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The map label for this gene is capL [H]

Identifier: 169824281

GI number: 169824281

Start: 645724

End: 647055

Strand: Direct

Name: capL [H]

Synonym: FMG_0584

Alternate gene names: 169824281

Gene position: 645724-647055 (Clockwise)

Preceding gene: 169824280

Following gene: 169824282

Centisome position: 35.92

GC content: 33.18

Gene sequence:

>1332_bases
ATGAATAATTTAAAAGAAGAATTATTGGGAAAAATCGAAGATAAATCTCTAGTTGTAGGGGTTGTAGGATTAGGTTATGT
AGGATTGCCATTAGCAGTAGAAAAAGCAAAAGCGGGCTACACTGTTATTGGATTCGATGTACAACCAGAAAAAGTTCAAA
TGGTTAATGATGGAGTTAATTACATTGGCGATGTTGTAGATTCAGAATTAAAAGCTATTGTTGAATCTGGAAAATTAAGA
GCTACTAGTGATTTCAAATCAGTTGCAAGCTGTGATTTCATAGCTATTGCCGTACCAACACCATTGGATATTTACCAACA
ACCAGACATTTCTTACGTAGAAAAATCAACTACAGATGTTTCTAAGCATTTGAAAAAAGGATCTATTGTTGTATTAGAAT
CCACTACTTATCCAGGAACTACTGAAGAATTAATGAGACCTATTTTGGAAAATGGTTCAGGATTAAAATGTGAAGAAGAT
TTTTACTTAGCATTCTCTCCTGAAAGAGTAGATCCAGGTAACAAACAATATAAAACTAAAAACACTCCTAAAGTTGTTGG
AGGAATTGGTTCAGAATCTACAGAAGTTGCAGCAGCATTGTACAGAAATGTACTTGAAGGAGAAGTTATGACTGTATCTT
CACCAAGAGTTGCTGAAATGGAAAAAATTCTTGAAAACACATACAGAAATGTAAACATAGGATTGGTAAATGAATTTGCC
AAATTAGCTAATAAAATGGATATCAATATGTGGGAAGTAGTTGACGCTGCTAAGACAAAACCATACGGATATCAAGCATT
CTATCCAGGTCCTGGTGTAGGTGGACACTGTATACCATTAGATCCATTCTATTTGACTTGGAAAGCAAGAGAATATGATG
TACACATGCCAATCATAGAAGCAAGTGGTACTGTAAATGATAGCATGCCTGAATGGGTAGTAGATAGATCAATGAAGATT
TTGTCTAGAAAATTCAAAAAACCATTGAATGGTTCAAAAGTTTTAATTTTAGGTATTGCTTATAAAAAAGATATCGACGA
TTTGAGAGATTCTCCTGCATTTGTCGTAATGGATAAATTCAGAGAAGAAGGAGCAATCGTAGATTATTATGATGGATTCA
ATCCTTCTTATTTCAACCCAGATGGATCTAAGACATACTCATTAAAAGAAATTAATCCAGAAGTAGTTAAGGGTTATGAT
TTAGTTGTAATAACTGCAGATCACACAAATGTTGATTACCAAATGGTTGTAGACAATGCACCATTTGTATTTGATACAAA
ATACGCTACAAGAGACGTAGAAAACAATAGAGATAAAATAGAATTATTATAA

Upstream 100 bases:

>100_bases
TGTGGAGAAAATCTAAAAAGAGTTTCCCTCACAGATTATATATGTGAAAAATGTGACAAGAAATATTTATTAAATGATTA
TAAATTGAGTGAGGTATCAA

Downstream 100 bases:

>100_bases
GAGGTAATATGCAAAAAATTAAATGTGCAATCATTGGTTGCGGTAGAATTTCTTATAAACACGTAGAAGGAATTGCAAAC
AACGATTCAGAAATAGAATT

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MNNLKEELLGKIEDKSLVVGVVGLGYVGLPLAVEKAKAGYTVIGFDVQPEKVQMVNDGVNYIGDVVDSELKAIVESGKLR
ATSDFKSVASCDFIAIAVPTPLDIYQQPDISYVEKSTTDVSKHLKKGSIVVLESTTYPGTTEELMRPILENGSGLKCEED
FYLAFSPERVDPGNKQYKTKNTPKVVGGIGSESTEVAAALYRNVLEGEVMTVSSPRVAEMEKILENTYRNVNIGLVNEFA
KLANKMDINMWEVVDAAKTKPYGYQAFYPGPGVGGHCIPLDPFYLTWKAREYDVHMPIIEASGTVNDSMPEWVVDRSMKI
LSRKFKKPLNGSKVLILGIAYKKDIDDLRDSPAFVVMDKFREEGAIVDYYDGFNPSYFNPDGSKTYSLKEINPEVVKGYD
LVVITADHTNVDYQMVVDNAPFVFDTKYATRDVENNRDKIELL

Sequences:

>Translated_443_residues
MNNLKEELLGKIEDKSLVVGVVGLGYVGLPLAVEKAKAGYTVIGFDVQPEKVQMVNDGVNYIGDVVDSELKAIVESGKLR
ATSDFKSVASCDFIAIAVPTPLDIYQQPDISYVEKSTTDVSKHLKKGSIVVLESTTYPGTTEELMRPILENGSGLKCEED
FYLAFSPERVDPGNKQYKTKNTPKVVGGIGSESTEVAAALYRNVLEGEVMTVSSPRVAEMEKILENTYRNVNIGLVNEFA
KLANKMDINMWEVVDAAKTKPYGYQAFYPGPGVGGHCIPLDPFYLTWKAREYDVHMPIIEASGTVNDSMPEWVVDRSMKI
LSRKFKKPLNGSKVLILGIAYKKDIDDLRDSPAFVVMDKFREEGAIVDYYDGFNPSYFNPDGSKTYSLKEINPEVVKGYD
LVVITADHTNVDYQMVVDNAPFVFDTKYATRDVENNRDKIELL
>Mature_443_residues
MNNLKEELLGKIEDKSLVVGVVGLGYVGLPLAVEKAKAGYTVIGFDVQPEKVQMVNDGVNYIGDVVDSELKAIVESGKLR
ATSDFKSVASCDFIAIAVPTPLDIYQQPDISYVEKSTTDVSKHLKKGSIVVLESTTYPGTTEELMRPILENGSGLKCEED
FYLAFSPERVDPGNKQYKTKNTPKVVGGIGSESTEVAAALYRNVLEGEVMTVSSPRVAEMEKILENTYRNVNIGLVNEFA
KLANKMDINMWEVVDAAKTKPYGYQAFYPGPGVGGHCIPLDPFYLTWKAREYDVHMPIIEASGTVNDSMPEWVVDRSMKI
LSRKFKKPLNGSKVLILGIAYKKDIDDLRDSPAFVVMDKFREEGAIVDYYDGFNPSYFNPDGSKTYSLKEINPEVVKGYD
LVVITADHTNVDYQMVVDNAPFVFDTKYATRDVENNRDKIELL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=370, Percent_Identity=22.1621621621622, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI48994968, Length=424, Percent_Identity=33.0188679245283, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI1788340, Length=377, Percent_Identity=26.2599469496021, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17560350, Length=387, Percent_Identity=25.0645994832041, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136908, Length=369, Percent_Identity=24.1192411924119, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 49223; Mature: 49223

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLKEELLGKIEDKSLVVGVVGLGYVGLPLAVEKAKAGYTVIGFDVQPEKVQMVNDGVN
CCCHHHHHHHCCCCCEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCHHHHEECCCHH
YIGDVVDSELKAIVESGKLRATSDFKSVASCDFIAIAVPTPLDIYQQPDISYVEKSTTDV
HHHHHHHHHHHHHHHCCCEEECHHHHHHHCCCEEEEECCCCHHCCCCCCCHHHHHCHHHH
SKHLKKGSIVVLESTTYPGTTEELMRPILENGSGLKCEEDFYLAFSPERVDPGNKQYKTK
HHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCCCCCCCCCCC
NTPKVVGGIGSESTEVAAALYRNVLEGEVMTVSSPRVAEMEKILENTYRNVNIGLVNEFA
CCCEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCEEEHHHHHHH
KLANKMDINMWEVVDAAKTKPYGYQAFYPGPGVGGHCIPLDPFYLTWKAREYDVHMPIIE
HHHHHCCCCHHHHHHHHCCCCCCEEEECCCCCCCCEEEECCCEEEEEEECEEEEEEEEEE
ASGTVNDSMPEWVVDRSMKILSRKFKKPLNGSKVLILGIAYKKDIDDLRDSPAFVVMDKF
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHHCCCEEEEEEHH
REEGAIVDYYDGFNPSYFNPDGSKTYSLKEINPEVVKGYDLVVITADHTNVDYQMVVDNA
HCCCCEEEECCCCCCCCCCCCCCCEEEEECCCHHHCCCEEEEEEEECCCCCEEEEEECCC
PFVFDTKYATRDVENNRDKIELL
CEEEECCHHHCCCCCCCCEEEEC
>Mature Secondary Structure
MNNLKEELLGKIEDKSLVVGVVGLGYVGLPLAVEKAKAGYTVIGFDVQPEKVQMVNDGVN
CCCHHHHHHHCCCCCEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCHHHHEECCCHH
YIGDVVDSELKAIVESGKLRATSDFKSVASCDFIAIAVPTPLDIYQQPDISYVEKSTTDV
HHHHHHHHHHHHHHHCCCEEECHHHHHHHCCCEEEEECCCCHHCCCCCCCHHHHHCHHHH
SKHLKKGSIVVLESTTYPGTTEELMRPILENGSGLKCEEDFYLAFSPERVDPGNKQYKTK
HHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCCCCCCCCCCC
NTPKVVGGIGSESTEVAAALYRNVLEGEVMTVSSPRVAEMEKILENTYRNVNIGLVNEFA
CCCEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCEEEHHHHHHH
KLANKMDINMWEVVDAAKTKPYGYQAFYPGPGVGGHCIPLDPFYLTWKAREYDVHMPIIE
HHHHHCCCCHHHHHHHHCCCCCCEEEECCCCCCCCEEEECCCEEEEEEECEEEEEEEEEE
ASGTVNDSMPEWVVDRSMKILSRKFKKPLNGSKVLILGIAYKKDIDDLRDSPAFVVMDKF
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHHCCCEEEEEEHH
REEGAIVDYYDGFNPSYFNPDGSKTYSLKEINPEVVKGYDLVVITADHTNVDYQMVVDNA
HCCCCEEEECCCCCCCCCCCCCCCEEEEECCCHHHCCCEEEEEEEECCCCCEEEEEECCC
PFVFDTKYATRDVENNRDKIELL
CEEEECCHHHCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]