Click here to switch to the map view.

The map label for this gene is adiC [H]

Identifier: 170025085

GI number: 170025085

Start: 3156604

End: 3157938

Strand: Reverse

Name: adiC [H]

Synonym: YPK_2861

Alternate gene names: 170025085

Gene position: 3157938-3156604 (Counterclockwise)

Preceding gene: 170025086

Following gene: 170025084

Centisome position: 67.34

GC content: 47.27

Gene sequence:

>1335_bases
ATGTCTACAGATGATCAGAAGGTAGGGTTAATTCCTGTAACCCTTATGGTTGCAGGAAATATAATGGGGTCTGGTGTTTT
TTTATTACCGGCAAATTTGGCTTCTACAGGTGGAATTGCGATATGGGGATGGCTAGTGACTATTATTGGTGCTCTAGCAC
TATCAATGGTTTACGCCAAAATGTCATCTTTGGATGATAGCCCAGGGGGGTCTTATGCTTATGCGCGGCGTGCCTTTGGG
CCATTTTTAGGTTATCAAACGAATGTCTTGTATTGGTTGGCATGTTGGATCGGTAATATTGCGATGGTCGTTATTGGGGT
CGGCTATCTCAGTTATTTTTTCCCTATTTTAAAAGAACCCATGGTATTAACGATTACTTGCGTAGTATTTCTATGGATAT
TTGTCGGGCTGAATATTATTGGGCCAAAAATGATCACCCGTGTACAAGCAGTAGCTACGTCACTGGCGCTTATTCCGATT
GTGGGTATCGCTTTATTTGGGTGGTTCTGGTTTAAGGGCGAAACCTATATGGCAGCCTGGAATGTCAGTGGGTTAGGTAC
CTTTGGTGCAATTCAAAGTACTCTGAATGTGACGCTGTGGTCATTTATCGGCGTCGAGACGGCATCGGTGGCGGCAGGGG
TAGTTAAAAATCCAAAACGTAATGTCCCGATTGCCACCGTGGGCGGGGTGTTAATTGCGGCTGTTTGTTATGTTCTTTCC
AGTAGCGCCATTATGGGAATGATCCCTAATGCAGAATTGCGTTTATCAGCATCGCCATTTGGTGATGCTGCCCGTTTAGC
TCTGGGAGATACGGCAGGGGCGGTCGTTTCACTCTGTGCGGCGGCGGGGTGTTTAGGGTCTTTAGGCGGTTGGACGCTGG
TGGCCGGGCAGACGGCTAAAGCGGCGGCTGATGATGGGCTGTTCCCCCCCATTTTCGGTAAGGTCAATAAAGCCGGTACG
CCAGTGGCCGGGTTACTTATTCTTGGCGTACTGATGACCATTTTCCAAATTAGCAGTATTTCGCCGAATGCGGCCAAAGA
GTTTGGCCTGGTTTCTTCCGTTTCTGTGATTTTTACTCTGGTACCGTACCTGTATACCTGTTCAGCCTTATTACTGGTTG
GTCATGGCCATTTAGGCAATCAAGTGAAAACGTATGTCGGCATAACCCTTATTGCTTTCGTGTATTGCATTTGGGCCGTA
GTCGGCTCGGGTGCCGAGGAAGTGATGTGGTCATTTGTTACCTTGATGGTTATCACCGCGCTTTATACTTTCAATTACAA
CCGTACCCACAAAAACCCATTCCCACTCGATGCACCTGTTAAGAACGGGCAGTAA

Upstream 100 bases:

>100_bases
TTTTTAACTTTATTTATAAAATATATCGTCTACCTTTATAACTGCGTCTGGCTATTCATCATCATTTTCAGCCTATTATA
GGGATTTGTAAGGATTACCT

Downstream 100 bases:

>100_bases
TACCCACTCCCATCTGTAGCTGGGTGGGCATCATTGATGTGATGAATTATAGATAAAGGGATAAATACGATGATTGATTT
AAGCAGTCACAAGAAACGCA

Product: arginine:agmatin antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSTDDQKVGLIPVTLMVAGNIMGSGVFLLPANLASTGGIAIWGWLVTIIGALALSMVYAKMSSLDDSPGGSYAYARRAFG
PFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKEPMVLTITCVVFLWIFVGLNIIGPKMITRVQAVATSLALIPI
VGIALFGWFWFKGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVETASVAAGVVKNPKRNVPIATVGGVLIAAVCYVLS
SSAIMGMIPNAELRLSASPFGDAARLALGDTAGAVVSLCAAAGCLGSLGGWTLVAGQTAKAAADDGLFPPIFGKVNKAGT
PVAGLLILGVLMTIFQISSISPNAAKEFGLVSSVSVIFTLVPYLYTCSALLLVGHGHLGNQVKTYVGITLIAFVYCIWAV
VGSGAEEVMWSFVTLMVITALYTFNYNRTHKNPFPLDAPVKNGQ

Sequences:

>Translated_444_residues
MSTDDQKVGLIPVTLMVAGNIMGSGVFLLPANLASTGGIAIWGWLVTIIGALALSMVYAKMSSLDDSPGGSYAYARRAFG
PFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKEPMVLTITCVVFLWIFVGLNIIGPKMITRVQAVATSLALIPI
VGIALFGWFWFKGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVETASVAAGVVKNPKRNVPIATVGGVLIAAVCYVLS
SSAIMGMIPNAELRLSASPFGDAARLALGDTAGAVVSLCAAAGCLGSLGGWTLVAGQTAKAAADDGLFPPIFGKVNKAGT
PVAGLLILGVLMTIFQISSISPNAAKEFGLVSSVSVIFTLVPYLYTCSALLLVGHGHLGNQVKTYVGITLIAFVYCIWAV
VGSGAEEVMWSFVTLMVITALYTFNYNRTHKNPFPLDAPVKNGQ
>Mature_443_residues
STDDQKVGLIPVTLMVAGNIMGSGVFLLPANLASTGGIAIWGWLVTIIGALALSMVYAKMSSLDDSPGGSYAYARRAFGP
FLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKEPMVLTITCVVFLWIFVGLNIIGPKMITRVQAVATSLALIPIV
GIALFGWFWFKGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVETASVAAGVVKNPKRNVPIATVGGVLIAAVCYVLSS
SAIMGMIPNAELRLSASPFGDAARLALGDTAGAVVSLCAAAGCLGSLGGWTLVAGQTAKAAADDGLFPPIFGKVNKAGTP
VAGLLILGVLMTIFQISSISPNAAKEFGLVSSVSVIFTLVPYLYTCSALLLVGHGHLGNQVKTYVGITLIAFVYCIWAVV
GSGAEEVMWSFVTLMVITALYTFNYNRTHKNPFPLDAPVKNGQ

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=357, Percent_Identity=24.9299719887955, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI115648022, Length=357, Percent_Identity=24.9299719887955, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI186910308, Length=355, Percent_Identity=24.2253521126761, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI186910306, Length=355, Percent_Identity=24.2253521126761, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI186910304, Length=355, Percent_Identity=24.2253521126761, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI187423910, Length=353, Percent_Identity=24.0793201133144, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI7657591, Length=353, Percent_Identity=24.0793201133144, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI2367353, Length=441, Percent_Identity=87.0748299319728, Blast_Score=780, Evalue=0.0,
Organism=Escherichia coli, GI1790575, Length=437, Percent_Identity=38.4439359267735, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI1786908, Length=417, Percent_Identity=33.5731414868106, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1787890, Length=450, Percent_Identity=28, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI87082250, Length=343, Percent_Identity=27.9883381924198, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI87081708, Length=410, Percent_Identity=24.1463414634146, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790653, Length=396, Percent_Identity=23.989898989899, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787768, Length=282, Percent_Identity=27.3049645390071, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=342, Percent_Identity=25.1461988304094, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71995388, Length=399, Percent_Identity=23.8095238095238, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995382, Length=399, Percent_Identity=23.8095238095238, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71993915, Length=386, Percent_Identity=24.3523316062176, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=358, Percent_Identity=26.8156424581006, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32566699, Length=314, Percent_Identity=23.2484076433121, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221331183, Length=424, Percent_Identity=24.0566037735849, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17647653, Length=424, Percent_Identity=24.0566037735849, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24664379, Length=424, Percent_Identity=24.0566037735849, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45550968, Length=422, Percent_Identity=22.9857819905213, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921172, Length=422, Percent_Identity=22.9857819905213, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641993, Length=341, Percent_Identity=24.633431085044, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641995, Length=341, Percent_Identity=24.633431085044, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46658; Mature: 46526

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDDQKVGLIPVTLMVAGNIMGSGVFLLPANLASTGGIAIWGWLVTIIGALALSMVYAK
CCCCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MSSLDDSPGGSYAYARRAFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKEP
HHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MVLTITCVVFLWIFVGLNIIGPKMITRVQAVATSLALIPIVGIALFGWFWFKGETYMAAW
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
NVSGLGTFGAIQSTLNVTLWSFIGVETASVAAGVVKNPKRNVPIATVGGVLIAAVCYVLS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
SSAIMGMIPNAELRLSASPFGDAARLALGDTAGAVVSLCAAAGCLGSLGGWTLVAGQTAK
CCHHEEECCCCCEEEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCHH
AAADDGLFPPIFGKVNKAGTPVAGLLILGVLMTIFQISSISPNAAKEFGLVSSVSVIFTL
HCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VPYLYTCSALLLVGHGHLGNQVKTYVGITLIAFVYCIWAVVGSGAEEVMWSFVTLMVITA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LYTFNYNRTHKNPFPLDAPVKNGQ
HHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STDDQKVGLIPVTLMVAGNIMGSGVFLLPANLASTGGIAIWGWLVTIIGALALSMVYAK
CCCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MSSLDDSPGGSYAYARRAFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKEP
HHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MVLTITCVVFLWIFVGLNIIGPKMITRVQAVATSLALIPIVGIALFGWFWFKGETYMAAW
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
NVSGLGTFGAIQSTLNVTLWSFIGVETASVAAGVVKNPKRNVPIATVGGVLIAAVCYVLS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
SSAIMGMIPNAELRLSASPFGDAARLALGDTAGAVVSLCAAAGCLGSLGGWTLVAGQTAK
CCHHEEECCCCCEEEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCHH
AAADDGLFPPIFGKVNKAGTPVAGLLILGVLMTIFQISSISPNAAKEFGLVSSVSVIFTL
HCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VPYLYTCSALLLVGHGHLGNQVKTYVGITLIAFVYCIWAVVGSGAEEVMWSFVTLMVITA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LYTFNYNRTHKNPFPLDAPVKNGQ
HHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]