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The map label for this gene is gyaR [H]

Identifier: 170023820

GI number: 170023820

Start: 1747561

End: 1748511

Strand: Direct

Name: gyaR [H]

Synonym: YPK_1579

Alternate gene names: 170023820

Gene position: 1747561-1748511 (Clockwise)

Preceding gene: 170023819

Following gene: 170023821

Centisome position: 37.27

GC content: 48.37

Gene sequence:

>951_bases
ATGAAAAACAGCAAACAAGCCGTATTGATAATCGCTCCGGTAATGGACTATCTGACTGAAAAGTTGGAACAAACTTTCAC
CGTCCATAAACTCTATCAGGTTACGGATCAGGCTGAATTTCTGGCAGAGCAGGGCAAGAATATTAAAGGTATCGTGACCA
GAGGTGATATTGGCGTCACTAATGAGGTACTGGCGTTATTGCCTGAAGTGCAGATCATCTCAATATTTGGTGTCGGGACT
GATGCCGTTGATCTGGATTATACCCGTGAGCGCAATATTATCGTGACTACCACGCCGGGTGTCTTGACGGATGATGTGGC
TGATACGGCTCTGGGGCTGATTATTGCCACCTCCCGCCGTTTCTATCAAGCCTCTCAGTTCCTCCGGGCAGGGGAGTGGC
CGAATGGCAGCTTGCCTTTGTCGTCTAAAGTGACGGGCAAACGCTTGGGGATCTTTGGTATGGGGCGTATTGGCCGCGCT
ATTGCCCGCCGTGCTGTCGGGTTTGATATGCAAATTGCCTATACTGACACCGTGCACGACAGCAGTCTGCCTTATCAATA
TGTGCCAGATTTAATTAGCCTGGCAAAGCAAAGCGATATTCTGGTGGTGGCAATTTCTGGTGGAAAAGACAGTGCGGGTT
TGGTTGATAAAGCCATTTTTGCCGCGATGCCTAATCATGGGATCCTGATTAACATTGCCCGTGGCAGTATGGTTAATCAG
GATGATCTCATCAGTGCGTTGCAACAGCAACAGATTGGCGGTGCTGGTCTGGATGTCTTCGCCGATGAGCCTCATGTACC
ACAAGCCTTGATTGAAATGGACAATGTATTCTTGCTGCCACATATTGCCAGTGCGACCACTGATACCCGGATCCAAATGA
GTGATATTGTGTTCTCAAATATTTTGGCCCATTTCTCTGGCGAAACGGCACCTACAGCGATTACCTATTAA

Upstream 100 bases:

>100_bases
GGTAATCAAGCCCGCCGCGATGGGCTGGCGTTATCAGCCGATAATTGTCTGCCACTATTCTGATTTCTTTTTGATTTATT
GACATGATCAGGTACTCGTA

Downstream 100 bases:

>100_bases
TAGAATCAATCACTCTTTAGTGATTTTAGTTATCCATGAGTAATAGCGCGTCAGAAAATAAAGTTTATCTGACGCGTCAA
TCGAAAATTATTTTTTGCTA

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MKNSKQAVLIIAPVMDYLTEKLEQTFTVHKLYQVTDQAEFLAEQGKNIKGIVTRGDIGVTNEVLALLPEVQIISIFGVGT
DAVDLDYTRERNIIVTTTPGVLTDDVADTALGLIIATSRRFYQASQFLRAGEWPNGSLPLSSKVTGKRLGIFGMGRIGRA
IARRAVGFDMQIAYTDTVHDSSLPYQYVPDLISLAKQSDILVVAISGGKDSAGLVDKAIFAAMPNHGILINIARGSMVNQ
DDLISALQQQQIGGAGLDVFADEPHVPQALIEMDNVFLLPHIASATTDTRIQMSDIVFSNILAHFSGETAPTAITY

Sequences:

>Translated_316_residues
MKNSKQAVLIIAPVMDYLTEKLEQTFTVHKLYQVTDQAEFLAEQGKNIKGIVTRGDIGVTNEVLALLPEVQIISIFGVGT
DAVDLDYTRERNIIVTTTPGVLTDDVADTALGLIIATSRRFYQASQFLRAGEWPNGSLPLSSKVTGKRLGIFGMGRIGRA
IARRAVGFDMQIAYTDTVHDSSLPYQYVPDLISLAKQSDILVVAISGGKDSAGLVDKAIFAAMPNHGILINIARGSMVNQ
DDLISALQQQQIGGAGLDVFADEPHVPQALIEMDNVFLLPHIASATTDTRIQMSDIVFSNILAHFSGETAPTAITY
>Mature_316_residues
MKNSKQAVLIIAPVMDYLTEKLEQTFTVHKLYQVTDQAEFLAEQGKNIKGIVTRGDIGVTNEVLALLPEVQIISIFGVGT
DAVDLDYTRERNIIVTTTPGVLTDDVADTALGLIIATSRRFYQASQFLRAGEWPNGSLPLSSKVTGKRLGIFGMGRIGRA
IARRAVGFDMQIAYTDTVHDSSLPYQYVPDLISLAKQSDILVVAISGGKDSAGLVDKAIFAAMPNHGILINIARGSMVNQ
DDLISALQQQQIGGAGLDVFADEPHVPQALIEMDNVFLLPHIASATTDTRIQMSDIVFSNILAHFSGETAPTAITY

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=254, Percent_Identity=39.3700787401575, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI23308577, Length=291, Percent_Identity=28.1786941580756, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI145580578, Length=267, Percent_Identity=27.7153558052434, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI4557499, Length=267, Percent_Identity=27.7153558052434, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI61743967, Length=255, Percent_Identity=28.2352941176471, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4557497, Length=255, Percent_Identity=28.2352941176471, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI145580575, Length=263, Percent_Identity=27.7566539923954, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI87082289, Length=322, Percent_Identity=33.8509316770186, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1787645, Length=262, Percent_Identity=27.4809160305344, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789279, Length=263, Percent_Identity=28.5171102661597, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87081824, Length=142, Percent_Identity=27.4647887323944, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=262, Percent_Identity=27.8625954198473, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25147481, Length=253, Percent_Identity=26.8774703557312, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=245, Percent_Identity=29.3877551020408, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320925, Length=282, Percent_Identity=29.4326241134752, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=264, Percent_Identity=28.7878787878788, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324964, Length=273, Percent_Identity=25.6410256410256, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=165, Percent_Identity=29.6969696969697, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=283, Percent_Identity=26.1484098939929, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45552429, Length=283, Percent_Identity=38.5159010600707, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI45551003, Length=283, Percent_Identity=38.5159010600707, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24585514, Length=283, Percent_Identity=38.5159010600707, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI28574282, Length=283, Percent_Identity=38.5159010600707, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI28574284, Length=283, Percent_Identity=38.5159010600707, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI28574286, Length=250, Percent_Identity=33.2, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28571528, Length=260, Percent_Identity=36.5384615384615, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24585516, Length=248, Percent_Identity=31.8548387096774, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646446, Length=255, Percent_Identity=29.8039215686275, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646448, Length=255, Percent_Identity=29.8039215686275, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646452, Length=255, Percent_Identity=29.8039215686275, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646450, Length=255, Percent_Identity=29.8039215686275, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI62472511, Length=255, Percent_Identity=29.8039215686275, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19921140, Length=318, Percent_Identity=25.1572327044025, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34147; Mature: 34147

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSKQAVLIIAPVMDYLTEKLEQTFTVHKLYQVTDQAEFLAEQGKNIKGIVTRGDIGVT
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCH
NEVLALLPEVQIISIFGVGTDAVDLDYTRERNIIVTTTPGVLTDDVADTALGLIIATSRR
HHHHHHCCCEEEEEEEECCCCCEECCCCCCCCEEEEECCCCEEHHHHHHHHHHHEECCHH
FYQASQFLRAGEWPNGSLPLSSKVTGKRLGIFGMGRIGRAIARRAVGFDMQIAYTDTVHD
HHHHHHHHHCCCCCCCCCCCCCCCCCCEECEEECHHHHHHHHHHHCCCCEEEEEECCCCC
SSLPYQYVPDLISLAKQSDILVVAISGGKDSAGLVDKAIFAAMPNHGILINIARGSMVNQ
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCH
DDLISALQQQQIGGAGLDVFADEPHVPQALIEMDNVFLLPHIASATTDTRIQMSDIVFSN
HHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHCCCEEEEECCCCCCCCCEEEHHHHHHHH
ILAHFSGETAPTAITY
HHHHHCCCCCCCEECC
>Mature Secondary Structure
MKNSKQAVLIIAPVMDYLTEKLEQTFTVHKLYQVTDQAEFLAEQGKNIKGIVTRGDIGVT
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCH
NEVLALLPEVQIISIFGVGTDAVDLDYTRERNIIVTTTPGVLTDDVADTALGLIIATSRR
HHHHHHCCCEEEEEEEECCCCCEECCCCCCCCEEEEECCCCEEHHHHHHHHHHHEECCHH
FYQASQFLRAGEWPNGSLPLSSKVTGKRLGIFGMGRIGRAIARRAVGFDMQIAYTDTVHD
HHHHHHHHHCCCCCCCCCCCCCCCCCCEECEEECHHHHHHHHHHHCCCCEEEEEECCCCC
SSLPYQYVPDLISLAKQSDILVVAISGGKDSAGLVDKAIFAAMPNHGILINIARGSMVNQ
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCH
DDLISALQQQQIGGAGLDVFADEPHVPQALIEMDNVFLLPHIASATTDTRIQMSDIVFSN
HHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHCCCEEEEECCCCCCCCCEEEHHHHHHHH
ILAHFSGETAPTAITY
HHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA