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The map label for this gene is lysP [H]

Identifier: 170024977

GI number: 170024977

Start: 3035431

End: 3036942

Strand: Reverse

Name: lysP [H]

Synonym: YPK_2752

Alternate gene names: 170024977

Gene position: 3036942-3035431 (Counterclockwise)

Preceding gene: 170024978

Following gene: 170024976

Centisome position: 64.76

GC content: 49.14

Gene sequence:

>1512_bases
ATGACTCAGCAAAATACTAAAATCCCAGCGCAGCAGGGTGCACAGCGCTTACGCCGGGAGCTTAAATCGCGGCATTTAGC
CATGATTGCTATCGGTGGTTCTATTGGTACCGGTTTATTTGTTGCCTCTGGTGCAACGGTATCGCAAGCCGGTCCAGGGG
GGGCATTGCTCTCCTACGCATTGATTGGCTTGATGGTTTACTTCCTGATGACCAGCTTGGGAGAATTGGCTGCGTTCATG
CCAGTTTCAGGCTCATTCTCTACTTATGGTTCTAAATATGTCGAGGAAGGCTTTGGCTTTGCCCTAGGTTGGAACTACTG
GTACAACTGGGCGGTAACCATCGCAGTTGACTTGGTAGCCGCACAGTTAGTGATGAACTACTGGTTCCCGGACGCGCCCG
GTTGGATCTGGAGTGCTTTATTCCTGGGCCTGATGTTCTTACTGAACTACATCTCAGTGAAAGGTTTCGGTGAAGCGGAA
TATTGGTTCTCGCTGATTAAAGTGACAACCGTGGTTATCTTCATCATCGTTGGTGTCATGATGATCACCGGTATCATGAA
AGGGGGCGAAACGGCGGGTTGGCATAACTGGACTATCGGTGATGCACCATTTGCTGGTGGTTTCTCTGCCATGATTGGGG
TGGCCATGATCGTCGGCTTCTCCTTCCAAGGGACTGAATTGATTGGTATTGCGGCTGGGGAATCCAAAGATCCAGGCAAA
AATATTCCAAAGGCAATTCGCAAAGTGTTCTGGCGTATTCTGTTGTTCTATATCTTCGCTATTCTGATTATTAGCCTGAT
TATTCCGTATACCGATCCCAGTTTGTTACGCAACGATGTGAAAGATATCAGCGTCAGCCCGTTCACACTGGTATTCCAGA
ATGCGGGTCTGTTATCAGCAGCGGCAGTGATGAATGCGGTTATTTTGACCGCTGTTTTATCGGCGGGTAACTCGGGGATG
TATGCCTCGACCCGTATGCTGTTTACCTTAGCCTCTGAAGGCAAAGCACCGCGTATTTTCGCCAAGTTATCTAAGGGCGG
TGTCCCTCGTAATGCGCTGTATGCCACGACAGTCGTTGCAGGTTTGTGCTTCCTGAGCTCCATGTTTGGTAACCAAACTG
TGTATTTGTGGTTACTGAATACCTCGGGGATGACTGGGTTTATCGCCTGGTTGGGTATTGCCATCAGCCACTACCGCTTC
CGTCGGGGCTATATGATGCAGGGCCGTGACTTGAACGATTTACCGTATCAGTCTGGTTTCTTCCCTCTGGGGCCGATTTT
TGCCTTCGTCCTGTGTCTAATCATCACGTTAGGCCAGAATTATCAGGCATTCCTGCAAGACCGTATTGATTGGTATGGCG
TGACGGCAACCTATATTGGTATTCCATTGTTCCTGGTGATTTGGTTTGGCTATAAGCTCAGCCGTGGTACCCGGGTAGTG
AAATACCAAGAGATGGAATTCCCAAAATGGCGTGATGAGAGTGAAGAGCATCAGAAACCGACAAGTCGGTGA

Upstream 100 bases:

>100_bases
CGGGATTATGAAGGTATCTTATATCCGTGCATTCTGGCTATCCGAGCCGGTGAGATTTGTTACAATCCCGCCTTATTTTT
AAGGGTGGATTAGGGTAAGA

Downstream 100 bases:

>100_bases
TGTGCTTGGCTCTATAACGTGCGGATGAAAGGGCGATAACGCTATCGCCCTTCTTTAGTGCCTATAAATTAGCGGTAACT
GACGCCAATACCAGTACGAA

Product: lysine transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTQQNTKIPAQQGAQRLRRELKSRHLAMIAIGGSIGTGLFVASGATVSQAGPGGALLSYALIGLMVYFLMTSLGELAAFM
PVSGSFSTYGSKYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMNYWFPDAPGWIWSALFLGLMFLLNYISVKGFGEAE
YWFSLIKVTTVVIFIIVGVMMITGIMKGGETAGWHNWTIGDAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESKDPGK
NIPKAIRKVFWRILLFYIFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQNAGLLSAAAVMNAVILTAVLSAGNSGM
YASTRMLFTLASEGKAPRIFAKLSKGGVPRNALYATTVVAGLCFLSSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRF
RRGYMMQGRDLNDLPYQSGFFPLGPIFAFVLCLIITLGQNYQAFLQDRIDWYGVTATYIGIPLFLVIWFGYKLSRGTRVV
KYQEMEFPKWRDESEEHQKPTSR

Sequences:

>Translated_503_residues
MTQQNTKIPAQQGAQRLRRELKSRHLAMIAIGGSIGTGLFVASGATVSQAGPGGALLSYALIGLMVYFLMTSLGELAAFM
PVSGSFSTYGSKYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMNYWFPDAPGWIWSALFLGLMFLLNYISVKGFGEAE
YWFSLIKVTTVVIFIIVGVMMITGIMKGGETAGWHNWTIGDAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESKDPGK
NIPKAIRKVFWRILLFYIFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQNAGLLSAAAVMNAVILTAVLSAGNSGM
YASTRMLFTLASEGKAPRIFAKLSKGGVPRNALYATTVVAGLCFLSSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRF
RRGYMMQGRDLNDLPYQSGFFPLGPIFAFVLCLIITLGQNYQAFLQDRIDWYGVTATYIGIPLFLVIWFGYKLSRGTRVV
KYQEMEFPKWRDESEEHQKPTSR
>Mature_502_residues
TQQNTKIPAQQGAQRLRRELKSRHLAMIAIGGSIGTGLFVASGATVSQAGPGGALLSYALIGLMVYFLMTSLGELAAFMP
VSGSFSTYGSKYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMNYWFPDAPGWIWSALFLGLMFLLNYISVKGFGEAEY
WFSLIKVTTVVIFIIVGVMMITGIMKGGETAGWHNWTIGDAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESKDPGKN
IPKAIRKVFWRILLFYIFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQNAGLLSAAAVMNAVILTAVLSAGNSGMY
ASTRMLFTLASEGKAPRIFAKLSKGGVPRNALYATTVVAGLCFLSSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFR
RGYMMQGRDLNDLPYQSGFFPLGPIFAFVLCLIITLGQNYQAFLQDRIDWYGVTATYIGIPLFLVIWFGYKLSRGTRVVK
YQEMEFPKWRDESEEHQKPTSR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=354, Percent_Identity=22.5988700564972, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788480, Length=476, Percent_Identity=87.3949579831933, Blast_Score=857, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=499, Percent_Identity=37.4749498997996, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1786789, Length=417, Percent_Identity=38.3693045563549, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI48994972, Length=477, Percent_Identity=35.6394129979036, Blast_Score=271, Evalue=1e-73,
Organism=Escherichia coli, GI1786302, Length=399, Percent_Identity=37.593984962406, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1790653, Length=453, Percent_Identity=35.9823399558499, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87081915, Length=515, Percent_Identity=32.4271844660194, Blast_Score=242, Evalue=5e-65,
Organism=Escherichia coli, GI1789017, Length=392, Percent_Identity=33.4183673469388, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI1786602, Length=396, Percent_Identity=36.6161616161616, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI87081869, Length=413, Percent_Identity=24.6973365617433, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082023, Length=328, Percent_Identity=25, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082250, Length=239, Percent_Identity=27.1966527196653, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=375, Percent_Identity=23.7333333333333, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=508, Percent_Identity=36.4173228346457, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6324990, Length=506, Percent_Identity=34.7826086956522, Blast_Score=316, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6324061, Length=510, Percent_Identity=35.0980392156863, Blast_Score=315, Evalue=9e-87,
Organism=Saccharomyces cerevisiae, GI6322892, Length=505, Percent_Identity=36.4356435643564, Blast_Score=304, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6324059, Length=499, Percent_Identity=35.8717434869739, Blast_Score=294, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6324924, Length=488, Percent_Identity=33.8114754098361, Blast_Score=290, Evalue=5e-79,
Organism=Saccharomyces cerevisiae, GI6321629, Length=496, Percent_Identity=31.6532258064516, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6324553, Length=430, Percent_Identity=35.1162790697674, Blast_Score=265, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6319824, Length=482, Percent_Identity=29.045643153527, Blast_Score=249, Evalue=7e-67,
Organism=Saccharomyces cerevisiae, GI6320717, Length=473, Percent_Identity=28.3298097251586, Blast_Score=243, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6322967, Length=484, Percent_Identity=30.9917355371901, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6321053, Length=482, Percent_Identity=28.6307053941909, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6319543, Length=482, Percent_Identity=29.4605809128631, Blast_Score=232, Evalue=9e-62,
Organism=Saccharomyces cerevisiae, GI6319542, Length=467, Percent_Identity=28.051391862955, Blast_Score=229, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6320251, Length=510, Percent_Identity=25.4901960784314, Blast_Score=226, Evalue=9e-60,
Organism=Saccharomyces cerevisiae, GI6319608, Length=505, Percent_Identity=29.1089108910891, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6324981, Length=498, Percent_Identity=32.3293172690763, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6320364, Length=558, Percent_Identity=26.7025089605735, Blast_Score=186, Evalue=8e-48,
Organism=Drosophila melanogaster, GI281366235, Length=394, Percent_Identity=22.0812182741117, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116007820, Length=394, Percent_Identity=22.0812182741117, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666159, Length=370, Percent_Identity=23.5135135135135, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221512776, Length=370, Percent_Identity=23.5135135135135, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 55382; Mature: 55250

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQNTKIPAQQGAQRLRRELKSRHLAMIAIGGSIGTGLFVASGATVSQAGPGGALLSYA
CCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHH
LIGLMVYFLMTSLGELAAFMPVSGSFSTYGSKYVEEGFGFALGWNYWYNWAVTIAVDLVA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHH
AQLVMNYWFPDAPGWIWSALFLGLMFLLNYISVKGFGEAEYWFSLIKVTTVVIFIIVGVM
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MITGIMKGGETAGWHNWTIGDAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESKDPGK
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
NIPKAIRKVFWRILLFYIFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQNAGLLSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHH
AAVMNAVILTAVLSAGNSGMYASTRMLFTLASEGKAPRIFAKLSKGGVPRNALYATTVVA
HHHHHHHHHHHHHHCCCCCCEEHHHHEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHH
GLCFLSSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYMMQGRDLNDLPYQSGF
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCC
FPLGPIFAFVLCLIITLGQNYQAFLQDRIDWYGVTATYIGIPLFLVIWFGYKLSRGTRVV
CCHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
KYQEMEFPKWRDESEEHQKPTSR
EEECCCCCCCCCCCHHHCCCCCC
>Mature Secondary Structure 
TQQNTKIPAQQGAQRLRRELKSRHLAMIAIGGSIGTGLFVASGATVSQAGPGGALLSYA
CCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHH
LIGLMVYFLMTSLGELAAFMPVSGSFSTYGSKYVEEGFGFALGWNYWYNWAVTIAVDLVA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHH
AQLVMNYWFPDAPGWIWSALFLGLMFLLNYISVKGFGEAEYWFSLIKVTTVVIFIIVGVM
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MITGIMKGGETAGWHNWTIGDAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESKDPGK
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
NIPKAIRKVFWRILLFYIFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQNAGLLSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHH
AAVMNAVILTAVLSAGNSGMYASTRMLFTLASEGKAPRIFAKLSKGGVPRNALYATTVVA
HHHHHHHHHHHHHHCCCCCCEEHHHHEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHH
GLCFLSSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYMMQGRDLNDLPYQSGF
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCC
FPLGPIFAFVLCLIITLGQNYQAFLQDRIDWYGVTATYIGIPLFLVIWFGYKLSRGTRVV
CCHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
KYQEMEFPKWRDESEEHQKPTSR
EEECCCCCCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]