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The map label for this gene is mtlD [H]

Identifier: 169833317

GI number: 169833317

Start: 458963

End: 460099

Strand: Direct

Name: mtlD [H]

Synonym: SPH_0507

Alternate gene names: 169833317

Gene position: 458963-460099 (Clockwise)

Preceding gene: 169832843

Following gene: 169833664

Centisome position: 20.44

GC content: 37.12

Gene sequence:

>1137_bases
ATGAAACATTCTGTTCATTTTGGTGCCGGTAATATCGGTCGTGGTTTTATAGGTGAAATTCTATTTAAAAATGGTTTCCA
TATTGATTTTGTGGATGTCAATAATCAGATAATTCATGCTCTAAATGAAAAGGGCAAGTATGAAATTGAAATTGCACAGA
AAGGACAGTCTCGTATAGAAGTAACTAATGTGGCTGGCATTAATAGCAAAGAACATCCTGAGCAAGTCATTGAAGCGATT
CAAAAGACGGATATTATTACTACTGCAATCGGACCTAATATACTCCCTTTTATCGCCGAACTTCTAGCCAAAGGAATCGA
AGCTCGCCGAGTTGCAGGAAATACACAGGCATTGGATGTTATGGCCTGTGAAAATATGATTGGCGGGTCTCAATTTCTTT
ATCAAGAAGTCAAGAAATATTTAAGTCCGGAAGGTTTGACATTTGCTGATAACTACATAGGTTTTCCAAATGCTGCAGTA
GACAGGATTGTTCCAGCACAAAGTCACGAAGATTCCCTTTTTGTTGTGGTCGAGCCCTTTAATGAATGGGTCGTGGAAAC
CAAGCGTCTTAAAAATCCAGATTTACGTCTAGAAGATGTGCATTATGAAGAAGATTTAGAACCCTTTATTGAGCGAAAAC
TTTTTTCAGTCAATTCTGGACATGCAACTTCAGCTTACATTGGTGCGCATTATGGTGCCAAGACAATTTTGGAAGCTCTT
CAAAATCCTAATATCAAATCTCGGATTGAATCTGTATTAGCTGAAATTCGGAGTCTCTTGATTGCCAAATGGAACTTTGA
TAAAAAAGAATTGGAGAATTATCACAAAGTCATTATAGAACGGTTTGAAAATCCTTTCATAGTGGACGAGGTTAGTCGCG
TAGCTCGTACTCCAATCCGAAAATTAGGCTATAATGAACGATTCATCCGGCCGATACGTGAATTGAAAGAACTCAGTTTG
TCATATAAAAACCTACTTAAAACAGTTGGCTATGCCTTTGACTATCGCGATGTAAATGATGAAGAAAGTATTCGATTAGG
TGAATTGTTGGCTATACAATCAGTCAAAGATGTTGTTATACAAGTTACAGGTTTAGACGACCAAGAATTGATTGAGCAAA
TTGTAGAGTATATTTAA

Upstream 100 bases:

>100_bases
AAAGAGGAAGTATTGCGCTTATTTGATGCTGTTGAATAATTGAATTTCGTCATTTGTCATCTAGTATATATGTCCCTCAA
ATAGGAAAAGGAGAAATTGA

Downstream 100 bases:

>100_bases
TCTTTTTCGAAAATCTCTTCAAATCAGGTTAGCATCCATCTGCAACCTCAAAACAGTATTTTGAGCTGACTTCGTCAGTC
TTATCTGCAACCTCAAAACA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIEVTNVAGINSKEHPEQVIEAI
QKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQALDVMACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAV
DRIVPAQSHEDSLFVVVEPFNEWVVETKRLKNPDLRLEDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEAL
QNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIRKLGYNERFIRPIRELKELSL
SYKNLLKTVGYAFDYRDVNDEESIRLGELLAIQSVKDVVIQVTGLDDQELIEQIVEYI

Sequences:

>Translated_378_residues
MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIEVTNVAGINSKEHPEQVIEAI
QKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQALDVMACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAV
DRIVPAQSHEDSLFVVVEPFNEWVVETKRLKNPDLRLEDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEAL
QNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIRKLGYNERFIRPIRELKELSL
SYKNLLKTVGYAFDYRDVNDEESIRLGELLAIQSVKDVVIQVTGLDDQELIEQIVEYI
>Mature_378_residues
MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIEVTNVAGINSKEHPEQVIEAI
QKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQALDVMACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAV
DRIVPAQSHEDSLFVVVEPFNEWVVETKRLKNPDLRLEDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEAL
QNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIRKLGYNERFIRPIRELKELSL
SYKNLLKTVGYAFDYRDVNDEESIRLGELLAIQSVKDVVIQVTGLDDQELIEQIVEYI

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790028, Length=376, Percent_Identity=35.6382978723404, Blast_Score=260, Evalue=9e-71,
Organism=Escherichia coli, GI1790779, Length=258, Percent_Identity=24.8062015503876, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788497, Length=291, Percent_Identity=25.085910652921, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787823, Length=246, Percent_Identity=23.9837398373984, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324401, Length=235, Percent_Identity=25.9574468085106, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320765, Length=235, Percent_Identity=25.9574468085106, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.17 [H]

Molecular weight: Translated: 42924; Mature: 42924

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIE
CCCCEECCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCEEEEEECCCCCEEE
VTNVAGINSKEHPEQVIEAIQKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQALDV
EEEEECCCCCCCHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHCCHHHHHHCCCCHHHHH
MACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAVDRIVPAQSHEDSLFVVVEPF
HHHHHHCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHCCCCCCCCCCEEEEEECH
NEWVVETKRLKNPDLRLEDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEAL
HHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHH
QNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIR
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHH
KLGYNERFIRPIRELKELSLSYKNLLKTVGYAFDYRDVNDEESIRLGELLAIQSVKDVVI
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHEE
QVTGLDDQELIEQIVEYI
EEECCCHHHHHHHHHHHC
>Mature Secondary Structure
MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIE
CCCCEECCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCEEEEEECCCCCEEE
VTNVAGINSKEHPEQVIEAIQKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQALDV
EEEEECCCCCCCHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHCCHHHHHHCCCCHHHHH
MACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAVDRIVPAQSHEDSLFVVVEPF
HHHHHHCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHCCCCCCCCCCEEEEEECH
NEWVVETKRLKNPDLRLEDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEAL
HHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHH
QNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIR
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHH
KLGYNERFIRPIRELKELSLSYKNLLKTVGYAFDYRDVNDEESIRLGELLAIQSVKDVVI
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHEE
QVTGLDDQELIEQIVEYI
EEECCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA