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The map label for this gene is hemH

Identifier: 170025410

GI number: 170025410

Start: 3492388

End: 3493350

Strand: Reverse

Name: hemH

Synonym: YPK_3193

Alternate gene names: 170025410

Gene position: 3493350-3492388 (Counterclockwise)

Preceding gene: 170025411

Following gene: 170025409

Centisome position: 74.49

GC content: 45.9

Gene sequence:

>963_bases
ATGATGCAAAGCAAACCCGGCGTATTAATGGTTAATTTGGGGACACCAGATGCTCCAACGTCGAAAGCTATCAAGCGTTA
TTTAGCTGAGTTTCTGAGTGACCGCCGGGTAGTTGATACTTCCCCATTGCTATGGTGGCCATTGCTGCATGGTGTTATTT
TACCGCTTCGGTCACCACGTGTAGCAAAACTTTATCAATCCGTTTGGATGGAAGAGGGCTCTCCTTTATTGGTTTATAGC
CGCCGCCAGCAGAAAGCACTGGCAGCAAGAATGCCTGATATTCCTGTAGAATTAGGCATGAGCTATGGTTCACCAAATTT
GCCAGAGGCTATTGAAAAGTTATTAGCGCAGGGCGTCACCAACCTGGTTATATTACCGCTTTACCCGCAATATTCCTGTT
CAACCAGCGCCGCTGTCTGGGATGCTGTTGCTCGGGTTCTGAAAGGTTACCGCCGTTTACCCTCAATTTCTTTTATTCGT
GATTATGCTGAGCATCCAGCGTATATTTCAGCATTAAAACAGAGTGTTGAGCGCTCTTTCGCGGAACATGGTCAGCCAGA
CCGATTAGTCATGTCTTTTCATGGCATTCCTAAGCGCTATGCGCAATTGGGTGATGATTATCCTATCCGCTGTGAAGATA
CCAGCCGGGCACTGAGGGCTGCATTACCTCTGCCTGCCGAGAAAATCATAATGACTTATCAATCCCGCTTTGGCCGTGAA
CCCTGGTTGACACCTTATACCGATGAAACCCTAAAAAGTTTACCTTCTCAAGGCGTTAAGCATATTCAGCTTATTTGCCC
AGGTTTCTCTGCCGATTGTCTGGAAACTCTGGAAGAAATAAAAGAGCAAAATCGAGAGTTTTTCTTGCATGCGGGCGGAG
AGAAGTTTGAATACATCCCAGCATTGAATGACGACGAGGGGCATATTGCCCTGTTAGAACAGTTAATTCGACATAATATA
TAA

Upstream 100 bases:

>100_bases
TTCTCGGTTAATTCTGGATGGCCTTATAGCTAAGGCGGTTTAAGGCCGCCTTAGCTATTTCAAGTAAGAAGGGCGTAGTA
CCTACAAAAGGAGATTTGGC

Downstream 100 bases:

>100_bases
TCGCTGCTAAACATTACATCTTTTGGTAGTTTATCACACTCAAAAATTTCACATTTTCAATCCAATGAAGAGTCAGTAAA
AAATATAAATAGTGGGTAAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MMQSKPGVLMVNLGTPDAPTSKAIKRYLAEFLSDRRVVDTSPLLWWPLLHGVILPLRSPRVAKLYQSVWMEEGSPLLVYS
RRQQKALAARMPDIPVELGMSYGSPNLPEAIEKLLAQGVTNLVILPLYPQYSCSTSAAVWDAVARVLKGYRRLPSISFIR
DYAEHPAYISALKQSVERSFAEHGQPDRLVMSFHGIPKRYAQLGDDYPIRCEDTSRALRAALPLPAEKIIMTYQSRFGRE
PWLTPYTDETLKSLPSQGVKHIQLICPGFSADCLETLEEIKEQNREFFLHAGGEKFEYIPALNDDEGHIALLEQLIRHNI

Sequences:

>Translated_320_residues
MMQSKPGVLMVNLGTPDAPTSKAIKRYLAEFLSDRRVVDTSPLLWWPLLHGVILPLRSPRVAKLYQSVWMEEGSPLLVYS
RRQQKALAARMPDIPVELGMSYGSPNLPEAIEKLLAQGVTNLVILPLYPQYSCSTSAAVWDAVARVLKGYRRLPSISFIR
DYAEHPAYISALKQSVERSFAEHGQPDRLVMSFHGIPKRYAQLGDDYPIRCEDTSRALRAALPLPAEKIIMTYQSRFGRE
PWLTPYTDETLKSLPSQGVKHIQLICPGFSADCLETLEEIKEQNREFFLHAGGEKFEYIPALNDDEGHIALLEQLIRHNI
>Mature_320_residues
MMQSKPGVLMVNLGTPDAPTSKAIKRYLAEFLSDRRVVDTSPLLWWPLLHGVILPLRSPRVAKLYQSVWMEEGSPLLVYS
RRQQKALAARMPDIPVELGMSYGSPNLPEAIEKLLAQGVTNLVILPLYPQYSCSTSAAVWDAVARVLKGYRRLPSISFIR
DYAEHPAYISALKQSVERSFAEHGQPDRLVMSFHGIPKRYAQLGDDYPIRCEDTSRALRAALPLPAEKIIMTYQSRFGRE
PWLTPYTDETLKSLPSQGVKHIQLICPGFSADCLETLEEIKEQNREFFLHAGGEKFEYIPALNDDEGHIALLEQLIRHNI

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=346, Percent_Identity=23.9884393063584, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI60499025, Length=346, Percent_Identity=23.9884393063584, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1786681, Length=316, Percent_Identity=67.4050632911392, Blast_Score=438, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6324750, Length=339, Percent_Identity=25.0737463126844, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17864156, Length=332, Percent_Identity=25.6024096385542, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24651774, Length=267, Percent_Identity=25.4681647940075, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_YERP3 (A7FL85)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001402013.1
- ProteinModelPortal:   A7FL85
- SMR:   A7FL85
- STRING:   A7FL85
- GeneID:   5386743
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_3053
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- ProtClustDB:   PRK00035
- BioCyc:   YPSE349747:YPSIP31758_3053-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36185; Mature: 36185

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQSKPGVLMVNLGTPDAPTSKAIKRYLAEFLSDRRVVDTSPLLWWPLLHGVILPLRSPR
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCH
VAKLYQSVWMEEGSPLLVYSRRQQKALAARMPDIPVELGMSYGSPNLPEAIEKLLAQGVT
HHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCC
NLVILPLYPQYSCSTSAAVWDAVARVLKGYRRLPSISFIRDYAEHPAYISALKQSVERSF
CEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHH
AEHGQPDRLVMSFHGIPKRYAQLGDDYPIRCEDTSRALRAALPLPAEKIIMTYQSRFGRE
HHCCCCCEEEEECCCCHHHHHHCCCCCCEEECHHHHHHHHHCCCCHHHHHHHHHHHCCCC
PWLTPYTDETLKSLPSQGVKHIQLICPGFSADCLETLEEIKEQNREFFLHAGGEKFEYIP
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEECC
ALNDDEGHIALLEQLIRHNI
CCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MMQSKPGVLMVNLGTPDAPTSKAIKRYLAEFLSDRRVVDTSPLLWWPLLHGVILPLRSPR
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCH
VAKLYQSVWMEEGSPLLVYSRRQQKALAARMPDIPVELGMSYGSPNLPEAIEKLLAQGVT
HHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCC
NLVILPLYPQYSCSTSAAVWDAVARVLKGYRRLPSISFIRDYAEHPAYISALKQSVERSF
CEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHH
AEHGQPDRLVMSFHGIPKRYAQLGDDYPIRCEDTSRALRAALPLPAEKIIMTYQSRFGRE
HHCCCCCEEEEECCCCHHHHHHCCCCCCEEECHHHHHHHHHCCCCHHHHHHHHHHHCCCC
PWLTPYTDETLKSLPSQGVKHIQLICPGFSADCLETLEEIKEQNREFFLHAGGEKFEYIP
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEECC
ALNDDEGHIALLEQLIRHNI
CCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA