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The map label for this gene is dapA [H]

Identifier: 170023604

GI number: 170023604

Start: 1502814

End: 1503713

Strand: Direct

Name: dapA [H]

Synonym: YPK_1362

Alternate gene names: 170023604

Gene position: 1502814-1503713 (Clockwise)

Preceding gene: 170023601

Following gene: 170023605

Centisome position: 32.05

GC content: 49.44

Gene sequence:

>900_bases
ATGTTTACGGGAAGCCCAATGTTTACAGGCAGCATAGTTGCGCTAATAACGCCAATGGACGACAACGGTGATGTCGATCG
TGCAAGCCTGAAGAGCCTGATTGATTACCACGTGGCCAGTGGGACTGCGGCGATCGTCTCTGTGGGGACGACGGGTGAGT
CAGCAACGTTGAATCATGATGAGCATGTCGATGTGGTCATGCAGACACTCGAACTGGCTGATGGCCGGATCCCGGTGATT
GCCGGAACGGGGGCCAATTCCACCTCCGAAGCCATTTCTCTCACTCAACGGTTTAATGATACCGGTGTTGTGGGCTGCTT
AACCGTGACGCCATATTATAACCGGCCAATGCAGGAAGGGTTATACCAACATTTTAAAGCGATCGCTGAAAGTACCGATT
TGCCACAAATTCTTTATAATGTGCCTTCGCGTACGGGTTGCGATATGTTACCGCCAACCATTGCTCGCTTAGCGAAGATT
AAAAATATTGTTGCGGTTAAAGAAGCCACAGGGAACTTAAGTCGGGTTAGTCAGATCCAAGTGCTGGTTGATGATGAAGA
TTTCATCCTGCTCAGTGGTGATGATGCGAGTGGACTGGACTTTATGCAACTGGGTGGTAAAGGTGTTATTTCTGTGACGG
CAAATATCGCTGCCCGTGAAATGGTTGAACTGTGCGCATTAGCAGCACAGGGAAATTTCGCCGAAGGTCGCCGTTTGAAT
CAGCGCTTGATGCCGTTGCATCAGCATTTATTTGTAGAAGCAAACCCAATTCCGGTTAAATGGGCCGCGAAGAGGTTGGG
ATTAATGGCAAATGATACTATGCGCCTGCCAATGACCCCACTGACTGATCCGGCCAAACGGATTGTGGAAGACGCGTTGA
AAAGCGCAGGTTTGCTGTAA

Upstream 100 bases:

>100_bases
AAAAAAACCTGCTGCCAAGCGCTTACAACACAGTTGTTTACTTGCTTTTGGATAGAGGTCAAAAGTACCATGAGGAACTT
GTTTGAGGAGGTGATAGCCA

Downstream 100 bases:

>100_bases
CTTCTTAGGGAAATTTGATGGCAATATCATTGCAAAAATCGACTGTGGTAAAAGTGGTAGGTGTTTCGCTGGTGATGTTA
CTGGCCGCCTGCTCGACGGA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MFTGSPMFTGSIVALITPMDDNGDVDRASLKSLIDYHVASGTAAIVSVGTTGESATLNHDEHVDVVMQTLELADGRIPVI
AGTGANSTSEAISLTQRFNDTGVVGCLTVTPYYNRPMQEGLYQHFKAIAESTDLPQILYNVPSRTGCDMLPPTIARLAKI
KNIVAVKEATGNLSRVSQIQVLVDDEDFILLSGDDASGLDFMQLGGKGVISVTANIAAREMVELCALAAQGNFAEGRRLN
QRLMPLHQHLFVEANPIPVKWAAKRLGLMANDTMRLPMTPLTDPAKRIVEDALKSAGLL

Sequences:

>Translated_299_residues
MFTGSPMFTGSIVALITPMDDNGDVDRASLKSLIDYHVASGTAAIVSVGTTGESATLNHDEHVDVVMQTLELADGRIPVI
AGTGANSTSEAISLTQRFNDTGVVGCLTVTPYYNRPMQEGLYQHFKAIAESTDLPQILYNVPSRTGCDMLPPTIARLAKI
KNIVAVKEATGNLSRVSQIQVLVDDEDFILLSGDDASGLDFMQLGGKGVISVTANIAAREMVELCALAAQGNFAEGRRLN
QRLMPLHQHLFVEANPIPVKWAAKRLGLMANDTMRLPMTPLTDPAKRIVEDALKSAGLL
>Mature_299_residues
MFTGSPMFTGSIVALITPMDDNGDVDRASLKSLIDYHVASGTAAIVSVGTTGESATLNHDEHVDVVMQTLELADGRIPVI
AGTGANSTSEAISLTQRFNDTGVVGCLTVTPYYNRPMQEGLYQHFKAIAESTDLPQILYNVPSRTGCDMLPPTIARLAKI
KNIVAVKEATGNLSRVSQIQVLVDDEDFILLSGDDASGLDFMQLGGKGVISVTANIAAREMVELCALAAQGNFAEGRRLN
QRLMPLHQHLFVEANPIPVKWAAKRLGLMANDTMRLPMTPLTDPAKRIVEDALKSAGLL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=230, Percent_Identity=25.6521739130435, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI13540533, Length=231, Percent_Identity=25.1082251082251, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788823, Length=293, Percent_Identity=78.839590443686, Blast_Score=489, Evalue=1e-139,
Organism=Escherichia coli, GI87082415, Length=299, Percent_Identity=28.4280936454849, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786463, Length=286, Percent_Identity=28.3216783216783, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789620, Length=235, Percent_Identity=29.7872340425532, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32047; Mature: 32047

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGSPMFTGSIVALITPMDDNGDVDRASLKSLIDYHVASGTAAIVSVGTTGESATLNHD
CCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
EHVDVVMQTLELADGRIPVIAGTGANSTSEAISLTQRFNDTGVVGCLTVTPYYNRPMQEG
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHH
LYQHFKAIAESTDLPQILYNVPSRTGCDMLPPTIARLAKIKNIVAVKEATGNLSRVSQIQ
HHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHEEHHCCCCHHHEEEEE
VLVDDEDFILLSGDDASGLDFMQLGGKGVISVTANIAAREMVELCALAAQGNFAEGRRLN
EEECCCCEEEEECCCCCCCHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHH
QRLMPLHQHLFVEANPIPVKWAAKRLGLMANDTMRLPMTPLTDPAKRIVEDALKSAGLL
HHHHHHHHHEEEECCCCCHHHHHHHCCEECCCCEECCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFTGSPMFTGSIVALITPMDDNGDVDRASLKSLIDYHVASGTAAIVSVGTTGESATLNHD
CCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
EHVDVVMQTLELADGRIPVIAGTGANSTSEAISLTQRFNDTGVVGCLTVTPYYNRPMQEG
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHH
LYQHFKAIAESTDLPQILYNVPSRTGCDMLPPTIARLAKIKNIVAVKEATGNLSRVSQIQ
HHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHEEHHCCCCHHHEEEEE
VLVDDEDFILLSGDDASGLDFMQLGGKGVISVTANIAAREMVELCALAAQGNFAEGRRLN
EEECCCCEEEEECCCCCCCHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHH
QRLMPLHQHLFVEANPIPVKWAAKRLGLMANDTMRLPMTPLTDPAKRIVEDALKSAGLL
HHHHHHHHHEEEECCCCCHHHHHHHCCEECCCCEECCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA