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The map label for this gene is gcvPB [H]

Identifier: 169824162

GI number: 169824162

Start: 522320

End: 523774

Strand: Direct

Name: gcvPB [H]

Synonym: FMG_0465

Alternate gene names: 169824162

Gene position: 522320-523774 (Clockwise)

Preceding gene: 169824161

Following gene: 169824163

Centisome position: 29.06

GC content: 35.74

Gene sequence:

>1455_bases
ATGGCTTATAATAAGTTAATATTTGAATTATCACAACCAGGTAGAACTGGATATAAACTTCCTGAATTAGACGTAGAAGA
AAAAGATAACTTAATTCCTGAAGAATTTTTATCAAATGAAGAATTAGATTTACCAGAAGTTAGTGAAGTTGACGTAGTTC
GTCACTATACTAACCTTTCAACTCTAAACTTCGGCGTAGATACAGGTATGTATCCATTAGGATCTTGTACAATGAAGTAC
AACCCTAAAATCAATGAAGAAATTGTAGCAAATCCAAAACTTGCTCGTCTTCACCCAAAACAAGACGATTACCAAGTTCA
AGGTGCATTGGAAGCAATGTATACTTTACAAAAATCACTATGCGAAGTATCTGGTATGGATTATATGACATTACAACCAG
CAGCAGGTGCTCACGGTGAAATCACAGCTATTACAATATTCAAAAAATATCATGAAGTTAATGGTAATTCTGAAAAGAAT
GAAATCATAGTTCCAGACTCAGCTCACGGTACTAACCCAGCAACAGCTGCAATGGCTGGATATAAAGTAGTAGAAGTTAA
ATCAAATGCAAATGGTGTAGTTGACGTTGAAGACTTAAGAAAAGTTGTAAACGAAAAAACAGCTGGTTTGATGTTAACTA
ACCCTAATACTTTAGGTTTATTTGAAACTAAAATCAAAGAAATCGCTGAAATAGTTCACGAAGCAGGCGGATTACTATAC
TACGATGGAGCAAATGCTAACGCCATTTTAGGACACGCAAGACCAGGGGACATGGGATTCGATGCAATCCACTTCAATGT
TCACAAAACATTCTCTACACCTCACGGTGGTGGAGGTCCAGGTGCAGGTCCTGTAGGTGTTAAGAAATTCTTAAGAGAAT
ATTTACCAAAACCAATCGTTGAAAAAGATGGAGATAAATATTTCTTAGATTATAGCATGGAACATTCTATTGGTAGAATG
AAAGACTTCCAAGGTCACTTCGGAATTTTAATGAGAGCATTGACTTATATCCTAACAATGGGTAGTGATGGATTGAAATG
TGCATCTACTACAGCGGTATTAAATGCAAACTATCTTCAAGCTCAATTAAAAGATGACTATAACTTACCACACGACTTCA
TCTGCAAACACGAATTCGTATTAGGCGGATTAAAGGATGATTGCGATGGACAAGTTAAGACATTGGATGTAGCTAAGAGA
CTGTTAGATATGGGATTCCATCCACCAACAGTATACTTCCCATTAATCGTTCACGAAGCATTAATGGTAGAACCTACTGA
AACTGAACCAAAACAAACTCTTGATGCTTTCGTAGCTGCAATGAAACAAATTGCACAAGAAGCAAGAGAAAACAAAGATA
TATTATTAGAAGCTCCTATTACAACTGTTGTTAGAAGACCAGATGAAACAGAAGCTGCTAAGAATTTAATATTGACTTTC
AAAAAAGGAGAATAA

Upstream 100 bases:

>100_bases
ACAAATGGATGTGGCAATGGTTTAATTATTGCTGTAACTGAAAAGAGAACAAAAGAAGAAATGGATAATTTCGTAGCAGC
AGTTAAGGAGGTATTATAAT

Downstream 100 bases:

>100_bases
TGACTAAAGATATCATTATTATCGGCGCTGGACCTGGTGGCTATGAAACGGCCATCAGGGCATGCCAGCTCGGTTTAAAT
GTAACTTTAATCGAAAAAGC

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MAYNKLIFELSQPGRTGYKLPELDVEEKDNLIPEEFLSNEELDLPEVSEVDVVRHYTNLSTLNFGVDTGMYPLGSCTMKY
NPKINEEIVANPKLARLHPKQDDYQVQGALEAMYTLQKSLCEVSGMDYMTLQPAAGAHGEITAITIFKKYHEVNGNSEKN
EIIVPDSAHGTNPATAAMAGYKVVEVKSNANGVVDVEDLRKVVNEKTAGLMLTNPNTLGLFETKIKEIAEIVHEAGGLLY
YDGANANAILGHARPGDMGFDAIHFNVHKTFSTPHGGGGPGAGPVGVKKFLREYLPKPIVEKDGDKYFLDYSMEHSIGRM
KDFQGHFGILMRALTYILTMGSDGLKCASTTAVLNANYLQAQLKDDYNLPHDFICKHEFVLGGLKDDCDGQVKTLDVAKR
LLDMGFHPPTVYFPLIVHEALMVEPTETEPKQTLDAFVAAMKQIAQEARENKDILLEAPITTVVRRPDETEAAKNLILTF
KKGE

Sequences:

>Translated_484_residues
MAYNKLIFELSQPGRTGYKLPELDVEEKDNLIPEEFLSNEELDLPEVSEVDVVRHYTNLSTLNFGVDTGMYPLGSCTMKY
NPKINEEIVANPKLARLHPKQDDYQVQGALEAMYTLQKSLCEVSGMDYMTLQPAAGAHGEITAITIFKKYHEVNGNSEKN
EIIVPDSAHGTNPATAAMAGYKVVEVKSNANGVVDVEDLRKVVNEKTAGLMLTNPNTLGLFETKIKEIAEIVHEAGGLLY
YDGANANAILGHARPGDMGFDAIHFNVHKTFSTPHGGGGPGAGPVGVKKFLREYLPKPIVEKDGDKYFLDYSMEHSIGRM
KDFQGHFGILMRALTYILTMGSDGLKCASTTAVLNANYLQAQLKDDYNLPHDFICKHEFVLGGLKDDCDGQVKTLDVAKR
LLDMGFHPPTVYFPLIVHEALMVEPTETEPKQTLDAFVAAMKQIAQEARENKDILLEAPITTVVRRPDETEAAKNLILTF
KKGE
>Mature_483_residues
AYNKLIFELSQPGRTGYKLPELDVEEKDNLIPEEFLSNEELDLPEVSEVDVVRHYTNLSTLNFGVDTGMYPLGSCTMKYN
PKINEEIVANPKLARLHPKQDDYQVQGALEAMYTLQKSLCEVSGMDYMTLQPAAGAHGEITAITIFKKYHEVNGNSEKNE
IIVPDSAHGTNPATAAMAGYKVVEVKSNANGVVDVEDLRKVVNEKTAGLMLTNPNTLGLFETKIKEIAEIVHEAGGLLYY
DGANANAILGHARPGDMGFDAIHFNVHKTFSTPHGGGGPGAGPVGVKKFLREYLPKPIVEKDGDKYFLDYSMEHSIGRMK
DFQGHFGILMRALTYILTMGSDGLKCASTTAVLNANYLQAQLKDDYNLPHDFICKHEFVLGGLKDDCDGQVKTLDVAKRL
LDMGFHPPTVYFPLIVHEALMVEPTETEPKQTLDAFVAAMKQIAQEARENKDILLEAPITTVVRRPDETEAAKNLILTFK
KGE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=408, Percent_Identity=39.7058823529412, Blast_Score=250, Evalue=2e-66,
Organism=Escherichia coli, GI1789269, Length=412, Percent_Identity=39.3203883495146, Blast_Score=248, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI17535605, Length=415, Percent_Identity=40.2409638554217, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI32564013, Length=374, Percent_Identity=40.6417112299465, Blast_Score=236, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6323843, Length=446, Percent_Identity=40.3587443946188, Blast_Score=287, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24645648, Length=412, Percent_Identity=41.0194174757282, Blast_Score=263, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53452; Mature: 53320

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYNKLIFELSQPGRTGYKLPELDVEEKDNLIPEEFLSNEELDLPEVSEVDVVRHYTNLS
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHCCC
TLNFGVDTGMYPLGSCTMKYNPKINEEIVANPKLARLHPKQDDYQVQGALEAMYTLQKSL
EEEECCCCCCCCCCCEEEEECCCCCCHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
CEVSGMDYMTLQPAAGAHGEITAITIFKKYHEVNGNSEKNEIIVPDSAHGTNPATAAMAG
HHHCCCCEEEECCCCCCCCCEEEEEEEEHHHHCCCCCCCCEEECCCCCCCCCCHHHHHCC
YKVVEVKSNANGVVDVEDLRKVVNEKTAGLMLTNPNTLGLFETKIKEIAEIVHEAGGLLY
EEEEEEECCCCCCEEHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCEEE
YDGANANAILGHARPGDMGFDAIHFNVHKTFSTPHGGGGPGAGPVGVKKFLREYLPKPIV
ECCCCCCEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCC
EKDGDKYFLDYSMEHSIGRMKDFQGHFGILMRALTYILTMGSDGLKCASTTAVLNANYLQ
CCCCCEEEEEECHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEECCCEEEEECHHHH
AQLKDDYNLPHDFICKHEFVLGGLKDDCDGQVKTLDVAKRLLDMGFHPPTVYFPLIVHEA
HHHCCCCCCCHHHHHCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LMVEPTETEPKQTLDAFVAAMKQIAQEARENKDILLEAPITTVVRRPDETEAAKNLILTF
HEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHCCCCHHHHHCCEEEEE
KKGE
ECCC
>Mature Secondary Structure 
AYNKLIFELSQPGRTGYKLPELDVEEKDNLIPEEFLSNEELDLPEVSEVDVVRHYTNLS
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHCCC
TLNFGVDTGMYPLGSCTMKYNPKINEEIVANPKLARLHPKQDDYQVQGALEAMYTLQKSL
EEEECCCCCCCCCCCEEEEECCCCCCHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
CEVSGMDYMTLQPAAGAHGEITAITIFKKYHEVNGNSEKNEIIVPDSAHGTNPATAAMAG
HHHCCCCEEEECCCCCCCCCEEEEEEEEHHHHCCCCCCCCEEECCCCCCCCCCHHHHHCC
YKVVEVKSNANGVVDVEDLRKVVNEKTAGLMLTNPNTLGLFETKIKEIAEIVHEAGGLLY
EEEEEEECCCCCCEEHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCEEE
YDGANANAILGHARPGDMGFDAIHFNVHKTFSTPHGGGGPGAGPVGVKKFLREYLPKPIV
ECCCCCCEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCC
EKDGDKYFLDYSMEHSIGRMKDFQGHFGILMRALTYILTMGSDGLKCASTTAVLNANYLQ
CCCCCEEEEEECHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEECCCEEEEECHHHH
AQLKDDYNLPHDFICKHEFVLGGLKDDCDGQVKTLDVAKRLLDMGFHPPTVYFPLIVHEA
HHHCCCCCCCHHHHHCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LMVEPTETEPKQTLDAFVAAMKQIAQEARENKDILLEAPITTVVRRPDETEAAKNLILTF
HEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHCCCCHHHHHCCEEEEE
KKGE
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA