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The map label for this gene is mutS2 [H]

Identifier: 169832578

GI number: 169832578

Start: 467327

End: 469663

Strand: Direct

Name: mutS2 [H]

Synonym: SPH_0515

Alternate gene names: 169832578

Gene position: 467327-469663 (Clockwise)

Preceding gene: 169833336

Following gene: 169834071

Centisome position: 20.81

GC content: 45.14

Gene sequence:

>2337_bases
ATGAATAAGAAAATATTAGAAACATTAGAGTTCGATAAGGTCAAGGCCTTGTTTGAGCCTCATTTGTTGACCGAGCAGGG
CTTGGAGCAATTGAGACAACTGGCTCCGACTGCCAAAGCAGATAAAATCAAACAGGCTTTTGCTGAGATGAAGGAAATGC
AGGCTCTTTTCGTCGAGCAACCGCATTTTACTATTCTCTCAACTAAGGAAATTGCAGGAGTCTGCAAGAGGTTGGAGATG
GGAGCGGATCTCAATATCGAGGAGTTCCTACTCTTGAAACGCGTGCTTCTTACCAGCCGAGAACTTCAAAGTTTTTACGC
CAATCTGGAAAATGTCAGCTTGGAAGAATTAGCCTTTTGGTTTGAGAAATTACATGATTTTCCGCAATTACAAGGAAATC
TTCAGGCCTTTAATGATGCGGGTTTCATTGAAAATTTTGCCAGTGAAGAATTGGCGCGAATCCGTCGAAAAATACATGAT
AGCGAGAGTCAGGTACGCGATGTTTTACAAGACTTGCTCAAGCAAAAAGCGCAGATGTTGACGGAAGGAATTGTTGCTAG
CAGAAATGGCCGTCAGGTTTTACCAGTCAAAAACACCTACCGCAATAAGATTGCAGGTGTCGTTCATGATATTTCTGCTA
GTGGAAACACCGTCTATATCGAACCACGTGAGGTAGTCAAACTGAGCGAAGAAATTGCTAGTCTGCGAGCAGATGAGCGC
TATGAAATGCTTCGCATTCTCCAAGAAATTTCTGAGCGTGTCCGCCCTCATGCGGCTGAGATTGCTAATGATGCTTGGAT
TATCGGTCATCTGGACTTGATTCGTGCCAAGGTTCGATTTATCCAAGAAAGACAAGCAGTCGTGCCTCAGCTGTCAGAAA
ATCAAGAGATTCAACTGCTCCATGTCTGCCATCCTTTGGTCAAAAATGCCGTCGCAAATGATGTCTATTTTGGTCAAGAT
TTAACAGCTATTGTCATTACAGGTCCCAATACAGGTGGGAAGACCATCATGCTCAAAACTCTGGGCTTGACACAGGTCAT
GGCCCAGTCAGGATTGCCGATTTTAGCAGACAAGGGAAGTCGTGTTGGTATTTTTGAAGAAATCTTTGCTGATATTGGAG
ATGAGCAGTCTATTGAGCAGAGCTTGTCTACCTTCTCTAGCCATATGACCAATATCGTGGATATTCTTGGTAAGGTCAAC
CAACATTCACTCTTACTTTTGGATGAGTTGGGGGCTGGTACTGATCCCCAAGAGGGAGCAGCCCTTGCCATGGCTATTCT
GGAGGACCTTCGCCTGCGTCAAATCAAGACCATGGCGACGACCCACTATCCAGAACTCAAGGCCTACGGTATTGAGACAG
CCTTTGTGCAAAATGCCAGTATGGAGTTTGATACTGCAACTCTTCGCCCGACCTATCGCTTTATGCAGGGTGTTCCTGGC
CGAAGTAATGCCTTTGAAATTGCCAAACGTCTAGGCCTATCTGAAGTTATCGTAGGAGATGCCAGTCAGCAGATCGATCA
GGACAATGACGTCAATCGTATCATTGAGCAATTAGAAGAGCAGACGCTGGAAAGCCGCAAACGCTTGGACAATATCCGTG
AGGTGGAGCAAGAAAATCTCAAGATGAACCGTGCGCTAAAAAAACTCTACAACGAGCTTAATCGTGAAAAGGAAACCGAG
CTTAACAAGGCGCGTGAACAGGCTGCTGAGATTGTGGATATGGCCCTAAGTGAAAGTGACCAGATTCTCAAAAATCTCCA
CAGTAAATCCCAACTCAAGCCCCACGAAATCATTGAAGCCAAGGCCAAGTTGAAAAAATTGGCTCCTGAAAAAGTGGACT
TGTCTAAAAACAAGGTCCTTCAAAAGGCCAAGAAAAAACGAGCTCCAAAGGTGGGAGATGATATCGTGGTTCTCAGTTAT
GGTCAGCGTGGTACCTTGACCAGTCAACTCAAGGACGGCCGCTGGGAAGCCCAAGTTGGCTTGATTAAGATGACCTTGGA
AGAGAAAGAGTTTGATCTTGTTCAAGCCCAGCAAGAAAAAGCAGTCAAGAAGAAACAGGTCAATGTTGTGAAACGAACTT
CTGGGCGAGGACCTCAAGCTAGACTGGATCTTCGAGGCAAGCGCTATGAAGAAGCCATGAATGAGCTAGATACCTTCATC
GACCAAGCCTTGCTTAACAATATGGCTCAAGTTGATATCATCCATGGTATCGGAACAGGAGTCATCCGTGAAGGAGTTAC
CAAATACTTGCAAAGAAACAAACATGTCAAGAGTTTCGGCTATGCCCCACAAAATGCTGGAGGCAGTGGTGCGACTATTG
TCACTTTTAAAGGATAG

Upstream 100 bases:

>100_bases
GGGCAGGAGTTTTCCTAGCCCTTTGTTTACAGATTTGACTCGAATCTATCAGAATGTAAAAAGCTACCACACCTAGACAT
TCAAAGACAAGGAAATAAAG

Downstream 100 bases:

>100_bases
CAGTATTCTGGACTTTATAAAGTAAAAACTGTTGAACTAATTTTTACTAATAAACACATTGACAAAAGCCAACATTTTTT
GTAAAATTAGAATCAATTAA

Product: MutS2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 778; Mature: 778

Protein sequence:

>778_residues
MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIKQAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEM
GADLNIEEFLLLKRVLLTSRELQSFYANLENVSLEELAFWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHD
SESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTVYIEPREVVKLSEEIASLRADER
YEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRAKVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVYFGQD
LTAIVITGPNTGGKTIMLKTLGLTQVMAQSGLPILADKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNIVDILGKVN
QHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYGIETAFVQNASMEFDTATLRPTYRFMQGVPG
RSNAFEIAKRLGLSEVIVGDASQQIDQDNDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETE
LNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSY
GQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKAVKKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFI
DQALLNNMAQVDIIHGIGTGVIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG

Sequences:

>Translated_778_residues
MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIKQAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEM
GADLNIEEFLLLKRVLLTSRELQSFYANLENVSLEELAFWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHD
SESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTVYIEPREVVKLSEEIASLRADER
YEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRAKVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVYFGQD
LTAIVITGPNTGGKTIMLKTLGLTQVMAQSGLPILADKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNIVDILGKVN
QHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYGIETAFVQNASMEFDTATLRPTYRFMQGVPG
RSNAFEIAKRLGLSEVIVGDASQQIDQDNDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETE
LNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSY
GQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKAVKKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFI
DQALLNNMAQVDIIHGIGTGVIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG
>Mature_778_residues
MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIKQAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEM
GADLNIEEFLLLKRVLLTSRELQSFYANLENVSLEELAFWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHD
SESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTVYIEPREVVKLSEEIASLRADER
YEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRAKVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVYFGQD
LTAIVITGPNTGGKTIMLKTLGLTQVMAQSGLPILADKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNIVDILGKVN
QHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYGIETAFVQNASMEFDTATLRPTYRFMQGVPG
RSNAFEIAKRLGLSEVIVGDASQQIDQDNDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETE
LNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSY
GQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKAVKKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFI
DQALLNNMAQVDIIHGIGTGVIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=336, Percent_Identity=28.8690476190476, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI284813531, Length=282, Percent_Identity=28.7234042553192, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4504191, Length=248, Percent_Identity=26.2096774193548, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI4557761, Length=198, Percent_Identity=31.3131313131313, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI26638666, Length=258, Percent_Identity=29.0697674418605, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI4505253, Length=258, Percent_Identity=29.0697674418605, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI26638664, Length=259, Percent_Identity=28.957528957529, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI262231786, Length=130, Percent_Identity=36.1538461538462, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1789089, Length=272, Percent_Identity=26.4705882352941, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17508445, Length=281, Percent_Identity=25.9786476868327, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17534743, Length=150, Percent_Identity=32.6666666666667, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17539736, Length=230, Percent_Identity=24.7826086956522, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17508447, Length=211, Percent_Identity=28.436018957346, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321912, Length=309, Percent_Identity=25.5663430420712, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319935, Length=237, Percent_Identity=30.8016877637131, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324482, Length=333, Percent_Identity=24.9249249249249, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321109, Length=205, Percent_Identity=28.2926829268293, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320302, Length=222, Percent_Identity=28.3783783783784, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320047, Length=272, Percent_Identity=25, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24584320, Length=323, Percent_Identity=26.9349845201238, Blast_Score=94, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24664545, Length=260, Percent_Identity=28.4615384615385, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 87621; Mature: 87621

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIKQAFAEMKEMQALFVEQ
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
PHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLTSRELQSFYANLENVSLEELAFW
CCEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
FEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHDSESQVRDVLQDLLKQKAQML
HHHHHHCHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTVYIEPREVVKLSEEIASLRADER
HHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCHHH
YEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRAKVRFIQERQAVVPQLSENQEIQLL
HHHHHHHHHHHHHHCCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
HVCHPLVKNAVANDVYFGQDLTAIVITGPNTGGKTIMLKTLGLTQVMAQSGLPILADKGS
HHHHHHHHHHHHCCCEECCCCEEEEEECCCCCCCEEEEEHHHHHHHHHHCCCCEEECCCC
RVGIFEEIFADIGDEQSIEQSLSTFSSHMTNIVDILGKVNQHSLLLLDELGAGTDPQEGA
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCCCCCHHH
ALAMAILEDLRLRQIKTMATTHYPELKAYGIETAFVQNASMEFDTATLRPTYRFMQGVPG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHCCCCCCCCCHHCCHHHHHHCCCCC
RSNAFEIAKRLGLSEVIVGDASQQIDQDNDVNRIIEQLEEQTLESRKRLDNIREVEQENL
CCHHHHHHHHCCCHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMNRALKKLYNELNREKETELNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHH
KAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVG
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHCCCCCHHHHH
LIKMTLEEKEFDLVQAQQEKAVKKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFI
HEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHH
DQALLNNMAQVDIIHGIGTGVIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG
HHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIKQAFAEMKEMQALFVEQ
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
PHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLTSRELQSFYANLENVSLEELAFW
CCEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
FEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHDSESQVRDVLQDLLKQKAQML
HHHHHHCHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTVYIEPREVVKLSEEIASLRADER
HHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCHHH
YEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRAKVRFIQERQAVVPQLSENQEIQLL
HHHHHHHHHHHHHHCCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
HVCHPLVKNAVANDVYFGQDLTAIVITGPNTGGKTIMLKTLGLTQVMAQSGLPILADKGS
HHHHHHHHHHHHCCCEECCCCEEEEEECCCCCCCEEEEEHHHHHHHHHHCCCCEEECCCC
RVGIFEEIFADIGDEQSIEQSLSTFSSHMTNIVDILGKVNQHSLLLLDELGAGTDPQEGA
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCCCCCHHH
ALAMAILEDLRLRQIKTMATTHYPELKAYGIETAFVQNASMEFDTATLRPTYRFMQGVPG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHCCCCCCCCCHHCCHHHHHHCCCCC
RSNAFEIAKRLGLSEVIVGDASQQIDQDNDVNRIIEQLEEQTLESRKRLDNIREVEQENL
CCHHHHHHHHCCCHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMNRALKKLYNELNREKETELNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHH
KAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVG
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHCCCCCHHHHH
LIKMTLEEKEFDLVQAQQEKAVKKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFI
HEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHH
DQALLNNMAQVDIIHGIGTGVIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG
HHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA