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The map label for this gene is zwf [H]

Identifier: 170024368

GI number: 170024368

Start: 2364075

End: 2365559

Strand: Reverse

Name: zwf [H]

Synonym: YPK_2134

Alternate gene names: 170024368

Gene position: 2365559-2364075 (Counterclockwise)

Preceding gene: 170024372

Following gene: 170024367

Centisome position: 50.44

GC content: 48.42

Gene sequence:

>1485_bases
ATGGCAGTAATGAATACAGTCCAGGTAGCCCAGGCGTGTGACCTGGTGATTTTCGGCGCTAAAGGTGATTTGGCTCGCCG
GAAACTGCTGCCTTCTCTTTACCAATTAGAAAAAGCGGGTCATATCCACCCAGATACTCGGATAATCGGTGTTGGCCGTG
CTGAGTGGGATAAAGATGCGTACACCGCTGTGGTAAAGGAAGCCCTCGATACCTTTATGAAAGAGCCGCTGGATGACGAG
CTATGGCAAAAACTCAGCTCGCGCCTCGACTTCTGCAATCTGGATGTGAATGACAGTAAGCATTTCACCAAATTAGGTAA
AATGCTCGATCAAAAACATCGCACCACGATTAACTACTTTGCTATGCCGCCGAGTACATTTGGTGCGATTTGTAAAGGCC
TGGGAGAAGCCGGGTTAAATAAAGAGCCTAGCCGAGTGGTAATGGAAAAACCATTGGGAACCGATTTAGCGTCCTCAAGG
GTAATTAACGATCAGGTAGCCGAGTATTTCAACGAATGTCAGGTTTACCGTATTGACCACTATTTAGGGAAAGAAACGGT
ATTAAACCTGTTGGCGCTTCGCTTCGCTAACTCGTTGTTCGCCTCAAACTGGGACAACCGCACTATCGATCATGTGCAAA
TTACCGTCGCAGAAGAGGTCGGAATTGAAGGGCGTTGGGGCTATTTTGATCAGGCCGGTCAGATGCGTGACATGATCCAA
AACCATCTGTTGCAAATCCTGACGATGATCGCCATGTCACCCCCCGCAGATCTCAGTACGGATCGCATCCGTGATGAAAA
AGTAAAAGTACTGCGTTCGCTGCGCCGTATTGATCACACCAATGTGCGCGAAACTACAGTTCGTGGGCAATATACTGCCG
GCTTTGTACAGGGCAATAAAGTGCCGGGTTATCTGGAAGAGGAAGGCGCGAATAAGAATAGCAATACCGAAACATTTGTG
TCTATTCGGGTGGATATCGATGACTGGCGTTGGGCTGGGGTACCTTTCTACCTGAGAACCGGTAAGCGCCTACCCAGCAA
ATGCTCTGAAGTTGTGGTTTACTTTAAGAACCCCGCACTGAATCTCTTCCGCGAATCTTATCAACAACTGCCACAAAACA
AACTGACAATTCGTCTGCAACCGGACGAAGGGATCGAAATTGAAGTGCTGAATAAAGTCCCCGGATTGGAACATAAGCAT
CGTTTACAAACCACTAAGCTTGATCTCAGTTTCTCCAAAACCTTCAATGAGCAGCATATTGCTGATGCCTATGAACGTCT
GCTACTGGAGACCATGCGGGGTATTCAAGCGCTGTTTGTGCGCCGTGATGAGGTCGAAGAGGCGTGGAAATGGGTCGATT
CTATTATGAATGCGTGGGCGGCAGATAATGAAGCACCAAAACCATACCAGTCCGGTACATGGGGGCCTGTGGCATCCGTT
GCTATGATCACCCGTGATGGCCGGTCATGGAATGAGTTCGAGTAA

Upstream 100 bases:

>100_bases
CTTTTTTGACGCATTTTTATCTGGGTTTACTGGCTATAGTCAAAGAGAGTACATTAGTAATGTAAGAAAATTACAAATAT
CCTGCAACGAGGAGAATAGC

Downstream 100 bases:

>100_bases
TCGCTAACCGCACGATAATAGCGCGCCACCAGAGGCGAATCTGATGGCGCGTGACTGCCAGGGAGAGCAGGGGGCAGCCT
GCGTAATAATAAAGAGCGAG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MAVMNTVQVAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYTAVVKEALDTFMKEPLDDE
LWQKLSSRLDFCNLDVNDSKHFTKLGKMLDQKHRTTINYFAMPPSTFGAICKGLGEAGLNKEPSRVVMEKPLGTDLASSR
VINDQVAEYFNECQVYRIDHYLGKETVLNLLALRFANSLFASNWDNRTIDHVQITVAEEVGIEGRWGYFDQAGQMRDMIQ
NHLLQILTMIAMSPPADLSTDRIRDEKVKVLRSLRRIDHTNVRETTVRGQYTAGFVQGNKVPGYLEEEGANKNSNTETFV
SIRVDIDDWRWAGVPFYLRTGKRLPSKCSEVVVYFKNPALNLFRESYQQLPQNKLTIRLQPDEGIEIEVLNKVPGLEHKH
RLQTTKLDLSFSKTFNEQHIADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSIMNAWAADNEAPKPYQSGTWGPVASV
AMITRDGRSWNEFE

Sequences:

>Translated_494_residues
MAVMNTVQVAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYTAVVKEALDTFMKEPLDDE
LWQKLSSRLDFCNLDVNDSKHFTKLGKMLDQKHRTTINYFAMPPSTFGAICKGLGEAGLNKEPSRVVMEKPLGTDLASSR
VINDQVAEYFNECQVYRIDHYLGKETVLNLLALRFANSLFASNWDNRTIDHVQITVAEEVGIEGRWGYFDQAGQMRDMIQ
NHLLQILTMIAMSPPADLSTDRIRDEKVKVLRSLRRIDHTNVRETTVRGQYTAGFVQGNKVPGYLEEEGANKNSNTETFV
SIRVDIDDWRWAGVPFYLRTGKRLPSKCSEVVVYFKNPALNLFRESYQQLPQNKLTIRLQPDEGIEIEVLNKVPGLEHKH
RLQTTKLDLSFSKTFNEQHIADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSIMNAWAADNEAPKPYQSGTWGPVASV
AMITRDGRSWNEFE
>Mature_493_residues
AVMNTVQVAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYTAVVKEALDTFMKEPLDDEL
WQKLSSRLDFCNLDVNDSKHFTKLGKMLDQKHRTTINYFAMPPSTFGAICKGLGEAGLNKEPSRVVMEKPLGTDLASSRV
INDQVAEYFNECQVYRIDHYLGKETVLNLLALRFANSLFASNWDNRTIDHVQITVAEEVGIEGRWGYFDQAGQMRDMIQN
HLLQILTMIAMSPPADLSTDRIRDEKVKVLRSLRRIDHTNVRETTVRGQYTAGFVQGNKVPGYLEEEGANKNSNTETFVS
IRVDIDDWRWAGVPFYLRTGKRLPSKCSEVVVYFKNPALNLFRESYQQLPQNKLTIRLQPDEGIEIEVLNKVPGLEHKHR
LQTTKLDLSFSKTFNEQHIADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSIMNAWAADNEAPKPYQSGTWGPVASVA
MITRDGRSWNEFE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=34.5755693581781, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI109389365, Length=480, Percent_Identity=34.7916666666667, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI52145310, Length=514, Percent_Identity=25.875486381323, Blast_Score=150, Evalue=4e-36,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=84.5213849287169, Blast_Score=887, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=35.0515463917526, Blast_Score=295, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6324088, Length=486, Percent_Identity=33.5390946502058, Blast_Score=281, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24643350, Length=471, Percent_Identity=35.8811040339703, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24643352, Length=471, Percent_Identity=35.8811040339703, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI221513548, Length=491, Percent_Identity=27.0875763747454, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56433; Mature: 56302

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVMNTVQVAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDA
CCCCHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHH
YTAVVKEALDTFMKEPLDDELWQKLSSRLDFCNLDVNDSKHFTKLGKMLDQKHRTTINYF
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCEEEEE
AMPPSTFGAICKGLGEAGLNKEPSRVVMEKPLGTDLASSRVINDQVAEYFNECQVYRIDH
ECCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEHHH
YLGKETVLNLLALRFANSLFASNWDNRTIDHVQITVAEEVGIEGRWGYFDQAGQMRDMIQ
HHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHCCCCCCCCCHHHHHHHHHHHH
NHLLQILTMIAMSPPADLSTDRIRDEKVKVLRSLRRIDHTNVRETTVRGQYTAGFVQGNK
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCEEEEEEECCC
VPGYLEEEGANKNSNTETFVSIRVDIDDWRWAGVPFYLRTGKRLPSKCSEVVVYFKNPAL
CCCCHHHCCCCCCCCCEEEEEEEEEECCCEECCCCCEECCCCCCCCCHHHEEEEECCCHH
NLFRESYQQLPQNKLTIRLQPDEGIEIEVLNKVPGLEHKHRLQTTKLDLSFSKTFNEQHI
HHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHEEEEEHHHHCCHHHH
ADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSIMNAWAADNEAPKPYQSGTWGPVASV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
AMITRDGRSWNEFE
HEEECCCCCCCCCC
>Mature Secondary Structure 
AVMNTVQVAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDA
CCCHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHH
YTAVVKEALDTFMKEPLDDELWQKLSSRLDFCNLDVNDSKHFTKLGKMLDQKHRTTINYF
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCEEEEE
AMPPSTFGAICKGLGEAGLNKEPSRVVMEKPLGTDLASSRVINDQVAEYFNECQVYRIDH
ECCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEHHH
YLGKETVLNLLALRFANSLFASNWDNRTIDHVQITVAEEVGIEGRWGYFDQAGQMRDMIQ
HHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHCCCCCCCCCHHHHHHHHHHHH
NHLLQILTMIAMSPPADLSTDRIRDEKVKVLRSLRRIDHTNVRETTVRGQYTAGFVQGNK
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCEEEEEEECCC
VPGYLEEEGANKNSNTETFVSIRVDIDDWRWAGVPFYLRTGKRLPSKCSEVVVYFKNPAL
CCCCHHHCCCCCCCCCEEEEEEEEEECCCEECCCCCEECCCCCCCCCHHHEEEEECCCHH
NLFRESYQQLPQNKLTIRLQPDEGIEIEVLNKVPGLEHKHRLQTTKLDLSFSKTFNEQHI
HHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHEEEEEHHHHCCHHHH
ADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSIMNAWAADNEAPKPYQSGTWGPVASV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
AMITRDGRSWNEFE
HEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]