Click here to switch to the map view.

The map label for this gene is galM [H]

Identifier: 170025168

GI number: 170025168

Start: 3244289

End: 3245359

Strand: Direct

Name: galM [H]

Synonym: YPK_2946

Alternate gene names: 170025168

Gene position: 3244289-3245359 (Clockwise)

Preceding gene: 170025167

Following gene: 170025169

Centisome position: 69.18

GC content: 51.54

Gene sequence:

>1071_bases
ATGCTGAAAAACGGCGCGGCATCACCAAACAGTGTTGACCCGTTAGCACCGGATGGTCACCCTTTTGAATTCACCAAATT
GCAGAATAAAAGCGGTATGACCGTCACCTTTATGAATTGGGGGGCAACCTGGTTATCGGCCATATTACCGCTGAAAAATG
GTGAGAAACGTGAATTGCTGCTGGGCTACCCGACACCGGCTGATTACCTGCATCAAGCCGCTTATCTCGGGGCCACGGTT
GGCCGTTATGCCAACCGGATAGCCAATGCGCAAATCACCTTGGATGGCGAAACAATCCAGTTGGTCCCGAACCAAGGCCC
TAACCAATTACACGGTGGCCCGGAAGGTTTCCATGCCCAGCGTTGGCAGAAAGTGACCCAAGATGACCACCAGGTTACCT
ATAAACTTGATTCACCAGATGGCGATCAAGGTTTCCCCGGTAATCTGACTGTTGAAGTACAGTACCTGCTAACCGAAGAT
AACCGGCTGGAAATTCATTATCAGGCACAGGTGGATAAAACCTGCCCGGTTAACCTGACCAATCATGCCTATTTCAACCT
TGACGGCGAAGGGCATGATGCCCGTTCACATCGTTTGCAACTGTTTGCAGACCGTTACCTGCCTGTCGACAGTGCGGGCA
TCCCAACCGGAGGACTCGCTGATGTCGAGAATACCGGTATGGATTTTCGCCAACCTAAAACATTGGCGCAGGATTTTCTA
CAAGATCGCTGCCAGCAACGAGTTAAAGGCTATGACCACGCTTATTTGCTGCACCGCACCTGTGGGGCCTTAGACTCTCC
GGCGGCACACTTGTGGTCATCCGATAACCAGGTGCAAATGAGTATGTTCACCTCAGCGCCTGCGTTGCAGCTTTACAGCG
GAAATTATCTTGCTGGCACACCCGCACGCAACGGCGGCACCTATGCCAGCTATGCGGGTGTGGCACTAGAAAGTGAATTT
TTGCCTGATAGCCCTAACCACCCTGAATGGCCACAGCCCGATTGTTGGCTAAAACCGGGGAAGACCTATCGCTCAACGAC
GGTTTATCACTTTATTGCGTTGCCTTTATAA

Upstream 100 bases:

>100_bases
TCGAGCAGGTTCGCACCACCGTTGCGCAAGAATACCCGGCACACAGCGGCGGCAAGAAAGAGACTTTTTATGTCTGTCAG
GCTTCACAAGGAGCGGGTTT

Downstream 100 bases:

>100_bases
ATGATGACGTTATGAATGATGACGTTATAAATGATGTATTACGAATACTCCTGGCGTAATACATCATGCCGCAACGGCCA
CCCGGTTCTCACTTCGGTAG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MLKNGAASPNSVDPLAPDGHPFEFTKLQNKSGMTVTFMNWGATWLSAILPLKNGEKRELLLGYPTPADYLHQAAYLGATV
GRYANRIANAQITLDGETIQLVPNQGPNQLHGGPEGFHAQRWQKVTQDDHQVTYKLDSPDGDQGFPGNLTVEVQYLLTED
NRLEIHYQAQVDKTCPVNLTNHAYFNLDGEGHDARSHRLQLFADRYLPVDSAGIPTGGLADVENTGMDFRQPKTLAQDFL
QDRCQQRVKGYDHAYLLHRTCGALDSPAAHLWSSDNQVQMSMFTSAPALQLYSGNYLAGTPARNGGTYASYAGVALESEF
LPDSPNHPEWPQPDCWLKPGKTYRSTTVYHFIALPL

Sequences:

>Translated_356_residues
MLKNGAASPNSVDPLAPDGHPFEFTKLQNKSGMTVTFMNWGATWLSAILPLKNGEKRELLLGYPTPADYLHQAAYLGATV
GRYANRIANAQITLDGETIQLVPNQGPNQLHGGPEGFHAQRWQKVTQDDHQVTYKLDSPDGDQGFPGNLTVEVQYLLTED
NRLEIHYQAQVDKTCPVNLTNHAYFNLDGEGHDARSHRLQLFADRYLPVDSAGIPTGGLADVENTGMDFRQPKTLAQDFL
QDRCQQRVKGYDHAYLLHRTCGALDSPAAHLWSSDNQVQMSMFTSAPALQLYSGNYLAGTPARNGGTYASYAGVALESEF
LPDSPNHPEWPQPDCWLKPGKTYRSTTVYHFIALPL
>Mature_356_residues
MLKNGAASPNSVDPLAPDGHPFEFTKLQNKSGMTVTFMNWGATWLSAILPLKNGEKRELLLGYPTPADYLHQAAYLGATV
GRYANRIANAQITLDGETIQLVPNQGPNQLHGGPEGFHAQRWQKVTQDDHQVTYKLDSPDGDQGFPGNLTVEVQYLLTED
NRLEIHYQAQVDKTCPVNLTNHAYFNLDGEGHDARSHRLQLFADRYLPVDSAGIPTGGLADVENTGMDFRQPKTLAQDFL
QDRCQQRVKGYDHAYLLHRTCGALDSPAAHLWSSDNQVQMSMFTSAPALQLYSGNYLAGTPARNGGTYASYAGVALESEF
LPDSPNHPEWPQPDCWLKPGKTYRSTTVYHFIALPL

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=321, Percent_Identity=36.1370716510903, Blast_Score=198, Evalue=5e-51,
Organism=Escherichia coli, GI1786971, Length=344, Percent_Identity=60.1744186046512, Blast_Score=437, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17557428, Length=329, Percent_Identity=33.7386018237082, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI115533334, Length=329, Percent_Identity=33.7386018237082, Blast_Score=199, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6319493, Length=341, Percent_Identity=30.791788856305, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322004, Length=359, Percent_Identity=28.133704735376, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324399, Length=310, Percent_Identity=26.7741935483871, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24668278, Length=348, Percent_Identity=33.6206896551724, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24659048, Length=371, Percent_Identity=32.3450134770889, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24583720, Length=352, Percent_Identity=32.1022727272727, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24641876, Length=359, Percent_Identity=26.7409470752089, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24668282, Length=364, Percent_Identity=28.8461538461538, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39413; Mature: 39413

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNGAASPNSVDPLAPDGHPFEFTKLQNKSGMTVTFMNWGATWLSAILPLKNGEKRELL
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHCCCCCCCCEEE
LGYPTPADYLHQAAYLGATVGRYANRIANAQITLDGETIQLVPNQGPNQLHGGPEGFHAQ
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCCCCCCCCHHH
RWQKVTQDDHQVTYKLDSPDGDQGFPGNLTVEVQYLLTEDNRLEIHYQAQVDKTCPVNLT
HHHHHCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEEECCCEEEEEEEEECCCCCCCEEC
NHAYFNLDGEGHDARSHRLQLFADRYLPVDSAGIPTGGLADVENTGMDFRQPKTLAQDFL
CCEEEEECCCCCCCHHHHEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
QDRCQQRVKGYDHAYLLHRTCGALDSPAAHLWSSDNQVQMSMFTSAPALQLYSGNYLAGT
HHHHHHHHCCCCCEEEEHHHHCCCCCCHHHHCCCCCEEEEEEECCCCEEEEECCCEEECC
PARNGGTYASYAGVALESEFLPDSPNHPEWPQPDCWLKPGKTYRSTTVYHFIALPL
CCCCCCCCHHCCCEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MLKNGAASPNSVDPLAPDGHPFEFTKLQNKSGMTVTFMNWGATWLSAILPLKNGEKRELL
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHCCCCCCCCEEE
LGYPTPADYLHQAAYLGATVGRYANRIANAQITLDGETIQLVPNQGPNQLHGGPEGFHAQ
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCCCCCCCCHHH
RWQKVTQDDHQVTYKLDSPDGDQGFPGNLTVEVQYLLTEDNRLEIHYQAQVDKTCPVNLT
HHHHHCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEEECCCEEEEEEEEECCCCCCCEEC
NHAYFNLDGEGHDARSHRLQLFADRYLPVDSAGIPTGGLADVENTGMDFRQPKTLAQDFL
CCEEEEECCCCCCCHHHHEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
QDRCQQRVKGYDHAYLLHRTCGALDSPAAHLWSSDNQVQMSMFTSAPALQLYSGNYLAGT
HHHHHHHHCCCCCEEEEHHHHCCCCCCHHHHCCCCCEEEEEEECCCCEEEEECCCEEECC
PARNGGTYASYAGVALESEFLPDSPNHPEWPQPDCWLKPGKTYRSTTVYHFIALPL
CCCCCCCCHHCCCEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]