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The map label for this gene is manY [H]

Identifier: 170024690

GI number: 170024690

Start: 2698997

End: 2699794

Strand: Direct

Name: manY [H]

Synonym: YPK_2465

Alternate gene names: 170024690

Gene position: 2698997-2699794 (Clockwise)

Preceding gene: 170024689

Following gene: 170024691

Centisome position: 57.55

GC content: 50.25

Gene sequence:

>798_bases
ATGGAGATAACAACTCTTCAGATTGTGCTGATATTTATCGTTGCATGTATCGCCGGGATGGGTTCCATTCTGGATGAGTT
CCAATTTCACCGCCCGCTCGTCGCCTGTACCTTGGTAGGTATGGTTCTGGGTGATATGAAAACCGGTATTATCATCGGTG
GTACCTTAGAAATGATCGCGCTTGGTTGGATGAACATCGGGGCTGCTGTAGCACCTGATGCGGCTCTGGCCTCAATTATT
TCAACCATCCTGGTTATCGCCGGGGGCCAAGATATCGGTGCCGGTATCGCCTTGGCGATCCCACTGGCTGCAGCCGGTCA
GGTGTTAACTATTATCGTGCGTACCATTACCGTGGCCTTCCAACACGCCGCTGATGGCGCTGCCGAACGTGGCAGTCTAC
GAGCGATTACCTGGCTCCACATCTCTGCCCTGTTCTTACAGGCAATGCGTATCGCCATTCCCGCGCTTATCGTTGCTCTG
TCCGTGGGTACATCTGAAGTTCAGATGATGCTCAGTTCAATTCCTGAAGTGGTTACCAGTGGCCTGAACATCGCCGGTGG
TATGATCGTTGTCGTTGGTTACGCCATGGTTATCAACATGATGCGTGCTGGCTACCTGATGCCATTCTTCTATTTAGGTT
TCGTTACTGCCGCATTTACCAACTTCAACCTGGTTGCATTGGGGGTTATTGGTGTGGTTATGGCTGTTCTTTATATCCAA
GTCAGCCCTAAATACAACAAGTCTCAGGTTGTACAGTCTGGCCCGGCCAATAACGATCTTGATAACGAATTAGACTAG

Upstream 100 bases:

>100_bases
AATAAATAGCTCCACTAAAAACTACGTAGAAAGGTAATACCCTGTCCTATTTTGGGGCTTGGTTATTTTACTCAGCTTTA
TTGGTCATAGGAGAAGTACA

Downstream 100 bases:

>100_bases
GAAAAGGTGAGAGAAATGGTTGATACAACAACTGTTGATACAACAACTGTTACTAAAACAACTACCGGTGAAAAGAAACT
CACGGCCAGCGACATTCGCG

Product: PTS system mannose/fructose/sorbose family IIC subunit

Products: protein histidine; sugar phosphate; D-glucosamine-6-phosphate [Cytoplasm]; pyruvate; glucose-6-phosphate [Cytoplasm]; N-acetyl-D-glucosamine-6-phosphate [Cytoplasm]; mannose-6-phosphate [Cytoplasm]; fructose-6-phosphate [Cytoplasm] [C]

Alternate protein names: EII-P-Man; EIIC-Man; PTS system mannose-specific EIIC component [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MEITTLQIVLIFIVACIAGMGSILDEFQFHRPLVACTLVGMVLGDMKTGIIIGGTLEMIALGWMNIGAAVAPDAALASII
STILVIAGGQDIGAGIALAIPLAAAGQVLTIIVRTITVAFQHAADGAAERGSLRAITWLHISALFLQAMRIAIPALIVAL
SVGTSEVQMMLSSIPEVVTSGLNIAGGMIVVVGYAMVINMMRAGYLMPFFYLGFVTAAFTNFNLVALGVIGVVMAVLYIQ
VSPKYNKSQVVQSGPANNDLDNELD

Sequences:

>Translated_265_residues
MEITTLQIVLIFIVACIAGMGSILDEFQFHRPLVACTLVGMVLGDMKTGIIIGGTLEMIALGWMNIGAAVAPDAALASII
STILVIAGGQDIGAGIALAIPLAAAGQVLTIIVRTITVAFQHAADGAAERGSLRAITWLHISALFLQAMRIAIPALIVAL
SVGTSEVQMMLSSIPEVVTSGLNIAGGMIVVVGYAMVINMMRAGYLMPFFYLGFVTAAFTNFNLVALGVIGVVMAVLYIQ
VSPKYNKSQVVQSGPANNDLDNELD
>Mature_265_residues
MEITTLQIVLIFIVACIAGMGSILDEFQFHRPLVACTLVGMVLGDMKTGIIIGGTLEMIALGWMNIGAAVAPDAALASII
STILVIAGGQDIGAGIALAIPLAAAGQVLTIIVRTITVAFQHAADGAAERGSLRAITWLHISALFLQAMRIAIPALIVAL
SVGTSEVQMMLSSIPEVVTSGLNIAGGMIVVVGYAMVINMMRAGYLMPFFYLGFVTAAFTNFNLVALGVIGVVMAVLYIQ
VSPKYNKSQVVQSGPANNDLDNELD

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system i

COG id: COG3715

COG function: function code G; Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-4 domain [H]

Homologues:

Organism=Escherichia coli, GI1788121, Length=269, Percent_Identity=87.732342007435, Blast_Score=420, Evalue=1e-119,
Organism=Escherichia coli, GI1789528, Length=264, Percent_Identity=25.3787878787879, Blast_Score=96, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004700
- InterPro:   IPR018404 [H]

Pfam domain/function: PF03609 EII-Sor [H]

EC number: NA

Molecular weight: Translated: 27650; Mature: 27650

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS51106 PTS_EIIC_TYPE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N p -phosphohistidine; sugar; phosphoenolpyruvate; glucosamine [Periplasm]; phosphoenolpyruvate; beta-D-glucose [Periplasm]; N-acetyl-D-glucosamine [Periplasm]; mannose [Periplasm]; fructose [Periplasm] [C]

Specific reaction: protein N p -phosphohistidine + sugar = protein histidine + sugar phosphate phosphoenolpyruvate + glucosamine [Periplasm] = D-glucosamine-6-phosphate [Cytoplasm] + pyruvate phosphoenolpyruvate + beta-D-glucose [Periplasm] = glucose-6-phosphate [Cytoplasm]

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]