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The map label for this gene is dxs [C]

Identifier: 170025597

GI number: 170025597

Start: 3710438

End: 3711382

Strand: Reverse

Name: dxs [C]

Synonym: YPK_3382

Alternate gene names: 170025597

Gene position: 3711382-3710438 (Counterclockwise)

Preceding gene: 170025598

Following gene: 170025596

Centisome position: 79.14

GC content: 52.59

Gene sequence:

>945_bases
ATGAGTAATGCAGAACATTTGGCCTCAGTGATGGTCGAGCAGTTTATCAAGGCGGTCGATAACGGCGTTGATTTGGTCCC
CGTGGTTGCTGACTCGACTTCAACGGCAAAAATTGGGCCGTTTATCACACGCTTCCCTGATCGGGTGGTCAACGTTGGGA
TTGCCGAACAGGCGATGGTGGGCATGGCGGTCGGCCTATCCATGGGGGGGAAAATTGCGGTGACCTGTAATGCCGCACCG
TTTCTGATTTCGCGTGCTAACGAGCAGTTGAAAATTGATATTTGTTACAACAACAGCAATGTAAAACTGTTCGGTTTGAA
CTCCGGTGCCAGCTACGGGCCACTGGCCAGTACACATCACTGTATCGATGACATCGCCATCCTACGTGGCTTCGGTAATA
TCGAAATCTACGCCCCTGCTGATCCCCAAGAGTGCCGTCAGATCATTGATTATGCGTTGGCCCATCAGGGTCCGGTATAT
ATTCGGTTGGATGGTAAAGCGTTGCCGCCACTGCATGATGAGCATTATCGATTTGCTCCCGGTCAAATTGATGTCTTGCA
AGAGGGACGGGATATTGCTCTGGTCGCGATGGGATCTACAGTACATGAAGCGGTCAGCGCGGCAGCCATACTGGCAGACA
ACAATATTTCTGCTGCGGTGGTCAACGTTTCCTCTATCCGCCCGTGTGATACTCAGCAACTGTTCGCCATCCTCCAACAG
AGTCAGCGGGTGATTACCATAGAAGAGCACAATATTAATGGCGGCGTGGGGAGTCTGGTCGCGGAAGTGCTGGCTGAGGC
GGGGAGTGGTACTCCATTAGTGAGACTGGGTATTCCTGACGGTGGTTATGCGATTGCCGCTGATCGGGCTGAGATGCGTG
CCTATCATGGTTTTGATGCGGCAGGCATTGTGGCTCGTGCTCTGCGGTTTTGCCGAGGGGAATAA

Upstream 100 bases:

>100_bases
GAAAAAGGTGCGGGGATCTCGTTTATTCAAGGGCGTGTGGAGTGGCACCACCGGGTGCCAAAAGGTGCTGAAATTGATCT
GGCGCTGGAGGAATTAAACG

Downstream 100 bases:

>100_bases
CGATGTCAACGCCAATCATTCTGGCTATTGATGAAGGGACAACCAACGCCAAAGCCATTGCGGTAGATCGTGCCGGGCGA
GTTCTGGCGAAAGCCTCGGT

Product: transketolase domain-containing protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSNAEHLASVMVEQFIKAVDNGVDLVPVVADSTSTAKIGPFITRFPDRVVNVGIAEQAMVGMAVGLSMGGKIAVTCNAAP
FLISRANEQLKIDICYNNSNVKLFGLNSGASYGPLASTHHCIDDIAILRGFGNIEIYAPADPQECRQIIDYALAHQGPVY
IRLDGKALPPLHDEHYRFAPGQIDVLQEGRDIALVAMGSTVHEAVSAAAILADNNISAAVVNVSSIRPCDTQQLFAILQQ
SQRVITIEEHNINGGVGSLVAEVLAEAGSGTPLVRLGIPDGGYAIAADRAEMRAYHGFDAAGIVARALRFCRGE

Sequences:

>Translated_314_residues
MSNAEHLASVMVEQFIKAVDNGVDLVPVVADSTSTAKIGPFITRFPDRVVNVGIAEQAMVGMAVGLSMGGKIAVTCNAAP
FLISRANEQLKIDICYNNSNVKLFGLNSGASYGPLASTHHCIDDIAILRGFGNIEIYAPADPQECRQIIDYALAHQGPVY
IRLDGKALPPLHDEHYRFAPGQIDVLQEGRDIALVAMGSTVHEAVSAAAILADNNISAAVVNVSSIRPCDTQQLFAILQQ
SQRVITIEEHNINGGVGSLVAEVLAEAGSGTPLVRLGIPDGGYAIAADRAEMRAYHGFDAAGIVARALRFCRGE
>Mature_313_residues
SNAEHLASVMVEQFIKAVDNGVDLVPVVADSTSTAKIGPFITRFPDRVVNVGIAEQAMVGMAVGLSMGGKIAVTCNAAPF
LISRANEQLKIDICYNNSNVKLFGLNSGASYGPLASTHHCIDDIAILRGFGNIEIYAPADPQECRQIIDYALAHQGPVYI
RLDGKALPPLHDEHYRFAPGQIDVLQEGRDIALVAMGSTVHEAVSAAAILADNNISAAVVNVSSIRPCDTQQLFAILQQS
QRVITIEEHNINGGVGSLVAEVLAEAGSGTPLVRLGIPDGGYAIAADRAEMRAYHGFDAAGIVARALRFCRGE

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=274, Percent_Identity=27.007299270073, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4507521, Length=274, Percent_Identity=27.007299270073, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI225637461, Length=252, Percent_Identity=28.1746031746032, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI225637459, Length=252, Percent_Identity=28.1746031746032, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI225637463, Length=252, Percent_Identity=28.1746031746032, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI133778974, Length=223, Percent_Identity=28.2511210762332, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1786622, Length=273, Percent_Identity=31.1355311355311, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17539652, Length=250, Percent_Identity=30.4, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24645119, Length=223, Percent_Identity=26.0089686098655, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI45551847, Length=223, Percent_Identity=26.0089686098655, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550715, Length=223, Percent_Identity=26.0089686098655, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666278, Length=225, Percent_Identity=24, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358145, Length=234, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650940, Length=234, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 33258; Mature: 33127

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAEHLASVMVEQFIKAVDNGVDLVPVVADSTSTAKIGPFITRFPDRVVNVGIAEQAMV
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCHHHHCCCCHHHHHH
GMAVGLSMGGKIAVTCNAAPFLISRANEQLKIDICYNNSNVKLFGLNSGASYGPLASTHH
HHHHHHCCCCEEEEEECCCCEEEECCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCHHH
CIDDIAILRGFGNIEIYAPADPQECRQIIDYALAHQGPVYIRLDGKALPPLHDEHYRFAP
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEECC
GQIDVLQEGRDIALVAMGSTVHEAVSAAAILADNNISAAVVNVSSIRPCDTQQLFAILQQ
CEEEEECCCCCEEEEEECCHHHHHHHHEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHC
SQRVITIEEHNINGGVGSLVAEVLAEAGSGTPLVRLGIPDGGYAIAADRAEMRAYHGFDA
CCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECHHHHHHHCCCCH
AGIVARALRFCRGE
HHHHHHHHHHHCCC
>Mature Secondary Structure 
SNAEHLASVMVEQFIKAVDNGVDLVPVVADSTSTAKIGPFITRFPDRVVNVGIAEQAMV
CCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCHHHHCCCCHHHHHH
GMAVGLSMGGKIAVTCNAAPFLISRANEQLKIDICYNNSNVKLFGLNSGASYGPLASTHH
HHHHHHCCCCEEEEEECCCCEEEECCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCHHH
CIDDIAILRGFGNIEIYAPADPQECRQIIDYALAHQGPVYIRLDGKALPPLHDEHYRFAP
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEECC
GQIDVLQEGRDIALVAMGSTVHEAVSAAAILADNNISAAVVNVSSIRPCDTQQLFAILQQ
CEEEEECCCCCEEEEEECCHHHHHHHHEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHC
SQRVITIEEHNINGGVGSLVAEVLAEAGSGTPLVRLGIPDGGYAIAADRAEMRAYHGFDA
CCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECHHHHHHHCCCCH
AGIVARALRFCRGE
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]