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The map label for this gene is dmsA [H]

Identifier: 170025609

GI number: 170025609

Start: 3723240

End: 3725690

Strand: Reverse

Name: dmsA [H]

Synonym: YPK_3394

Alternate gene names: 170025609

Gene position: 3725690-3723240 (Counterclockwise)

Preceding gene: 170025610

Following gene: 170025608

Centisome position: 79.45

GC content: 52.75

Gene sequence:

>2451_bases
ATGAAAGAGACCAACGAATCCCGGCTGTTAACGACAGGTGTCACCCGCCGAAAACTGGTCCAAACCACGCTTGTCGGCGG
ACTGGCTATGGCAACCGGGGCGTTTTCGTTACCGTTCTCCCGTACCGCACGAGCCGTTCAATCCGCACTCAACCCCACCT
CAGCCAACGACGGTAAAGTGATCTGGAGCGCCTGCACCGTTAACTGCGGCAGCCGCTGCCCGCTGCGTATGCATGTGGCT
GAGGGCGAAATCAAATATGTCGAAACGGATAACACCGGTGATGATAATTTTGAGGGGCTACACCAGGTACGCGCCTGTCT
GCGAGGGCGGTCTATGCGCCGCCGGGTCTATAACCCAGACCGCTTAAAATACCCGATGAAACGAATCGGTGCCCGTGGTG
AAGGGAAATTCAAACGTATCTCGTGGGAAGAGGCATTCGAGACTATCGTTGGCAGCATGCAGAATATTATCAAGGAATAT
GGCAATGAAGCCATTTACCTGAATTACGGTACCGGCACGATAGGCGGCACCATGACCCGCTCTTGGCCGCCGGGCGCGAC
GCTCTTGGCTCGCTTGATGAATTGCTGCGGTGGCTACCTCAACCAGTATGGTGATTACAGTACCGCACAGATTGCCGCGG
GACTCAATTATACCTACGGTGGCTGGGCTGACGGTAACAGCCCGTCCGATATCGAAAACAGTAAGCTGGTGGTGTTGTTC
GGTAATAACCCGGCTGAAACCCGGATGAGTGGCGGTGGGGTCACCTATTATCTGGAGCAGGCACGAGAGAAATCCAATGC
CAAAATGATCGTGATTGACCCCCGTTATACCGACACTGCCGCAGGCCGTGAAGATGAATGGATCCCACTACGACCAGGCA
CTGATGCCGCATTGGCCTCTGCGTTAGCTTATGTGATGATCACTGAAAATCTGGTGGATCAACCCTTCCTTGACCAATAT
TGCGTTGGTTATGACGAGAAGACGCTACCAGAAGGCGCACCCGAAAATAGTCACTACAAAGCCTATATTTTAGGGCAGGG
CGCAGATAAAACCGCCAAAACCCCACAATGGGCAGCGGCTATCACCGGTATTCCCGCCGCAAAAATCATTACGCTAGGCC
GTGAAATAGGGTCAGTGAAGCCGGCTTATATTTCCCAAGGTTGGGGGCCACAACGCCATTCCAACGGCGAAAACACCAGC
CGAGCCATTGCCATGTTGGCAATCTTGACCGGTAATGTCGGTATTAATGGCGGTAACTCCGGTGCTCGTGAAGGCTCCTA
CAGCCTGCCGTTTGTCCGTATGCCTACCTTTGAAAACCCAGTCAAAACCAGTATCTCTATGTTCTTGTGGACCGATGCCA
TTGAGCGTGGACCTGAAATGACCGCCACCCGTGATGGGGTTCAGGGGAAAGATAAGCTGGATGTCCCGATCAAATTTATT
TGGAACTACGCCAGTAACTGTTTGGTGAATCAACATTCTGAAATCAATCGCACCCATGACATTCTGCAAGACGATGAGAA
ATGCGAAATGATTGTGGTCATTGATAACCACATGACCTCGTCGGCTGAATACGCTGATATTATCCTGCCAGACTGTACCG
CCTCCGAGCAGATGGACTTCTGTCTGGATGCCTCTAGCGGCAATATGGCCTATGTCATTTTTGCTGATCAGGTGATTAAA
CCGCGTTTTGAGTGCAAAAATATTTATGACATCACCAGTGGATTGGCAAGACACATGGGGGTCGAGCAGAAGTTTACCGA
AGGGCGAACGCAAGAAGAGTGGATGCGCCACCTCTACCAGCAATCGCAAGCCGCAATCCCTGAACTGCCTTCTTTCGAGG
ATTTCCGCGCTCAGGGCATGTTTAAAAAACGTGACCCGGCAGGCCATCACGTTGCCTATCACGATTTCCGCACCGATCCG
GTTGCTAACCCACTGAGTACCCCATCAGGCAAAATTGAGATCTATTCTGCGGCGCTGGCCGAGATTGCCGCGACTTGGGA
ACTGCAAAAAGATGATGTTATCGATCCGTTGCCCGTGTATGCCGCCGGTTTTGAAAGCCATGTTGATCCACTGATCGAAC
AGTATCCGTTGCAATTAACCGGCTTCCACTACAAGGCCAGAACTCACTCCACCTACGGTAACGTAGATGTGTTGAAAGCC
TCCTGTCTTCAGGAGATGTGGATTAACCCGATGGATGCCGAACGGCGAGGGATCAGCAATGGCGATATGGTGCGGATCTT
CAATGGCCGTGGTGAAGTACAGATTAATGCCAAAGTCACTCCGCGCATGATGCCGGGGGTTGTCGCTTTGGGTGAGGGGG
CGTGGTACAGCCCCGATGCGAAGCGTATTGATCGGGCGGGCAGTATCAACGTATTGACCACCCAGCGCCCCTCCCCGTTG
GCGAAAGGGAACCCATCCCACACCAACCTCGTTCAAGTCGCCAAGGCATAA

Upstream 100 bases:

>100_bases
CCCCAATCTCCTGCTGATCTGCTCATTTTTTTTGAATTATTCGGGCGCCATCCGCACTGGGTGACTCTCATTTTCTGGAA
TGCAACTAAGTGGGAATCTT

Downstream 100 bases:

>100_bases
GGAGCTGACTGATGACAACGCAATATGGTTTTTACATCGACTCCAGCCGTTGTACAGGGTGTAAAACGTGCGAGTTGGCC
TGCAAAGACTTTAAAAATCT

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 816; Mature: 816

Protein sequence:

>816_residues
MKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSALNPTSANDGKVIWSACTVNCGSRCPLRMHVA
EGEIKYVETDNTGDDNFEGLHQVRACLRGRSMRRRVYNPDRLKYPMKRIGARGEGKFKRISWEEAFETIVGSMQNIIKEY
GNEAIYLNYGTGTIGGTMTRSWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSKLVVLF
GNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALASALAYVMITENLVDQPFLDQY
CVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAAITGIPAAKIITLGREIGSVKPAYISQGWGPQRHSNGENTS
RAIAMLAILTGNVGINGGNSGAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKLDVPIKFI
WNYASNCLVNQHSEINRTHDILQDDEKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDFCLDASSGNMAYVIFADQVIK
PRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQQSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAYHDFRTDP
VANPLSTPSGKIEIYSAALAEIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYGNVDVLKA
SCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDAKRIDRAGSINVLTTQRPSPL
AKGNPSHTNLVQVAKA

Sequences:

>Translated_816_residues
MKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSALNPTSANDGKVIWSACTVNCGSRCPLRMHVA
EGEIKYVETDNTGDDNFEGLHQVRACLRGRSMRRRVYNPDRLKYPMKRIGARGEGKFKRISWEEAFETIVGSMQNIIKEY
GNEAIYLNYGTGTIGGTMTRSWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSKLVVLF
GNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALASALAYVMITENLVDQPFLDQY
CVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAAITGIPAAKIITLGREIGSVKPAYISQGWGPQRHSNGENTS
RAIAMLAILTGNVGINGGNSGAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKLDVPIKFI
WNYASNCLVNQHSEINRTHDILQDDEKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDFCLDASSGNMAYVIFADQVIK
PRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQQSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAYHDFRTDP
VANPLSTPSGKIEIYSAALAEIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYGNVDVLKA
SCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDAKRIDRAGSINVLTTQRPSPL
AKGNPSHTNLVQVAKA
>Mature_816_residues
MKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSALNPTSANDGKVIWSACTVNCGSRCPLRMHVA
EGEIKYVETDNTGDDNFEGLHQVRACLRGRSMRRRVYNPDRLKYPMKRIGARGEGKFKRISWEEAFETIVGSMQNIIKEY
GNEAIYLNYGTGTIGGTMTRSWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSKLVVLF
GNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALASALAYVMITENLVDQPFLDQY
CVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAAITGIPAAKIITLGREIGSVKPAYISQGWGPQRHSNGENTS
RAIAMLAILTGNVGINGGNSGAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKLDVPIKFI
WNYASNCLVNQHSEINRTHDILQDDEKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDFCLDASSGNMAYVIFADQVIK
PRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQQSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAYHDFRTDP
VANPLSTPSGKIEIYSAALAEIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYGNVDVLKA
SCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDAKRIDRAGSINVLTTQRPSPL
AKGNPSHTNLVQVAKA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=815, Percent_Identity=81.3496932515337, Blast_Score=1399, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=810, Percent_Identity=66.0493827160494, Blast_Score=1130, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=819, Percent_Identity=63.1257631257631, Blast_Score=1092, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=761, Percent_Identity=31.6688567674113, Blast_Score=298, Evalue=1e-81,
Organism=Escherichia coli, GI145693196, Length=755, Percent_Identity=30.4635761589404, Blast_Score=279, Evalue=6e-76,
Organism=Escherichia coli, GI87081994, Length=745, Percent_Identity=31.2751677852349, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI3868721, Length=761, Percent_Identity=25.3613666228647, Blast_Score=146, Evalue=5e-36,
Organism=Escherichia coli, GI3868720, Length=472, Percent_Identity=27.5423728813559, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1787477, Length=302, Percent_Identity=27.4834437086093, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1787741, Length=308, Percent_Identity=26.6233766233766, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI3868719, Length=478, Percent_Identity=25.5230125523013, Blast_Score=87, Evalue=6e-18,
Organism=Escherichia coli, GI1788534, Length=811, Percent_Identity=22.8113440197287, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 89947; Mature: 89947

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSALNPTSANDGKV
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEE
IWSACTVNCGSRCPLRMHVAEGEIKYVETDNTGDDNFEGLHQVRACLRGRSMRRRVYNPD
EEEEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCH
RLKYPMKRIGARGEGKFKRISWEEAFETIVGSMQNIIKEYGNEAIYLNYGTGTIGGTMTR
HHHCCHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
SWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSKLVVLF
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
GNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALAS
CCCCHHCEECCCCEEEHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCHHHHHH
ALAYVMITENLVDQPFLDQYCVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAA
HHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHH
ITGIPAAKIITLGREIGSVKPAYISQGWGPQRHSNGENTSRAIAMLAILTGNVGINGGNS
HCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
GAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKLDVPIKFI
CCCCCCCCCCEEECCCCCCCHHHHHHHHEEHHHHHCCCCCCCCCCCCCCCCCCCCCHHHH
WNYASNCLVNQHSEINRTHDILQDDEKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDF
HHHHHHHEECCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCE
CLDASSGNMAYVIFADQVIKPRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQ
EEECCCCCEEEEEEECCHHCCCHHCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHH
QSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAYHDFRTDPVANPLSTPSGKIEIYSAALA
HHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHHHH
EIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYGNVDVLKA
HHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHH
SCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDA
HHHHHHCCCCCCHHHCCCCCCCEEEEECCCCEEEEEEEECCCCCCCEEEECCCCCCCCCH
KRIDRAGSINVLTTQRPSPLAKGNPSHTNLVQVAKA
HHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MKETNESRLLTTGVTRRKLVQTTLVGGLAMATGAFSLPFSRTARAVQSALNPTSANDGKV
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEE
IWSACTVNCGSRCPLRMHVAEGEIKYVETDNTGDDNFEGLHQVRACLRGRSMRRRVYNPD
EEEEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCH
RLKYPMKRIGARGEGKFKRISWEEAFETIVGSMQNIIKEYGNEAIYLNYGTGTIGGTMTR
HHHCCHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
SWPPGATLLARLMNCCGGYLNQYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSKLVVLF
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
GNNPAETRMSGGGVTYYLEQAREKSNAKMIVIDPRYTDTAAGREDEWIPLRPGTDAALAS
CCCCHHCEECCCCEEEHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCHHHHHH
ALAYVMITENLVDQPFLDQYCVGYDEKTLPEGAPENSHYKAYILGQGADKTAKTPQWAAA
HHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHH
ITGIPAAKIITLGREIGSVKPAYISQGWGPQRHSNGENTSRAIAMLAILTGNVGINGGNS
HCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
GAREGSYSLPFVRMPTFENPVKTSISMFLWTDAIERGPEMTATRDGVQGKDKLDVPIKFI
CCCCCCCCCCEEECCCCCCCHHHHHHHHEEHHHHHCCCCCCCCCCCCCCCCCCCCCHHHH
WNYASNCLVNQHSEINRTHDILQDDEKCEMIVVIDNHMTSSAEYADIILPDCTASEQMDF
HHHHHHHEECCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCE
CLDASSGNMAYVIFADQVIKPRFECKNIYDITSGLARHMGVEQKFTEGRTQEEWMRHLYQ
EEECCCCCEEEEEEECCHHCCCHHCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHH
QSQAAIPELPSFEDFRAQGMFKKRDPAGHHVAYHDFRTDPVANPLSTPSGKIEIYSAALA
HHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHHHH
EIAATWELQKDDVIDPLPVYAAGFESHVDPLIEQYPLQLTGFHYKARTHSTYGNVDVLKA
HHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHH
SCLQEMWINPMDAERRGISNGDMVRIFNGRGEVQINAKVTPRMMPGVVALGEGAWYSPDA
HHHHHHCCCCCCHHHCCCCCCCEEEEECCCCEEEEEEEECCCCCCCEEEECCCCCCCCCH
KRIDRAGSINVLTTQRPSPLAKGNPSHTNLVQVAKA
HHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]