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The map label for this gene is gcvR [H]

Identifier: 170023603

GI number: 170023603

Start: 1502098

End: 1502712

Strand: Reverse

Name: gcvR [H]

Synonym: YPK_1361

Alternate gene names: 170023603

Gene position: 1502712-1502098 (Counterclockwise)

Preceding gene: 170023607

Following gene: 170023602

Centisome position: 32.04

GC content: 48.46

Gene sequence:

>615_bases
ATGTTTACCATGGTAACCCCAAAGAGCATGACAGGAAGAGCGATTTTGCCGCAGCTTGATGAACATTATCTGGTCATTAC
CGCACTCGGTGCTGACCGCCCAGGGATCGTCAATACCATCACCCGCCATGTCAGTAGCTGCGGTTGTAATATTGAAGATA
GTCGGCTGGCTATGTTCGGTGAGGAGTTCACCTTTATTATGCTGCTGTCAGGCAGTTGGAACGCCGTTACCCTGCTGGAA
TCAACTCTGCCGCAAAAAGGTGCAGAGCTTGATTTGCTGATTGTCATGAAGCGAACCAACGCTCAAGGGCAGAAAGCTAT
GCCAACCACTGTCTGGGTAAAAGTTGAAGTGAATGACTCCCCCCACATTATTGAACGGTTTACCAACCTGTTCCATTGCC
ACAATATGAATATCGCGGAGTTAGTCTCCAAAACTCAGCCGGCAGACGGCGAGACACCGCCATTGCTACATATACAGATG
AGTGCACACAGTCCTGCCAGCCAAAACAGTTCAATAATCGAACATGATTTTTATCAACTCTGTACAGAACTCAACGCGCA
GGGCAGTATTAGCGTGGTGAGCTATCCACAGCATGATGACCGAATGGAGAGTTAG

Upstream 100 bases:

>100_bases
GGCTATCACCTCCTCAAACAAGTTCCTCATGGTACTTTTGACCTCTATCCAAAAGCAAGTAAACAACTGTGTTGTAAGCG
CTTGGCAGCAGGTTTTTTTT

Downstream 100 bases:

>100_bases
TGATGAGCCCATTGAAAGCCGGTGATATAGCGCCGAAATTTAGTTTACCCGATCAAGATGGCGAGCAAATTAGTTTGGCC
GACTTCCAGGGACAGCGTGT

Product: glycine cleavage system transcriptional repressor

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MFTMVTPKSMTGRAILPQLDEHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMFGEEFTFIMLLSGSWNAVTLLE
STLPQKGAELDLLIVMKRTNAQGQKAMPTTVWVKVEVNDSPHIIERFTNLFHCHNMNIAELVSKTQPADGETPPLLHIQM
SAHSPASQNSSIIEHDFYQLCTELNAQGSISVVSYPQHDDRMES

Sequences:

>Translated_204_residues
MFTMVTPKSMTGRAILPQLDEHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMFGEEFTFIMLLSGSWNAVTLLE
STLPQKGAELDLLIVMKRTNAQGQKAMPTTVWVKVEVNDSPHIIERFTNLFHCHNMNIAELVSKTQPADGETPPLLHIQM
SAHSPASQNSSIIEHDFYQLCTELNAQGSISVVSYPQHDDRMES
>Mature_204_residues
MFTMVTPKSMTGRAILPQLDEHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMFGEEFTFIMLLSGSWNAVTLLE
STLPQKGAELDLLIVMKRTNAQGQKAMPTTVWVKVEVNDSPHIIERFTNLFHCHNMNIAELVSKTQPADGETPPLLHIQM
SAHSPASQNSSIIEHDFYQLCTELNAQGSISVVSYPQHDDRMES

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=181, Percent_Identity=75.6906077348066, Blast_Score=290, Evalue=5e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 22639; Mature: 22639

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTMVTPKSMTGRAILPQLDEHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMFG
CCEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEC
EEFTFIMLLSGSWNAVTLLESTLPQKGAELDLLIVMKRTNAQGQKAMPTTVWVKVEVNDS
CCEEEEEEEECCCCEEEEEHHHCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEECCC
PHIIERFTNLFHCHNMNIAELVSKTQPADGETPPLLHIQMSAHSPASQNSSIIEHDFYQL
CHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHH
CTELNAQGSISVVSYPQHDDRMES
HHHCCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MFTMVTPKSMTGRAILPQLDEHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMFG
CCEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEC
EEFTFIMLLSGSWNAVTLLESTLPQKGAELDLLIVMKRTNAQGQKAMPTTVWVKVEVNDS
CCEEEEEEEECCCCEEEEEHHHCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEECCC
PHIIERFTNLFHCHNMNIAELVSKTQPADGETPPLLHIQMSAHSPASQNSSIIEHDFYQL
CHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHH
CTELNAQGSISVVSYPQHDDRMES
HHHCCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]