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The map label for this gene is tktB [C]

Identifier: 170025598

GI number: 170025598

Start: 3711375

End: 3712205

Strand: Reverse

Name: tktB [C]

Synonym: YPK_3383

Alternate gene names: 170025598

Gene position: 3712205-3711375 (Counterclockwise)

Preceding gene: 170025599

Following gene: 170025597

Centisome position: 79.16

GC content: 52.35

Gene sequence:

>831_bases
ATGAATCCGTATTCACTGTCAATCGATGAGCTGGTGAGAAAGGCGCGGGCGATCCGCCGCCGTATCGTCCTGCTTAATGC
GAACAGCCCCGCAGGTGGGCATACCGGTGCTGATCTTTCGCAGGTAGAGATTCTGACGGCACTCTATTTTCGTATCCTCA
ATTGTGCGCCGGAGAGGCTTACGGATCCGGAGCGCGATATCTATGTGCAATCTAAAGGCCATGCGGTTGGCGGCTATTAT
TGCTGTTTGGCCGAAGCCCGTTATTTCCCAGAAGAGTGGTTGGCGACTTATCAACGTGCCGACTCTCATCTGCCAGGCCA
CCCTGTAAAACACAAAACGCCAGGCATTGAACTCAATACCGGGGCTTTAGGGCACGGTTTACCGGTGGCGGTTGGTATCG
CACTGGCGGCAAAACGAGCCAACAGCAAACGTCGGGTCTTTGTCCTGACAGGTGATGGCGAACTGGCCGAAGGCAGCAAC
TGGGAAGCAGCGTTAGTGGCTGCTCACTATCAATTAGACAATCTGGTGATCATCAACGACAAAAATAAACTGCAACTGGC
AGGGACCACTAAATCAATTATGAATACCGATCCGCTGGCAGATAAATGGCGGGCGTTTGGTCTACAAGTCACTGAATGCC
GTGGGAATGACATGCAATCGGTGGTGGAAACACTGGAGACCCTACCACAAAACGGTAAACCCAATGTGGTGATCGCCAAC
ACCGAAAAAGGTGCGGGGATCTCGTTTATTCAAGGGCGTGTGGAGTGGCACCACCGGGTGCCAAAAGGTGCTGAAATTGA
TCTGGCGCTGGAGGAATTAAACGATGAGTAA

Upstream 100 bases:

>100_bases
CGGAGGGGGGATCTCCGGACAGGCTTGATGAAAGCTATTTTTTTAGTCTCATCGAGAATAAATATTCGGTAATGAGTAAA
AATTCAAGAGAGGTAATGTC

Downstream 100 bases:

>100_bases
TGCAGAACATTTGGCCTCAGTGATGGTCGAGCAGTTTATCAAGGCGGTCGATAACGGCGTTGATTTGGTCCCCGTGGTTG
CTGACTCGACTTCAACGGCA

Product: transketolase domain-containing protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MNPYSLSIDELVRKARAIRRRIVLLNANSPAGGHTGADLSQVEILTALYFRILNCAPERLTDPERDIYVQSKGHAVGGYY
CCLAEARYFPEEWLATYQRADSHLPGHPVKHKTPGIELNTGALGHGLPVAVGIALAAKRANSKRRVFVLTGDGELAEGSN
WEAALVAAHYQLDNLVIINDKNKLQLAGTTKSIMNTDPLADKWRAFGLQVTECRGNDMQSVVETLETLPQNGKPNVVIAN
TEKGAGISFIQGRVEWHHRVPKGAEIDLALEELNDE

Sequences:

>Translated_276_residues
MNPYSLSIDELVRKARAIRRRIVLLNANSPAGGHTGADLSQVEILTALYFRILNCAPERLTDPERDIYVQSKGHAVGGYY
CCLAEARYFPEEWLATYQRADSHLPGHPVKHKTPGIELNTGALGHGLPVAVGIALAAKRANSKRRVFVLTGDGELAEGSN
WEAALVAAHYQLDNLVIINDKNKLQLAGTTKSIMNTDPLADKWRAFGLQVTECRGNDMQSVVETLETLPQNGKPNVVIAN
TEKGAGISFIQGRVEWHHRVPKGAEIDLALEELNDE
>Mature_276_residues
MNPYSLSIDELVRKARAIRRRIVLLNANSPAGGHTGADLSQVEILTALYFRILNCAPERLTDPERDIYVQSKGHAVGGYY
CCLAEARYFPEEWLATYQRADSHLPGHPVKHKTPGIELNTGALGHGLPVAVGIALAAKRANSKRRVFVLTGDGELAEGSN
WEAALVAAHYQLDNLVIINDKNKLQLAGTTKSIMNTDPLADKWRAFGLQVTECRGNDMQSVVETLETLPQNGKPNVVIAN
TEKGAGISFIQGRVEWHHRVPKGAEIDLALEELNDE

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=252, Percent_Identity=34.9206349206349, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4507521, Length=252, Percent_Identity=34.9206349206349, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI133778974, Length=255, Percent_Identity=32.9411764705882, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI225637459, Length=246, Percent_Identity=28.8617886178862, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI225637461, Length=172, Percent_Identity=32.5581395348837, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI225637463, Length=172, Percent_Identity=32.5581395348837, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1788808, Length=281, Percent_Identity=32.0284697508897, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI48994911, Length=275, Percent_Identity=29.0909090909091, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539652, Length=234, Percent_Identity=36.3247863247863, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319593, Length=275, Percent_Identity=31.2727272727273, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325331, Length=257, Percent_Identity=31.9066147859922, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551847, Length=276, Percent_Identity=34.0579710144928, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45550715, Length=276, Percent_Identity=34.0579710144928, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24666278, Length=246, Percent_Identity=34.1463414634146, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24645119, Length=233, Percent_Identity=34.7639484978541, Blast_Score=124, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 30280; Mature: 30280

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPYSLSIDELVRKARAIRRRIVLLNANSPAGGHTGADLSQVEILTALYFRILNCAPERL
CCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHC
TDPERDIYVQSKGHAVGGYYCCLAEARYFPEEWLATYQRADSHLPGHPVKHKTPGIELNT
CCCCCEEEEEECCCCCCCEEEEEHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
GALGHGLPVAVGIALAAKRANSKRRVFVLTGDGELAEGSNWEAALVAAHYQLDNLVIIND
CCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEEECCEEEEEC
KNKLQLAGTTKSIMNTDPLADKWRAFGLQVTECRGNDMQSVVETLETLPQNGKPNVVIAN
CCEEEEECCHHHHCCCCCCHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCCCCCEEEEE
TEKGAGISFIQGRVEWHHRVPKGAEIDLALEELNDE
CCCCCCCCEEEHHHHHHHCCCCCCEEEEEHHCCCCC
>Mature Secondary Structure
MNPYSLSIDELVRKARAIRRRIVLLNANSPAGGHTGADLSQVEILTALYFRILNCAPERL
CCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHC
TDPERDIYVQSKGHAVGGYYCCLAEARYFPEEWLATYQRADSHLPGHPVKHKTPGIELNT
CCCCCEEEEEECCCCCCCEEEEEHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
GALGHGLPVAVGIALAAKRANSKRRVFVLTGDGELAEGSNWEAALVAAHYQLDNLVIIND
CCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEEECCEEEEEC
KNKLQLAGTTKSIMNTDPLADKWRAFGLQVTECRGNDMQSVVETLETLPQNGKPNVVIAN
CCEEEEECCHHHHCCCCCCHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCCCCCEEEEE
TEKGAGISFIQGRVEWHHRVPKGAEIDLALEELNDE
CCCCCCCCEEEHHHHHHHCCCCCCEEEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]