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The map label for this gene is purC [H]

Identifier: 170023606

GI number: 170023606

Start: 1504860

End: 1505573

Strand: Direct

Name: purC [H]

Synonym: YPK_1364

Alternate gene names: 170023606

Gene position: 1504860-1505573 (Clockwise)

Preceding gene: 170023605

Following gene: 170023608

Centisome position: 32.09

GC content: 45.38

Gene sequence:

>714_bases
ATGCAAAAGCTAGCTGAGTTGTATCGTGGGAAGGCGAAAACCGTCTATACCACCGAAAATCCTGACCTACTGGTATTGGA
GTTCCGTAACGATACGTCAGCACTGGATGGTCAGCGCATTGAGCAGTTCGATCGTAAAGGTATGGTTAATAATAAGTTTA
ACCATTTCATTATGACGAAATTGGAAGAGGCGGGTATTCCTACCCAAATGGAACGCCTGCTGTCAGATACCGAAGTACTG
GTGAAAAAACTGGAGATGATCCCGGTTGAGTGCGTTATTCGTAACCGTGCTGCAGGTTCTTTAGTCAAGCGTCTGGGGAT
CGAAGAAGGTTTGTCACTGAATCCACCGTTGTTTGACCTCTTTTTGAAAAATGACGCAATGCATGACCCGATGGTTAATG
AGTCCTACTGTAAAACCTTTGGTTGGGCGACAGAAGCGCAATTGGCCCGAATGAAAGAACTGAGCTATTTGGCGAATGAT
GTGCTGAGCAAATTGTTTGATGATGCCGGTTTAATTCTGGTGGATTTCAAACTTGAGTTCGGTCTGTTTAACGGTGAAGT
GGTATTAGGGGATGAATTCTCTCCTGATGGTAGCCGTCTGTGGGATAAGAAAACCCTGAACAAGATGGATAAAGACCGTT
ATCGCCAGAGCCTGGGCGGTTTGATTGAAGCCTACGAAGAAGTTGCGCACCGTATCGGCGTAAAATTAGACTAA

Upstream 100 bases:

>100_bases
AGCCAGATTAGCGCAACCGCGATAAAATAAAACCAAAGGGGCTTCGGCCCCTTTCGTTATTTCATGACGACTAAAATGGT
CACATCACTGGAGTAATAAG

Downstream 100 bases:

>100_bases
CAGCGCAATCGATTACGTTTCTCTGTCGTGAGCGTTATCGGGGGGCGGTGGCCTTTATCTCCCCCCAAACTCGTCATTCT
TGACACCATAGCGTCACCTG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMTKLEEAGIPTQMERLLSDTEVL
VKKLEMIPVECVIRNRAAGSLVKRLGIEEGLSLNPPLFDLFLKNDAMHDPMVNESYCKTFGWATEAQLARMKELSYLAND
VLSKLFDDAGLILVDFKLEFGLFNGEVVLGDEFSPDGSRLWDKKTLNKMDKDRYRQSLGGLIEAYEEVAHRIGVKLD

Sequences:

>Translated_237_residues
MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMTKLEEAGIPTQMERLLSDTEVL
VKKLEMIPVECVIRNRAAGSLVKRLGIEEGLSLNPPLFDLFLKNDAMHDPMVNESYCKTFGWATEAQLARMKELSYLAND
VLSKLFDDAGLILVDFKLEFGLFNGEVVLGDEFSPDGSRLWDKKTLNKMDKDRYRQSLGGLIEAYEEVAHRIGVKLD
>Mature_237_residues
MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMTKLEEAGIPTQMERLLSDTEVL
VKKLEMIPVECVIRNRAAGSLVKRLGIEEGLSLNPPLFDLFLKNDAMHDPMVNESYCKTFGWATEAQLARMKELSYLAND
VLSKLFDDAGLILVDFKLEFGLFNGEVVLGDEFSPDGSRLWDKKTLNKMDKDRYRQSLGGLIEAYEEVAHRIGVKLD

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=245, Percent_Identity=31.0204081632653, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI5453539, Length=245, Percent_Identity=31.0204081632653, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI119220559, Length=252, Percent_Identity=29.7619047619048, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1788820, Length=237, Percent_Identity=86.9198312236287, Blast_Score=431, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17531275, Length=224, Percent_Identity=28.125, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18860083, Length=221, Percent_Identity=31.2217194570136, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24583917, Length=222, Percent_Identity=29.2792792792793, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27030; Mature: 27030

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMTK
CCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
LEEAGIPTQMERLLSDTEVLVKKLEMIPVECVIRNRAAGSLVKRLGIEEGLSLNPPLFDL
HHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHCHHCCCCCCCCHHHH
FLKNDAMHDPMVNESYCKTFGWATEAQLARMKELSYLANDVLSKLFDDAGLILVDFKLEF
HCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEE
GLFNGEVVLGDEFSPDGSRLWDKKTLNKMDKDRYRQSLGGLIEAYEEVAHRIGVKLD
EEECCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMTK
CCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
LEEAGIPTQMERLLSDTEVLVKKLEMIPVECVIRNRAAGSLVKRLGIEEGLSLNPPLFDL
HHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHCHHCCCCCCCCHHHH
FLKNDAMHDPMVNESYCKTFGWATEAQLARMKELSYLANDVLSKLFDDAGLILVDFKLEF
HCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEE
GLFNGEVVLGDEFSPDGSRLWDKKTLNKMDKDRYRQSLGGLIEAYEEVAHRIGVKLD
EEECCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA