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The map label for this gene is ydhC [H]

Identifier: 170024098

GI number: 170024098

Start: 2066854

End: 2068056

Strand: Reverse

Name: ydhC [H]

Synonym: YPK_1859

Alternate gene names: 170024098

Gene position: 2068056-2066854 (Counterclockwise)

Preceding gene: 170024100

Following gene: 170024097

Centisome position: 44.1

GC content: 50.54

Gene sequence:

>1203_bases
ATGAAAACGTCATCCAGTTTCATGTTCTATCTGGCCGGCCTGAGTATGCTGGGTTATTTGGCCACAGACATGTATCTCCC
CGCCTTCGGTGCAATGCAACGCGAACTGCAAACCACCGCCGGTGCCATCAGCGCCAGTTTAAGTATTTTTCTGGCCGGTT
TTGCCATAGCACAGCTTATCTGGGGGCCCCTTTCAGACAAATTGGGCCGCAAGCCTGTCCTGTTAGCGGGTTTGGGGTTA
TTTGCCATCGGTTGCTTAGGGATGTTATGGGTTGAAAATGCCACTCAATTGTTGGTTCTACGCTTCATACAAGCCGTGGG
CGTCTGTTCAGCGGCGGTGAGCTGGCAGGCTTTAGTGGTAGACCGCTATCGCGACGGGAAGGCCAACCGCGTGTTTGCCA
CTATAATGCCGCTGGTTGCCTTATCACCCGCATTAGCGCCGTTATTAGGTGCCTGGTTACTGAACCACTTCAGTTGGCGG
TCAATTTTTGTAGTTCTATTAGCCATTACACTGCTCTTACTGATCCCGACAATGGTGCTGCAAGAAAGGAAAAAAGCACG
CGCCGATAACAGCGATCAACCTAAAAACACGGTGAGTTTCTGGCAACTGCTCCAATCACCCACATTCAGTGGCAACGTCA
TGATCTTTGCTGCCTGTAGTGCTGGCTTCTTTGCTTGGCTAACGGGTTCACCTTTCATTCTGGAAAATATGGGGTACAGC
CCAAATGTTATTGGCTTGAGTTATGTCCCACAGACGCTGGCTTTTCTGCTTGGTGGATTTGGTTGCCGCAGTGCACTTGC
CCACATAAAAGGGAACACCCTGCTACCCTGGCTGTTAGTGGGCTATGCTGGCAGCATGATTGCCCTGTACTTGATCGCCA
CCTTAACAACGCCATCATTGCTCACGTTGCTTATCCCTTTCTGCTTAATGGCGCTTGTGAATGGTGCCTGCTACCCTATT
ATCGTAGCGAATGCATTAATGCCGTTTCCAGACAATACCGGCAAAGCGGCGGCCTTGCAGAATACCCTGCAACTCGGTTT
GTGCTTTGTGGCCAGTATGTTGGTATCGGCCTATATCAGCCAGCCGCTCTTGGCGACAGTGACAGTGATGCTATTGACGG
TAGTTTTGGCGGCTTTGGGTTACGGCATCCATTGTTACGCGTTACGTAAAGACAAAACCAGATTGATGACTCGGACACCA
TAA

Upstream 100 bases:

>100_bases
TTTGCAACAATAATCAGTAACGACAATAACCGTATTCTGTAGCACCCTTTTACTACACAAATAATTTACCTGCACAATTA
TGATAAAAGAGAAATAAAGA

Downstream 100 bases:

>100_bases
CCAAAATGAGTCGAGTGGTTGGAAAGCAGCCAGTAGATATGCAGCTTGGTGTATGACGGGTATATAGCCCAACACATAAT
TCCCTTGGGAAATAGTCACT

Product: inner membrane transport protein YdhC

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKTSSSFMFYLAGLSMLGYLATDMYLPAFGAMQRELQTTAGAISASLSIFLAGFAIAQLIWGPLSDKLGRKPVLLAGLGL
FAIGCLGMLWVENATQLLVLRFIQAVGVCSAAVSWQALVVDRYRDGKANRVFATIMPLVALSPALAPLLGAWLLNHFSWR
SIFVVLLAITLLLLIPTMVLQERKKARADNSDQPKNTVSFWQLLQSPTFSGNVMIFAACSAGFFAWLTGSPFILENMGYS
PNVIGLSYVPQTLAFLLGGFGCRSALAHIKGNTLLPWLLVGYAGSMIALYLIATLTTPSLLTLLIPFCLMALVNGACYPI
IVANALMPFPDNTGKAAALQNTLQLGLCFVASMLVSAYISQPLLATVTVMLLTVVLAALGYGIHCYALRKDKTRLMTRTP

Sequences:

>Translated_400_residues
MKTSSSFMFYLAGLSMLGYLATDMYLPAFGAMQRELQTTAGAISASLSIFLAGFAIAQLIWGPLSDKLGRKPVLLAGLGL
FAIGCLGMLWVENATQLLVLRFIQAVGVCSAAVSWQALVVDRYRDGKANRVFATIMPLVALSPALAPLLGAWLLNHFSWR
SIFVVLLAITLLLLIPTMVLQERKKARADNSDQPKNTVSFWQLLQSPTFSGNVMIFAACSAGFFAWLTGSPFILENMGYS
PNVIGLSYVPQTLAFLLGGFGCRSALAHIKGNTLLPWLLVGYAGSMIALYLIATLTTPSLLTLLIPFCLMALVNGACYPI
IVANALMPFPDNTGKAAALQNTLQLGLCFVASMLVSAYISQPLLATVTVMLLTVVLAALGYGIHCYALRKDKTRLMTRTP
>Mature_400_residues
MKTSSSFMFYLAGLSMLGYLATDMYLPAFGAMQRELQTTAGAISASLSIFLAGFAIAQLIWGPLSDKLGRKPVLLAGLGL
FAIGCLGMLWVENATQLLVLRFIQAVGVCSAAVSWQALVVDRYRDGKANRVFATIMPLVALSPALAPLLGAWLLNHFSWR
SIFVVLLAITLLLLIPTMVLQERKKARADNSDQPKNTVSFWQLLQSPTFSGNVMIFAACSAGFFAWLTGSPFILENMGYS
PNVIGLSYVPQTLAFLLGGFGCRSALAHIKGNTLLPWLLVGYAGSMIALYLIATLTTPSLLTLLIPFCLMALVNGACYPI
IVANALMPFPDNTGKAAALQNTLQLGLCFVASMLVSAYISQPLLATVTVMLLTVVLAALGYGIHCYALRKDKTRLMTRTP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=383, Percent_Identity=65.5352480417755, Blast_Score=486, Evalue=1e-139,
Organism=Escherichia coli, GI1788509, Length=415, Percent_Identity=27.2289156626506, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1787065, Length=217, Percent_Identity=26.2672811059908, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790794, Length=225, Percent_Identity=25.3333333333333, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790146, Length=221, Percent_Identity=28.9592760180996, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082312, Length=331, Percent_Identity=24.4712990936556, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324264, Length=194, Percent_Identity=25.2577319587629, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319657, Length=199, Percent_Identity=29.1457286432161, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43051; Mature: 43051

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHCCCCCC
>Mature Secondary Structure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CCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]