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The map label for this gene is mscM [H]

Identifier: 170023882

GI number: 170023882

Start: 1819765

End: 1821009

Strand: Reverse

Name: mscM [H]

Synonym: YPK_1641

Alternate gene names: 170023882

Gene position: 1821009-1819765 (Counterclockwise)

Preceding gene: 170023884

Following gene: 170023874

Centisome position: 38.83

GC content: 50.12

Gene sequence:

>1245_bases
ATGCAACAAAGAATAAGCCAGTGGCTGGAAAGATTGGGGATGGAGTTCTCCGATGTGATGTCATTGACGATGGTGATTGG
GCTAATATTATTGATTTCTGTGATGATCCATCTGGTGCTACACCGTGTAGTTCTGGCCGCCCTCCAGCGCCGTGGGCAAC
AATCGCAACGCATCTGGCAACAGGCCATCACAAAACACAAACTGTTCCAACGCGTAGCGCTACTGCTGCAAGGGATCATC
ATCAATCTCCAGGCCGTACTGTGGTTGCAAAACGGCAGCCAGACGCAGGCAGTTATCGTTACCGCCGCGCAGGTGTGGAT
TATGGCCTTCGCTCTGCTGGCTCTATTTTCTTTACTTGATACCTTGCTAGCCCTGCTCCGCCAGAGTTCAGTTGCTCATC
AATTACCCCTGCGCGGTATCTGCCAAGGGCTGAAACTGGTGGCTGCGATATTTATCGGCATCATGATCGTTTCGCTGTTG
ATGGGCCGATCACCCCTGTTGCTACTCAGCGGCTTAGGGGCCATGACGGCAGTATTGATGTTGGTGTTCAAAGACCCAAT
CCTTGGTCTGGTGGCAGGTATTCAGCTCTCTGCTAACGATATGCTAAAAATTGGCGATTGGCTGGAAATGCCAAAATATG
GGGCTGATGGCGCAGTGACCGATATTGGCCTGACTACAGTAAAAGTAAGAAATTGGGATAACACCGTCACGACCATCCCA
ACTTATGCGCTTATTTCCGATTCCTTCAAGAACTGGCGCTCAATGTCGGAATCCGGTGGCCGACGTATAAAACGCAGCAT
CAATATTGATACCACCAGCGTACATTTTCTGTCAGAACAGGAACAACAGCGCCTCACCCTCAACCCGCTGTTACAACACT
ACCTCAGTGAAAAATCGCAGGAACTGAACCAATATAATCAGCAGATAGCCCTCGACCTCAGTTCACCACTCAATGGCCGC
CGCCTGACTAACATTGGAACGTTGCGCGCCTATCTGGTGGCTTATCTGCGGGCACATCTGGGGATCCATCAGTCGATGAC
ATTAATGGTGCGCCAACTTGCCCCAACACCCGAGGGCTTGCCGCTAGAAGTTTATGCTTTTACCAACACCACGATATGGG
CAGAATACGAAGGTATTCAGGCAGATATTTTTGACCACATCTTTGCCGTGGTGAGTGAGTTTGATCTGCGAATCCACCAA
ACACCAAGCGGTAACGATATGCGCAGTATGCTTGCCAAAGTCTAA

Upstream 100 bases:

>100_bases
CAGAACCACAATGTAAAAAAGGGTAAACAGGTGCCCCCCCTGCGCCTATAGCCTTTAGGCTAAGGCCTTTTAGTCAGATT
GATGCTTTATAGGAGCAGTG

Downstream 100 bases:

>100_bases
CGAAATCATTTTTACTGGTAATTATCCTCAGCTAATTGCCAGTAAATGCCCCCTACCCGCCACTCTCTTGGTAGCAACCA
TAATTAATATGTGAGGCCCG

Product: mechanosensitive ion channel MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MQQRISQWLERLGMEFSDVMSLTMVIGLILLISVMIHLVLHRVVLAALQRRGQQSQRIWQQAITKHKLFQRVALLLQGII
INLQAVLWLQNGSQTQAVIVTAAQVWIMAFALLALFSLLDTLLALLRQSSVAHQLPLRGICQGLKLVAAIFIGIMIVSLL
MGRSPLLLLSGLGAMTAVLMLVFKDPILGLVAGIQLSANDMLKIGDWLEMPKYGADGAVTDIGLTTVKVRNWDNTVTTIP
TYALISDSFKNWRSMSESGGRRIKRSINIDTTSVHFLSEQEQQRLTLNPLLQHYLSEKSQELNQYNQQIALDLSSPLNGR
RLTNIGTLRAYLVAYLRAHLGIHQSMTLMVRQLAPTPEGLPLEVYAFTNTTIWAEYEGIQADIFDHIFAVVSEFDLRIHQ
TPSGNDMRSMLAKV

Sequences:

>Translated_414_residues
MQQRISQWLERLGMEFSDVMSLTMVIGLILLISVMIHLVLHRVVLAALQRRGQQSQRIWQQAITKHKLFQRVALLLQGII
INLQAVLWLQNGSQTQAVIVTAAQVWIMAFALLALFSLLDTLLALLRQSSVAHQLPLRGICQGLKLVAAIFIGIMIVSLL
MGRSPLLLLSGLGAMTAVLMLVFKDPILGLVAGIQLSANDMLKIGDWLEMPKYGADGAVTDIGLTTVKVRNWDNTVTTIP
TYALISDSFKNWRSMSESGGRRIKRSINIDTTSVHFLSEQEQQRLTLNPLLQHYLSEKSQELNQYNQQIALDLSSPLNGR
RLTNIGTLRAYLVAYLRAHLGIHQSMTLMVRQLAPTPEGLPLEVYAFTNTTIWAEYEGIQADIFDHIFAVVSEFDLRIHQ
TPSGNDMRSMLAKV
>Mature_414_residues
MQQRISQWLERLGMEFSDVMSLTMVIGLILLISVMIHLVLHRVVLAALQRRGQQSQRIWQQAITKHKLFQRVALLLQGII
INLQAVLWLQNGSQTQAVIVTAAQVWIMAFALLALFSLLDTLLALLRQSSVAHQLPLRGICQGLKLVAAIFIGIMIVSLL
MGRSPLLLLSGLGAMTAVLMLVFKDPILGLVAGIQLSANDMLKIGDWLEMPKYGADGAVTDIGLTTVKVRNWDNTVTTIP
TYALISDSFKNWRSMSESGGRRIKRSINIDTTSVHFLSEQEQQRLTLNPLLQHYLSEKSQELNQYNQQIALDLSSPLNGR
RLTNIGTLRAYLVAYLRAHLGIHQSMTLMVRQLAPTPEGLPLEVYAFTNTTIWAEYEGIQADIFDHIFAVVSEFDLRIHQ
TPSGNDMRSMLAKV

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=410, Percent_Identity=62.9268292682927, Blast_Score=539, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 46315; Mature: 46315

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQRISQWLERLGMEFSDVMSLTMVIGLILLISVMIHLVLHRVVLAALQRRGQQSQRIWQ
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QAITKHKLFQRVALLLQGIIINLQAVLWLQNGSQTQAVIVTAAQVWIMAFALLALFSLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TLLALLRQSSVAHQLPLRGICQGLKLVAAIFIGIMIVSLLMGRSPLLLLSGLGAMTAVLM
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVFKDPILGLVAGIQLSANDMLKIGDWLEMPKYGADGAVTDIGLTTVKVRNWDNTVTTIP
HHHHHHHHHHHHCCEECCCCHHHHHHHHHCCCCCCCCCEEECCEEEEEEECCCCCCHHCC
TYALISDSFKNWRSMSESGGRRIKRSINIDTTSVHFLSEQEQQRLTLNPLLQHYLSEKSQ
HHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELNQYNQQIALDLSSPLNGRRLTNIGTLRAYLVAYLRAHLGIHQSMTLMVRQLAPTPEGL
HHHHHHHHEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
PLEVYAFTNTTIWAEYEGIQADIFDHIFAVVSEFDLRIHQTPSGNDMRSMLAKV
CEEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHCC
>Mature Secondary Structure
MQQRISQWLERLGMEFSDVMSLTMVIGLILLISVMIHLVLHRVVLAALQRRGQQSQRIWQ
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QAITKHKLFQRVALLLQGIIINLQAVLWLQNGSQTQAVIVTAAQVWIMAFALLALFSLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TLLALLRQSSVAHQLPLRGICQGLKLVAAIFIGIMIVSLLMGRSPLLLLSGLGAMTAVLM
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVFKDPILGLVAGIQLSANDMLKIGDWLEMPKYGADGAVTDIGLTTVKVRNWDNTVTTIP
HHHHHHHHHHHHCCEECCCCHHHHHHHHHCCCCCCCCCEEECCEEEEEEECCCCCCHHCC
TYALISDSFKNWRSMSESGGRRIKRSINIDTTSVHFLSEQEQQRLTLNPLLQHYLSEKSQ
HHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELNQYNQQIALDLSSPLNGRRLTNIGTLRAYLVAYLRAHLGIHQSMTLMVRQLAPTPEGL
HHHHHHHHEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
PLEVYAFTNTTIWAEYEGIQADIFDHIFAVVSEFDLRIHQTPSGNDMRSMLAKV
CEEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]