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The map label for this gene is adiA [H]

Identifier: 170025084

GI number: 170025084

Start: 3154228

End: 3156534

Strand: Reverse

Name: adiA [H]

Synonym: YPK_2860

Alternate gene names: 170025084

Gene position: 3156534-3154228 (Counterclockwise)

Preceding gene: 170025085

Following gene: 170025080

Centisome position: 67.31

GC content: 46.77

Gene sequence:

>2307_bases
ATGATTGATTTAAGCAGTCACAAGAAACGCAACGTTTTAGTGGTTGACAGCAATATTCGTGATATCAATACCGCTAATGG
TCGGGCGGTAAACGAACTTATCATTGCGCTTAATGACATTAATTTTAATGTGATTGCGGCGGCGACGTTTGAAGATGGCG
CGGCAACAGTGATCTCCGACTCTTCGTTGTGCTGTATTTTTGTCGATTGGACTTCGGGTGGTAATGATGATGAATCCCAT
AGTCAGGCATTTGCATTGCTACAAGACATTCGTCGCCGTAATAAATCAGTGCCTGTGTTATTGATGGCTGAGCATTCATG
TATCAATAGCTTAAGTTTGGAGACCATGCAGCTTGTTAATGAATTTGTTTGGATGCATGAAGATACCTCCGAGTTTATCG
CTGCTCGTGCCAAAGCACTCATCATCAAGTATTACCAGCAGTTGCTGCCGCCTTTTACGCAAGCGCTGTTTCAATATACG
CAAGATAATCCTGAATATTCATGGGCTGCCCCCGGTCATCAAGGGGGCGTTGCCTTCAGTAAGACGGCGGTTGGACGCGA
GTTTCTTGATTTCTTTGGCGAGAATCTATTTCGTACGGATACTGGTATTGAACGTGAGTCATTGGGATCTTTACTGGATC
ACAGTGGGCCGATAAAAGAGTCAGAAGCGTATGCCGCACAAGTTTTTGGTGCACATGCAAGTTACTCGATGCTTAATGGC
ACATCGAGCTCTAATCGCGCCATTATGGCCGCTGTCGTGGGAGATAAGCAGATCGCATTGTGTGATCGTAACTGTCATAA
ATCCATTGAGCAGGGATTGGTCCTGTCGGGTGCATTACCGGTATTTTTTATTCCAACCCGTAACCGCTATGGCATTATTG
GACCAATTCCTAAAGCACAATTCCAACCCACGGCTATTGCACAAAAAATTGAACAAAACCCCTTAAAGTCATTGGCTTGT
GATAGCAAGCCCGTCTATGCAGTTATCACGAATTGTACCTATGACGGTATGTGCTATAACGCCCAACAGGCACAGGATTT
ATTGGCAAAAAGTGTTGATCAGATTCATTTCGACGAAGCTTGGTACGCCTATGCCCGTTTTAATCCCCTTTATCGGGAGC
GTTTTGCGATGCGTGGTGACCCGGCTGACCATGATGCGCTGGGACCAACTATTTTTGCTACACAATCAACGCATAAATTA
TTGGCAGCGCTGTCGCAAGCTTCTTATATTCATGTGAGAAATGGCAAAAAGCCGATAGAACATTCGCGGTTTAATGAGTC
GTATATGTTGCAGTCAACCACTTCGCCATTGTACGCCATTATTGCTGCCAATGAAGTGGGGGCGGCGATGATGGAAGGCG
GGCAGGGGCTAGCATTGACACAAGAGGTGATCGATGAAGCTGTTGATTTTCGGTTGGCGCTGGCTCGTGCACATGATGCT
TTTGCAAAACAAGGCGAATGGTTCTTTAAACCTTGGAATACACCGGAAATAACGGATAGCAAAAGCGGTAAAAAGTTACC
TTTCTCCCAAGCATCACGAGAGCAACTGACAACCGATCCCGCCTGTTGGGTTCTCAAGCCGGGAGACCCGTGGCATGGTT
TCGAGCAGTTGGAAGAAGATTGGTGCATGTTGGATCCGATCAAGGCCGGGATTATGGTGCCGGGAATGGGGGATGACGGT
AAGTTGTCAGAAAAGGGAATTCCCGCAGCGATAGTGACCGCCTTCCTTGGGCAGCGGGGAATTGTACCGTCGCGGACCAC
GGATTTTATGGTGCTGTGCTTGTTTTCGGTGGGTGTAACGAAAGGTAAATGGGGCACACTCATTAATGTGTTACTGGAAT
TTAAGCAGCACTACGATAGCAATACACCGATATCGGTGTGCCTACCTGACTTGGCGAAAAATTATCCTCATCAATACGCT
CATAAGGGGTTAAAAGTGTTGTGTGATGAGATGTTTGCTTATATGAAGATCAGTGAAATGGATAAACTGCAAGCTGAGGC
ATTTAGCCATTTGCCTACGCCAGTGGTCTTACCCCGTCAGGCTTTTCAAGATCATATGGCTGGGCGGTGTGAGCTACTAC
CTATCGATAAGCTCGCTGGGCGTGTTACCGCTGTCGGGGTTATTCCATATCCGCCGGGCATCCCAATTGTCATGCCGGGG
GAGAGTTTTGGTAGCCATGAAGAACCATGGCTACGTTATATCTTAAGTATCACCAAATGGGGTCAGCATTTTCCCGGCTT
CGAGAAGATCTTGGAAGGGTCCGAGCAGAAGAATGGGCAATATTTTATTTGGGTACTAAAGCAGTAA

Upstream 100 bases:

>100_bases
ACTCGATGCACCTGTTAAGAACGGGCAGTAATACCCACTCCCATCTGTAGCTGGGTGGGCATCATTGATGTGATGAATTA
TAGATAAAGGGATAAATACG

Downstream 100 bases:

>100_bases
ATGCGCCTAGGGCAGGTCTCTCACCGCTGCTCCGCCCTAAAGCTGTCAGCCCAAAATACGGCCAGTCAAAAGAAACTGTC
AGTCAAAAGAAACTGCCGGC

Product: lysine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 768; Mature: 768

Protein sequence:

>768_residues
MIDLSSHKKRNVLVVDSNIRDINTANGRAVNELIIALNDINFNVIAAATFEDGAATVISDSSLCCIFVDWTSGGNDDESH
SQAFALLQDIRRRNKSVPVLLMAEHSCINSLSLETMQLVNEFVWMHEDTSEFIAARAKALIIKYYQQLLPPFTQALFQYT
QDNPEYSWAAPGHQGGVAFSKTAVGREFLDFFGENLFRTDTGIERESLGSLLDHSGPIKESEAYAAQVFGAHASYSMLNG
TSSSNRAIMAAVVGDKQIALCDRNCHKSIEQGLVLSGALPVFFIPTRNRYGIIGPIPKAQFQPTAIAQKIEQNPLKSLAC
DSKPVYAVITNCTYDGMCYNAQQAQDLLAKSVDQIHFDEAWYAYARFNPLYRERFAMRGDPADHDALGPTIFATQSTHKL
LAALSQASYIHVRNGKKPIEHSRFNESYMLQSTTSPLYAIIAANEVGAAMMEGGQGLALTQEVIDEAVDFRLALARAHDA
FAKQGEWFFKPWNTPEITDSKSGKKLPFSQASREQLTTDPACWVLKPGDPWHGFEQLEEDWCMLDPIKAGIMVPGMGDDG
KLSEKGIPAAIVTAFLGQRGIVPSRTTDFMVLCLFSVGVTKGKWGTLINVLLEFKQHYDSNTPISVCLPDLAKNYPHQYA
HKGLKVLCDEMFAYMKISEMDKLQAEAFSHLPTPVVLPRQAFQDHMAGRCELLPIDKLAGRVTAVGVIPYPPGIPIVMPG
ESFGSHEEPWLRYILSITKWGQHFPGFEKILEGSEQKNGQYFIWVLKQ

Sequences:

>Translated_768_residues
MIDLSSHKKRNVLVVDSNIRDINTANGRAVNELIIALNDINFNVIAAATFEDGAATVISDSSLCCIFVDWTSGGNDDESH
SQAFALLQDIRRRNKSVPVLLMAEHSCINSLSLETMQLVNEFVWMHEDTSEFIAARAKALIIKYYQQLLPPFTQALFQYT
QDNPEYSWAAPGHQGGVAFSKTAVGREFLDFFGENLFRTDTGIERESLGSLLDHSGPIKESEAYAAQVFGAHASYSMLNG
TSSSNRAIMAAVVGDKQIALCDRNCHKSIEQGLVLSGALPVFFIPTRNRYGIIGPIPKAQFQPTAIAQKIEQNPLKSLAC
DSKPVYAVITNCTYDGMCYNAQQAQDLLAKSVDQIHFDEAWYAYARFNPLYRERFAMRGDPADHDALGPTIFATQSTHKL
LAALSQASYIHVRNGKKPIEHSRFNESYMLQSTTSPLYAIIAANEVGAAMMEGGQGLALTQEVIDEAVDFRLALARAHDA
FAKQGEWFFKPWNTPEITDSKSGKKLPFSQASREQLTTDPACWVLKPGDPWHGFEQLEEDWCMLDPIKAGIMVPGMGDDG
KLSEKGIPAAIVTAFLGQRGIVPSRTTDFMVLCLFSVGVTKGKWGTLINVLLEFKQHYDSNTPISVCLPDLAKNYPHQYA
HKGLKVLCDEMFAYMKISEMDKLQAEAFSHLPTPVVLPRQAFQDHMAGRCELLPIDKLAGRVTAVGVIPYPPGIPIVMPG
ESFGSHEEPWLRYILSITKWGQHFPGFEKILEGSEQKNGQYFIWVLKQ
>Mature_768_residues
MIDLSSHKKRNVLVVDSNIRDINTANGRAVNELIIALNDINFNVIAAATFEDGAATVISDSSLCCIFVDWTSGGNDDESH
SQAFALLQDIRRRNKSVPVLLMAEHSCINSLSLETMQLVNEFVWMHEDTSEFIAARAKALIIKYYQQLLPPFTQALFQYT
QDNPEYSWAAPGHQGGVAFSKTAVGREFLDFFGENLFRTDTGIERESLGSLLDHSGPIKESEAYAAQVFGAHASYSMLNG
TSSSNRAIMAAVVGDKQIALCDRNCHKSIEQGLVLSGALPVFFIPTRNRYGIIGPIPKAQFQPTAIAQKIEQNPLKSLAC
DSKPVYAVITNCTYDGMCYNAQQAQDLLAKSVDQIHFDEAWYAYARFNPLYRERFAMRGDPADHDALGPTIFATQSTHKL
LAALSQASYIHVRNGKKPIEHSRFNESYMLQSTTSPLYAIIAANEVGAAMMEGGQGLALTQEVIDEAVDFRLALARAHDA
FAKQGEWFFKPWNTPEITDSKSGKKLPFSQASREQLTTDPACWVLKPGDPWHGFEQLEEDWCMLDPIKAGIMVPGMGDDG
KLSEKGIPAAIVTAFLGQRGIVPSRTTDFMVLCLFSVGVTKGKWGTLINVLLEFKQHYDSNTPISVCLPDLAKNYPHQYA
HKGLKVLCDEMFAYMKISEMDKLQAEAFSHLPTPVVLPRQAFQDHMAGRCELLPIDKLAGRVTAVGVIPYPPGIPIVMPG
ESFGSHEEPWLRYILSITKWGQHFPGFEKILEGSEQKNGQYFIWVLKQ

Specific function: ADC can be found in two forms:biodegradative and biosynthetic. The biodegradative form may play a role in regulating pH by consuming proteins [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI221142684, Length=757, Percent_Identity=52.3117569352708, Blast_Score=840, Evalue=0.0,
Organism=Escherichia coli, GI1790573, Length=742, Percent_Identity=36.6576819407008, Blast_Score=501, Evalue=1e-143,
Organism=Escherichia coli, GI1786384, Length=739, Percent_Identity=36.5358592692828, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI87082193, Length=730, Percent_Identity=32.6027397260274, Blast_Score=352, Evalue=4e-98,
Organism=Escherichia coli, GI1786909, Length=692, Percent_Identity=31.5028901734104, Blast_Score=328, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 85198; Mature: 85198

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLSSHKKRNVLVVDSNIRDINTANGRAVNELIIALNDINFNVIAAATFEDGAATVISD
CCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCEEEEEEEEECCCCEEEEEC
SSLCCIFVDWTSGGNDDESHSQAFALLQDIRRRNKSVPVLLMAEHSCINSLSLETMQLVN
CCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHH
EFVWMHEDTSEFIAARAKALIIKYYQQLLPPFTQALFQYTQDNPEYSWAAPGHQGGVAFS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCCCCCCEEH
KTAVGREFLDFFGENLFRTDTGIERESLGSLLDHSGPIKESEAYAAQVFGAHASYSMLNG
HHHHHHHHHHHHCCHHEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHCCC
TSSSNRAIMAAVVGDKQIALCDRNCHKSIEQGLVLSGALPVFFIPTRNRYGIIGPIPKAQ
CCCCCCEEEEEEECCCEEEEECCHHHHHHHCCEEEECCCCEEEEECCCCCCEECCCCCCC
FQPTAIAQKIEQNPLKSLACDSKPVYAVITNCTYDGMCYNAQQAQDLLAKSVDQIHFDEA
CCHHHHHHHHHHCHHHHHCCCCCCEEEEEECCCCCCEECCHHHHHHHHHHHHHHHHHCHH
WYAYARFNPLYRERFAMRGDPADHDALGPTIFATQSTHKLLAALSQASYIHVRNGKKPIE
HHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCEEEEECCCCCCC
HSRFNESYMLQSTTSPLYAIIAANEVGAAMMEGGQGLALTQEVIDEAVDFRLALARAHDA
CCCCCCCEEEEECCCCEEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FAKQGEWFFKPWNTPEITDSKSGKKLPFSQASREQLTTDPACWVLKPGDPWHGFEQLEED
HHHCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEECCCCCCCCHHHHHCC
WCMLDPIKAGIMVPGMGDDGKLSEKGIPAAIVTAFLGQRGIVPSRTTDFMVLCLFSVGVT
CCEECCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
KGKWGTLINVLLEFKQHYDSNTPISVCLPDLAKNYPHQYAHKGLKVLCDEMFAYMKISEM
CCCHHHHHHHHHHHHHHCCCCCCCEEECHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
DKLQAEAFSHLPTPVVLPRQAFQDHMAGRCELLPIDKLAGRVTAVGVIPYPPGIPIVMPG
HHHHHHHHHHCCCCEECCHHHHHHHHCCCEEEEEHHHHCCCEEEEEEEECCCCCCEEECC
ESFGSHEEPWLRYILSITKWGQHFPGFEKILEGSEQKNGQYFIWVLKQ
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MIDLSSHKKRNVLVVDSNIRDINTANGRAVNELIIALNDINFNVIAAATFEDGAATVISD
CCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCEEEEEEEEECCCCEEEEEC
SSLCCIFVDWTSGGNDDESHSQAFALLQDIRRRNKSVPVLLMAEHSCINSLSLETMQLVN
CCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHH
EFVWMHEDTSEFIAARAKALIIKYYQQLLPPFTQALFQYTQDNPEYSWAAPGHQGGVAFS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCCCCCCEEH
KTAVGREFLDFFGENLFRTDTGIERESLGSLLDHSGPIKESEAYAAQVFGAHASYSMLNG
HHHHHHHHHHHHCCHHEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHCCC
TSSSNRAIMAAVVGDKQIALCDRNCHKSIEQGLVLSGALPVFFIPTRNRYGIIGPIPKAQ
CCCCCCEEEEEEECCCEEEEECCHHHHHHHCCEEEECCCCEEEEECCCCCCEECCCCCCC
FQPTAIAQKIEQNPLKSLACDSKPVYAVITNCTYDGMCYNAQQAQDLLAKSVDQIHFDEA
CCHHHHHHHHHHCHHHHHCCCCCCEEEEEECCCCCCEECCHHHHHHHHHHHHHHHHHCHH
WYAYARFNPLYRERFAMRGDPADHDALGPTIFATQSTHKLLAALSQASYIHVRNGKKPIE
HHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCEEEEECCCCCCC
HSRFNESYMLQSTTSPLYAIIAANEVGAAMMEGGQGLALTQEVIDEAVDFRLALARAHDA
CCCCCCCEEEEECCCCEEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FAKQGEWFFKPWNTPEITDSKSGKKLPFSQASREQLTTDPACWVLKPGDPWHGFEQLEED
HHHCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEECCCCCCCCHHHHHCC
WCMLDPIKAGIMVPGMGDDGKLSEKGIPAAIVTAFLGQRGIVPSRTTDFMVLCLFSVGVT
CCEECCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
KGKWGTLINVLLEFKQHYDSNTPISVCLPDLAKNYPHQYAHKGLKVLCDEMFAYMKISEM
CCCHHHHHHHHHHHHHHCCCCCCCEEECHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
DKLQAEAFSHLPTPVVLPRQAFQDHMAGRCELLPIDKLAGRVTAVGVIPYPPGIPIVMPG
HHHHHHHHHHCCCCEECCHHHHHHHHCCCEEEEEHHHHCCCEEEEEEEECCCCCCEEECC
ESFGSHEEPWLRYILSITKWGQHFPGFEKILEGSEQKNGQYFIWVLKQ
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8383109; 7610040; 9278503; 2830169; 4204273 [H]