHHHHHHHHHHH
SLPTKQCQLH
CCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8874804; 11586360; 12142430; 8418825