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The map label for this gene is fadR [H]

Identifier: 170024343

GI number: 170024343

Start: 2340069

End: 2340788

Strand: Reverse

Name: fadR [H]

Synonym: YPK_2109

Alternate gene names: 170024343

Gene position: 2340788-2340069 (Counterclockwise)

Preceding gene: 170024346

Following gene: 170024341

Centisome position: 49.92

GC content: 46.11

Gene sequence:

>720_bases
ATGGTTATAAAGGCGCAAAGTCCTGCCGGTTTCGCGGAAGAGTATATTATTGAAAGTATTTGGAATAATCGCTTTCCTCC
AGGATCTATTTTGCCCGCGGAGCGTGAACTTTCTGAGCTGATTGGTGTGACTCGCACAACATTGCGCGAAGTACTACAAC
GGCTAGCCCGCGATGGCTGGCTCACTATTCAGCACGGTAAGCCAACGAAAGTAAACAATTTTTGGGAGACATCTGGTCTA
AATATTTTGGAAACACTGGCGCGGCTTGACCATGACAGCGTTCCACAATTGATAGATAACTTACTGGCTGTTCGAACCAA
TATTGCCACTATTTTTGTGCGGACAGCTATCCGTCATCATCCAGAAAAAGCGCAAGAAATTTTGGCGCGAGCGAAAACAG
TGGATGATAACGCAGAAGCCTTTACTGCTCTTGATTATGGTATTTTCCGTGGTTTGGCATTTGCCTCAGGCAATCCGATT
TATGGTTTGATTCTTAATGGTTTGAAAGGGCTTTACACCCGAGTAGGGCGTTATTACTTTTCTAATCCAGAAGCGCGCAA
GCTGGCACTGACTTTTTACAATAAACTGTCGACGTTATGTGATACAGAATCTTATGATCAGGTACTAGAGTGCCTGCGCA
CATACGGCAAAGAGAGCGGGGCTATCTGGCATAGCATGCAGGGCACCATGCCAAGTGATTTGGCCGAAGCGCGTCGTTAG

Upstream 100 bases:

>100_bases
TTCACCATTTGTTCGGCTCTGGCGCTATATTGGATTACACTCGTCTGGTATGATGAGCGGACTAAATTGCTGATATTTAT
CGCTACGGAACGTCAAAAAC

Downstream 100 bases:

>100_bases
GCGATAAAGCAGAAAAGCGAAGGGGCGTTTAATGCCCCTGAGGTTATTGACAACGCTATTTTTAGCCTCGTGAGTGAAGG
GGTGACCGCACCTCGGGGCA

Product: fatty acid metabolism regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MVIKAQSPAGFAEEYIIESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL
NILETLARLDHDSVPQLIDNLLAVRTNIATIFVRTAIRHHPEKAQEILARAKTVDDNAEAFTALDYGIFRGLAFASGNPI
YGLILNGLKGLYTRVGRYYFSNPEARKLALTFYNKLSTLCDTESYDQVLECLRTYGKESGAIWHSMQGTMPSDLAEARR

Sequences:

>Translated_239_residues
MVIKAQSPAGFAEEYIIESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL
NILETLARLDHDSVPQLIDNLLAVRTNIATIFVRTAIRHHPEKAQEILARAKTVDDNAEAFTALDYGIFRGLAFASGNPI
YGLILNGLKGLYTRVGRYYFSNPEARKLALTFYNKLSTLCDTESYDQVLECLRTYGKESGAIWHSMQGTMPSDLAEARR
>Mature_239_residues
MVIKAQSPAGFAEEYIIESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL
NILETLARLDHDSVPQLIDNLLAVRTNIATIFVRTAIRHHPEKAQEILARAKTVDDNAEAFTALDYGIFRGLAFASGNPI
YGLILNGLKGLYTRVGRYYFSNPEARKLALTFYNKLSTLCDTESYDQVLECLRTYGKESGAIWHSMQGTMPSDLAEARR

Specific function: Multifunctional regulator of fatty acid metabolism [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787436, Length=235, Percent_Identity=82.1276595744681, Blast_Score=409, Evalue=1e-116,
Organism=Escherichia coli, GI1789621, Length=229, Percent_Identity=27.0742358078603, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014178
- InterPro:   IPR008920
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07840 FadR_C; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 26902; Mature: 26902

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIKAQSPAGFAEEYIIESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGW
CEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTIQHGKPTKVNNFWETSGLNILETLARLDHDSVPQLIDNLLAVRTNIATIFVRTAIRHH
EEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
PEKAQEILARAKTVDDNAEAFTALDYGIFRGLAFASGNPIYGLILNGLKGLYTRVGRYYF
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
SNPEARKLALTFYNKLSTLCDTESYDQVLECLRTYGKESGAIWHSMQGTMPSDLAEARR
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHCC
>Mature Secondary Structure
MVIKAQSPAGFAEEYIIESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGW
CEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTIQHGKPTKVNNFWETSGLNILETLARLDHDSVPQLIDNLLAVRTNIATIFVRTAIRHH
EEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
PEKAQEILARAKTVDDNAEAFTALDYGIFRGLAFASGNPIYGLILNGLKGLYTRVGRYYF
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
SNPEARKLALTFYNKLSTLCDTESYDQVLECLRTYGKESGAIWHSMQGTMPSDLAEARR
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA; DNA [C]

Specific reaction: Activates transcription of at least two genes required for unsaturated fatty acid biosynthesis; activates the iclR gene encoding the transcription regulator of the aceBAKoperon which in turn encodes the glyoxylate shunt enzymes Protein + DNA = Protein-DN

General reaction: NA

Inhibitor: Fatty acyl CoA compounds [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA