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The map label for this gene is gcvPA [H]

Identifier: 169824161

GI number: 169824161

Start: 520972

End: 522318

Strand: Direct

Name: gcvPA [H]

Synonym: FMG_0464

Alternate gene names: 169824161

Gene position: 520972-522318 (Clockwise)

Preceding gene: 169824160

Following gene: 169824162

Centisome position: 28.98

GC content: 33.85

Gene sequence:

>1347_bases
ATGTATCCATACATCTCAGTTACTGATCAAGAAATTGAGGAAATGCTAAAAACAATTGGCATTTCCTCTCTAGATGAACT
ATATTCAGACGTTCCTGAAAATGTTCAATTTAAAGGCGAGTTAAATATTCCTAAAGCAAAAAGTGAAGAAGAAGTTAGAA
GATACTTCAAAGACATTTTTGCTAAGAACATATCTACTGATGATAAGGTTTGTTTCTTGGGTGGTGGAGCTTATGATAGA
TACGTTCCTTCAGTTATCCCAGCAATGGCAAGCAGAAGTGAATTCTACACTTCATATACACCTTACCAACCAGAAATAAG
CCAAGGTACTCTTTCCTATATTTTTGAATATCAAACAATGATGGCAAACCTTACTGGTATGCCAATATCAAACGCTTCTT
TATATGATGGTGGAACAGCTATCACAGAAGCAGCTTTGATGACTATCCAAAAGTCCAAAAAATCTAAAATTCTATGTGCT
GACACAGTTAGCCCTTCAGCAAAAGAAATATTGTTGACTTATTGTCACGATAGAGGAGTTGAAGTAGAATTTGTTCCTAT
GAAAGATTTATTAACAGATATGGACGAATTGGAAAAAATGATGACAGACGAAGTTGGTACAGTTATCGTTCAATCTCCAA
ACTATTACGGATATATCGAAGATGTTAAAAAATATGAAGAGTTGACTCACTCTATCAAGAAAAACTACTTGATTATGTCA
GCAGATCCAATGAGTTTAGGCTTATTAAAGAAACCATCTGAATACAACGTTGATGTTGTTGTAGGTGAAGCTCAACAATT
CGGAGTTAACTTACAATATGGTGGACCTTATTTAGGATATATGTGCTTTACTGATGAATTTGTTAGAAAATTCCCTGGCC
GTGTTGTAGGACAAACTACTGACGAAGACGGCAAGAGATCATTCGTTTTAACACTTTCAGCAAGAGAACAACACATTAAA
CGTGATAGAGCAACTTCAAATATCTGTTCTAACCAAGGCGTTAACTTACTTGCAGCAAGTATTTATTTATCACTTTTAGG
TAAAGCTGGTATTAAAGAAGTAGCAACTCAATCATTACAAAAAGCTCATTATCTATTTGACGAATTAAAGAAATTAGATA
AGGTTAAAGTTCTTAGTGAAAAACCATTCTTTGATGAATTCACTATCGGTTTTGACAAAGACACTGAAGAAGTTAAGAAA
GCATTATTTGATAAAGGATTCTTAGCTGGAATTAGCATTAAAGAAGCTACAAATGGATGTGGCAATGGTTTAATTATTGC
TGTAACTGAAAAGAGAACAAAAGAAGAAATGGATAATTTCGTAGCAGCAGTTAAGGAGGTATTATAA

Upstream 100 bases:

>100_bases
CTCCATATGAAAGCTGGATTGCTAAGGTTAAATTCGAAGACTTCGATGAATCTAAACTAATGAATGCTGATGAATACGAA
AAATTCTTAGGAGAATTATA

Downstream 100 bases:

>100_bases
TATGGCTTATAATAAGTTAATATTTGAATTATCACAACCAGGTAGAACTGGATATAAACTTCCTGAATTAGACGTAGAAG
AAAAAGATAACTTAATTCCT

Product: glycine dehydrogenase subunit

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MYPYISVTDQEIEEMLKTIGISSLDELYSDVPENVQFKGELNIPKAKSEEEVRRYFKDIFAKNISTDDKVCFLGGGAYDR
YVPSVIPAMASRSEFYTSYTPYQPEISQGTLSYIFEYQTMMANLTGMPISNASLYDGGTAITEAALMTIQKSKKSKILCA
DTVSPSAKEILLTYCHDRGVEVEFVPMKDLLTDMDELEKMMTDEVGTVIVQSPNYYGYIEDVKKYEELTHSIKKNYLIMS
ADPMSLGLLKKPSEYNVDVVVGEAQQFGVNLQYGGPYLGYMCFTDEFVRKFPGRVVGQTTDEDGKRSFVLTLSAREQHIK
RDRATSNICSNQGVNLLAASIYLSLLGKAGIKEVATQSLQKAHYLFDELKKLDKVKVLSEKPFFDEFTIGFDKDTEEVKK
ALFDKGFLAGISIKEATNGCGNGLIIAVTEKRTKEEMDNFVAAVKEVL

Sequences:

>Translated_448_residues
MYPYISVTDQEIEEMLKTIGISSLDELYSDVPENVQFKGELNIPKAKSEEEVRRYFKDIFAKNISTDDKVCFLGGGAYDR
YVPSVIPAMASRSEFYTSYTPYQPEISQGTLSYIFEYQTMMANLTGMPISNASLYDGGTAITEAALMTIQKSKKSKILCA
DTVSPSAKEILLTYCHDRGVEVEFVPMKDLLTDMDELEKMMTDEVGTVIVQSPNYYGYIEDVKKYEELTHSIKKNYLIMS
ADPMSLGLLKKPSEYNVDVVVGEAQQFGVNLQYGGPYLGYMCFTDEFVRKFPGRVVGQTTDEDGKRSFVLTLSAREQHIK
RDRATSNICSNQGVNLLAASIYLSLLGKAGIKEVATQSLQKAHYLFDELKKLDKVKVLSEKPFFDEFTIGFDKDTEEVKK
ALFDKGFLAGISIKEATNGCGNGLIIAVTEKRTKEEMDNFVAAVKEVL
>Mature_448_residues
MYPYISVTDQEIEEMLKTIGISSLDELYSDVPENVQFKGELNIPKAKSEEEVRRYFKDIFAKNISTDDKVCFLGGGAYDR
YVPSVIPAMASRSEFYTSYTPYQPEISQGTLSYIFEYQTMMANLTGMPISNASLYDGGTAITEAALMTIQKSKKSKILCA
DTVSPSAKEILLTYCHDRGVEVEFVPMKDLLTDMDELEKMMTDEVGTVIVQSPNYYGYIEDVKKYEELTHSIKKNYLIMS
ADPMSLGLLKKPSEYNVDVVVGEAQQFGVNLQYGGPYLGYMCFTDEFVRKFPGRVVGQTTDEDGKRSFVLTLSAREQHIK
RDRATSNICSNQGVNLLAASIYLSLLGKAGIKEVATQSLQKAHYLFDELKKLDKVKVLSEKPFFDEFTIGFDKDTEEVKK
ALFDKGFLAGISIKEATNGCGNGLIIAVTEKRTKEEMDNFVAAVKEVL

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=426, Percent_Identity=33.8028169014084, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI1789269, Length=395, Percent_Identity=31.6455696202532, Blast_Score=168, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17535605, Length=404, Percent_Identity=34.6534653465347, Blast_Score=204, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6323843, Length=397, Percent_Identity=35.5163727959698, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24645648, Length=405, Percent_Identity=34.0740740740741, Blast_Score=227, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 50191; Mature: 50191

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPYISVTDQEIEEMLKTIGISSLDELYSDVPENVQFKGELNIPKAKSEEEVRRYFKDIF
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHH
AKNISTDDKVCFLGGGAYDRYVPSVIPAMASRSEFYTSYTPYQPEISQGTLSYIFEYQTM
HHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHH
MANLTGMPISNASLYDGGTAITEAALMTIQKSKKSKILCADTVSPSAKEILLTYCHDRGV
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCC
EVEFVPMKDLLTDMDELEKMMTDEVGTVIVQSPNYYGYIEDVKKYEELTHSIKKNYLIMS
EEEEEEHHHHHCCHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEE
ADPMSLGLLKKPSEYNVDVVVGEAQQFGVNLQYGGPYLGYMCFTDEFVRKFPGRVVGQTT
CCCCCCCCCCCCCCCCEEEEEECHHHHCEEEEECCCEEEHHHHHHHHHHHCCCCEECCCC
DEDGKRSFVLTLSAREQHIKRDRATSNICSNQGVNLLAASIYLSLLGKAGIKEVATQSLQ
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
KAHYLFDELKKLDKVKVLSEKPFFDEFTIGFDKDTEEVKKALFDKGFLAGISIKEATNGC
HHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHCCCCEECEEHHHCCCCC
GNGLIIAVTEKRTKEEMDNFVAAVKEVL
CCCEEEEEECHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MYPYISVTDQEIEEMLKTIGISSLDELYSDVPENVQFKGELNIPKAKSEEEVRRYFKDIF
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHH
AKNISTDDKVCFLGGGAYDRYVPSVIPAMASRSEFYTSYTPYQPEISQGTLSYIFEYQTM
HHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHH
MANLTGMPISNASLYDGGTAITEAALMTIQKSKKSKILCADTVSPSAKEILLTYCHDRGV
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCC
EVEFVPMKDLLTDMDELEKMMTDEVGTVIVQSPNYYGYIEDVKKYEELTHSIKKNYLIMS
EEEEEEHHHHHCCHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEE
ADPMSLGLLKKPSEYNVDVVVGEAQQFGVNLQYGGPYLGYMCFTDEFVRKFPGRVVGQTT
CCCCCCCCCCCCCCCCEEEEEECHHHHCEEEEECCCEEEHHHHHHHHHHHCCCCEECCCC
DEDGKRSFVLTLSAREQHIKRDRATSNICSNQGVNLLAASIYLSLLGKAGIKEVATQSLQ
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
KAHYLFDELKKLDKVKVLSEKPFFDEFTIGFDKDTEEVKKALFDKGFLAGISIKEATNGC
HHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHCCCCEECEEHHHCCCCC
GNGLIIAVTEKRTKEEMDNFVAAVKEVL
CCCEEEEEECHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA