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The map label for this gene is yfjP [H]

Identifier: 170024612

GI number: 170024612

Start: 2622927

End: 2623538

Strand: Direct

Name: yfjP [H]

Synonym: YPK_2387

Alternate gene names: 170024612

Gene position: 2622927-2623538 (Clockwise)

Preceding gene: 170024611

Following gene: 170024616

Centisome position: 55.93

GC content: 49.18

Gene sequence:

>612_bases
GTGTTCTATACCTACGGCGAAACAGAAATAAATCATCTGAAACGGCGGGATAAAAAAATGGCCGCAGCTATTGAGCGTTT
GGGGATGTTAGAGCGCCCATTATCGCCGGACTTATTCGCTGCATTGATCAGAAATATTGTTGATCAGCAAATTTCAGTTA
AAGCGGCGCAAACCGTTAATACACGCTTAACCCTATTATTGGGTAGCATCACCCCCGCCACCGTTGCCGCTGCCTCCGCC
GAGGCGATTCAACGCTGTGGTATGACCATGAGGAAAGCGGGTTATATTAAAGGGGCGGCCGATGCGGCCATTAATGGTTC
GCTGGATTTATCTGTTATTGCGCAATTGCCTGATAACGAGGTTATTACACAGCTTTCACGTCTTGACGGCGTAGGGGTTT
GGACAGCGGAAATGCTGTTGATCTCCTCATTGTCACGGCCAGATATTGTCAGTTGGGGAGATTTAGCCATCCGCCGCGGC
ATGATGAATTTATATCGCCATAAAACCCTGCCCCGTGAGCGTTTCGAGCGCTATCGCCGCCGATATACCCCATACGGAAC
AACTGCCTCTCTTTATTTATGGGCGTTGTCACACAAAACGCTGGAGGATTGA

Upstream 100 bases:

>100_bases
AATCGCTACCGGCCTCCTGGTCAGTACGTATTTTATCTGTCATTTTTCTATCGCTTTTCTATTACCCCAAATAATTCGAG
TTGCAGGAAGGAGTGGGCTG

Downstream 100 bases:

>100_bases
TCAATCACGCAGTAAGCCATTAGTCTTATTGAGCAATTTACGTTCGAATGAATTAACAGTGATTTTTTACCCCACGGTTC
TATATCCCTATCCCCACCAT

Product: HhH-GPD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MFYTYGETEINHLKRRDKKMAAAIERLGMLERPLSPDLFAALIRNIVDQQISVKAAQTVNTRLTLLLGSITPATVAAASA
EAIQRCGMTMRKAGYIKGAADAAINGSLDLSVIAQLPDNEVITQLSRLDGVGVWTAEMLLISSLSRPDIVSWGDLAIRRG
MMNLYRHKTLPRERFERYRRRYTPYGTTASLYLWALSHKTLED

Sequences:

>Translated_203_residues
MFYTYGETEINHLKRRDKKMAAAIERLGMLERPLSPDLFAALIRNIVDQQISVKAAQTVNTRLTLLLGSITPATVAAASA
EAIQRCGMTMRKAGYIKGAADAAINGSLDLSVIAQLPDNEVITQLSRLDGVGVWTAEMLLISSLSRPDIVSWGDLAIRRG
MMNLYRHKTLPRERFERYRRRYTPYGTTASLYLWALSHKTLED
>Mature_203_residues
MFYTYGETEINHLKRRDKKMAAAIERLGMLERPLSPDLFAALIRNIVDQQISVKAAQTVNTRLTLLLGSITPATVAAASA
EAIQRCGMTMRKAGYIKGAADAAINGSLDLSVIAQLPDNEVITQLSRLDGVGVWTAEMLLISSLSRPDIVSWGDLAIRRG
MMNLYRHKTLPRERFERYRRRYTPYGTTASLYLWALSHKTLED

Specific function: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2- methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alkylbase DNA glycosidase alkA family [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=197, Percent_Identity=24.8730964467005, Blast_Score=61, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320990, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: =3.2.2.21 [H]

Molecular weight: Translated: 22730; Mature: 22730

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYTYGETEINHLKRRDKKMAAAIERLGMLERPLSPDLFAALIRNIVDQQISVKAAQTVN
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TRLTLLLGSITPATVAAASAEAIQRCGMTMRKAGYIKGAADAAINGSLDLSVIAQLPDNE
HHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHCCCCCCHHHEEECCCHH
VITQLSRLDGVGVWTAEMLLISSLSRPDIVSWGDLAIRRGMMNLYRHKTLPRERFERYRR
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RYTPYGTTASLYLWALSHKTLED
HCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFYTYGETEINHLKRRDKKMAAAIERLGMLERPLSPDLFAALIRNIVDQQISVKAAQTVN
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TRLTLLLGSITPATVAAASAEAIQRCGMTMRKAGYIKGAADAAINGSLDLSVIAQLPDNE
HHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHCCCCCCHHHEEECCCHH
VITQLSRLDGVGVWTAEMLLISSLSRPDIVSWGDLAIRRGMMNLYRHKTLPRERFERYRR
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RYTPYGTTASLYLWALSHKTLED
HCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377 [H]