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The map label for this gene is lpxK

Identifier: 170024889

GI number: 170024889

Start: 2930565

End: 2931551

Strand: Reverse

Name: lpxK

Synonym: YPK_2664

Alternate gene names: 170024889

Gene position: 2931551-2930565 (Counterclockwise)

Preceding gene: 170024890

Following gene: 170024887

Centisome position: 62.51

GC content: 52.89

Gene sequence:

>987_bases
ATGATTGAGCGTATCTGGTCTGGTCAATCGCGGCTGTATTTACTGCTGCTGCCGTTGTCCTGGTTATATGGTGCTGTCAC
TTGGTTGATCCGAGCCAGTTATCGCTTGGGGCTGCGTTCGGCATGGCGTTCGCCGGTTCCTGTGATCATTGTGGGGAATC
TTACTGCGGGGGGGAACGGTAAAACACCGGTGGTGATCTGGTTGGTTGAACAGCTACAACAGCGTGGCTATCGTGTGGGT
GTCGTGTCTCGTGGCTACGGCGGTAAATCAGCGGTCTACCCGCTACTGCTGTCGGATAACACCACCACTGCTCAGGCGGG
TGATGAACCGGTTCTTATCTTTCAGCGGACGGGGGCACCGGTTGCGGTGTCACCCAAACGGGCAGACGCTATCAAAGCCT
TACTGCAATCTCATGCGGTAGATTTCATCATTACTGATGACGGCTTACAACATTATGCGCTACAGCGTGATTTTGAGTTG
GTCGTCATTGATGGCGTCCGCCGTTTTGGGAATGGCTGGTGGTTGCCAGCCGGCCCTATGCGGGAGCGGGAGGGCAGATT
GCGGTCAGTAGATGCGGCAATCACCAACGGTGGCCTCGCTGCTGAGGGGGAGATCCCCATGCAACTGGTTGCGCGGGAGG
CCGTCAATTTGGTTACGGGGCAGCGCCAACCTGCGGAACAGCTACAGCATGTCGTTGCTATGGCCGGAATTGGTCATCCT
CCTCGCTTTTTTGCCACGCTAAATTTGTTAGGAATTAAACCTGAAAATGAGCATGCTTTTGCTGACCATCAGGATTATTC
ATTGGCACAATTAAGCCGGTTGACTTCCGGCCCTCAAATTTTATTGATGACAGAAAAGGATGCCGTTAAGTGCCGGGCTT
TTGCTCTGCCGAATTGGTGGTACTTACCTGTCGATGCGCAACTACCGTCCGATAGGGCAGATAAACTATTGTTAAATATT
CAGGCGCTATCTCCTGATACTAAGTAG

Upstream 100 bases:

>100_bases
TGGTCATTGAAGACGGGCGTATTGTGGAGCGTGGTGTACACGCTGAATTGCTGGTCCAGCAAGGTGTCTATGCGCAGCTC
AACCGTATGCAGTTTGGCCA

Downstream 100 bases:

>100_bases
CTCCCTTTTATTGGCTTAACAACGTTAGTTTGAGGGCGGCTGCACATTCAGCAACGGAACGTTGCTGGGTTGCTTCGTAG
AGTTGCAGTTCATCAATAAC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MIERIWSGQSRLYLLLLPLSWLYGAVTWLIRASYRLGLRSAWRSPVPVIIVGNLTAGGNGKTPVVIWLVEQLQQRGYRVG
VVSRGYGGKSAVYPLLLSDNTTTAQAGDEPVLIFQRTGAPVAVSPKRADAIKALLQSHAVDFIITDDGLQHYALQRDFEL
VVIDGVRRFGNGWWLPAGPMREREGRLRSVDAAITNGGLAAEGEIPMQLVAREAVNLVTGQRQPAEQLQHVVAMAGIGHP
PRFFATLNLLGIKPENEHAFADHQDYSLAQLSRLTSGPQILLMTEKDAVKCRAFALPNWWYLPVDAQLPSDRADKLLLNI
QALSPDTK

Sequences:

>Translated_328_residues
MIERIWSGQSRLYLLLLPLSWLYGAVTWLIRASYRLGLRSAWRSPVPVIIVGNLTAGGNGKTPVVIWLVEQLQQRGYRVG
VVSRGYGGKSAVYPLLLSDNTTTAQAGDEPVLIFQRTGAPVAVSPKRADAIKALLQSHAVDFIITDDGLQHYALQRDFEL
VVIDGVRRFGNGWWLPAGPMREREGRLRSVDAAITNGGLAAEGEIPMQLVAREAVNLVTGQRQPAEQLQHVVAMAGIGHP
PRFFATLNLLGIKPENEHAFADHQDYSLAQLSRLTSGPQILLMTEKDAVKCRAFALPNWWYLPVDAQLPSDRADKLLLNI
QALSPDTK
>Mature_328_residues
MIERIWSGQSRLYLLLLPLSWLYGAVTWLIRASYRLGLRSAWRSPVPVIIVGNLTAGGNGKTPVVIWLVEQLQQRGYRVG
VVSRGYGGKSAVYPLLLSDNTTTAQAGDEPVLIFQRTGAPVAVSPKRADAIKALLQSHAVDFIITDDGLQHYALQRDFEL
VVIDGVRRFGNGWWLPAGPMREREGRLRSVDAAITNGGLAAEGEIPMQLVAREAVNLVTGQRQPAEQLQHVVAMAGIGHP
PRFFATLNLLGIKPENEHAFADHQDYSLAQLSRLTSGPQILLMTEKDAVKCRAFALPNWWYLPVDAQLPSDRADKLLLNI
QALSPDTK

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=325, Percent_Identity=70.1538461538462, Blast_Score=461, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_YERP3 (A7FJW3)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001401541.1
- ProteinModelPortal:   A7FJW3
- STRING:   A7FJW3
- GeneID:   5385277
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_2576
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   PRK00652
- BioCyc:   YPSE349747:YPSIP31758_2576-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 36139; Mature: 36139

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERIWSGQSRLYLLLLPLSWLYGAVTWLIRASYRLGLRSAWRSPVPVIIVGNLTAGGNG
CCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECEECCCCC
KTPVVIWLVEQLQQRGYRVGVVSRGYGGKSAVYPLLLSDNTTTAQAGDEPVLIFQRTGAP
CCCEEEEEHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCC
VAVSPKRADAIKALLQSHAVDFIITDDGLQHYALQRDFELVVIDGVRRFGNGWWLPAGPM
EEECCCHHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCEEEEEECHHHHCCCEECCCCCC
REREGRLRSVDAAITNGGLAAEGEIPMQLVAREAVNLVTGQRQPAEQLQHVVAMAGIGHP
HHHCCCCEEEHHEEECCCEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
PRFFATLNLLGIKPENEHAFADHQDYSLAQLSRLTSGPQILLMTEKDAVKCRAFALPNWW
CCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCEE
YLPVDAQLPSDRADKLLLNIQALSPDTK
EEEECCCCCCCCCCEEEEEEEECCCCCC
>Mature Secondary Structure
MIERIWSGQSRLYLLLLPLSWLYGAVTWLIRASYRLGLRSAWRSPVPVIIVGNLTAGGNG
CCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECEECCCCC
KTPVVIWLVEQLQQRGYRVGVVSRGYGGKSAVYPLLLSDNTTTAQAGDEPVLIFQRTGAP
CCCEEEEEHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCC
VAVSPKRADAIKALLQSHAVDFIITDDGLQHYALQRDFELVVIDGVRRFGNGWWLPAGPM
EEECCCHHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCEEEEEECHHHHCCCEECCCCCC
REREGRLRSVDAAITNGGLAAEGEIPMQLVAREAVNLVTGQRQPAEQLQHVVAMAGIGHP
HHHCCCCEEEHHEEECCCEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
PRFFATLNLLGIKPENEHAFADHQDYSLAQLSRLTSGPQILLMTEKDAVKCRAFALPNWW
CCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCEE
YLPVDAQLPSDRADKLLLNIQALSPDTK
EEEECCCCCCCCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA