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The map label for this gene is hmsR [H]

Identifier: 170024468

GI number: 170024468

Start: 2482935

End: 2484269

Strand: Reverse

Name: hmsR [H]

Synonym: YPK_2239

Alternate gene names: 170024468

Gene position: 2484269-2482935 (Counterclockwise)

Preceding gene: 170024469

Following gene: 170024467

Centisome position: 52.98

GC content: 51.01

Gene sequence:

>1335_bases
ATGATCGATAGAATTATTGCTTTACTCATCCTATGTCTGGTGCTGAGTATCCCTGCGGGAATGATTTTGCTCTTTACCGG
CGATGTACTGCTGAACTTTGTTTTCTTCTATCCACTTTTTATGTCCGGTATTTGGATAACCGGGGGGGTCTATTTCTGGC
TACGCCGAGAGAGGCACTGGCCGTGGGGCGATGATGTCCCCGCACCAGAGCTGAAAGGTCATCCGCTCGTGTCTATCTTA
GTCCCTTGTTTCAATGAGGGGTTGAATGCACGGGAAACCATTCACGCAGCACTGGCACAGACCTACACCAATATTGAAGT
TATTGCTATTAACGATGGCTCCAGTGACGATACCGCACAAGTCCTAGATGCGCTGCTTGCTGAAGATCCACGCTTGCGCG
TCATTCATCTGGCTCATAATCAGGGTAAAGCGATTGCCCTGCGTATGGGGGCCGCCGCCGCCCGCAGTGAATATCTGGTC
TGTATCGATGGTGATGCCTTGTTGGACAAGAATGCGGTGCCTTATCTGGTCGCGCCACTGATTGCGAATCCGCGTACTGG
CGCGGTGACCGGTAACCCACGTATTCGTACCCGTTCGACATTGATTGGCCGCGTTCAGGTCGGGGAGTTCTCTTCGATCA
TTGGTTTGATTAAGCGGACACAGCGAGTCTACGGCCAAGTGTTTACCGTCTCCGGTGTGGTCGCCGCTTTTCGCCGTAGA
GCACTGGCGGATGTTGGCTACTGGAGCCCGGATATGATCACGGAAGATATTGATATTAGTTGGAAACTACAGCTGAAGCA
CTGGTCGGTATTCTTCGAACCCCGTGGGTTGTGTTGGATTTTGATGCCTGAAACCCTGCGCGGCTTGTGGAAACAGCGTC
TCCGCTGGGCGCAAGGCGGTGCGGAAGTATTTTTGAAAAATATGTTCAAACTTTGGCGCTGGCGTAACCGCCGGATGTGG
CTGCTGTTTCTGGAGTATTCGTTGTCGATCACTTGGGCATTCACTTACCTGTTTAGCATCACATTATACCTATTGGGGCT
GGTTATCACTCTGCCGCCGGGTATTCATGTTCAAAGTGTCTTCCCGCCAGCCTTTACCGGGATGGTATTGGCACTGACAT
GTCTATTGCAATTTGCTATTAGTCTGGTGATCGAACGCCGCTATGAACCTAAACTGGGTCATTCCCTGTTTTGGATTATC
TGGTATCCCATGGTTTATTGGATGCTTAACTTGTTTACCACGGTGGTGTCGTTCCCGAAAGTGATGCTTATCACCAAGCG
TAAGCGTGCGCGTTGGGTAAGCCCTGATCGCGGCATTGGGAGGGTGAAATCATGA

Upstream 100 bases:

>100_bases
GGTGCGCAAAGTTTTGGTTACTACCCGGATAACTTTATTACTGGCGAACCACCGCTAAAAGATGTCCGCCCTGTGCTGTC
TTCTGCCTGGTACCCTTTAT

Downstream 100 bases:

>100_bases
GTACGCCCCTGATTTTTACGGAACAGCGTCTGCTACCGCGTTGGATTGACATTATCATTACGGCGTTAGCCTGGTTTGGT
TTTGTCTTCCTGCTGGTGCG

Product: N-glycosyltransferase

Products: NA

Alternate protein names: PGA synthase; Poly-beta-1,6-GlcNAc synthase; Biofilm PGA synthesis protein PgaC; N-acetylglucosaminyltransferase PgaC [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MIDRIIALLILCLVLSIPAGMILLFTGDVLLNFVFFYPLFMSGIWITGGVYFWLRRERHWPWGDDVPAPELKGHPLVSIL
VPCFNEGLNARETIHAALAQTYTNIEVIAINDGSSDDTAQVLDALLAEDPRLRVIHLAHNQGKAIALRMGAAAARSEYLV
CIDGDALLDKNAVPYLVAPLIANPRTGAVTGNPRIRTRSTLIGRVQVGEFSSIIGLIKRTQRVYGQVFTVSGVVAAFRRR
ALADVGYWSPDMITEDIDISWKLQLKHWSVFFEPRGLCWILMPETLRGLWKQRLRWAQGGAEVFLKNMFKLWRWRNRRMW
LLFLEYSLSITWAFTYLFSITLYLLGLVITLPPGIHVQSVFPPAFTGMVLALTCLLQFAISLVIERRYEPKLGHSLFWII
WYPMVYWMLNLFTTVVSFPKVMLITKRKRARWVSPDRGIGRVKS

Sequences:

>Translated_444_residues
MIDRIIALLILCLVLSIPAGMILLFTGDVLLNFVFFYPLFMSGIWITGGVYFWLRRERHWPWGDDVPAPELKGHPLVSIL
VPCFNEGLNARETIHAALAQTYTNIEVIAINDGSSDDTAQVLDALLAEDPRLRVIHLAHNQGKAIALRMGAAAARSEYLV
CIDGDALLDKNAVPYLVAPLIANPRTGAVTGNPRIRTRSTLIGRVQVGEFSSIIGLIKRTQRVYGQVFTVSGVVAAFRRR
ALADVGYWSPDMITEDIDISWKLQLKHWSVFFEPRGLCWILMPETLRGLWKQRLRWAQGGAEVFLKNMFKLWRWRNRRMW
LLFLEYSLSITWAFTYLFSITLYLLGLVITLPPGIHVQSVFPPAFTGMVLALTCLLQFAISLVIERRYEPKLGHSLFWII
WYPMVYWMLNLFTTVVSFPKVMLITKRKRARWVSPDRGIGRVKS
>Mature_444_residues
MIDRIIALLILCLVLSIPAGMILLFTGDVLLNFVFFYPLFMSGIWITGGVYFWLRRERHWPWGDDVPAPELKGHPLVSIL
VPCFNEGLNARETIHAALAQTYTNIEVIAINDGSSDDTAQVLDALLAEDPRLRVIHLAHNQGKAIALRMGAAAARSEYLV
CIDGDALLDKNAVPYLVAPLIANPRTGAVTGNPRIRTRSTLIGRVQVGEFSSIIGLIKRTQRVYGQVFTVSGVVAAFRRR
ALADVGYWSPDMITEDIDISWKLQLKHWSVFFEPRGLCWILMPETLRGLWKQRLRWAQGGAEVFLKNMFKLWRWRNRRMW
LLFLEYSLSITWAFTYLFSITLYLLGLVITLPPGIHVQSVFPPAFTGMVLALTCLLQFAISLVIERRYEPKLGHSLFWII
WYPMVYWMLNLFTTVVSFPKVMLITKRKRARWVSPDRGIGRVKS

Specific function: Probable N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N- acetylglucosamine to produce the linear homopolymer poly-beta-1,6- N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide [H]

COG id: COG1215

COG function: function code M; Glycosyltransferases, probably involved in cell wall biogenesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 2 family [H]

Homologues:

Organism=Escherichia coli, GI1787259, Length=441, Percent_Identity=66.2131519274376, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI1790044, Length=89, Percent_Identity=31.4606741573034, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: NA

Molecular weight: Translated: 50664; Mature: 50664

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRIIALLILCLVLSIPAGMILLFTGDVLLNFVFFYPLFMSGIWITGGVYFWLRRERHW
CHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEEECCCC
PWGDDVPAPELKGHPLVSILVPCFNEGLNARETIHAALAQTYTNIEVIAINDGSSDDTAQ
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH
VLDALLAEDPRLRVIHLAHNQGKAIALRMGAAAARSEYLVCIDGDALLDKNAVPYLVAPL
HHHHHHCCCCCEEEEEEECCCCCEEEEEECCHHCCCCEEEEECCCHHCCCCCCCHHHHHH
IANPRTGAVTGNPRIRTRSTLIGRVQVGEFSSIIGLIKRTQRVYGQVFTVSGVVAAFRRR
HCCCCCCCCCCCCCEEEHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALADVGYWSPDMITEDIDISWKLQLKHWSVFFEPRGLCWILMPETLRGLWKQRLRWAQGG
HHHHCCCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCH
AEVFLKNMFKLWRWRNRRMWLLFLEYSLSITWAFTYLFSITLYLLGLVITLPPGIHVQSV
HHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
FPPAFTGMVLALTCLLQFAISLVIERRYEPKLGHSLFWIIWYPMVYWMLNLFTTVVSFPK
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
VMLITKRKRARWVSPDRGIGRVKS
EEEEECHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIDRIIALLILCLVLSIPAGMILLFTGDVLLNFVFFYPLFMSGIWITGGVYFWLRRERHW
CHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEEECCCC
PWGDDVPAPELKGHPLVSILVPCFNEGLNARETIHAALAQTYTNIEVIAINDGSSDDTAQ
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH
VLDALLAEDPRLRVIHLAHNQGKAIALRMGAAAARSEYLVCIDGDALLDKNAVPYLVAPL
HHHHHHCCCCCEEEEEEECCCCCEEEEEECCHHCCCCEEEEECCCHHCCCCCCCHHHHHH
IANPRTGAVTGNPRIRTRSTLIGRVQVGEFSSIIGLIKRTQRVYGQVFTVSGVVAAFRRR
HCCCCCCCCCCCCCEEEHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALADVGYWSPDMITEDIDISWKLQLKHWSVFFEPRGLCWILMPETLRGLWKQRLRWAQGG
HHHHCCCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCH
AEVFLKNMFKLWRWRNRRMWLLFLEYSLSITWAFTYLFSITLYLLGLVITLPPGIHVQSV
HHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
FPPAFTGMVLALTCLLQFAISLVIERRYEPKLGHSLFWIIWYPMVYWMLNLFTTVVSFPK
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
VMLITKRKRARWVSPDRGIGRVKS
EEEEECHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]